Journal
E-POLYMERS
Volume 19, Issue 1, Pages 87-91Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/epoly-2019-0011
Keywords
biomaterials; tissue regeneration; stem cell transplantation; scaffold; type I collagen
Categories
Funding
- China Postdoctoral Science Foundation [2015M582206]
- National Natural Science Foundation of China [NSFC 81471306]
- Key scientific research projects of higher education institutions in Henan province [16A430030]
- Special Foundation of Research, Development and Promotion in Henan province [182102310076]
- Joint Fund for Fostering Talents of NCIR-MMT HNKL-MMT [MMT2017-01, MMT2017-04]
Ask authors/readers for more resources
In the past few decades, stem cell transplantation has been generally accepted as an effective method on the treatment of tissue and organ injury. However, the insufficient number of transplanted stem cells and low survival rate that caused by series of negative conditions limit the therapeutic effect. In this contribution, we developed an injectable hydrogel composed of sodium alginate (SA) and Type I collagen (Coll), as the tissue scaffold to create better growth microenvironment for the stem cells. Compared the traditional SA scaffold, the Coll/SA hydrogel inherits its biomimetic properties, and simultaneously has shorter gelation time which means less loss of the transplanted stem cells. The mesenchyma stem cell (MSC) culture experiments indicated that the Coll/SA hydrogel could prevent the MSC apoptosis and contributed to faster MSC proliferation. It is highlighted that this Coll/SA hydrogel may have potential application for tissue regeneration and organ repair as the stem cell scaffold.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available