Review
Plant Sciences
Mutiu Idowu Kazeem, Habeeb Adebodun Bankole, Azeez Ayomide Fatai, Gbemisola Morounke Saibu, Adedoja Dorcas Wusu
Summary: Aloe is a commonly used medicinal plant for treating various conditions, including inflammation, infection, cancer, and diabetes mellitus. However, there is a lack of comprehensive reports on all Aloe species with antidiabetic properties. This review revealed that Aloe vera is the most common Aloe species with antidiabetic potentials.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Agriculture, Multidisciplinary
Jonatan Jafet Uuh-Narvaez, Elizabeth Negrete-Leon, Juan Jose Acevedo-Fernandez, Maira Rubi Segura-Campos
Summary: This study provides evidence on the potential health benefits of Mayan plant foods in lowering blood sugar levels, suggesting that these foods could contribute to the development of therapeutic diet strategies for diabetes prevention and treatment.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Xuefeng Wang, Yaozhu Fan, Feiran Xu, Jing Xie, Xiaoyu Gao, Lingfei Li, Yang Tian, Jun Sheng
Summary: In this study, a highly active hypoglycemic peptide, MoHpP-2, was identified from Moringa oleifera seed protein hydrolysates. MoHpP-2 was found to be a stable amphipathic peptide with a beta-turn structure and exhibited hypoglycemic activity by affecting the PI3K and AMPK pathways in HepG2 cells. Molecular docking analysis showed that MoHpP-2 interacted with alpha-glucosidase through hydrogen bonding and hydrophobic forces. Therefore, MoHpP-2 from M. oleifera seeds could be utilized to develop hypoglycemic functional foods.
Article
Biochemistry & Molecular Biology
Dolores G. Aguila-Munoz, Fabiola E. Jimenez-Montejo, Victor E. Lopez-Lopez, Aaron Mendieta-Moctezuma, Jorge Rodriguez-Antolin, Jorge Cornejo-Garrido, Maria C. Cruz-Lopez
Summary: This study evaluated the antihyperglycemic activity of Rumex crispus L. and found that the methanol extract inhibited alpha-glucosidase more effectively than other extracts. The methanol extract of the flowers showed the highest inhibition, and a bioactive fraction also demonstrated good alpha-glucosidase inhibition. In a preliminary study, R. crispus L. significantly reduced glucose levels and improved lipid, renal, and hepatic profiles in rats with diabetes, making it a potential auxiliary drug for diabetes treatment.
Article
Biochemistry & Molecular Biology
Apsara Kavital, M. B. Hiremath, A. H. M. Vishwanath Swamy, Santosh B. Patil
Summary: This research investigates the hypoglycemic activity of Syzygium cumini seed extracts using in vitro, in vivo, and in silico methods. The results show that the extracts are able to inhibit both alpha-amylase and alpha-glucosidase enzymes, suggesting their potential use in the management of diabetes mellitus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Hamza Mechchate, Imane Es-safi, Abdelhadi Louba, Ali S. Alqahtani, Fahd A. Nasr, Omar M. Noman, Muhammad Farooq, Mohammed S. Alharbi, Abdulaziz Alqahtani, Amina Bari, Hicham Bekkari, Dalila Bousta
Summary: The hydroethanolic extract of Withania frutescens demonstrated inhibitory effects on the activities of alpha-amylase and alpha-glucosidase, contributing to its potential in controlling and preventing postprandial hyperglycemia. Additionally, the extract showed long-term antidiabetic effects and protective effects on the liver and kidney in diabetic mice.
Article
Food Science & Technology
Kenia Leticia Ferreira Pessanha, Joao Paulo de Menezes, Andrea dos Anjos Silva, Marcus Vinicius da Silva Ferreira, Cristina Yoshie Takeiti, Carlos Wanderlei Piler Carvalho
Summary: Millet is a small gluten-free cereal originated from Africa, providing rich dietary fiber, vitamins, minerals, proteins, and phenolic compounds, making it suitable for producing whole grain bread. The use of extrusion increased the antioxidant capacity and enzymatic inhibition of millet flour.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Ren-Feng Li, Jian-Xing Yang, Jing Liu, Guo-Min Ai, Hui-Yan Zhang, Li-Yue Xu, Si-Bing Chen, Hong-Xin Zhang, Xiao-Liu Li, Zhi-Ran Cao, Ke-Rang Wang
Summary: The paper synthesized two positional isomeric perylene bisimide derivatives and studied their performance in glycosidase inhibition and hypoglycemic effects. PBI-4DNJ-1 exhibited potent hypoglycemic effects in mice, with the highest binding and hydrogen bond energy related to the isomeric effect on hypoglycemic activity. This work introduced a new approach to develop antihyperglycemic agents in the field of multivalent glycomimetics.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Food Science & Technology
Zhaohang Zuo, Weiqiao Pang, Wei Sun, Baoxin Lu, Liang Zou, Dongjie Zhang, Ying Wang
Summary: This study investigated the effects of the MT-kidney bean polyphenol complex on blood glucose levels and gut microbiota in rats with type 2 diabetes. The complex improved weight loss, increased blood glucose and lipids, and insulin resistance. It also alleviated damage to the pancreas and liver, increased short-chain fatty acid concentrations, and reversed gut microbiota dysbiosis.
Review
Pharmacology & Pharmacy
Prajakta H. H. Murudkar, Mukul S. S. Tambe, S. B. Chandrasekar, Bhavani Boddeda, Anil T. T. Pawar
Summary: Diabetes mellitus is a widely recognized endocrine disorder with various causes and life-threatening complications. Herbal remedies are becoming popular due to their lesser side effects and affordability. This study summarizes the commonly utilized polyherbal formulations in Ayurvedic, Chinese, and Unani medicinal systems for the management of diabetes mellitus, enhancing the existing knowledge of researchers.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Hanlei Wang, Kun Zhang, Xuelin Chen, Mei Han, Jing Lu, Yumei Zhang
Summary: This study evaluated the hypoglycemic effect of Ficus tikoua and explored its potential mechanisms. The results showed that Ficus tikoua extracts inhibited alpha-glucosidase activity, promoted glucose uptake, and improved blood glucose levels and islet damage in diabetic mice. The subfraction NBF2 exhibited stronger activity and promoted glucose uptake via the P13K/AKT and AMPK pathways.
Article
Food Science & Technology
Carmen Berraquero-Garcia, Fernando Rivero-Pino, J. Lizeth Ospina, Raul Perez-Galvez, F. Javier Espejo-Carpio, Antonio Guadix, Pedro J. Garcia-Moreno, Emilia M. Guadix
Summary: Food antidiabetic peptides inhibit key enzymes involved in glycemic index regulation and their activity and structural features have been extensively studied. In this work, the use of in silico analysis tools to predict the activity of DPP-IV-inhibitory peptides is evaluated, along with the potential degradation of active peptides during digestion. This study contributes to our understanding of the structure-activity relationship and stability of antidiabetic peptides.
Article
Spectroscopy
Mohammad Ezati, Fahimeh Ghavamipour, Hadi Adibi, Khadijeh Pouraghajan, Seyed Shahriar Arab, Reza H. Sajedi, Reza Khodarahmi
Summary: Curcumin has an important role in preventing various diseases, including diabetes. In this study, curcumin-fused aldohexose derivatives were synthesized and found to inhibit two enzymes related to hyperglycemia. Spectral analysis confirmed the formation of the target compounds. In vivo studies showed that one of the compounds could lower blood glucose levels in rats.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Applied
Lizma Febrina, Nizar Happyana, Yana Maolana Syah
Summary: The study evaluated the metabolite profiles of civet coffees and found that they exhibited higher anti-diabetic activity and unique metabolomes compared to regular coffee.
Article
Plant Sciences
Ozair Alam, Sameena Naaz, Vrinda Sharma, Ajay Manaithiya, Jalaluddin Khan, Afshar Alam, Kahksha
Summary: Gymnema species in traditional herbal medicine have various therapeutic activities, including anti-diabetic, anti-inflammatory, anti-bacterial functions, etc. This review analyzed recent studies on the anti-diabetic potential of traditional Gymnema species. Gymnema sylvestre, the most studied species, contains pharmacologically active compounds that play a crucial role in diabetes treatment. Other Gymnema species also exhibit similar pharmacological actions.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Viviane O. Almeida, Aline M. Pascoal, Mayara C. Ferreira, Ricardo R. Morais, Moemy G. Moraes, Karla A. Batista, Katia F. Fernandes
FOOD HYDROCOLLOIDS
(2020)
Article
Environmental Sciences
Josemar Goncalves de Oliveira Filho, Juliana Moraes Rodrigues, Anna Carolina Fernandes Valadares, Adrielle Borges de Almeida, Erika Valencia-Mejia, Katia Flavia Fernandes, Ailton Cesar Lemes, Cassia Cristina Fernandes Alves, Heloisa Alves de Figueiredo Sousa, Edilsa Rosa da Silva, Mariana Buranelo Egea, Fabio Henrique Dyszy
Summary: This study successfully produced protein hydrolysates with antioxidant and antibacterial activities from cottonseed byproduct through the selection of proteolytic enzymes and thermal treatment. The hydrolysates showed higher antioxidant activity and ACE inhibition when produced using Alcalase (R), and were able to inhibit the growth of specific pathogens such as Colletotrichum gloeosporioides and Staphylococcus aureus.
WASTE AND BIOMASS VALORIZATION
(2021)
Article
Food Science & Technology
Bruna R. Moreira, Marcos A. Pereira-Junior, Katia F. Fernandes, Karla A. Batista
Article
Biochemistry & Molecular Biology
Viviane O. Almeida, Maria C. B. Di-Medeiros, Karla A. Batista, Moemy G. Moraes, Katia F. Fernandes
Summary: The study evaluated the starches from underground stems of Trimezia Pont-Vona under different environmental conditions. Results showed that the starch properties varied with phenological status, with changes in yield, amylose content, DP values, and crystallinity. The adaptive strategies involving morphological and physicochemical properties of starch granules in response to drought stress and sprouting were observed in T. juncifolia underground stems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Bruna M. Miranda, Maria C. B. Di-Medeiros, Karla A. Batista, Elaine R. Carbonero, Katia F. Fernandes, Flavio A. Silva
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Physical
Cassio Nazareno Silva da Silva, Maria Carolina Bezerra Di-Medeiros, Luciano Morais Liao, Katia Flavia Fernandes, Karla de Aleluia Batista
Summary: The study focused on developing cashew gum polysaccharide nanoparticles grafted with polypropylene glycol as carriers for diclofenac sodium. The optimized formulation showed efficient entrapment of diclofenac and sustained release for up to 68 hours. The physicochemical characterization indicated that the nanoparticles have a globular shape with smooth surfaces and are effective in loading and releasing drugs with similar structures to diclofenac sodium.
Article
Biology
H. S. C. Paula, S. B. Santiago, L. A. Araujo, C. F. Pedroso, T. A. Marinho, I. A. J. Goncalves, T. A. P. Santos, R. S. Pinheiro, G. A. Oliveira, K. A. Batista
Summary: The lack of effective and specific treatment for COVID-19 has led to the testing of various drugs, including antibiotics, with therapeutic potential. Although antibiotics do not directly treat viral infections, they are used against secondary bacterial infections. However, there are concerns about the potential increase in antimicrobial resistance due to the widespread use of antibiotics in COVID-19 treatment.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Chemistry, Applied
Bruna M. Miranda, Viviane O. Almeida, Karla A. Batista, Katia F. Fernandes, Flavio A. Silva
Summary: In this study, the functional properties of a galactose-rich heteropolysaccharide (GH) were investigated. GH exhibited antioxidant activity and favorable emulsion properties, making it a promising polysaccharide for food applications.
FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Erika Valencia-Mejia, Yeli Y. Leon-Wilchez, Juan L. Monribot-Villanueva, Monica Ramirez-Vazquez, Israel Bonilla-Landa, Jose A. Guerrero-Analco
Summary: In this study, the antifungal activity of the crude extract and fractions of Cestrum nocturnum against Fusarium solani and F. kuroshium was investigated. The isolated compound, pennogenin tetraglycoside, showed significant antifungal activity against F. kuroshium, which is the first plant natural product reported to be active against this phytopathogen. This finding is of great importance for managing Fusarium dieback, a plant disease affecting numerous species including avocado.
Article
Multidisciplinary Sciences
Rafael Alves Guimaraes, Gabriela Moreira Policena, Hellen da Silva Cintra de Paula, Charlise Fortunato Pedroso, Raquel Silva Pinheiro, Alexander Itria, Olavo de Oliveira Braga Neto, Adriana Melo Teixeira, Irisleia Aires Silva, Geraldo Andrade de Oliveira, Karla de Aleluia Batista
Summary: The COVID-19 pandemic has led to a significant decrease in hospital admissions for NCDs in Brazil, with a decrease of 27.0%. This decrease was observed for all types of NCDs, including cancer, diabetes mellitus, cardiovascular diseases, and chronic respiratory diseases. The decrease in hospital admissions was seen across all age groups, sexes, and regions of Brazil, with the Northern and Southern regions experiencing the largest decrease.
Article
Chemistry, Applied
Ladyslene C. Paula, Ailton C. Lemes, Erika Valencia-Mejia, Bruna R. Moreira, Thiago S. Oliveira, Ivan T. N. Campos, Hiasmin F. S. Neri, Claudio Brondani, Paulo C. Ghedini, Karla A. Batista, Katia F. Fernandes
Summary: This study evaluated the effect of hardening on the biological potential of bean protein and peptides, and found that hardening reduced the antioxidant activity but had minimal impact on vascular reactivity. Thermal treatment increased the antioxidant and vasorelaxant potential of these fractions. Hardening did not definitively affect the bioactivity of the obtained peptide-rich fractions.
Article
Biochemistry & Molecular Biology
Jose A. Guerrero-Analco, Diana L. Murrieta-Leon, Stefany Licona-Velazquez, Juan L. Monribot-Villanueva, Luis A. Ibarra-Juarez, Guadalupe Hernandez-Cervantes, Monica Ramirez-Vazquez, Oscar Carmona-Hernandez, Jose A. Lozada-Garcia, Efrain Pucheta-Fiscal, Yeli Y. Leon-Wilchez, Jose A. Martinez-Viveros, Erika Valencia-Mejia
Summary: This study evaluated the antifungal and insecticidal activities of 34 extracts from 27 plant species against Fusarium phytopathogens and Xyleborus Scolytine ambrosia beetles. The results showed that 16 extracts exhibited significant mycelial growth inhibition against F. solani, with the highest activities observed in extracts from S. nudum and M. argyrophylla. Moreover, 13 extracts showed antifungal activity against F. kuroshium, with the highest activities observed in extracts from C. nocturnum and M. argyrophylla. Ten extracts also caused mortality in at least one of the tested beetle species, mainly from Solanaceae species. In addition, 39 phenolic compounds were identified in the most active species, which may contribute to their biological effects against the causative agents of Fusarium dieback and laurel wilt.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Medicinal
Daiany Priscilla Bueno da Silva, Iziara Ferreira Florentino, Lorrane Kelle da Silva Moreira, Carina Sofia Cardoso, James Oluwagbamigbe Fajemiroye, Paulo Cesar Ghedini, Murion Monteiro de Godoi, Fernanda Cristina Alcantara dos Santos, Karla de Aleluia Batista, Marcos Antonio Pereira-Junior, Katia Flavia Fernandes, Boniek Gontijo Vaz, Marcella Rodrigues Ferreira, Elson Alves Costa
Summary: The study investigated the antinociceptive and anti-inflammatory activities of a polysaccharide-free extract of cashew gum in a chronic model of complete Freund's adjuvant-induced arthritis. Results showed significant therapeutic potential of the extract, supporting its use in developing new analgesic and anti-inflammatory drugs in the future.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2021)
Article
Biology
D. Graziani, J. V. V. Ribeiro, V. S. Cruz, R. M. Gomes, E. G. Araujo, A. C. M. Santos Junior, H. C. M. Tomaz, C. H. Castro, W. Fontes, K. A. Batista, K. F. Fernandes, C. H. Xavier
Summary: The study found that PV3 peptides extracted from low-commercial-value beans have little cytotoxicity, exert antioxidant effects, and increase NO release in endothelial cells.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)
