Journal
EXPERIMENTAL GERONTOLOGY
Volume 120, Issue -, Pages 28-34Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2019.02.010
Keywords
Depressive symptoms; Lifestyle intervention; Omega-3; Prevention; Randomized controlled trial
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Funding
- Gerontopole of Toulouse
- French Ministry of Health
- Pierre Fabre Research Institute (manufacturer of the omega-3 supplement)
- Exhonit Therapeutics SA
- Avid Radiopharmaceuticals Inc
- French National Agency for Research [ANR-11-LABX-0018-01]
- University Hospital Center of Toulouse
- Association Monegasque pour la Recherche sur la maladie d'Alzheimer (AMPA)
- UMR 1027 Unit INSERM-University of Toulouse III
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Background: We tested the associations of a lifestyle multidomain intervention (MI), omega-3 supplementation (O3) or their combination with the change of clinically meaningful depressive symptoms in older adults. Methods: Secondary analysis of the 3-year Multidomain Alzheimer Preventive Trial (MAPT), in which 1679 people, >= 70 years with memory complaints were randomized into: MI, O3, MI + O3, or placebo. MI was composed of nutritional and physical activity counselling and cognitive training. O3 supplementation corresponded to a daily dose of 1000 mg of omega-3. Discrete-time cox regressions were performed for each outcome. Three binary variables of incidence of depressive symptoms were created from the 15-item geriatric depression scale (GDS-15): minimum clinically meaningful depressive symptoms (>= 2-point increase in GDS-15), moderate depressive symptoms (GDS-15 >= 5), and severe depressive symptoms (GDS-15 >= 10) DS. Results: Discrete-time cox proportional hazards have found no associations for all of the analysis. The incidence of severe depressive symptoms across groups were, respectively: 1.1, 2.4, 2.3 and 2.5 per 100 person year for MI + O3, for O3, for MI, for placebo. There was a trend for a decreased risk of developing severe DS compared to placebo in the MI + O3 group (p = 0.085 after adjustment). Conclusions: To conclude, we did not find any association of a lifestyle multidomain intervention with the onset of clinically depressive symptoms in older adults with memory complaints. A study with a more intensive multidomain intervention might bring further insights on this topic.
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