Review
Biochemistry & Molecular Biology
Alessandro Conforti, Salvatore Longobardi, Luigi Carbone, Giuseppe Gabriele Iorio, Federica Cariati, Maria Rosaria Campitiello, Ida Strina, Michela Palese, Thomas D'Hooghe, Carlo Alviggi
Summary: Intrauterine injection of human chorionic gonadotropin (hCG) may have a promising effect on improving embryo implantation in IVF, especially in women undergoing cleavage-stage embryo transfer. However, caution should be exercised in interpreting these results due to the lack of data on live birth rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Zhijin Hou, Fangjie Jiang, Jie Yang, Yang Liu, Hao Zha, Xiaoling Yang, Jia Bie, Yushi Meng
Summary: In this systematic review and meta-analysis, it was found that G-CSF administration via subcutaneous injection or intrauterine infusion during both fresh and frozen embryo transfer cycles for RIF patients can improve the clinical pregnancy rate. However, the effectiveness of G-CSF in improving livebirth rates of RIF patients remains uncertain and further research is recommended.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Obstetrics & Gynecology
Yaling Xiao, Xue Wang, Ting Gui, Tao Tao, Wei Xiong
Summary: In comparison with single good-quality embryo transfer, double embryo transfer of one good-quality embryo and one poor-quality embryo does not significantly affect the pregnancy rate but increases the rate of multiple pregnancies and multiple births.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Karim S. Abdallah, Ahmad Makhlouf, Esraa Badran, Ihab M. El-Nashar, Tarek K. Al-Hussaini, Tarek Farghaly, Hazem S. Mohamed, Ben W. Mol, Ahmed M. Abdelmagied
Summary: The study did not find a significant improvement in live birth rates with intrauterine administration of HCG before embryo transfer in women undergoing IVF, although a smaller, clinically important difference could not be ruled out. Treatment outcomes in the control group were lower than expected.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Endocrinology & Metabolism
Zhonghua Zhao, Yan Chen, Hongxia Deng, Lu Huang, Danhua Lu, Xiaoyang Shen, Liangzhi Xu
Summary: A systematic review and meta-analysis found that the stage of embryo transfer had a significant impact on obstetric and perinatal outcomes in programmed frozen-thawed embryo transfer (FET) and natural FET cycles. Programmed FET cycles had higher risks of hypertensive disorders of pregnancy, gestational hypertension, preeclampsia, gestational diabetes mellitus, large for gestational age, macrosomia, preterm delivery, placenta previa, postpartum haemorrhage, and preterm premature rupture of membranes compared to natural FET cycles with overall embryo transfer and blastocyst transfer. However, there were no clear differences in outcomes between programmed FET cycles and natural FET cycles with cleavage-stage embryo transfer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Xiangfei Wang, Ruolin Mao, Meng Wang, Rui Long, Lei Jin, Lixia Zhu
Summary: This meta-analysis investigates the impact of recryopreservation on embryo viability and the outcomes of in vitro fertilization (IVF). The findings suggest that recryopreservation can result in decreased embryo survival, clinical pregnancy rates, and live birth rates compared to single cryopreservation.
FERTILITY AND STERILITY
(2023)
Article
Reproductive Biology
Eduardo Antonio de Almeida Rossignolo, Nathalia Covre da Silva, Rafael Luiz Stolf, Fabio Luiz Bim Cavalieri, Antonio Hugo Bezerra Colombo, Marcia Aparecida Andreazzi, Marcelo Marcondes Seneda, Fabio Morotti
Summary: This study compared the reproductive performance of embryo recipients treated with hCG or eCG. The results showed that nulliparous recipients treated with hCG had lower conception and pregnancy rates but higher estrus intensity and CL quality.
Review
Obstetrics & Gynecology
Sara J. Bergenheim, Marte Saupstad, Nina Pistoljevic, Anders Nyboe Andersen, Julie Lyng Forman, Kristine Lossl, Anja Pinborg
Summary: The number of frozen embryo transfer cycles in Europe has been steadily increasing, with immediate FET potentially leading to higher live birth and pregnancy rates compared to postponed FET. However, more high-quality evidence from randomized controlled trials is needed to confirm these findings and determine the best clinical practice.
HUMAN REPRODUCTION UPDATE
(2021)
Review
Obstetrics & Gynecology
K. T. Y. Wong, K. R. Carson, J. M. G. Crane
Summary: In vitro methods of conception are associated with an increased risk of stillbirth in singleton gestations, but the baseline risk is low. Subgroup analysis did not demonstrate an increased risk when comparing in vitro methods to non-in vitro methods in the context of subfertility.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Endocrinology & Metabolism
Shujuan Ma, Yangqin Peng, Liang Hu, Xiaojuan Wang, Yiquan Xiong, Yi Tang, Jing Tan, Fei Gong
Summary: By conducting a systematic review and meta-analysis, sufficient evidence was gathered to support the use of single embryo transfer (SET) as an effective method for reducing multiple pregnancy rates compared to double embryo transfer (DET). However, it was also found that SET may decrease live birth rates for women with a defined embryo quality or advanced age.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Review
Genetics & Heredity
Yanan Chang, Minghong Shen, Sha Wang, Xiao Li, Hua Duan
Summary: This study conducted a systematic review and meta-analysis to evaluate the reproductive outcomes of frozen embryo transfer compared with fresh embryo transfer in women with endometriosis. The analysis included six studies and found that frozen embryo transfer resulted in a higher frequency of live births and a lower miscarriage rate compared to fresh embryo transfer. However, more research is needed to provide more robust evidence.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Reproductive Biology
M. Besbaci, A. Abdelli, I. Belabdi, D. Raboisson
Summary: The meta-analysis showed that the use of NSAIDs at the time of embryo transfer can improve pregnancy rates in cows, especially those experiencing difficulties during the process. However, further research is needed to analyze the influence of factors such as NSAID molecules, COX inhibitor type, and embryo processing on the relationship between NSAIDs and pregnancy rates.
Review
Endocrinology & Metabolism
Yangqin Peng, Shujuan Ma, Liang Hu, Xiaojuan Wang, Yiquan Xiong, Minghong Yao, Jing Tan, Fei Gong
Summary: This study compared the outcomes of two consecutive cycles of single embryo transfer (2SETs) with one cycle of double embryo transfer (DET) and found that 2SETs had a similar cumulative live birth rate but a lower cumulative multiple birth rate, and improved maternal and neonatal adverse outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Ruxin Wang, Haixia Huang, Yong Tan, Guicheng Xia
Summary: This study aimed to explore the efficacy of atosiban on pregnancy outcomes in patients with repeated embryo implantation failure who underwent in vitro fertilization-embryo transfer (IVF-ET). A systematic search of English and Chinese databases found that atosiban was associated with a higher clinical pregnancy rate in patients with repeated implantation failure. However, more thorough and larger prospective randomized controlled studies are needed to confirm this conclusion.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Roberto Matorras, Jose Ignacio Pijoan, Irantzu Perez-Ruiz, Lucia Lainz, Iker Malaina, Sonia Borjaba
Summary: Immediate frozen embryo transfer after ovarian stimulation may lead to a higher biochemical pregnancy rate and a non-significant trend towards better clinical pregnancy rate compared to delaying the transfer by at least one cycle. This approach also helps to avoid prolonging stress on prospective parents.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Mingxia Gao, Chong Cao, Xuehong Zhang, Fabing Tang, Lihui Zhao, Sisi Luo, Lifei Li
GYNECOLOGICAL ENDOCRINOLOGY
(2019)