Article
Ophthalmology
Chunyan Lei, Rui Hua, Jianan Duan, Meixia Zhang
Summary: This case report describes a novel presentation of RPE aperture secondary to acute CSC, with improvements in visual acuity and subretinal fluid absorption during follow-up. The findings suggest a possible pathological mechanism involving increased hydrostatic pressure in relatively healthy RPE leading to RPE aperture.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Woo Hyuk Lee, Bum Jun Kim, Yong Seop Han
Summary: This study presents a case of bilateral spontaneous large RPE tears in a patient with acute CSC without bullous RD, leading to decreased visual acuity. The findings suggest that large PED and old age may play a role in the development of RPE tears in CSC patients, emphasizing the importance of careful treatment consideration in such cases.
Article
Multidisciplinary Sciences
Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Takuya Iwasaki, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi
Summary: The study quantitatively evaluated retinal pigment epithelium changes in patients with age-related macular degeneration using prototype multi-contrast optical coherence tomography. The results showed that multi-contrast OCT is useful for objective evaluation of changes in the retinal pigment epithelium.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Endocrinology & Metabolism
Zhongjie Fu, Lois E. H. Smith
Summary: Pathologic angiogenesis in eye diseases leading to blindness can be attributed to cell senescence, as demonstrated by the bioinformatics study conducted by Crespo-Garcia, Tsuruda, and Dejda. Their findings were validated in human and mouse retina models, where clearance of senescent cells effectively suppressed neovessel growth.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Ophthalmology
Yang Meng, Liao Chen, Lu Li, Yishuang Xu, Yu Su, Lu Zhang, Zuohuizi Yi, Changzheng Chen
Summary: This article reports a rare case of a patient with central serous chorioretinopathy whose pigment epithelial detachment (PED) exhibited time-dependent recurrence and resolution. The abnormal diurnal variation of cortisol was considered as the internal factor affecting PED. This finding may provide new insights for the treatment strategy of central serous chorioretinopathy.
Article
Medicine, General & Internal
Zhengwei Zhang, Xiaona Bao, Zhifeng Wu, Jie Zhang
Summary: Half-dose or reduced-fluence photodynamic therapy (PDT) with verteporfin is recognized as an effective treatment for chronic central serous chorioretinopathy (CSC). However, a case was reported where choroidal neovascularization (CNV) developed only 3 weeks after such treatment, which had not been reported before. The patient was successfully treated with intravitreal injections of aflibercept after developing CNV.
Article
Medicine, General & Internal
Yuying Ji, Yuhong Gan, Yongyue Su, Yining Zhang, Miaoling Li, Lan Mi, Chengguo Zuo, Feng Wen
Summary: This study found that macular pigment optical density (MPOD) decreased within 7 degrees of eccentricity in patients with acute central serous chorioretinopathy (CSC), but there were no changes in serum lutein and zeaxanthin levels. The decrease in MPOD may be due to subretinal fluid. Further investigation is needed to determine the involvement of local oxidative stress in CSC and whether supplementation with lutein and zeaxanthin is beneficial.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
D. S. Maltsev, A. N. Kulikov, M. A. Burnasheva, J. Chhablani
Summary: The purpose of this study was to evaluate retinal pigment epithelium (RPE) alteration in central serous chorioretinopathy (CSC) using optical coherence tomography (OCT) en face imaging approach. The study found that OCT proved to be a reliable tool for the noninvasive evaluation of RPE status in CSC, with high correlation between measurements derived from OCT, fluorescein angiography (FA), and fundus autofluorescence (FAF).
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Liang Han, Jose Ronaldo Lima de Carvalho, Rait Parmann, Tongalp H. Tezel, Stanley Chang, Tarun Sharma, Janet R. Sparrow
Summary: qAF was correlated with SD-OCT detectable features in CSC patients, while NIR-AF images were helpful in detecting lesions. Elevated qAF levels were associated with specific CSC-related abnormalities, indicating a potential role in disease progression.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Tingting Liu, Wei Lin, Shuping Zhou, Xiangjuan Meng
Summary: This study in Chinese patients with CSCR found that 7.23% of patients had CNV, with age and duration of CSCR being correlated with CNV occurrence. FIPED was present in all eyes with CNV, and the width and area of PED were greater in the CNV group. Female gender and poor vision were identified as risk factors for CNV in CSCR eyes. Additionally, choroidal thickness was significantly different between eyes with CNV and eyes without CNV.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Chika Tanaka, Chiharu Iwahashi, Yuki Komuku, Kenta Hozumi, Keiichi Mitarai, Fumi Gomi
Summary: With increasing age, the male/female ratio of CSC patients decreases, especially in those aged over 70, who are more likely to have bilateral macular abnormalities and multiple drusen. Best corrected visual acuity (BCVA) and subfoveal choroidal thickness (SCT) decrease with age, while patients aged 50-70 have the highest rate of flat retinal pigment epithelium (RPE) elevation on OCT.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Fabrizio Giansanti, Stefano Mercuri, Federica Serino, Tomaso Caporossi, Alfonso Savastano, Clara Rizzo, Francesco Faraldi, Stanislao Rizzo, Daniela Bacherini
Summary: This study aimed to evaluate the ability of SLO retromode imaging compared to FAF in identifying outer retinal features in CSCR patients. The results showed that SLO retromode imaging had higher sensitivity than FAF in detecting SRF and RPE dystrophy, but it couldn't provide qualitative information about lesion depth and RPE cell health status.
Article
Ophthalmology
Kumiko Hirayama, Manabu Yamamoto, Takeya Kohno, Akika Kyo, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, Shigeru Honda
Summary: The study investigates the effect of selective retina therapy (SRT) for macular serous retinal detachment (MSRD) associated with tilted disc syndrome (TDS). SRT may promote absorption of MSRD and maintenance of best-corrected visual acuity (BCVA) for TDS. Randomized and prospective clinical studies are needed to evaluate the effectiveness of SRT for MSRD associated with TDS.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Medicine, General & Internal
Ahmed Ibrar, Maghsoudlou Panayiotis, El-Ashry Mohamed
Summary: Retinal detachments are a potentially sight-threatening ophthalmic emergency that may result in significant, irreversible vision loss. Risk factors include advancing age, myopia, and trauma. Prompt detection and treatment are crucial in preventing retinal detachment.
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2021)
Article
Ophthalmology
Susana Penas, Teresa Araujo, Ana Maria Mendonca, Simao Faria, Jorge Silva, Aurelio Campilho, Maria Lurdes Martins, Vania Sousa, Amandio Rocha-Sousa, Angela Carneiro, Fernando Falcao-Reis
Summary: This study investigates the retinal and choroidal vascular reactivity to carbogen in patients with central serous chorioretinopathy (CSC). The results suggest that the vascular reactivity in the choroidal vessels of CSC patients is significantly higher compared to controls.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Letter
Ophthalmology
Etienne Boulanger, Andrew Eller, Jay Chhablani
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ramesh Venkatesh, Shama Sharief, Chaitra Jayadev, Nikitha Gurram Reddy, Rubble Mangla, Rohit Agrawal, Naresh Kumar Yadav, Jay Chhablani
Summary: This study reports a case series of tamoxifen retinopathy (TR) with and without type 2 macular telangiectasia (MacTel) and compares their clinical and imaging findings.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Claudio Iovino, Prithvi Ramtohul, Adrian Au, Veronica Romero-Morales, SriniVas Sadda, K. Bailey Freund, David Sarraf
Summary: Vitelliform lesions (VLs) are a common manifestation of various macular disorders, characterized by the accumulation of yellowish subretinal material due to retinal pigment epithelium (RPE) impairment and phagocytic dysfunction. VLs can be distinguished using advanced retinal imaging techniques based on subretinal hyperreflectivity and hyperautofluorescence. Genetic or acquired retinal diseases can lead to VLs, with different causes seen in younger and older patients. Macular atrophy and neovascularization are the main causes of visual impairment in eyes with VLs. Histopathological studies have provided insights into the composition and location of the vitelliform material and the role of RPE cell dysfunction. Understanding the nature and course of vitelliform maculopathies is important for diagnosis and management.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Sonny Caplash, Thamolwan Surakiatchanukul, Supriya Arora, Dmitrii S. Maltsev, Sumit Randhir Singh, Niroj Kumar Sahoo, Deepika Parameshwarappa, Alexei N. Kulikov, Claudio Iovino, Filippo Tatti, Ramkailash Gujar, Ramesh Venkatesh, Nikitha Gurram Reddy, Ram Snehith, Enrico Peiretti, Marco Lupidi, Jay Chhablani
Summary: This study used multimodal imaging to evaluate predictors for choroidal neovascularization (CNV) associated with central serous chorioretinopathy (CSCR). The results showed that complex CSCR and older age were significant predictors for CNV development.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Rossella Spena, Cristina Bovone, Nicolo Ciarmatori, Marco Pellegrini, Angeli Christy Yu, Giorgio Zauli, Massimo Busin
Summary: The purpose of this paper is to report the clinical manifestations, diagnostic evaluation, management, and outcomes of microsporidial keratitis in post-keratoplasty eyes. The study found that confocal microscopy can be used for the in vivo detection of pathogenic microorganisms and therapeutic keratoplasty with topical fumagillin can lead to a satisfactory visual prognosis for microsporidial stromal keratitis in post-keratoplasty eyes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Tomaso Caporossi, Alessandra Scampoli, Filippo Tatti, Lorenzo Mangoni, Matteo Mario Carla, Emanuele Siotto Pintor, Francesca Frongia, Claudio Iovino, Patrizio Bernardinelli, Enrico Peiretti
Summary: We evaluated a new surgical technique for primary rhegmatogenous retinal detachment (RRD) involving vitrectomy near the retinal break and drainage of subretinal fluid. The technique showed promising results with no statistically significant difference in visual acuity before and after surgery. Primary anatomic success was achieved in 86% of patients at 6 months follow-up. Potential complications were minimal, except for two cases of retinal re-detachment due to incorrect head position. Further studies are needed to assess the long-term efficacy of the technique.
Review
Medicine, General & Internal
Elena Bolletta, Luca De Simone, Marco Pellegrini, Chiara Preziosa, Valentina Mastrofilippo, Chantal Adani, Pietro Gentile, Fabrizio Gozzi, Luca Cimino
Summary: The choroid, located between the retina and the sclera, is highly susceptible to inflammation in multisystemic diseases and is the most common site of metastasis in the eye. This review article focuses on the OCT findings that can help differentiate between inflammatory and neoplastic lesions affecting the choroidal profile. Choroidal imaging techniques, such as EDI-OCT and SS-OCT, have provided a deeper analysis of the choroid.
Review
Ophthalmology
Francesco Romano, Francesca Lamanna, Pierre Henry Gabrielle, Kelvin Y. C. Teo, Maurizio Battaglia Parodi, Pierluigi Iacono, Samantha Fraser-Bell, Elisa E. Cornish, Marco Nassisi, Francesco Viola, Aniruddha Agarwal, Anindya Samanta, Jay Chhablani, Giovanni Staurenghi, Alessandro Invernizzi
Summary: Retinal vein occlusion is a common retinal vascular disorder that affects both men and women equally. The diagnosis and management of this condition have improved significantly over the past few decades, with new imaging techniques and alternative treatment options available. Despite the better long-term outcomes, there are still cases that require more aggressive approaches, such as surgery. This comprehensive review aims to combine old and new research to provide retina specialists with updated knowledge on the pathophysiology, clinical features, and treatment strategies of retinal vein occlusion.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Nishant V. Radke, Shaheeda Mohamed, Richard B. Brown, Ilyana Ibrahim, Jay Chhablani, Hivam V. Amin, Chi-Wai Tsang, Marten E. Brelen, Nikhil S. Raichand, Dong Fang, Shaochong Zhang, Hong Dai, Guy Li Jia Chen, Chui Ming Gemmy Cheung, Seenu M. Hariprasad, Taraprasad Das, Dennis S. C. Lam
Summary: Frequent injections of antivascular endothelial growth factor in neovascular age-related macular degeneration often result in poor compliance and suboptimal outcomes. Brolucizumab, a longer-acting agent, has been approved for treating nAMD and has shown reduced injection frequency, better anatomic outcomes, and noninferior vision gains compared with aflibercept. However, there is a higher-than-expected incidence of intraocular inflammation associated with brolucizumab, requiring proper preinjection screening and high-vigilance care.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Rubble Mangla, Ramesh Venkatesh, Rohini Sangoram, Isha Acharya, Yash Parmar, Vishma Prabhu, Naresh Kumar Yadav, Jay Chhablani
Summary: The purpose of this study was to investigate the OCT changes in eyes with acute CRAO of different severity and at different disease stages. The study found that patients with different severity and disease stages of CRAO exhibited different characteristics on OCT, including retinal thinning, opacification, and other abnormalities. OCT is a useful tool for determining the severity of retinal ischemia, disease stage, tissue damage mechanism, and final visual outcome in CRAO patients.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Article
Ophthalmology
Sai Prashanti Chitturi, Ramesh Venkatesh, Rubble Mangla, Yash Parmar, Rohini Sangoram, Naresh Kumar Yadav, Jay Chhablani
Summary: This study compared real-life data on delayed intravitreal treatment of diabetic macular edema (DME) patients to early treatment. The results showed that late-treated DME eyes required more injections and focal laser sessions, and had decreased visual acuity after 1 year. Therefore, adherence to early treatment in real-life can help prevent long-term vision loss.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Article
Ophthalmology
Kantiya K. Jindachomthong, Howard Cabral, Manju L. Subramanian, Steven Ness, Nicole H. Siegel, Jay Chhablani, Samuel X. Hsu, Xuejing Chen
Summary: This retrospective observational study investigated the long-term incidence of delayed retinal tears in patients with acute, symptomatic posterior vitreous detachment (PVD) without concurrent retinal tears. The study found that 7.39% of patients developed delayed retinal tears within 6.24 years after PVD diagnosis, with many developing tears well after the typical 6-week follow-up time. Lattice degeneration emerged as a significant risk factor for delayed tears.
OPHTHALMOLOGY RETINA
(2023)
Review
Ophthalmology
Simon Ka-Ho Szeto, Vivian Wing Ki Hui, Vivianna Siu, Shaheeda Mohamed, Carmen K. M. Chan, Carol Yim Lui Cheung, Yi Ting Hsieh, Colin S. Tan, Jay Chhablani, Timothy Y. Y. Lai, Danny Siu-Chun Ng
Summary: With advanced imaging techniques, ophthalmologists increasingly rely on ocular imaging for disease diagnosis and management, including ultra-widefield fundus angiography, fundus autofluorescence, optical coherence tomography, and optical coherence tomography angiography. This review summarizes the clinical applications and latest indications of multimodal imaging in various eye diseases.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Marco Lupidi, Lorenzo Mangoni, Chiara Centini, Gregorio Pompucci, Luca Lanzafame, Luca Danieli, Daniela Fruttini, Enrico Peiretti, Jay Chhablani, Cesare Mariotti
Summary: The aim of this study was to compare 20 kHz and 85 kHz A-scan rate OCT images in terms of qualitative and quantitative differences. The study included 60 healthy subjects and measured retinal layer thickness in three different positions. The results showed no significant differences in retinal layer thickness between the two scan rates. However, the 20 kHz images had a higher quality index and a higher percentage of patients with inner plexiform layer multilaminarity compared to the 85 kHz images.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ninan Jacob, Mudit Tyagi, Jay Chhablani, Raja Narayanan, Anup Kelgaonkar, Mukesh Jain, Sumit Randhir Singh, Niroj Kumar Sahoo
Summary: This paper evaluates the role of retinal pigment epithelium (RPE) as a biomarker of inflammation in acute Vogt-Koyanagi-Harada (VKH) disease. The study found a significant decrease in RPE thickness and a significant increase in RPE reflectivity following resolution of the disease. Furthermore, there was a significant correlation between RPE and choroidal thickness during the acute stage of the disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
