Prospects for the introduction of targeted antioxidant drugs for the prevention and treatment of diseases related to free radical pathology

Wpływ stosowania dożylnej N-acetylocysteiny w zapobieganiu migotaniu przedsionków po pomostowaniu aortalno-wieńcowym: badanie z randomizacją i grupą kontrolną prowadzone metodą podwójnie ślepej próby

(2018) Aria Soleimani et al.   Kardiologia Polska

Oral antioxidant therapy for prevention and treatment of preeclampsia: Meta-analysis of randomized controlled trials

(2018) M.B. Tenório et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Mechanism and Therapies of Oxidative Stress-Mediated Cell Death in Ischemia Reperfusion Injury

(2018) Haobo Li et al.   Oxidative Medicine and Cellular Longevity

Iron promotes oxidative cell death caused by bisretinoids of retina

(2018) Keiko Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis

(2018) Shing Chan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

The risk of cancer attributable to diagnostic medical radiation: Estimation for France in 2015

(2018) Claire Marant‐Micallef et al.   INTERNATIONAL JOURNAL OF CANCER

Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies

(2017) Konstantinos Mantzarlis et al.   Oxidative Medicine and Cellular Longevity

N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis

(2017) Philippe Conus et al.   SCHIZOPHRENIA BULLETIN

Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer

(2017) Daniel Monti et al.   SEMINARS IN ONCOLOGY

Effects of N-acetylcysteine treatment in acute respiratory distress syndrome: A meta-analysis

(2017) Ying Zhang et al.   Experimental and Therapeutic Medicine

Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children

(2017) Robert S. B. Clark et al.   PLoS One

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

Iron deposition is associated with differential macrophage infiltration and therapeutic response to iron chelation in prostate cancer

(2017) Avigdor Leftin et al.   Scientific Reports

An assessment of the variation in the concentration of acetylcysteine in infusions for the treatment of paracetamol overdose

(2016) George P. Bailey et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A Phase II Randomized Placebo-Controlled Trial of Oral N -acetylcysteine for Protection of Melanocytic Nevi against UV-Induced Oxidative Stress In Vivo

(2016) Pamela B. Cassidy et al.   Cancer Prevention Research

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Current Drug Managements of Wilson's Disease: From West to East

(2016) Wen-Jie Li et al.   Current Neuropharmacology

Redox signaling: An evolution from free radicals to aging

(2016) Henry Jay Forman   FREE RADICAL BIOLOGY AND MEDICINE

Heavy Metals, Cardiovascular Disease, and the Unexpected Benefits of Chelation Therapy

(2016) Gervasio A. Lamas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics

(2016) Kyung Chan Park et al.   Metallomics

Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial

(2016) Deepti Saxena et al.   PLoS One

Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial

(2015) Gunnar M Buyse et al.   LANCET

Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology

(2015) Christina Kontoghiorghe et al.   MOLECULES

Characterization of the Neuroprotective Potential of Derivatives of the Iron Chelating Drug Deferiprone

(2015) Pamela Maher et al.   NEUROCHEMICAL RESEARCH

MRI and oxidative stress markers in neurological worsening of Wilson disease following penicillamine

(2015) A. Ranjan et al.   NEUROTOXICOLOGY

Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians’ Health Study II randomized trial

(2014) Lu Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Elimination of Ascorbic Acid After High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation

(2014) Torben K. Nielsen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation

(2014) Elizabeth D. Hood et al.   BIOMATERIALS

Copper Chelators: Chemical Properties and Bio-medical Applications

(2014) M. Tegoni et al.   CURRENT MEDICINAL CHEMISTRY

Antioxidant targeting by deferiprone in diseases related to oxidative damage

(2014) Christina et al.   Frontiers in Bioscience-Landmark

N-Acetylcysteine Supplementation Reduces Oxidative Stress and DNA Damage in Children with β-Thalassemia

(2014) Zeynep Canan Ozdemir et al.   HEMOGLOBIN

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

(2014) Giovanni Pagano et al.   Oxidative Medicine and Cellular Longevity

Potential clinical applications of chelating drugs in diseases targeting transferrin-bound iron and other metals

(2013) Christina N Kontoghiorghe et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction

(2013) Gervasio A. Lamas et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dietary supplements and prostate cancer: a systematic review of double-blind, placebo-controlled randomised clinical trials

(2013) Paul Posadzki et al.   MATURITAS

Dietary Antioxidants and Prostate Cancer: A Review

(2013) Terrence M. Vance et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Selective Divalent Copper Chelation for the Treatment of Diabetes Mellitus

(2012) G. J.S. Cooper   CURRENT MEDICINAL CHEMISTRY

Effect of high-dose intravenous vitamin C on inflammation in cancer patients

(2012) Nina Mikirova et al.   Journal of Translational Medicine

Liver iron and serum ferritin levels are misleading for estimating cardiac, pancreatic, splenic and total body iron load in thalassemia patients: factors influencing the heterogenic distribution of excess storage iron in organs as identified by MRI T2*

(2012) Annita Kolnagou et al.   TOXICOLOGY MECHANISMS AND METHODS

EDTA chelation reappraisal following new clinical trials and regular use in millions of patients: review of preliminary findings and risk/benefit assessment

(2012) Tammy Born et al.   TOXICOLOGY MECHANISMS AND METHODS

Effect of deferiprone, an oral iron chelator, in diabetic and non-diabetic glomerular disease

(2012) Mohan M. Rajapurkar et al.   TOXICOLOGY MECHANISMS AND METHODS

Efficacy, Compliance And Toxicity Factors Are Affecting The Rate Of Normalization Of Body Iron Stores In Thalassemia Patients Using The Deferiprone And Deferoxamine Combination Therapy

(2011) Annita Kolnagou et al.   HEMOGLOBIN

Interactions Of Hydroxycarbamide (Hydroxyurea) With Iron And Copper: Implications On Toxicity and Therapeutic Strategies

(2011) Eleni Konstantinou et al.   HEMOGLOBIN

Iron-related MRI images in patients with pantothenate kinase-associated neurodegeneration (PKAN) treated with deferiprone: Results of a phase II pilot trial

(2011) Giovanna Zorzi et al.   MOVEMENT DISORDERS

Nanocarriers for vascular delivery of antioxidants

(2011) Elizabeth Hood et al.   Nanomedicine

Safety issues of iron chelation therapy in patients with normal range iron stores including thalassaemia, neurodegenerative, renal and infectious diseases

(2010) G J Kontoghiorghes et al.   Expert Opinion On Drug Safety

Iron Accumulation in the Substantia Nigra of Patients With Alzheimer Disease and Parkinsonism

(2009) Sonia Brar et al.   ARCHIVES OF NEUROLOGY

Cisplatin Overdose

(2009) Roger Y. Tsang et al.   DRUG SAFETY

Risk/Benefit Assessment, Advantages Over Other Drugs and Targeting Methods in the Use of Deferiprone as a Pharmaceutical Antioxidant in Iron Loading and Non Iron Loading Conditions

(2009) George J. Kontoghiorghes et al.   HEMOGLOBIN

A New Era in Iron Chelation Therapy: The Design of Optimal, Individually Adjusted Iron Chelation Therapies for the Complete Removal of Iron Overload in Thalassemia and other Chronically Transfused Patients

(2009) George J. Kontoghiorghes   HEMOGLOBIN

Impact of antioxidant supplementation on chemotherapeutic toxicity: A systematic review of the evidence from randomized controlled trials

(2008) Keith I. Block et al.   INTERNATIONAL JOURNAL OF CANCER

MRI assessment of basal ganglia iron deposition in Parkinson's disease

(2008) Lauren I. Wallis et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Regression of symptoms after selective iron chelation therapy in a case of neurodegeneration with brain iron accumulation

(2008) Gian Luca Forni et al.   MOVEMENT DISORDERS