Journal
EXPERIMENTAL CELL RESEARCH
Volume 382, Issue 2-3, Pages -Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2019.06.026
Keywords
Collective invasion; Leader cell; K14; Delta;Np63 alpha; Dll4; Cysteine protease cathepsin B
Categories
Funding
- National Natural Science Foundation of China [81672672, 81772891, 81572650, 81621062]
- National Program on Key Research Project of China [2016YFC0902700]
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Most recently, mounting evidence has shown that cancer cells can invade as a cohesive and multicellular group with coordinated movement, which is called collective invasion. In this cohesive cancer cell group, cancer cells at the front of collective invasion are defined as leader cell that are responsible for many aspects of collective invasion, including sensing the microenvironment, determining the invasion direction, modifying the path of invasion and transmitting information to other cells. To fulfill their dispensable roles, leader cells are required to embark on some specific phenotypes with unusual expression of some proteins and it's very important to investigate into these proteins as they may serve as potential therapeutic targets. Here, in this review we will summarize current knowledge on four emerging proteins highly expressed in leader cells including K14, Delta Np63 alpha, Dll4 and cysteine protease cathepsin B (CTSB), with a focus on their important roles in collective invasion and special mechanisms by which they promote collective invasion.
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