Article
Chemistry, Physical
Jingyuan Wang, Ning Cai, Vincent Chan, Huan Zeng, Hongrui Shi, Yanan Xue, Faquan Yu
Summary: The development of nano-hydroxyapatite (n-HAP) reinforced chitosan/gelatin polyelectrolyte complex (PEC) nanofiber membrane with encapsulated tetracycline hydrochloride has shown great potential in achieving long-term drug release and enhancing antibacterial efficacy against common pathogens such as S. aureus. The composite membrane possesses good water retention, high rigidity, prolonged sustained drug release, and prolonged antibacterial therapeutic efficacy, making it a promising platform for developing novel antimicrobial wound dressings.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Engineering, Environmental
Chin-San Wu, Dung-Yi Wu, Shan-Shue Wang
Summary: Polymer composites fabricated from bio-based materials have potential applications in bone tissue engineering, demonstrating good mechanical properties and biocompatibility.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Chemistry, Physical
Jinxing Cao, Xin Liu, Xiaohong Jiang, Ruizhe Lian, Bin Du, Aleksandr Rogachev
Summary: The study fabricated bioactive films containing magnesium particles using pulsed laser deposition, which exhibited excellent drug release performance in simulated body fluids. A sustained-release effect was verified by obtaining ciprofloxacin hydrochloride films through low energy electron beam deposition and layering growth of CIP and Mg-HA films.
APPLIED SURFACE SCIENCE
(2021)
Article
Polymer Science
Gustavo Cabrera-Barjas, Liliam Becheran, Oscar Valdes, Ady Giordano, Rodrigo Segura-del Rio, Gaston Bravo-Arrepol, Esteban F. Duran-Lara, Juan Cea, Alex Berg, Johana Castanos, Saddys Rodriguez-Llamazares, Gast on Fuentes, Plamen Katsarov, Paolina Lukova, Cedric Delattre
Summary: The overuse of antibiotics can lead to the development of resistance to targeted bacteria. A controlled release system, such as the nanocomposite films prepared in this study, can provide a solution for achieving higher drug efficiency without overdosing and drug resistance. The films, made from chitosan reinforced with cellulose nanofibrils, showed promising properties for antibiotic release. The content of nanofibers in the film formulation affected the swelling capacity, stiffness, and tensile strength of the films, as well as the release rate of vancomycin, suggesting the potential application of these films for pharmaceutical purposes.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ilya Nifant'ev, Dmitry Gavrilov, Alexander Tavtorkin, Maria Chinova, Victoria Besprozvannykh, Pavel Komarov, Vladimir Zaitsev, Irina Podoprigora, Pavel Ivchenko
Summary: Bioresorbable materials play a crucial role in bone repair and infection prevention in orthopedic surgery. Nonwoven electrospun fibers are considered promising for wound dressing and tissue engineering, with lower hindrance to bone matrix regeneration compared to dense materials. Combining biodegradable polyesters, calcium phosphates, and antibiotics shows high potential for forming electrospun fibers, but faces challenges due to the incompatibility of the main organic and inorganic ingredients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Ilker S. Bayer
Summary: Polysaccharides are complex molecules with exceptional properties and can be chemically modified. They have increased application in drug encapsulation and release in nanoscale synthesis due to their biocompatibility and biodegradability. This review focuses on studying sustained drug release from nanoscale polysaccharides, particularly drug release kinetics and mathematical modeling. It highlights the importance of modeling in predicting the behavior of specific polysaccharide matrices and reducing experimental trial and error.
Article
Biochemistry & Molecular Biology
Michelle Fiona Kilb, Yannik Moos, Stefanie Eckes, Joy Braun, Ulrike Ritz, Daniela Nickel, Katja Schmitz
Summary: Collagen laminates can be bonded using photochemical crosslinking for differential release on different surfaces, providing controlled release advantages. The use of an additively manufactured sample holder enables the study of vancomycin release in two directions, allowing for control over antibiotic release profiles and direction.
Article
Nanoscience & Nanotechnology
Lan Zhang, Yang Xue, Sanjana Gopalakrishnan, Kai Li, Yong Han, Vincent M. Rotello
Summary: Titanium is commonly used in medical implants due to its mechanical strength and biocompatibility. Recent studies have focused on developing coatings to enhance the properties of Ti implants, with Ca- and Si-based ceramic coatings being able to release ions to improve bone integration. However, the high degradation rates of these ceramics may reduce cell viability, requiring the use of polymeric or protein-based coatings to modulate degradation while maintaining stability and biocompatibility.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Multidisciplinary
Simin Sharifi, Asma Zaheri Khosroshahi, Solmaz Maleki Dizaj, Yashar Rezaei
Summary: In this study, hydroxyapatite-gelatin/curcumin nanofibrous composites were prepared and evaluated for their antimicrobial effects. The results showed that these nanocomposites had significant antimicrobial effects against various bacteria. They can be potentially used in dental tissue engineering or as dental materials, either as alternatives or in combination with chemical antimicrobials to reduce bacterial resistance.
Article
Nanoscience & Nanotechnology
Haijun Li, Dongbei Li, Fangman Chen, Chao Yang, Xiaogai Li, Yuan Zhang, Chunlan Hua, Xiaoxu Ma, Xin Zhao, Dan Shao, Yingshuai Wang, Liang Ming
Summary: The study developed a new material, Ag-MONs@GEN, for the treatment of antibiotic-resistant bacteria, demonstrating excellent antibacterial activity against various strains through controlled release of GEN and silver ions. Furthermore, the nanoplatform showed high safety profiles in cell experiments.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Materials Science, Ceramics
Reka Barabas, Noemi-Izabella Farkas, Csaba Levente Nagy, Oana Cadar, Corina Moisa, Liliana Bizo
Summary: The study showed that various additives had limited impact on improving drug adsorption, and density functional theory evaluated the interactions of nano-Hap-based NCs. In desorption experiments, functionalized multiwall carbon nanotubes and graphene oxide had positive effects on anti-inflammatory drugs, while gelatin increased the adsorption capacity of NCs.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Environmental
Yun-Jin Jeong, Songah Jeong, Seokjae Kim, Hea Ji Kim, Juyeong Jo, Arunkumar Shanmugasundaram, Hyungwoo Kim, Eunpyo Choi, Dong-Weon Lee
Summary: Controlled drug eluting cardiovascular scaffolds (CDECS) using gold particles incorporated carbon nanofibers reinforced poly-caprolactone (PCL) scaffolds have the potential for improved mechanical properties, controlled drug delivery, and targeted therapies.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Rahila Batul, Abdul Khaliq, Ahmed Alafnan, Mrinal Bhave, Aimin Yu
Summary: This study investigates the drug loading and release behavior of gentamicin loaded into polydopamine nanoparticles. The release kinetics of gentamicin is found to be influenced by the pH and surface charge of the nanoparticles. The findings suggest that the in situ loading method using polydopamine nanoparticles can provide sustained drug release over a period of seven days.
APPLIED SCIENCES-BASEL
(2022)
Article
Polymer Science
Valeria Friuli, Silvia Pisani, Bice Conti, Giovanna Bruni, Lauretta Maggi
Summary: This article discusses the challenge in the pharmaceutical sector of developing controlled release oral dosage forms for poorly soluble drugs. The researchers successfully prepared polymeric nanofibers loaded with two model drugs using the electrospinning technique. These nanofibers were then incorporated into tablet formulations, resulting in improved release performances.
Article
Food Science & Technology
Tiantian Min, Xiaoli Sun, Zhipeng Yuan, Liping Zhou, Xiangyu Jiao, Junwei Zha, Zhu Zhu, Yongqiang Wen
Summary: This study aimed to explore a new pathway for developing active packaging materials by loading thyme essential oil into electrospun PLA nanofibers and coating them with PVA/PEG blends. The results showed excellent hydrophilicity and antibacterial activities of the packaging film, with controlled release rate of thyme essential oil based on humidity levels.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Anatomy & Morphology
Yaroslav Kolinko, Anna Maleckova, Petra Kochova, Martina Grajciarova, Tereza Blassova, Tomas Kural, Andriy Trailin, Lenka Cervenkova, Jirina Havrankova, Lucie Vistejnova, Pavla Tonarova, Vladimira Moulisova, Miroslav Jirik, Anna Zavadakova, Filip Tichanek, Vaclav Liska, Milena Kralickova, Kirsti Witter, Zbynek Tonar
Summary: This study aims to provide an overview of the use of virtual microscopy in the context of developing sampling strategies of FOVs for stereological quantification. Through 18 specific examples, the research explains how to sample for different histological scenarios and offers practical implications.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2022)
Article
Dentistry, Oral Surgery & Medicine
V. Machon, M. Bartos, T. Suchy, J. Levorova, R. Foltan
Summary: This study used micro-computed tomography (micro-CT) to evaluate the bone architecture of the condylar head and determine if there are differences between different types of unilateral condylar hyperplasia (UCH). The study found no significant differences in bone structure between the various types of condylar hyperplasia. There were also no significant differences in bone structure between the anterior and posterior portions of the condylar head.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Surgery
Filip Jonas, Peter Kesa, Petr Paral, Jan Pankrac, Marie Hubalek Kalbacova, Jakub Miletin, Andrej Sukop, Martin Molitor, Krystof Stanek, Ludek Sefc, Ondrej Mestak
Summary: The combination of VLN flap and VEGF-C resulted in the fastest regeneration, while the addition of ADSC had an insignificant effect in the study. Furthermore, we demonstrated the feasibility of using ultrasound-photoacoustic imaging as an assessment tool for lymphatic drainage recovery in a VLNT model.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2023)
Article
Construction & Building Technology
Ivana Perna, Tomas Hanzlicek, Adam Lucanik, Monika Supova
Summary: This article summarizes the partial results of a project focused on the research and development of new grinding tools using hybrid binder based on inorganic polymers. A clay-slag geopolymer with corundum abrasive grains was used for the first time to prepare novel abrasive tools for metal grinding. The effect of different grain sizes and content of brown and white corundum grains was investigated. It has been confirmed through experiments and scanning electron analysis (SEM) that geopolymer grinding stones have good grinding properties. The results show that geopolymer matrix can replace ceramic binder in grinding tools for metal grinding, providing an opportunity for sustainable development of new abrasive materials.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Elena Filova, Monika Supova, Adam Eckhardt, Marek Vrbacky, Andreu Blanquer, Martina Travnickova, Jarmila Knitlova, Tomas Suchy, Sarka Ryglova, Martin Braun, Zuzana Burdikova, Martin Schatz, Vera Jencova, Maxim Lisnenko, Lubos Behalek, Renata Prochazkova, Radek Sedlacek, Kristyna Kubasova, Lucie Bacakova
Summary: Scaffolds made of degradable polymers, such as collagen, are used for bioartificial vascular grafts or patches. In this study, collagen gel reinforced with collagen particles and adipose tissue-derived stem cells (ASCs) was incubated with different mediums to promote cell differentiation. The constructs were then endothelialised with human umbilical vein endothelial cells (ECs). Immunofluorescence staining and mass spectrometry were performed to evaluate cell differentiation and extracellular matrix proteins. Mechanical properties of the gels with ASCs were measured. The results suggest that PVA_PL_part collagen construct has the highest potential for functional vascular remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Monika Supova, Tomas Suchy, Hynek Chlup, Jan Stipek, Rudolf Zitny, Ales Landfeld, Jan Skocilas, Margit Zaloudkova, Sarka Ryglova, Martin Braun, Jaromir Stancl, Milan Houska
Summary: This study analyzed the chemical compositions and structures of two different bovine collagen gels with glycerol and their effects on rheological properties. Although minor differences were found in primary and secondary structures, significant differences were observed in rheological properties. These differences were correlated with the directionality of collagen fibril bundles. The results suggest that the tertiary and quaternary structures of collagen have a greater impact on its rheological properties compared to the primary and secondary structures.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Polymer Science
Milan Houska, Ales Landfeld, Pavla Novotna, Jan Strohalm, Monika Supova, Tomas Suchy, Hynek Chlup, Jan Skocilas, Jan Stipek, Margit Zaloudkova, Miloslav Sulc
Summary: Currently, there is limited research on the physical properties and structure of collagen treated with high-pressure technologies. This study aimed to investigate whether this modern gentle technology has a significant impact on collagen properties. Results showed that the rheological and mechanical properties of collagen were not significantly affected by pressure, while the thermal properties depended on both pressure value and hold time. Analysis of amino acids and FTIR indicated minor changes in collagen structure and preserved polymer integrity. SEM analysis revealed no changes in collagen fibril ordering orientation over longer distances.
Article
Pharmacology & Pharmacy
Marek Pokorny, Jolana Kubickova, Jan Klemes, Tomas Medek, Adam Brydl, Martina Pachovska, Tereza Hanova, Josef Chmelar, Vladimir Velebny
Summary: This study developed a method for continuous deposition of active ingredients onto braided threads, ensuring precise and uniform content. The method offers advantages in terms of speed, scalability, and cost-efficiency, and has potential applications beyond dental care.
Article
Biology
Iwona Lasocka, Ewa Skibniewska, Michal Skibniewski, Lidia Szulc-Dabrowska, Elzbieta Jastrzebska, Iwona Pasternak, Sitek Jakub, Marie Hubalek-Kalbacova
Summary: This study investigated the response of human bone marrow mesenchymal stem cells (hBM-MSCs) to a graphene monolayer scaffold based on cytoskeleton architecture. The results showed that graphene did not damage or disturb the cell cytoskeleton, linker proteins, or gap junction protein. Additionally, cells growing on the graphene monolayer were more spread than those growing on glass, suggesting that graphene could reinforce MSC cultivation without affecting their cytoskeleton, which is crucial for cell integrity, connections, and migration in skin wound healing.
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Vera Hedvicakova, Radmila Zizkova, Matej Buzgo, Lucie Vistejnova, Pavel Klein, Maria Hovorakova, Martin Bartos, Klara Steklikova, Jitka Lunackova, Eva Sebova, Iveta Paurova, Miroslava Rysova, Eva Filova, Michala Rampichova
Summary: Osteoporosis is a severe health problem with social and economic impacts on society. The standard treatment consists of the systemic administration of drugs such as bisphosphonates, with alendronate (ALN) being one of the most common. Nevertheless, complications of systemic administration occur with this drug. Therefore, it is necessary to develop new strategies, such as local administration.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Immunology
M. Sojka, M. Umrian, M. Kanikova, K. Petrovicova
Summary: This study isolated various species of Vibrio bacteria, including potentially pathogenic strains, from artificial recreational pools in Slovakia. The presence of these bacteria in pools filled with thermal mineralized waters, even after disinfection with chlorine compounds, suggests a potential health risk.
EPIDEMIOLOGIE MIKROBIOLOGIE IMUNOLOGIE
(2022)
Article
Medicine, Research & Experimental
Ondrej Troup, Adam Skalicky, Lucie Vistejnova, Pavel Klein, Anna Maleckova, Blanka Florova, Tomas Malkus, Jiri Molacek, Vladislav Treska, Miroslav Kriz, J. A. N. Zeman, Tomas Skalicky
Summary: The study aimed to investigate the effect of bevacizumab on vascular and biliary microarchitecture in healthy liver parenchyma and its ability to regenerate following major hepatectomy. The results showed that bevacizumab treatment did not impair liver regeneration after hepatectomy.
Review
Obstetrics & Gynecology
Michal Koucky, Rasha Kamel, Lucie Vistejnova, Vladimir Kalis, Khaled M. Ismail
Summary: This study conducted a systematic review of international guidelines on the prevention and management of childbirth-related bacterial infections. The findings showed concordance in some aspects, but also identified areas of discordance.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
