Article
Surgery
Alisha Fernandes, Chao Li, Daniel French, James Ellsmere
Summary: This retrospective study compared the long-term outcomes of EMR and esophagectomy for the treatment of intramucosal adenocarcinoma (IMC) in the esophagus. The study found that both procedures had comparable recurrence rates and disease-free survival at 10 years. However, EMR was associated with significantly lower procedure-related morbidity.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Alisha Fernandes, Chao Li, Daniel French, James Ellsmere
Summary: This retrospective study compared the outcomes of endoscopic mucosal resection (EMR) and esophagectomy for the treatment of esophageal intramucosal adenocarcinoma (IMC) in 10-year follow-up. The results showed that EMR and esophagectomy had similar recurrence rates and disease-free survival, but EMR had lower incidence of procedure-related morbidity.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Kesha Oza, Tejasvi Peesay, Benjamin Greenspun, John E. Carroll, Shervin Shafa, Jay C. Zeck, Nadim G. Haddad, Marc Margolis, Puja Gaur Khaitan
Summary: The study reviewed the experience of endoscopic mucosal resections in 80 patients with early-stage esophageal cancer, finding that endoscopic resections are a safe and effective treatment. Patients who require repeat resection or surgery should undergo esophagectomy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Paul Doumbe-Mandengue, Anna Pellat, Arthur Belle, Einas Abou Ali, Rachel Hallit, Frederic Beuvon, Benoit Terris, Stanislas Chaussade, Romain Coriat, Maximilien Barret
Summary: This study compared the efficacy of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in the treatment of early esophageal adenocarcinoma. The results showed that ESD was superior to EMR in terms of surgical characteristics and treatment outcomes. ESD should be more widely adopted for the resection of esophageal lesions suspected of harboring early esophageal adenocarcinoma.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Review
Oncology
Franz Ludwig Dumoulin, Fabian Dario Rodriguez-Monaco, Alanna Ebigbo, Ingo Steinbruck
Summary: Esophageal adenocarcinoma is the most common subtype of esophageal cancer in Western societies and its incidence is increasing. The development and validation of artificial intelligence systems in the field of gastroenterology may help address unresolved issues in the prevention and surveillance of this cancer.
Review
Gastroenterology & Hepatology
Motasem Alkhayyat, Prabhat Kumar, Krishna O. Sanaka, Prashanthi N. Thota
Summary: The incidence of Barrett's esophagus and esophageal adenocarcinoma has been increasing, leading to a search for chemoprevention strategies. Proton-pump inhibitors and Aspirin have shown effectiveness in reducing cancer incidence in Barrett's patients. Other agents lack sufficient evidence for chemoprevention in these patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
D. Chamil Codipilly, Lovekirat Dhaliwal, Meher Oberoi, Parth Gandhi, Michele L. Johnson, Ramona M. Lansing, W. Scott Harmsen, Kenneth K. Wang, Prasad G. Iyer
Summary: Endoscopic submucosal dissection (ESD) achieves higher complete remission rates of dysplasia in Barrett's esophagus patients compared to cap-assisted endoscopic mucosal resection (cEMR), although rates of complete remission of intestinal metaplasia (CRIM) at 2 years and complication rates are similar between the two groups.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston T. Agoston, Kunal Jajoo, Jon M. Davison, Katie S. Nason, Gad Getz, Kenneth K. Wang, Yu Imamura, Robert Odze, Adam J. Bass, Matthew D. Stachler, Cheng-Zhong Zhang
Summary: By analyzing chromosomal copy-number evolution in early cancers and precancerous lesions of the esophagus, the authors reveal signatures of ongoing chromosomal instability and its role in promoting tumor progression.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Zachary L. Smith, Abigail M. Thorgerson, Aprill Z. Dawson, Sachin Wani
Summary: This study provides real-world data on critical outcomes for Barrett's esophagus patients undergoing endoscopic eradication therapy (EET), demonstrating a low risk of incident esophageal adenocarcinoma, all-cause mortality, and the need for esophagectomy.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Oncology
Lei Chen, Farah Ballout, Heng Lu, Tianling Hu, Shoumin Zhu, Zheng Chen, Dunfa Peng
Summary: In this study, the gene expression of NEK family members in esophageal adenocarcinoma and its precancerous condition was analyzed. The findings suggest that upregulation of certain NEKs may be important in the development of esophageal adenocarcinoma.
Article
Oncology
Anshuman Panda, Gyan Bhanot, Shridar Ganesan, Manisha Bajpai
Summary: Stable cell lines derived from primary tissues and tumors are commonly used in medical research. This study evaluated gene expression profiles of esophageal tissues and cell lines, finding discrepancies in the gene expression profiles of Barrett's esophagus (BE) cell lines compared to primary BE tissues and esophageal adenocarcinoma (EAC) tumors. Exposure to an acidic bile environment did not alter the squamous-like gene expression pattern of a BE cell line. The findings underscore the importance of carefully selecting appropriate in vitro tools for studying esophageal adenocarcinoma.
Editorial Material
Gastroenterology & Hepatology
Katherine Wong, Alexander Podboy, Jonathan Lavezo, Aparna Goel
DIGESTIVE DISEASES AND SCIENCES
(2020)
Editorial Material
Gastroenterology & Hepatology
George Cholankeril, Alexander Podboy, Vasiliki Irene Aivaliotis, Branden Tarlow, Edward A. Pham, Sean P. Spencer, Donghee Kim, Ann Hsing, Aijaz Ahmed
Article
Surgery
Alexander J. Podboy, Joo Ha Hwang, Homero Rivas, Dan Azagury, Mary Hawn, James Lau, Afrin Kamal, Shai Friedland, George Triadafilopoulos, Thomas Zikos, John O. Clarke
Summary: This study compared the long-term clinical efficacy of POEM versus HM for the treatment of achalasia. The results showed that both procedures have similar long-term efficacy, adverse event rates, and reflux rates, with POEM showing greater efficacy in Type III Achalasia.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
George Cholankeril, Alexander Podboy, Vasiliki Irene Aivaliotis, Edward A. Pham, Sean P. Spencer, Donghee Kim, Aijaz Ahmed
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Editorial Material
Gastroenterology & Hepatology
Alexander Podboy, George Cholankeril, Lisa Cianfichi, Edward Guzman, Aijaz Ahmed, Subhas Banerjee
Letter
Cardiac & Cardiovascular Systems
Alexander J. Podboy, John O. Clarke, Linda A. Nguyen, Joshua J. Mooney, Gundeep S. Dhillon, Joo Ha Hwang
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2020)
Article
Immunology
George Cholankeril, Alexander Podboy, Omar S. Alshuwaykh, Donghee Kim, Fasiha Kanwal, Carlos O. Esquivel, Aijaz Ahmed
Article
Cardiac & Cardiovascular Systems
Allison Ducharme-Smith, C. Anwar A. Chahal, Hiroyiku Sawatari, Alex Podboy, Akil Sherif, Christopher G. Scott, Peter A. Brady, Bernard J. Gersh, Virend K. Somers, Vuyisile T. Nkomo, Patricia A. Pellikka
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Review
Gastroenterology & Hepatology
Alexander Podboy, Jacky Yuan, Christopher Donald Stave, Shannon Melissa Chan, Joo Ha Hwang, Anthony Yuen Bun Teoh
Summary: This study compared the efficacy of PT-GBD, ETP-GBD, and EUS-GBD in patients with acute cholecystitis. It found that EUS-GBD had the highest technical and clinical success rates, with the lowest risk of recurrent cholecystitis.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Jaeil Chung, Kelly Wang, Alexander Podboy, Srinivas Gaddam, Simon K. Lo
Summary: This study aimed to demonstrate the feasibility, safety, and effectiveness of endoscopic suturing (ES) for the closure of mucosal defects after endoscopic mucosal resection (EMR) of duodenal adenomas. ES was found to be technically successful in all cases and no complications such as bleeding or duodenal stricture were encountered. ES should be considered as an option for preventing or treating perforations associated with EMR of large duodenal adenomas.
CLINICAL ENDOSCOPY
(2022)
Letter
Gastroenterology & Hepatology
Anuragh R. Gudur, Calvin Geng, Andrew Y. Wang, Alexander Podboy
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Respiratory System
Thomas A. Zikos, George Triadafilopoulos, Afrin Kamal, Alexander Podboy, Irene S. Sonu, Kirsten A. Regalia, Monica C. Nandwani, Linda A. Nguyen, Nielsen Q. Fernandez-Becker, John O. Clarke
JOURNAL OF THORACIC DISEASE
(2020)
Review
Gastroenterology & Hepatology
Alexander Podboy, Shai Friedland
INTERNATIONAL JOURNAL OF GASTROINTESTINAL INTERVENTION
(2019)
Review
Gastroenterology & Hepatology
Alexander Podboy, Joo Ha Hwang
INTERNATIONAL JOURNAL OF GASTROINTESTINAL INTERVENTION
(2019)