Article
Medicine, General & Internal
Thierry Carrel, Thoralf M. Sundt, Yskert von Kodolitsch, Martin Czerny
Summary: Despite advancements in the prevention, diagnosis, and treatment of acute aortic dissection, it remains a complex cardiovascular event with high mortality and morbidity rates. Recent research has improved our understanding of the disease's pathophysiology and led to reevaluations of existing classifications. There is a shift towards a unified naming system based on morphology and function. The location and extent of the initial tear, as well as the affected aortic segments, determine the appropriate management approach - emergency surgery, endovascular intervention, or medical treatment. Ongoing scientific evidence continues to shape the management and follow-up of acute aortic dissection, the most severe form of acute aortic syndrome.
Article
Medicine, General & Internal
Lingyu Xing, Yannan Zhou, Yi Han, Chen Chen, Zegang Dong, Xinde Zheng, Dongxu Chen, Yao Yu, Fengqing Liao, Shuai Guo, Chenling Yao, Min Tang, Guorong Gu
Summary: A bedside prognosis prediction model based on clinical and image parameters can effectively determine the in-hospital outcomes of acute aortic dissection. The model incorporates factors such as age, Marfan syndrome, type A aortic dissection, surgical repair, and maximum false lumen diameter to rapidly predict in-hospital mortality rate.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Likun Sun, Xin Li, Quanming Li, Ming Li, Hao He, Tun Wang, Jiehua Li, Chang Shu
Summary: The study revealed that besides the enlargement of the ascending aorta and aortic arch, there were significant increases in aortic diameters and lengths in aTBAD patients. Additionally, there were significant rises in aortic arch angulation and tortuosity, as well as a higher prevalence of type III arch configuration in aTBAD group. Multivariable models showed that aortic arch angulation, tortuosity, and type III arch were independent geometric predictors of aTBAD, with high predictive capacity demonstrated through ROC analysis.
WORLD JOURNAL OF SURGERY
(2021)
Article
Public, Environmental & Occupational Health
Junquan Chen, Yunpeng Bai, Hong Liu, Mingzhen Qin, Zhigang Guo
Summary: The study aimed to create a prediction model for in-hospital death in Chinese patients with acute type A aortic dissection (ATAAD). A retrospective derivation cohort of 340 patients from Tianjin and a retrospective validation cohort of 153 patients from Nanjing were used. Variable selection was done using least absolute shrinkage and selection operator analysis, and risk scoring was done using logistic regression coefficients. A risk classifier was established based on independent baseline data using a multivariable logistic model. The prediction performance was evaluated using the receiver operating characteristic curve (ROC). Individualized clinical decision-making was conducted using decision curve analysis (DCA). The risk prediction model showed good performance in predicting in-hospital death in ATAAD patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Evan J. Friend, Pavel Leinveber, Marek Orban, John Hochhold, Anna Svatikova, Virend K. Somers, Gregg S. Pressman
Summary: This study found a high prevalence of OSA in patients with acute aortic dissection, but it was not associated with nocturnal presentation. The presence of underlying OSA may be associated with larger aortic diameters at the time of dissection. Although the differences did not reach statistical significance, the study was limited by a small sample size.
CLINICAL CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tuo Guo, Zhuo Fang, Guifang Yang, Yang Zhou, Ning Ding, Wen Peng, Xun Gong, Huaping He, Xiaogao Pan, Xiangping Chai
Summary: Acute aortic dissection is a potentially fatal cardiovascular disorder with high mortality rates. This study utilized machine learning algorithms to predict in-hospital mortality, finding that the extreme gradient boost model was the most effective and identified treatment, type of acute aortic dissection, and ischemia-modified albumin levels as significant predictors of mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yue Yuan, Zhiyu Xia, Lei Wang, Qi Sun, Wendan Wang, Chen Chai, Tiantian Wang, Xiaowei Zhang, Long Wu, Zehai Tang
Summary: This study aims to investigate the risk factors for in-hospital death in patients with acute aortic dissection (AAD) and provide a simple prediction model to assist clinicians in determining the prognosis of AAD patients. It was found that hypotension and liver dysfunction were independent risk factors for in-hospital death in type A AAD patients, while tachycardia and liver dysfunction were independent risk factors for type B AAD patients. Based on these results, a predictive model was developed to help clinicians determine the prognosis of type A AAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Health Care Sciences & Services
Eduardo Bossone, Andreina Carbone, Kim A. Eagle
Summary: Cardiovascular disease (CVD) is the leading cause of death and morbidity worldwide, and there are differences in the epidemiology and management of CVD between male and female patients. In the case of acute aortic dissection (AAD), women are typically older than men at the time of diagnosis and have a less abrupt onset of pain, leading to delayed presentation to the emergency department. Women also have a higher prevalence of hypertension and chronic obstructive pulmonary disease. In type A AAD, women are more prone to pleural effusion and coronary artery compromise, but experience fewer neurological and malperfusion symptoms. They undergo surgical treatment less frequently and have higher in-hospital mortality rates. In contrast, there are no significant differences in in-hospital mortality between genders in type B AAD. Further studies are needed to develop gender-specific strategies for preventive, diagnostic, and therapeutic approaches to AAD.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Pengfei Huang, Hongyan Wang, Dong Ma, Yongbo Zhao, Xiao Liu, Peng Su, Jinjin Zhang, Shuo Ma, Zhe Pan, Juexin Shi, Fangfang Hou, Nana Zhang, Xiaohui Zheng, Nan Liu, Ling Zhang
Summary: This study found that the admission serum sodium level of AAD patients has a significant impact on postoperative in-hospital mortality, with higher sodium levels associated with increased risk of death.
Article
Cardiac & Cardiovascular Systems
Kevin M. Harris, Christoph A. Nienaber, Mark D. Peterson, Elise M. Woznicki, Alan C. Braverman, Santi Trimarchi, Truls Myrmel, Reed Pyeritz, Stuart Hutchison, Craig Strauss, Marek P. Ehrlich, Thomas G. Gleason, Amit Korach, Daniel G. Montgomery, Eric M. Isselbacher, Kim A. Eagle
Summary: This study examined the early mortality rates for patients with TAAAD in the contemporary era and found that the mortality rate for the medical group was 0.5% per hour (23.7% at 48 hours), while for the surgical group, 48-hour mortality decreased to 4.4%.
Article
Medicine, General & Internal
Kensuke Hori, Nagisa Morikawa, Eiki Tayama, Yoshihiro Fukumoto
Summary: A study found that the use of anti-thrombotic drugs during the acute phase of aortic dissection does not increase in-hospital mortality. In patients with type A dissection, those who received anti-thrombotic treatment during hospitalization had significantly lower mortality compared to those who did not receive treatment.
Article
Cardiac & Cardiovascular Systems
Yaoyao Zhou, Qifeng Zhu, Po Hu, Huajun Li, Xinping Lin, Xianbao Liu, Zhaoxia Pu, Jian'an Wang
Summary: This study aimed to investigate the short-term trajectory of NT-proBNP following TAVR and its association with clinical outcomes in TAVR recipients. Three distinct NT-proBNP trajectories were identified, and patients with different trajectories had significantly different risks of all-cause death and cardiac death. These findings highlight the prognostic value of NT-proBNP trajectory in TAVR recipients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
I-Min Su, Huei-Kai Huang, Peter Pin-Sung Liu, Jin-Yi Hsu, Shu-Man Lin, Ching-Hui Loh
Summary: The study found that patients admitted for acute aortic dissection during weekends had a higher risk of mortality compared to those admitted on weekdays, while admission during the holiday season did not result in a significantly higher mortality risk.
Article
Cardiac & Cardiovascular Systems
Lauren Huckaby, Ibrahim Sultan, Santi Trimarchi, Bradley Leshnower, Edward P. Chen, Derek R. Brinster, Truls Myrmel, Anthony L. Estrera, Daniel G. Montgomery, Amit Korach, Hans -Henning Eckstein, Joseph S. Coselli, Takeyoshi Ota, Clayton A. Kaiser, Kim A. Eagle, Himanshu J. Patel, Thomas G. Gleason
Summary: In-hospital mortality remains higher among women with TAAD but shows improvement in the last decade. Significant differences in presentation were noted in women, including older age and greater evidence of malperfusion. Although no distinctions in 5-year mortality or reintervention were observed, a tailored surgical approach should be considered to reduce sex disparities in early mortality rates for TAAD.
ANNALS OF THORACIC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Bartosz Rylski, Oliver Schilling, Martin Czerny
Summary: Remarkable progress has been made in aortic medicine in recent decades, leading to significant changes in the understanding and treatment of thoracic aortic dissection. This state-of-the-art review article explores the mechanisms of acute aortic dissection, the impact of its entry location and dissection extension on clinical presentation and treatment decisions, and presents the latest evidence on novel treatment methods and discussions on dissection classification. Future aspects of treating acute aortic dissection are also discussed.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Changyi Li, Jingrui Zhang, Songnan Li, Caihua Sang, Nian Liu, Xin Du, Jianzeng Dong, Changsheng Ma
Summary: This study demonstrates that the 2D2G technique is safe, feasible, and time-saving for difficult TSP in atrial fibrillation patients. Successful LA access, total TSP time, and ablation time were significantly improved with the 2D2G technique compared to the conventional approach. No major complications occurred in either group, and all patients successfully underwent CPVI.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Zhen Huang, Pan Huang, Binbin Du, Lingyao Kong, Wenyuan Zhang, Yanzhou Zhang, Jianzeng Dong
Summary: The prevalence of cardiac injury is significantly increased in COVID-19 patients, particularly in those with severe disease and non-survivors. Cardiac injury is associated with a significant increase in the risk of poor outcomes, including severe disease, admission to ICU, and mortality.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Caihua Sang, Yiwei Lai, Deyong Long, Mengmeng Li, Rong Bai, Chenxi Jiang, Wei Wang, Songnan Li, Ribo Tang, Xueyuan Guo, Nian Liu, Xin Zhao, Song Zuo, Songnan Wen, Man Ning, Jiahui Wu, Xin Du, Jianzeng Dong, Changsheng Ma
Summary: The study demonstrates that ethanol infusion into the vein of Marshall is feasible and effective for the treatment of perimitral atrial tachycardia, particularly in patients with Marshall bundle-related tachycardia. It was found that patients with Marshall bundle-related tachycardia were more responsive to the treatment.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guanxing Pan, Lin Chang, Jianjun Zhang, Yangyang Liu, Liang Hu, Si Zhang, Jian Zhang, Jianlin Qiao, Ziga Jakopin, Hu Hu, Jianzeng Dong, Zhongren Ding
Summary: The study found that as a NOD2 antagonist, GSK669 not only has anti-inflammatory effects, but also acts as an efficient and safe antiplatelet agent by targeting GPVI, with antioxidant properties. The drug is also able to effectively inhibit thrombus formation, showing potential therapeutic advantages in treating atherothrombosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Wang-Yang Yang, Xin Du, Ameenathul M. Fawzy, Liu He, Hong-Wei Li, Jian-Zeng Dong, Gregory Y. H. Lip, Chang-Sheng Ma
Summary: Progression from paroxysmal atrial fibrillation (AF) to more sustained subtypes is common and associated with comorbidities, use of rhythm control strategies, and increased risk of ischemic stroke/systemic embolism and cardiovascular hospitalizations. Older age, heart failure, hypertension, and other factors increase the incidence of AF progression, while antiarrhythmic drug use and AF ablation are inversely related to it, showing effectiveness in preventing AF progression.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Xin Su, Xin Zhao, Jia-Long Deng, Song-Nan Li, Xin Du, Jian-Zeng Dong, Chang-Sheng Ma
Summary: The meta-analysis showed that antiviral therapy for HCV is associated with a reduced risk of cardiovascular disease (CVD) events. Individuals with sustained virological response (SVR) have a lower risk of CVD events compared to those without SVR.
JOURNAL OF VIRAL HEPATITIS
(2021)
Review
Cardiac & Cardiovascular Systems
Xin Zhao, Xin Su, De-Yong Long, Cai-Hua Sang, Rong Bai, Ri-Bo Tang, Nian Liu, Chen-Xi Jiang, Song-Nan Li, Xue-Yuan Guo, Wei Wang, Du Xin, Jian-Zeng Dong, Rong-Hui Yu, Chang-Sheng Ma
Summary: AF-CA in patients with situs inversus dextrocardia can be challenging due to contrary anatomy. Improved procedures and ablation strategies can ensure successful procedures, but long-term outcomes may not be favorable, indicating the need for further optimization in treatment strategies.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Cell & Tissue Engineering
Lu Wang, Xiaowei Li, Wanrong Fu, Shuai Zhang, Wenting Du, Jing Zhao, Mengduan Liu, Mengyu Wang, Yangyang Liu, Liang Hu, Zhongren Ding, Ling Li, Xiaoyan Zhao, Jianzeng Dong
Summary: An iPSC line was generated from PBMCs of a 41-year-old male patient with hypertrophic cardiomyopathy and a G3755A heterozygote mutation in the MYH6 gene. The generated iPSC line expressed pluripotency markers, had a normal karyotype, carried the specific mutation, and showed the potential to differentiate into three germ layers in vitro.
STEM CELL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Mengduan Liu, Xiaowei Li, Wanrong Fu, Mengyu Wang, Yangyang Liu, Lu Wang, Liang Hu, Xiaoyan Zhao, Jianzeng Dong
Summary: Induced pluripotent stem cells (iPSCs) are a valuable tool for studying drug and disease mechanisms, capable of generating different types of somatic cells. Reprogramming peripheral blood mononuclear cells can yield iPSCs with stable pluripotency, able to differentiate into three germ layers in vitro.
STEM CELL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Zhaojie Dong, Xin Du, Shangxin Lu, Chao Jiang, Shijun Xia, Liu He, Xin Su, Zhaoxu Jia, Deyong Long, Caihua Sang, Ribo Tang, Nian Liu, Rong Bai, Ronghui Yu, Jianzeng Dong, Changsheng Ma
Summary: More than one-third of atrial fibrillation (AF) patients in this study were hospitalized at least once during a follow-up of over 3 years. Patients aged 65 years or older were mainly hospitalized for non-cardiovascular diseases rather than AF. Patients with comorbidities such as heart failure, coronary artery disease, ischemic stroke/transient ischemic attack, diabetes, chronic obstructive pulmonary disease, gastrointestinal disorder, and renal dysfunction had higher risks of hospitalization.
BMC CARDIOVASCULAR DISORDERS
(2021)
Editorial Material
Medicine, General & Internal
Chao Liu, Li-Li Xiao, Lu Wang, Fu-Qiang Sun, Xing-Xing Yao, Yan-Zhou Zhang, Xiao-Yan Zhao, Ling Li, Xiao-Fang Wang, Jian-Zeng Dong
CHINESE MEDICAL JOURNAL
(2021)
Correction
Oncology
Shuangshuang Lu, Zhe Zhang, Pan Du, Louisa S. Chard, Wenli Yan, Margueritte El Khouri, Zhizhong Wang, Zhongxian Zhang, Yongchao Chu, Dongling Gao, Qinxian Zhang, Lirong Zhang, Ai Nagano, Jun Wang, Claude Chelala, Jing Liu, Jiekai Chen, Pentao Liu, Yunshu Dong, Shengdian Wang, Xiaozhu Li, Jianzeng Dong, Nick R. Lemoine, Duanqing Pei, Yaohe Wang
CLINICAL CANCER RESEARCH
(2021)
Article
Cell & Tissue Engineering
Guangli Guo, Wanrong Fu, Xiaowei Li, Jianzeng Dong, Xiaoyan Zhao, Yanzhou Zhang
Summary: This study successfully established a hiPSCs line capable of differentiating into all three germ layers, providing a new research model for studying HCM.
STEM CELL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Xiaoxu Tian, Wanrong Fu, Guangli Guo, Shujian Huang, Yiming Dong, Xiaowei Li, Jianzeng Dong, Xiaoyan Zhao, Yanzhou Zhang
Summary: Hypertrophic cardiomyopathy, associated with ALPK3 gene mutation, is the most common monogenic cardiomyopathy in humans. The study reports the generation and characterization of a human induced pluripotent stem cell line ZZUNEUi015-A derived from a patient with heterozygous mutation in ALPK3 gene, maintaining pluripotency and normal karyotype and differentiating into three germ layers in vitro.
STEM CELL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Shujian Huang, Wanrong Fu, Guangli Guo, Xiaoxu Tiana, Xiaoyan Zhao, Jianzeng Dong, Xiaowei Li, Haibo Yang
Summary: In this study, PBMCs from a DCM patient with TTN gene mutation were reprogrammed into iPSCs, showing pluripotency and normal karyotype, with differentiation potential into three germ layers demonstrated in vitro.
STEM CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.
