Journal
GENE
Volume 700, Issue -, Pages 85-95Publisher
ELSEVIER
DOI: 10.1016/j.gene.2019.02.066
Keywords
Breast cancer; miR-155-3p; MYD88; Cells apoptosis; Migration; Paclitaxel resistance
Categories
Funding
- Key Program of College Discipline (major) Top-notch Talent Academic Subsidize of Anhui [gxbjZD27, 2017H110]
- Major Program of Anhui Educational Committee [KJ2015ZD29, KJ2016SD37]
- Scientific Research Foundation of Bengbu Medical College [BYKY181OZD]
- Bengbu Municipal Scientific Research Key Projects [20150309]
- program for graduates research of Bengbu Medical College [Byycxz1615]
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MiR-155-3p, which is derived from the same pre-miRNA as miR-155-5p, the latter has been reported to be dysregulated in multiple tumor tissues and associated with clinicopathologic markers, tumor subtypes, and poor survival rates. However, the biological effects of miR-155-3p are rarely explored. In this study, we find that miR155-3p was down-regulated in breast cancer and MYD88 was validated as the target for miR-155-3p. Moreover, miR-155-3p showed a negative effect on apoptosis, invasion and metastasis, reverses paclitaxel resistance by suppression of the corresponding target gene MYD88 in vitro and in vivo experiments. Taking together, our studies suggest that miR-155-3p, which serve as a negative regulatory mechanism for breast cancer development. The mechanism further complicates the regulatory network in human breast cancer.
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