Article
Nutrition & Dietetics
Bartosz Fotschki, Ewelina Cholewinska, Katarzyna Ognik, Michal Sojka, Joanna Milala, Joanna Fotschki, Wieslaw Wiczkowski, Jerzy Juskiewicz
Summary: The required amount of berry polyphenols for health benefits is difficult to achieve through fresh fruit consumption, suggesting polyphenol-rich extracts as a dietary alternative. This study fed rats high-fat diets supplemented with 0.1 or 0.3% raspberry polyphenols and found that the higher dose of extract had more noticeable health-promoting effects, including reduced white adipose tissue weight, hepatic triglyceride content, and plasma IL-6 concentration, as well as increased acetic acid concentration in the cecal digesta. The enhanced content of ellagitannin and anthocyanin metabolites in the blood plasma of rats administered the high dose extract may partially explain these effects.
Article
Biochemistry & Molecular Biology
Ning Jin, Shouyu Zhang, Shibo Sun, Minghuo Wu, Xiaojing Yang, Jianqiang Xu, Kun Ma, Shui Guan, Weiping Xu
Summary: This study developed an efficient method for the recovery of ellagic acid from raspberry wine pomace. By using sodium bicarbonate assisted extraction, the yield of ellagic acid and its antioxidant activity were significantly improved.
Article
Pharmacology & Pharmacy
Nina A. Hering, Julia Luettig, Britta Jebautzke, Jorg D. Schulzke, Rita Rosenthal
Summary: The study found that ellagic acid and urolithin A affect intestinal barrier function in distinct ways, with ellagic acid acting preventively by strengthening the barrier per se and urolithin A protecting against inflammation-induced barrier dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Food Science & Technology
Deming Looi, Mohanambal Moorthy, Nathorn Chaiyakunapruk, Uma Devi Palanisamy
Summary: The consumption of ellagitannin-rich fruits may have a significant effect in reducing diastolic blood pressure, especially in patients with hypertension and metabolic syndrome. There is a positive correlation between polyphenol dosage and changes in systolic blood pressure.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Physical
Elham Yadollahi, Behzad Shareghi, Sadegh Farhadian, Fatemeh Hashemi Shahraki
Summary: This study investigates the interaction between trypsin and ellagic acid through various techniques. The results demonstrate that ellagic acid interacts with trypsin, leading to conformational and functional changes in the enzyme.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Medicinal
Fahimeh Zamani-Garmsiri, Solaleh Emamgholipour, Soheil Rahmani Fard, Ghasem Ghasempour, Roya Jahangard Ahvazi, Reza Meshkani
Summary: Polyphenols have potential benefits in health status, especially in obesity-related metabolic disorders, but further high-quality research is needed to establish their clinical efficacy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Environmental Sciences
Ashley Mulcahy Toney, Mahaa Albusharif, Duncan Works, Luke Polenz, Stacie Schlange, Virginia Chaidez, Amanda E. Ramer-Tait, Soonkyu Chung
Summary: Red raspberry polyphenols and their metabolite urolithin A have differential effects on neuroprotection, impacting microglial responses under various inflammatory conditions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Agriculture, Multidisciplinary
Jose M. Villalgordo, Laura Trulli, Rocio Garcia-Villalba, Victor Garcia, Yusuf Althobaiti, Francisco A. Tomas-Barberan
Summary: Urolithins are human gut microbiota metabolites produced from ellagic acid. They are better absorbed than ellagic acid and have biological activities that may be responsible for the health effects observed after consuming foods containing ellagitannins and ellagic acid. This study successfully synthesized urolithin glucuronide conjugates and characterized their properties.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Applied
Yat-Tin Chan, Jiating Huang, Ho-Ching Wong, Jun Li, Danyue Zhao
Summary: Polyphenols, present in plant-based foods, have various health benefits but are poorly absorbed. The colon, where most polyphenols are metabolized into more bioavailable compounds, plays a critical role in realizing the health benefits. This study explored the interactions between polyphenols and gut microbiota from different sources. By characterizing black raspberry polyphenols, anaerobic fermentations were conducted with microbiota from humans, rats, mice, and infants to compare the phenolic profile and microbiota composition. Bioinformatics analysis revealed unique interactions between polyphenols and gut microbiota, identifying potential bacterial species for producing bioactive and bioavailable phenolic metabolites.
Review
Food Science & Technology
Lidija Jakobek, Christopher Blesso
Summary: This paper reviews the current understanding of the beneficial effects of native phenolic compounds and their metabolites on the health of the digestive system, including gastrointestinal and urinary tract disorders and liver health. The studies mainly link the benefits in the gastrointestinal and urinary tract to whole foods rich in phenolics or the amount of phenolic compounds/antioxidants in food. However, the bioactivity of parent phenolic compounds in the digestive tract and their impact on gut microbiota should not be ignored. The influence of metabolites and catabolites may be more important for the liver and urinary tract.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Alessandro Ratti, Enrico M. A. Fassi, Fabio Forlani, Matteo Mori, Federica Villa, Francesca Cappitelli, Jacopo Sgrignani, Gabriella Roda, Andrea Cavalli, Stefania Villa, Giovanni Grazioso
Summary: Bacterial biofilm is a major cause of persistent infection and antibiotic resistance. This study investigates the antibiofilm properties and mode of action of ellagic acid (EA), a natural polyphenol. The researchers propose that EA disrupts the bacterial redox homeostasis mediated by the NADH:quinone oxidoreductase enzyme WrbA, leading to its antibiofilm activity. These findings provide new insights into the potential use of EA for treating biofilm-related infections.
Article
Engineering, Environmental
Angeles Trujillo-Reyes, Erika Sinisgalli, Juan Cubero-Cardoso, Ana G. G. Perez, Antonio Serrano, Rafael Borja, Fernando G. G. Fermoso
Summary: This study investigates the direct effect of different mechanical treatments on the chemical composition and anaerobic digestion of lignocellulosic substrates. The results show that mechanical treatments can increase the solubilisation of substrates, resulting in enhanced anaerobic digestion.
Review
Biochemistry & Molecular Biology
Ralitza Alexova, Simona Alexandrova, Stela Dragomanova, Reni Kalfin, Ayten Solak, Sidharth Mehan, Maria Cristina Petralia, Paolo Fagone, Katia Mangano, Ferdinando Nicoletti, Lyubka Tancheva
Summary: Pomegranate is a rich source of polyphenols that have anti-inflammatory and antioxidant activity, and can support the immune system during viral infection and recovery. Studies have shown that pomegranate polyphenol extract and its components can control immune cell infiltration, regulate cytokine secretion, inhibit viruses like SARS-CoV-2, and modulate the NF-κB pathway. Further research is needed to understand the interactions between polyphenols, viruses, and the host immune response.
Article
Food Science & Technology
Wenjing Lu, Meng Xu, Youwei Yuan, Xuemei Zhang, Jianxin Tan, Junping He, Yiling Tian
Summary: The study found that raspberry extract and ellagic acid have similar antioxidant capacities and equivalent cell proliferation-promoting capabilities. In the mouse test, raspberry extract effectively promoted a reduction in wound area.
FOOD QUALITY AND SAFETY
(2021)
Article
Chemistry, Organic
Francesc Navarro, Salha Hamri, Rosa Reches, Miquel Vinas, Daniel Jahani, Jaume Ginard, Josep Vilardell, Olga Abian, M. Dolors Pujol
Summary: Researchers have successfully synthesized ellagic acid from methyl gallate through a five-step synthetic route with a 38% overall yield. The synthesis involves ketal protection, regioselective bromination, bis-lactonization, C-C bond formation between the aromatic rings of the galloyl groups, and ketal deprotection. Ellagic acid exhibits slight inhibitory activity against SARS-CoV-2 3CLpro.
SYNTHESIS-STUTTGART
(2023)
Article
Biochemistry & Molecular Biology
Bartosz Fotschki, Katarzyna Ognik, Joanna Fotschki, Dorota Napiorkowska, Ewelina Cholewinska, Magdalena Krauze, Jerzy Juskiewicz
Summary: The study investigated the effects of chromium supplementation and switching dietary habits on lipid metabolism, inflammation, and oxidative stress in Wistar rats. The combination of chromium nanoparticles and dietary changes showed the strongest reduction in fat content and cholesterol in the liver. This combination also had favorable antioxidative effects. Supplementation with chromium nanoparticles alone also improved lipid metabolism and oxidative stress, although to a lesser extent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Joanna Fotschki, Anna M. M. Ogrodowczyk, Barbara Wroblewska, Jerzy Juskiewicz
Summary: The vegetable processing industry generates large amounts of by-products that are susceptible to microbial degradation. Inadequate management leads to the loss of valuable compounds in vegetable by-products. Scientists are exploring the possibility of reusing discarded biomass to create higher value products. The by-products contain bioactive compounds with health-promoting properties. This review emphasizes the importance of these by-products in promoting health through their impact on the microbiota, immune system, and gut milieu.
Article
Nutrition & Dietetics
Ewelina Cholewinska, Aleksandra Marzec, Przemyslaw Solek, Bartosz Fotschki, Piotr Listos, Katarzyna Ognik, Jerzy Juskiewicz
Summary: The aim of this study was to investigate the effects of different types of dietary fibre (cellulose, inulin, pectin, and psyllium) in combination with recommended or enhanced levels of CuNPs on selected biological parameters of intestinal integrity in rats. The results showed that replacing CuCO3 with CuNPs in the diet reduced lactic acid and apoptosis markers levels in the small intestine, but it also increased DNA oxidation. Inulin had the most beneficial effect on DNA repair mechanisms, while pectin had the highest ability to inhibit inflammatory processes and apoptotic cell death in the small intestine. These findings suggest that dietary fibre supplementation can protect the small intestine against oxidative effects of CuNPs by enhancing the intestinal barrier.
Article
Biochemistry & Molecular Biology
Monika Cendrowska-Pinkosz, Magdalena Krauze, Jerzy Juskiewicz, Bartosz Fotschki, Katarzyna Ognik
Summary: The aim of this study is to evaluate the effect of different forms and dosages of copper on neurodegenerative markers in the brain and jejunum. The experiment involved feeding male Wistar rats a rat diet with two CuCO3 dosages and two CuNP dosages. Nanoparticles reduced the level of GAChE, increased the levels of AChE and LRP1, and decreased β-amyloid and Tau protein in both the brain and intestine of rats. The highest levels of beneficial markers and lowest levels of toxic markers were observed in rats receiving a standard dose of Cu.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Michal Majewski, Leszek Gromadzinski, Ewelina Cholewinska, Katarzyna Ognik, Bartosz Fotschki, Jerzy Juskiewicz
Summary: This study aimed to investigate the effects of dietary fiber supplementation with different types of nanoparticles on the cardiovascular system in rats. The results showed that compared to pectin, inulin and psyllium supplementation with a standard dose of copper nanoparticles improved antioxidant capacity and reduced heart malondialdehyde levels. Furthermore, with an enhanced dose of copper nanoparticles, inulin and psyllium enhanced vasodilation through up-regulation of COX-2-derived vasodilator prostanoids.
Article
Nutrition & Dietetics
Jerzy Juskiewicz, Katarzyna Ognik, Joanna Fotschki, Dorota Napiorkowska, Ewelina Cholewinska, Katarzyna Grzelak-Blaszczyk, Magdalena Krauze, Bartosz Fotschki
Summary: This study assessed the changes in faecal microbial activity in obese rats fed high-fat or low-fat diets supplemented with different forms of chromium. The results showed that switching from a high-fat to a low-fat diet had beneficial effects, and supplementing with chromium nanoparticles further modulated microbial activity.
Article
Nutrition & Dietetics
Bartosz Fotschki, Michal Sojka, Monika Kosmala, Jerzy Juskiewicz
Summary: Previous studies have shown that dietary supplementation with prebiotic fructooligosaccharides (FOSs) and polyphenols can alleviate disorders related to the early stage of nonalcoholic fatty liver disease (NAFLD). This experiment aimed to investigate whether raspberry polyphenols together with FOSs can regulate advanced-stage NAFLD in genetically obese Zucker rats. The results showed that the addition of FOSs and raspberry polyphenolic extract to the diet reduced liver fat accumulation, improved antioxidant potential, lowered plasma enzyme activities, and increased insulin sensitivity. These effects may be attributed to the upregulation of specific receptors in the liver responsible for regulating lipid metabolism and glucose and bile acid synthesis.
Article
Nutrition & Dietetics
Bartosz Fotschki, Katarzyna Ognik, Ewelina Cholewinska, Katarzyna Grzelak-Blaszczyk, Kamil Myszczynski, Magdalena Krauze, Jerzy Juskiewicz
Summary: This study aimed to investigate the effects of supplementation with chromium nanoparticles (Cr-NPs) on the gut microenvironment in rats fed a high-fat diet. The results showed that Cr-NPs mainly acted by altering the activity of gut microbiota, leading to decreased concentration of short-chain fatty acids and increased level of cecal lithocholic acid. Switching to a low-fat diet had a more significant impact on obesity-related disorders, improving microbial activity, composition, and the production of short-chain fatty acids.
Article
Agriculture, Dairy & Animal Science
Janusz Strychalski, Dorota Kowalska, Slawomir Grinholc, Jerzy Juskiewicz, Bartosz Fotschki, Andrzej Gugolek
Summary: The study found that dietary supplementation with black cumin seed meal had no significant impact on the growth performance of rabbits but reduced coccidia oocyst counts in adult rabbit feces. It also decreased the presence of putrefactive compounds and intestinal viscosity, as well as increased liver weight and plasma albumin levels.
ANNALS OF ANIMAL SCIENCE
(2023)
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)