The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

(2018) Seung Woo Cho et al.   CELL

Long noncoding RNA lncHand2 promotes liver repopulation via c-Met signaling

(2018) Yanying Wang et al.   JOURNAL OF HEPATOLOGY

The Long Noncoding RNA CAREL Controls Cardiac Regeneration

(2018) Benzhi Cai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Enhancer redundancy provides phenotypic robustness in mammalian development

(2018) Marco Osterwalder et al.   NATURE

Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis -Regulatory Element Marked by a Long Non-coding RNA

(2017) Walter K. Mowel et al.   IMMUNITY

Allelic reprogramming of 3D chromatin architecture during early mammalian development

(2017) Zhenhai Du et al.   NATURE

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

(2017) Kathrin Leppek et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity

(2017) David Zemmour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

(2017) Rudi Micheletti et al.   Science Translational Medicine

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

LncRNA TINCR attenuates cardiac hypertrophy by epigenetically silencing CaMKII

(2017) Mingjing Shao et al.   Oncotarget

HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development

(2017) Frédéric Laurent et al.   Cell Reports

Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells

(2016) Sai Luo et al.   Cell Stem Cell

Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac Cells

(2016) Guang Li et al.   DEVELOPMENTAL CELL

Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development

(2016) Kelly M. Anderson et al.   NATURE

Long noncoding RNA Chast promotes cardiac remodeling

(2016) Janika Viereck et al.   Science Translational Medicine

Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation

(2015) Yafei Yin et al.   Cell Stem Cell

A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node

(2015) W. Ye et al.   DEVELOPMENT

A comparative encyclopedia of DNA elements in the mouse genome

(2014) Feng Yue et al.   NATURE

A long noncoding RNA protects the heart from pathological hypertrophy

(2014) Pei Han et al.   NATURE

The rise of regulatory RNA

(2014) Kevin V. Morris et al.   NATURE REVIEWS GENETICS

Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9

(2014) Jinxiong Han et al.   RNA Biology

Physiological roles of long noncoding RNAs: insight from knockout mice

(2014) Lingjie Li et al.   TRENDS IN CELL BIOLOGY

Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease

(2014) Aibin He et al.   Nature Communications

Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium

(2014) Nathan J. VanDusen et al.   Cell Reports

The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse

(2013) Phillip Grote et al.   DEVELOPMENTAL CELL

Overdosage of Hand2 causes limb and heart defects in the human chromosomal disorder partial trisomy distal 4q

(2013) Masaru Tamura et al.   HUMAN MOLECULAR GENETICS

Promoter directionality is controlled by U1 snRNP and polyadenylation signals

(2013) Albert E. Almada et al.   NATURE

Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure

(2013) Ellen Dirkx et al.   NATURE CELL BIOLOGY

Embryonic Heart Progenitors and Cardiogenesis

(2013) T. Brade et al.   Cold Spring Harbor Perspectives in Medicine

Twist factor regulation of non-cardiomyocyte cell lineages in the developing heart

(2012) Nathan J. VanDusen et al.   DIFFERENTIATION

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Non-coding RNAs as regulators of embryogenesis

(2011) Andrea Pauli et al.   NATURE REVIEWS GENETICS

Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development

(2010) Kristen L. Holler et al.   DEVELOPMENTAL BIOLOGY

Hand2 function in second heart field progenitors is essential for cardiogenesis

(2010) Takatoshi Tsuchihashi et al.   DEVELOPMENTAL BIOLOGY

Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma

(2009) Harald Voth et al.   BMC MOLECULAR BIOLOGY

Genomic and Transcriptional Co-Localization of Protein-Coding and Long Non-Coding RNA Pairs in the Developing Brain

(2009) Jasmina Ponjavic et al.   PLoS Genetics

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field Development

(2008) Yuka Morikawa et al.   CIRCULATION RESEARCH

The developmental genetics of congenital heart disease

(2008) Benoit G. Bruneau   NATURE