Review
Biochemistry & Molecular Biology
Ting Xu, Hongmei Ding, Jie Chen, Jiahui Lei, Meng Zhao, Bingyu Ji, Youguo Chen, Songbing Qin, Qinqin Gao
Summary: This article provides an update on the roles of aberrant DNA methylation in endometrial carcinogenesis and discusses the opportunities and challenges of utilizing DNA methylation in the management and prevention of endometrial cancer.
Article
Biochemistry & Molecular Biology
Andrea G. Izquierdo, Hatim Boughanem, Angel Diaz-Lagares, Isabel Arranz-Salas, Manel Esteller, Francisco J. Tinahones, Felipe F. Casanueva, Manuel Macias-Gonzalez, Ana B. Crujeiras
Summary: The study identified specific epigenetic marks in visceral adipose tissue associated with colorectal cancer, potentially providing useful tools for prediction and personalized treatment of CRC.
Article
Biochemistry & Molecular Biology
Yeong-Chin Jou, Shou-Chieh Wang, Yuan-Chang Dia, Shou-Tsung Wang, Min-Hua Yu, Hsin-Yi Yang, Lei-Chin Chen, Cheng-Huang Shen, Yi-Wen Liu
Summary: The study demonstrated that GSTM5 acts as a tumor suppressor in bladder cancer cells without significantly affecting chemoresistance to cisplatin and mitomycin C, and the cellular levels of GSH are key mechanisms underlying the anticancer effect of GSTM5. Low gene expression and high DNA methylation levels of GSTM5 may serve as tumor markers for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Genetics & Heredity
Melva Gutierrez-Angulo, Maria de la Luz Ayala-Madrigal, Jose Miguel Moreno-Ortiz, Jorge Peregrina-Sandoval, Fernando Daniel Garcia-Ayala
Summary: Colorectal cancer is a complex disease influenced by genetics, epigenetics, and environmental factors. DNA methylation, particularly in tumor suppressor genes, plays a role in the development of cancer. The composition of gut microbiota, including enrichment of certain bacteria like Fusobacterium nucleatum and Hungatella hathewayi, is associated with changes in DNA methylation patterns in colorectal cancer. These changes can affect gene expression and impact the prognosis of colorectal cancer patients.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Tianyuan Liu, Xuan Zhao, Yuan Lin, Qi Luo, Shaosen Zhang, Yiyi Xi, Yamei Chen, Lin Lin, Wenyi Fan, Jie Yang, Yuling Ma, Alok K. Maity, Yanyi Huang, Jianbin Wang, Jiang Chang, Dongxin Lin, Andrew E. Teschendorff, Chen Wu
Summary: This study develops a computational strategy to identify stem-like preneoplastic cells that may drive cancer progression by dissecting the heterogeneity of differentiation states within a preneoplastic cell population.
Article
Multidisciplinary Sciences
Sheersh Massey, Mohammad Aasif Khan, Safia Obaidur Rab, Saad Mustafa, Asifa Khan, Zoya Malik, Rahimunnisa Shaik, Mohit Kumar Verma, S. V. S. Deo, Syed Akhtar Husain
Summary: This study investigates the role of the MEN1 gene in breast cancer and finds that aberrant expression of MEN1 is associated with the development and progression of the disease.
Review
Medicine, General & Internal
Oscar Rapado-Gonzalez, Jose Luis Lopez-Cedrun, Rafael Lopez-Lopez, Ana Maria Rodriguez-Ces, Maria Mercedes Suarez-Cunqueiro
Summary: Oral carcinogenesis is a multistep process involving multiple genetic and epigenetic alterations. Aberrant promoter hypermethylation leading to gene silencing is an important epigenetic event in cancer development, with potential as a biomarker for early diagnosis and therapy. Detection of methylated genes in saliva could be a noninvasive approach for oral cancer screening and early diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zhangjie Wang, Na Shen, Ziao Wang, Lei Yu, Song Yang, Yang Wang, Yu Liu, Gaohua Han, Qi Zhang
Summary: This study reveals that TRIM3 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by promoting cell death and inhibiting tumorigenesis. TRIM3 directly interacts with SLC7A11/xCT, leading to its degradation and inhibition of NSCLC development. Low TRIM3 expression is associated with a worse prognosis in NSCLC.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Pharmacology & Pharmacy
Yuchong Peng, Rong Tang, Liuyang Ding, Rirong Zheng, Youhong Liu, Linglong Yin, Yongming Fu, Tanggang Deng, Xiong Li
Summary: In this study, a potentially effective component, diosgenin (DSG), was identified from traditional Chinese medicine (TCM) for the treatment of prostate cancer (PCa) by using network pharmacology and molecular docking. DSG specifically targeted UHRF1 protein and induced its degradation through the ubiquitin-proteasome pathway. DSG reduced DNA methylation and increased the expression of tumor suppressor genes, resulting in cell cycle arrest, cellular senescence, and inhibition of tumor growth. This study revealed a novel anticancer mechanism of DSG and provided a promising strategy for discovering new molecule-targeted drugs from small-molecule natural products.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Mary L. Stackpole, Weihua Zeng, Shuo Li, Chun-Chi Liu, Yonggang Zhou, Shanshan He, Angela Yeh, Ziye Wang, Fengzhu Sun, Qingjiao Li, Zuyang Yuan, Asli Yildirim, Pin-Jung Chen, Paul Winograd, Benjamin Tran, Yi-Te Lee, Paul Shize Li, Zorawar Noor, Megumi Yokomizo, Preeti Ahuja, Yazhen Zhu, Hsian-Rong Tseng, James S. Tomlinson, Edward Garon, Samuel French, Clara E. Magyar, Sarah Dry, Clara Lajonchere, Daniel Geschwind, Gina Choi, Sammy Saab, Frank Alber, Wing Hung Wong, Steven M. Dubinett, Denise R. Aberle, Vatche Agopian, Steven-Huy B. Han, Xiaohui Ni, Wenyuan Li, Xianghong Jasmine Zhou
Summary: Early cancer detection using cell-free DNA faces challenges of low tumor DNA fraction, molecular heterogeneity, and limited sample sizes. In this study, the authors developed a cost-effective method called cfMethyl-Seq to profile the methylome of cell-free DNA and detect and locate cancer. The approach achieved high sensitivity and accuracy for detecting and identifying the tissue-of-origin of various cancer types.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Yo Han Hong, Nur Aziz, Jae Gwang Park, Dagyeong Lee, Jin Kyeong Kim, Seung A. Kim, Wooram Choi, Chae Young Lee, Hwa Pyoung Lee, Ha Thi Huyen Trang, Han Gyung Kim, Young-Jun Jeon, Bokyoung Kim, Younghoon Kim, Kyung-Hee Kim, Byong Chul Yoo, Jeung-Whan Han, Narayana Parameswaran, Ji Hye Kim, Hoon Hur, Jae Youl Cho
Summary: The study explored the pathological role of a nonhistone methyltransferase in gastric cancer (GC), identified EEF1AKMT3 as a novel tumor suppressive methyltransferase, and revealed its mechanism of action through regulating the methylation of MAP2K7 and the degradation of TP53. The findings suggest potential targeted therapy in GC by manipulating the dysregulated EEF1AKMT3/MAP2K7/TP53 signaling axis.
Article
Oncology
Arnaud Carrier, Cecile Desjobert, Valerie Lobjois, Lise Rigal, Florence Busato, Jorg Tost, Miquel Ensenyat-Mendez, Diego M. Marzese, Anne Pradines, Gilles Favre, Laurence Lamant, Luisa Lanfrancone, Chantal Etievant, Paola B. Arimondo, Joelle Riond
Summary: Protocadherin proteins play an important role in cell adhesion and signaling pathways. The study found that the PCDHB15 gene's specific exon is hypermethylated in melanoma, leading to its silencing. This silencing contributes to the aggressiveness of melanoma.
CLINICAL EPIGENETICS
(2022)
Review
Biochemistry & Molecular Biology
Rakesh Srivastava, Niraj Lodhi
Summary: Mammalian genomic DNA methylation is an important epigenetic modification that regulates gene expression during development. Aberrant DNA methylation can lead to various inheritable diseases, including cancer. Recent research has uncovered the dynamic regulation of DNA methylation and emphasized the role of PARP1 enzyme in its maintenance.
Article
Endocrinology & Metabolism
Yu Wang, Yuhao Luo, Shaozhi Fu, Lijia He, Guangrui Pan, Dongmei Fan, Qinglian Wen, Yu Fan
Summary: ZSCAN18 is downregulated in breast cancer and its expression is associated with clinicopathological parameters. It plays a role in the cell cycle and glycolysis signaling pathway by inhibiting the expression of genes in these pathways. ZSCAN18 is also part of a physical complex with ZNF396 and PGBD1 in breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chan Wang, Jiaxin Chen, Yeye Kuang, Xiaoqing Cheng, Min Deng, Zhinong Jiang, Xiaotong Hu
Summary: The study found that TRPM4 is a novel methylated tumor suppressor gene that is downregulated in colorectal cancer. TRPM4 activates calpain-mediated cleavage of FAK through modulating the PI3K/Akt/mTOR signaling cascade, thereby impeding CRC migration and invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)