Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 90, Issue -, Pages 349-362Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2019.04.300
Keywords
Acquired immune response; Fish IgM; Sparus aurata; Enteromyxum leei; Parasite resistance; Gene expression
Funding
- EU H2020 program
- Spanish Ministry of Economy and Competitiveness through ParaFishControl [634429, AGL-2013-48560-R]
- Generalitat Valenciana [APOSTD/2016/037]
- CSIC PIE project [201740E013]
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The myxozoan parasite Enteromyxum leei causes chronic enteritis in gilthead sea bream (GSB, Sparus aurata) leading to intestinal dysfunction. Two trials were performed in which GSB that had survived a previous infection with E. leei (SUR), and naive GSB (NAI), were exposed to water effluent containing parasite stages. Humoral factors (total IgM and IgT, specific anti-E. leei IgM, total serum peroxidases), histopathology and gene expression were analysed. Results showed that SUR maintained high levels of specific anti-E. leei IgM (up to 16 months), expressed high levels of immunoglobulins at the intestinal mucosa, particularly the soluble forms, and were resistant to re-infection. Their acquired-type response was complemented by other immune effectors locally and systemically, like cell cytotoxicity (high granzyme A expression), complement activity (high c3 and fucolectin expression), and serum peroxidases. In contrast to NAI, SUR displayed a post-inflammatory phenotype in the intestine and head kidney, characteristic of inflammation resolution (low il1 beta, high il10 and low hsp90 alpha expression).
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