Article
Agriculture, Dairy & Animal Science
Aiyun Xu, Xiang Zhu, Tao Song, Zhenyuan Zhang, Fei Fei, Qingxiao Zhu, Xinyue Chang, Hongmei Liu, Fangfang Chen, Fazhi Xu, Lin Li, Xuelan Liu
Summary: In this study, chicken mitochondrial-targeted NLRX1 protein was identified. It was found to negatively regulate type-I interferon production by attenuating the STING-TBK1 interaction. This finding is important for understanding the innate immune response in chickens.
Article
Multidisciplinary Sciences
Annemarie Steiner, Katja Hrovat-Schaale, Ignazia Prigione, Chien-Hsiung Yu, Pawat Laohamonthonkul, Cassandra R. Harapas, Ronnie Ren Jie Low, Dominic De Nardo, Laura F. Dagley, Michael J. Mlodzianoski, Kelly L. Rogers, Thomas Zillinger, Gunther Hartmann, Michael P. Gantier, Marco Gattorno, Matthias Geyer, Stefano Volpi, Sophia Davidson, Seth L. Masters
Summary: Deficiency in COPI complex I may lead to aberrant activation of the STING pathway and inflammatory diseases, with cGAS possibly being the upstream immune sensor driving this process. Targeted inhibition of the cGAS/STING pathway can alleviate inflammation in diseases such as COPA syndrome.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Zhonghua Gao, Zhongguo Gao, Hao Zhang, Shoubo Hou, Yunhua Zhou, Xiangjie Liu
Summary: The cGAS-STING signaling pathway detects dsDNA to trigger innate immune responses and has emerged as a critical mediator of inflammation. Activating the STING/IFN-beta pathway reduces bone resorption, while activation of STING/NF-kappa B increases bone resorption and decreases bone formation, leading to osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Genevieve Trombly, Afaf Milad Said, Alexei P. Kudin, Viktoriya Peeva, Janine Altmueller, Kerstin Becker, Karl Koehrer, Gabor Zsurka, Wolfram S. Kunz
Summary: The study investigated the effects of hydrogen peroxide on mitochondrial DNA integrity. The results showed that hydrogen peroxide treatment resulted in DNA breaks, which were then repaired through rapid repair of single-strand breaks and degradation of double-strand breaks-generated linear fragments. Inactivation of mitochondrial DNA degradation resulted in the persistence of linear fragments in mutant cells without affecting the repair of single-strand breaks. These findings highlight the interplay between DNA repair and degradation processes, and the potential generation of somatic mitochondrial DNA deletions.
Article
Biochemistry & Molecular Biology
Min Chen, Lijie Yao, Lijuan Zhou, Pei Yang, Weihao Zou, Liqing Xu, Shengmin Li, Hongjuan Peng
Summary: TgROP18(I) inhibits type I interferon responses to facilitate parasitic replication in various host cells.
Article
Biochemistry & Molecular Biology
Pu Song, Weiwei Yang, Karen F. Lou, Hao Dong, Heng Zhang, Beiming Wang, Danying Chen
Summary: The study reveals that UNC13D, associated with familial hemophagocytic lymphohistiocytosis (FHL3), acts as a negative regulator of STING-mediated innate immune response. UNC13D inhibits STING oligomerization and promotes the production of interferon-beta (IFN-beta) induced by DNA viruses. UNC13D deficiency also leads to increased basal level of proinflammatory cytokines.
Article
Cell Biology
Andong Qin, Zhenke Wen, Sidong Xiong
Summary: This study reveals that Coxsackievirus B3 infection of cardiac myocytes leads to the release of mitochondrial DNA (mtDNA), triggering cardiac macrophage inflammation through the STING dependent mechanism. The mtDNA released by infected cells plays a crucial role in inducing macrophage inflammatory response. Additionally, myocardial mtDNA is identified as a central element driving cardiac inflammation in Coxsackievirus B3-induced viral myocarditis, and STING is considered a promising therapeutic target for protection against RNA viral infections.
Article
Biochemistry & Molecular Biology
Libao Liu, Shuai Huang, Yingzhen Du, Hao Zhou, Kai Zhang, Jinyuan He
Summary: This study shows that deletion of Lats2 gene can protect against acute myocardial infarction (AMI) by reducing cardiac injury and preserving cardiac structure and function. This protective effect may be attributed to the inhibition of mitochondrial fission, release of mtDNA, and activation of the STING/p65 pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jay Kumar, Ghulam Mohammad, Kumari Alka, Renu A. Kowluru
Summary: Mitochondrial dysfunction plays a critical role in the development of diabetic retinopathy. Hyperglycemia downregulates the mtDNA-encoded LncRNA cytochrome B (LncCytB) in retinal endothelial cells, leading to impaired mtDNA packaging and increased vulnerability to damage.
Article
Immunology
Cheng An, Fei Sun, Can Liu, Shaojun Huang, Tao Xu, Chengxin Zhang, Shenglin Ge
Summary: This study found that IQGAP1 induces endothelial cell pyroptosis by regulating mitochondrial function and activating the DNA sensor cGAS-STING. The results showed that IQGAP1 promotes oxidative stress and mtDNA release, activates the cGAS-STING signaling pathway, and leads to NLRP3-mediated pyroptosis. This study expands the understanding of the mechanisms underlying atherosclerosis and identifies new pharmacological targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Lu Zhou, Yi-Fei Zhang, Fu-Hua Yang, Han-Qing Mao, Zhi Chen, Lu Zhang
Summary: This study identified the role of mtDNA as an inflammatory driver in odontoblasts, which defended against bacterial invasion through the cGAS-STING pathway. The findings suggest that targeting the mtDNA-cGAS-STING axis could be a potential therapeutic strategy for preventing severe bacterial inflammation in pulpitis.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Cell Biology
Qing Tu, Yi Li, Jiali Zhu, Long Guo, Chenchen Liu, Lu Liu, Yuan Yuan, Yun Zou, Feng Chen, Liangfang Yao, Jinbao Li
Summary: This study demonstrated that mtDNA promotes immunoparalysis of DCs and contributes to sepsis-associated immunosuppression by activating STING signaling. Our findings suggest that mtDNA mediates immunoparalysis of DCs in sepsis, providing new insights into the molecular pathogenesis of immunosuppressive DCs in sepsis.
CELL PROLIFERATION
(2022)
Review
Biochemistry & Molecular Biology
Claire Coderch, Javier Arranz-Herrero, Estanislao Nistal-Villan, Beatriz de Pascual-Teresa, Sergio Rius-Rocabert
Summary: STING is an adaptor protein involved in immune response activation in vertebrates. Its induction can trigger early immune response and be used in cancer immune treatments. Understanding the activation of STING is crucial in designing therapeutic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Xutong Zhao, Meng Yu, Yawen Zhao, Yiming Zheng, Lingchao Meng, Kang Du, Zhiying Xie, He Lv, Wei Zhang, Jing Liu, Qingqing Wang, Yun Yuan, Zhaoxia Wang, Jianwen Deng
Summary: The study demonstrated that circulating cell-free mtDNA levels were significantly increased in patients with mitochondrial diseases, indicating an association with activation of the cGAS-STING pathway and inflammation.
JOURNAL OF NEUROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Tess C. Leuthner, Joel N. Meyer
Summary: Mitochondrial dysfunction is a key aspect of aging, and mitochondrial genome instability can lead to dysfunction and accelerated aging. Recent evidence suggests that environmental stressors like pollutants and pharmaceuticals can contribute to increased mtDNA mutations, potentially impacting aging and disease. More research is needed to understand the effects of chemical exposures on mtDNA mutations and instability, especially in the context of aging, as they may serve as sensitive biomarkers for exposure.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yuting Fang, Xuemei Zhang, Chang Lu, Yibing Yin, Xuexue Hu, Wenchun Xu, Yusi Liu, Hong Wang
CANADIAN JOURNAL OF MICROBIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Guangying Wu, Xuemei Zhang, Xu Chen, Jian Wang, Jing Yang, Ling Wang, Si Sun, Yuhong Qi, Hong Wang, Yibing Yin, Wenchun Xu
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Immunology
Sijie Li, Hong Zhang, Jiangming Xiao, Taixian Yuan, Zhaoche Shu, Yajun Min, Wenchun Xu, Yibing Yin, Xuemei Zhang
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Immunology
Yang Peng, Xiaofang Wang, Hong Wang, Wenchun Xu, Kaifeng Wu, Xuemei Go, Yibing Yin, Xuemei Zhang
Summary: IL-4 plays a protective role in influenza/S. pneumoniae co-infected pneumonia by reducing post-influenza susceptibility to S. pneumoniae through suppressing cell pyroptosis, leading to decreased mortality and bacterial loads.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yajun Min, Wenchun Xu, Yunju Xiao, Jiangming Xiao, Zhaoche Shu, Sijie Li, Jinghui Zhang, Yusi Liu, Yibing Yin, Xuemei Zhang, Jiangping Meng
Summary: This study focused on improving the stability of protein vaccines by biomineralization technology, successfully preparing mineralized protein nanoparticles that were resistant to degradation and thermally stable. The mineralized proteins retained their immunoreactivity, providing a safe and cost-effective method for vaccine administration.
Article
Endocrinology & Metabolism
Bei Xu, Yue Feng, Lingling Gan, Yamei Zhang, Wenqiang Jiang, Jiafu Feng, Lin Yu
Summary: Vitamin D is crucial for calcium and bone metabolism, with its insufficiency affecting skeletal mineralization and bone growth rate in children. Short-stature children have lower vitamin D levels compared to healthy subjects. Ratios of C3-epi/25(OH)D3 and 25(OH)D2/25(OH)D3 may serve as alternative markers for evaluating vitamin D metabolism/storage in short-stature children.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Bei Xu, Yan Chen, Xi Chen, Lingling Gan, Yamei Zhang, Jiafu Feng, Lin Yu
Summary: The study suggests that metabolic reprogramming, particularly in lipid metabolism, is a key feature of PCa. The 18 lipid or lipid-associated metabolites identified may serve as potential diagnostic markers for distinguishing between PCa patients and BPH individuals with PSA levels in the 4-10 ng/ml gray zone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Microbiology
Xuemei Gou, Wenchun Xu, Yusi Liu, Yang Peng, Wenlong Xu, Yibing Yin, Xuemei Zhang
Summary: This study reveals a novel mechanism for the development of pneumosepsis caused by Streptococcus pneumoniae and the critical protective role of IL-6. IL-6 prevents macrophage death and lung inflammation injury during pneumococcal pneumosepsis. These findings are important for the early identification and treatment of pneumococcal pneumosepsis.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Danlin Weng, Song Gao, Hailan Shen, Shifei Yao, Qi Huang, Yanyu Zhang, Wenjie Huang, Yan Wang, Xuemei Zhang, Yibing Yin, Wenchun Xu
Summary: This study found that CD5L has anti-inflammatory effects and regulates Th2 immune responses in allergic asthma through increasing CD11c(high) alveolar macrophages and inhibiting NLRP3 inflammasome activation. These findings suggest that CD5L may be a potential therapeutic target for asthma treatment.
Article
Pharmacology & Pharmacy
Chen Yan, Dan Wu, Lingling Gan, Jun Wang, Wenyu Yang, Bei Xu
Summary: This study used a metabolomics approach to analyze the metabolic response of NSCLC patients to EGFR-TKIs or PD-1/PD-L1 inhibitors. The results showed that these treatments induce changes in carnitine, amino acids, fatty acids, and lipids, and alter associated metabolic pathways. These findings provide new clues for understanding the antitumor mechanisms of these treatments from a metabolic perspective.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Yamei Zhang, Lingling Gan, Jie Tang, Dan Liu, Gang Chen, Bei Xu
Summary: This study utilized a metabolomics approach to identify five serum metabolites that have the potential to serve as indicators for the differential diagnosis of SLE and LN. Glycerolphospholipid metabolism may play a crucial role in the development of SLE into LN.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bei Xu, Yamei Zhang, Gang Chen, Jiafu Feng, Lingling Gan
Summary: The MPVLR is associated independently with inflammation in non-dialysis patients with CKD, and it may be useful for monitoring inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Yapeng Zhang, Jinghui Zhang, Jiangming Xiao, Hanyi Wang, Rui Yang, Xinlin Guo, Yuqiang Zheng, Yibing Yin, Xuemei Zhang
Summary: Natural transformation is important for the emergence of drug-resistant bacteria. The study identifies a transcriptional regulator called CcpA that directly regulates comCDE transcription, thereby participating in natural transformation process and being regulated by carbon source signals.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Yuan Zhang, Hao Li, Fang Wang, Chang Liu, Gadi V. P. Reddy, Hu Li, Zhihong Li, Yucheng Sun, Zihua Zhao
Summary: This study reveals the heightened virulence of entomopathogenic nematodes and bacteria against wax moths. It identifies actinomycin D as a novel biomarker of insect sepsis and uncovers the role of X. bovienii in inducing apoptosis and sepsis through actinomycin D production. These findings have important implications for studying the mechanism of sepsis and developing innovative biotic pesticides.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Zhaoche Shu, Jun Yuan, Hong Wang, Jinghui Zhang, Sijie Li, Hong Zhang, Yusi Liu, Yibing Yin, Xuemei Zhang
