Inhibition of Heat Shock Protein 90 as a Novel Platform for the Treatment of Cancer

GALNT5 uaRNA promotes gastric cancer progression through its interaction with HSP90

(2018) Hui Guo et al.   ONCOGENE

3′-epi-12β-hydroxyfroside, a new cardenolide, induces cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in lung cancer cells

(2018) Yan Sun et al.   Theranostics

Heat shock proteins and cancer: How can nanomedicine be harnessed?

(2017) Félix Sauvage et al.   JOURNAL OF CONTROLLED RELEASE

The Plasticity of the Hsp90 Co-chaperone System

(2017) Priyanka Sahasrabudhe et al.   MOLECULAR CELL

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?

(2017) Stuart K. Calderwood   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Hsp90 and FKBP51: complex regulators of psychiatric diseases

(2017) Marangelie Criado-Marrero et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Heat Shock Proteins and Cancer

(2017) Jianming Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Rosemary extract reduces Akt/mTOR/p70S6K activation and inhibits proliferation and survival of A549 human lung cancer cells

(2016) Jessy Moore et al.   BIOMEDICINE & PHARMACOTHERAPY

Heat Shock Proteins and Diabetes

(2016) Marzie Zilaee et al.   Canadian Journal of Diabetes

Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells

(2016) R. Ferraldeschi et al.   CANCER RESEARCH

Systemic genome screening identifies the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma

(2016) Chuan-chuan Zhou et al.   HEPATOLOGY

In vitro study comparing the efficacy of the water-soluble HSP90 inhibitors, 17-AEPGA and 17-DMAG, with that of the non-water-soluble HSP90 inhibitor, 17-AAG, in breast cancer cell lines

(2016) Tarik Ghadban et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress

(2016) C. Y. Wang et al.   MOLECULAR CANCER THERAPEUTICS

HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells

(2015) Dae-Hee Lee et al.   CELLULAR SIGNALLING

Advances in the care of patients with mucinous colorectal cancer

(2015) Niek Hugen et al.   Nature Reviews Clinical Oncology

Regulating the cytoprotective response in cancer cells using simultaneous inhibition of Hsp90 and Hsp70

(2015) Y. Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

(2015) Toshihide Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp90 interaction with clients

(2015) G. Elif Karagöz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells

(2015) Yu-Jia Chang et al.   TUMOR BIOLOGY

The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells

(2015) Diana Spiegelberg et al.   Oncotarget

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells

(2014) Jian Kang et al.   BMC CANCER

HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization

(2014) N. Azoitei et al.   CANCER RESEARCH

Ganetespib, a Novel Hsp90 Inhibitor in Patients With KRAS Mutated and Wild Type, Refractory Metastatic Colorectal Cancer

(2014) Andrea Cercek et al.   Clinical Colorectal Cancer

Inhibition of HSP90 by AT13387 Delays the Emergence of Resistance to BRAF Inhibitors and Overcomes Resistance to Dual BRAF and MEK Inhibition in Melanoma Models

(2014) T. Smyth et al.   MOLECULAR CANCER THERAPEUTICS

Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2

(2013) Cindy Gallerne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells

(2013) KATHRIN ZITZMANN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Molecular Mechanism of 17-Allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL Receptor Tyrosine Kinase Degradation

(2013) Gnana Prakasam Krishnamoorthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma

(2013) Srikanth R. Ambati et al.   Molecular Oncology

A global view of Hsp90 functions

(2013) Gabriela Chiosis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The chaperone Hsp90: changing partners for demanding clients

(2013) Alina Röhl et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure, Function and Regulation of the Hsp90 Machinery

(2013) Johannes Buchner et al.   Biomedical Journal

Hsp90 inhibitor NVP-AUY922 enhances radiation sensitivity of tumor cell lines under hypoxia

(2012) Cholpon S. Djuzenova et al.   CANCER BIOLOGY & THERAPY

The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells

(2012) Ai‑min Leng et al.   CELL BIOLOGY INTERNATIONAL

Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33

(2012) Ninel Azoitei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

(2012) Sandra Misale et al.   NATURE

Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer

(2012) XIAO-HONG BAO et al.   ONCOLOGY REPORTS

Evidence of Prognostic Relevant Expression Profiles of Heat-Shock Proteins and Glucose-Regulated Proteins in Oesophageal Adenocarcinomas

(2012) Julia Slotta-Huspenina et al.   PLoS One

Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

(2012) S. Tsutsumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution and function of diverse Hsp90 homologs and cochaperone proteins

(2011) Jill L. Johnson   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia

(2011) Hudan Liu et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Molecular basis for the actions of Hsp90 inhibitors and cancer therapy

(2011) Hiroshi Yamaki et al.   JOURNAL OF ANTIBIOTICS

Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53

(2011) Franz Hagn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heterogeneity and dynamics in the assembly of the Heat Shock Protein 90 chaperone complexes

(2011) I.-o. Ebong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis

(2010) Carmen Palacios et al.   LEUKEMIA RESEARCH

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Geldanamycin and its anti-cancer activities

(2009) Yayoi Fukuyo et al.   CANCER LETTERS

Targeting heat shock protein 90 with non-quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma

(2009) Marco Breinig et al.   HEPATOLOGY

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90

(2009) Martin Hessling et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

(2007) Paul A. Brough et al.   JOURNAL OF MEDICINAL CHEMISTRY