Review
Anesthesiology
Jonathan Rankin, Benjamin Rudy-Froese, Curtis Hoyt, Keenu Ramsahoi, Liam Gareau, William Howatt, Lisa Carlesso
Summary: This scoping review analyzed various quantitative sensory testing methodologies used in the assessment of sensitization in individuals with knee osteoarthritis. It found high variability in the definitions of sensitization, with only a small portion of studies fully operationalizing it. The review provides an overview of common methods of quantitative sensory testing and highlights the need for standardized definitions in future research and clinical practice.
Review
Clinical Neurology
Wei Li, Yinan Gong, Jingyi Liu, Yongming Guo, Huiling Tang, Siru Qin, Yadan Zhao, Songtao Wang, Zhifang Xu, Bo Chen
Summary: Chronic low back pain involves pathophysiological mechanisms of lumbar structures, including sensitization of both peripheral and central systems. Dysfunction in the processing of sensory information in the brain and the pain modulatory system contributes to pain amplification in the central nervous system. Abnormalities in brain biochemical metabolism, activation of glial cells, and inflammation also play significant roles in the development of chronic low back pain.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jeongkeun Song, Hyunjoong Kim, Jihye Jung, Seungwon Lee
Summary: This study aimed to demonstrate the therapeutic effect of combining soft-tissue mobilization (STM) with pain neuroscience education (PNE) for chronic nonspecific low back pain with central sensitization. The results showed that the group receiving STM plus PNE had significant improvement in pain intensity, central sensitization, pressure pain, pain cognition, and disability compared to the group receiving only STM.
Article
Biology
Xiaoping Zheng, Michiel F. Reneman, Jone Ansuategui Echeita, Rita H. R. Schiphorst Preuper, Herbert Kruitbosch, Egbert Otten, Claudine J. C. Lamoth
Summary: This study found that patients with chronic low back pain (CLBP) exhibit different motor control strategies, with CLBP- patients showing a looser and more stable gait, while CLBP+ patients showing a more regular, less variable, and more predictable gait pattern.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Anesthesiology
Jason Zafereo, Sharon Wang-Price, Enas Kandil
Summary: A cutoff score of 33.5 on the CSI may be useful for discriminating widespread pain sensitivity and quality of life impairments in participants with CMP. The high CSI group showed significantly lower pain thresholds and larger impairments in quality of life measures compared to the low CSI group and asymptomatic controls. Anxiety, pain interference, and CSI scores demonstrated the highest number of significant associations with QST measures.
Review
Health Care Sciences & Services
Hidenori Suzuki, Shu Tahara, Mao Mitsuda, Hironori Izumi, Satoshi Ikeda, Kazushige Seki, Norihiro Nishida, Masahiro Funaba, Yasuaki Imajo, Kiminori Yukata, Takashi Sakai
Summary: QST and PPT are useful in the analysis of neck/shoulder and low back pain. However, there is currently a lack of reliable reference values for PPT in these conditions. This article reviews previous studies and provides a summary of the current data on PPT values.
Article
Anesthesiology
Hester L. den Bandt, Kelly Ickmans, Lynn Leemans, Jo Nijs, Lennard Voogt
Summary: This study investigates the differences in quantitative sensory testing (QST) between patients with acute, chronic low back pain (LBP) and pain-free controls (PFCs) in primary care. The results show enhanced nociceptive processing and disturbed top-down nociceptive modulation in patients with acute and chronic LBP in primary care.
CLINICAL JOURNAL OF PAIN
(2022)
Article
Orthopedics
Doha Dahmani, Fatima Zahrae Taik, Imane Berrichi, Maryam Fourtassi, Fatima Ezzahra Abourazzak
Summary: This study investigated the involvement of central sensitization (CS) in knee osteoarthritis (KOA) and chronic low back pain (CLBP). The results showed that CS scores were significantly correlated with pain intensity and disability in both groups. In addition, CS was highly correlated with symptoms of depression, anxiety, and pain catastrophizing. These findings provide further evidence for the impact of CS on pain, function, and physical performance in KOA and CLBP patients.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Computer Science, Interdisciplinary Applications
Xiaoping Zheng, Michiel F. Reneman, Rita H. R. Schiphorst Preuper, Egbert Otten, Claudine J. C. Lamoth
Summary: This study used advanced unsupervised machine learning, Hidden semi-Markov model (HSMM), to investigate the physical activity intensity patterns in patients with chronic low back pain (CLBP). The results showed that there were differences in physical activity intensity patterns between CLBP- and CLBP + patients, with CLBP + patients engaging in longer bouts of activity.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Clinical Neurology
Koji Akeda, Norihiko Takegami, Junichi Yamada, Tatsuhiko Fujiwara, Akinobu Nishimura, Akihiro Sudo
Summary: This study investigated the association of central sensitization (CS) with chronic low back pain (cLBP) in a population-based cohort in a Japanese mountain village. The results showed a significant correlation between CS and pain intensity, health-related quality of life, and disability index in cLBP patients.
JOURNAL OF PAIN RESEARCH
(2021)
Review
Orthopedics
K. R. Arant, J. N. Katz, T. Neogi
Summary: This review outlines the most commonly used quantitative sensory tests to identify pain sensitization in knee osteoarthritis (OA) patients. Findings suggest that lower PPT thresholds, inefficient CPM, and facilitated TS are common in knee OA patients, and that QST measures are more closely associated with pain severity than OA radiographic severity. QST may have a role in personalized, more effective treatment of OA.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Chemistry, Analytical
Noy Turgeman Dahan, Jean-Jacques Vatine, Irit Weissman-Fogel, Hana Karpin, Sharon Shmuely, Tami Bar-Shalita
Summary: This study developed a reliable and valid protocol called Quantitative Dynamic Allodynography (QDA) for measuring Dynamic Mechanical Allodynia (DMA) in a clinical setting. The QDA showed high test-retest and inter-rater reliability, and correlated with other measures of pain and quality of life.
Review
Neurosciences
Ya-Jing Liu, Yue-Ling Li, Zhong-Han Fang, Hong-Lin Liao, Yan-Yan Zhang, Jiu Lin, Fei Liu, Jie-Fei Shen
Summary: This review focuses on the pivotal roles and mechanisms of NMDARs in the trigeminal nervous system under orofacial neuropathic and inflammatory pain conditions. The types, components, and distribution of NMDARs in the trigeminal nervous system are summarized. The regulatory roles of NMDARs in the peripheral mechanisms of chronic orofacial pain following neuropathic injury and inflammation, as well as their functional roles and mechanisms in the ascending and descending circuits, are discussed.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Physiology
Chengjin Li, Hee Jin Kim, Seung Keun Back, Heung Sik Na
Summary: In chronic pathological conditions, the antagonism between pain and itch becomes less obvious. Pain can induce itch in some patients, and bradykinin may trigger itch in patients with atopic dermatitis. Common mechanisms underlying chronic pain and itch suggest a need for new therapeutics against both chronic dysesthesias.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Review
Rheumatology
Anne-Priscille Trouvin, Nadine Attal, Serge Perrot
Summary: The persistence of pain in inflammatory rheumatic diseases suggests the involvement of central sensitization, but the inconsistent results of other sensory tests prevent confirmation of this hypothesis.
Article
Clinical Neurology
Vanessa E. Miller, Charles Poole, Yvonne Golightly, Deborah Barrett, Ding-Geng Chen, Richard Ohrbach, Joel D. Greenspan, Roger B. Fillingim, Gary D. Slade
Article
Anesthesiology
Shad B. Smith, Marc Parisien, Eric Bair, Inna Belfer, Anne-Julie Chabot-Dore, Pavel Gris, Samar Khoury, Shannon Tansley, Yelizaveta Torosyan, Dmitri Zaykin, Olaf Bernhardt, Priscila de Oliveira Serrano, Richard Gracely, Deepti Jain, Marjo-Riitta Jaervelin, Linda Kaste, Kathleen Kerr, Thomas Kocher, Raija Lahdesmaki, Nadia Laniado, Cathy Laurie, Cecelia Laurie, Minna Mannikko, Carolina Meloto, Andrea Nackley, Sarah Nelson, Paula Pesonen, Margarete Ribeiro-Dasilva, Celia Rizzatti-Barbosa, Anne Sanders, Christian Schwahn, Kirsi Sipila, Tamar Sofer, Alexander Teumer, Jeffrey Mogil, Roger Fillingim, Joel Greenspan, Richard Ohrbach, Gary Slade, William Maixner, Luda Diatchenko
Article
Anesthesiology
Sonia Snarma, Jean Wactawski-Wende, Michael J. LaMonte, Jiwei Znao, Gary D. Slade, Eric Baire, Joel D. Greenspan, Roger B. Fillingim, William Maixner, Richard Ohrbach
Article
Neuroimaging
Shana A. B. Burrowes, Chandler Sours Rhodes, Timothy J. Meeker, Joel D. Greenspan, Rao P. Gullapalli, David A. Seminowicz
BRAIN IMAGING AND BEHAVIOR
(2020)
Meeting Abstract
Clinical Neurology
N. Emerson, M. Saffer, T. Meeker, J. Greenspan, C. Campbell, A. Korzeniewska, F. Lenz
Meeting Abstract
Clinical Neurology
T. Meeker, N. Emerson, J. Greenspan, C. Campbell, A. Korzeniewska, M. Saffer, F. Lenz
Article
Neurosciences
Timothy J. Meeker, Michael L. Keaser, Shariq A. Khan, Rao P. Gullapalli, David A. Seminowicz, Joel D. Greenspan
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Clinical Neurology
Samar Khoury, Marjo H. Piltonen, Anh-Tien Ton, Tiffany Cole, Alexander Samoshkin, Shad B. Smith, Inna Belfer, Gary D. Slade, Roger B. Fillingim, Joel D. Greenspan, Richard Ohrbach, William Maixner, G. Gregory Neely, Adrian W. R. Serohijos, Luda Diatchenko
ANNALS OF NEUROLOGY
(2019)
Article
Anesthesiology
Richard Ohrbach, Gary D. Slade, Eric Bair, Nuvan Rathnayaka, Luda Diatchenko, Joel D. Greenspan, William Maixner, Roger B. Fillingim
EUROPEAN JOURNAL OF PAIN
(2020)
Article
Neurosciences
Nichole M. Emerson, Timothy J. Meeker, Joel D. Greenspan, Mark Saffer, Claudia M. Campbell, Anna Korzeniewska, Fred A. Lenz
JOURNAL OF NEUROPHYSIOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
S. Sharma, R. Ohrbach, R. B. Fillingim, J. D. Greenspan, G. Slade
JOURNAL OF DENTAL RESEARCH
(2020)
Article
Anesthesiology
Chika Okusogu, Yang Wang, Titilola Akintola, Nathaniel R. Haycock, Nandini Raghuraman, Joel D. Greenspan, Jane Phillips, Susan G. Dorsey, Claudia M. Campbell, Luana Colloca
Article
Neurosciences
Timothy J. Meeker, Nichole M. Emerson, Jui-Hong Chien, Mark Saffer, Oscar Joseph Bienvenu, Anna Korzeniewska, Joel D. Greenspan, Frederick Arthur Lenz
Summary: The study suggests that sustained attention to painful stimuli leads to a decrease in response willingness over time on task, while the ability to discriminate between target and nontarget remains unchanged. High trait anxiety is associated with slower reaction times and decreased willingness to respond during the task, highlighting the important role of trait anxiety in pain vigilance.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Rehabilitation
Timothy J. Meeker, Rithvic Jupudi, Frederik A. Lenz, Joel D. Greenspan
CURRENT PHYSICAL MEDICINE AND REHABILITATION REPORTS
(2020)
Article
Neurosciences
Gary D. Slade, Jonathan D. Rosen, Richard Ohrbach, Joel D. Greenspan, Roger B. Fillingim, Marc Parisien, Samar Khoury, Luda Diatchenko, William Maixner, Eric Bair