Journal
FERTILITY AND STERILITY
Volume 111, Issue 6, Pages 1065-1075Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2019.03.015
Keywords
PCOS; offspring; growth; neurodevelopment; cardiometabolic health
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Maternal PCOS status may negatively influence offspring infant and childhood growth, cardiometabolic health, reproductive health, and neurodevelopment. Current findings across studies are divergent, often because of small numbers of subjects, as well as heterogeneous selection criteria, ethnicities, and definitions of control groups. Coexisting maternal obesity, pregnancy complications, and comorbidity make it difficult to identify the contribution of maternal PCOS. Large, prospective, international, multiethnic studies with standardized investigation protocols and questionnaires on PCOS offspring health and development are needed. ((C) 2019 by American Society for Reproductive Medicine.)
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