Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 56, Issue -, Pages 16-23Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2018.10.012
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Funding
- National Brain Research Program of Hungary [2017-1.2.1-NKP-2017-00002]
- Excellence Program for Higher Education of Hungary [FIKP-2018]
- Swedish Medical Research Council
- Novo Nordisk Foundation
- Hjamfonden
- European Research Council [2015-AdG-695136]
- Medical University of Vienna
- European Commission FP7 program (Marie Curie Actions, EMBOCOFUND2012) [aALTF 493-2017, GA-2012-600394]
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Volume transmission is a mode of intercellular communication using cerebral liquor to deliver signal molecules over long distances and allow their action for extended periods. For hypothalamic neuropeptides, nerve endings amongst ependymal cells are seen as a site of release into the cerebrospinal fluid. Recent single-cell RNA-seq data identify tanycytes and ventricular ependyma as alternative sources by being unexpectedly rich in neuroactive substances. This notion, coupled with circuit analysis showing regionalized innervation of periventricular ependyma by intrahypothalamic neurons, could allow for the integration of hypothalamic neuronal activity patterns with brain-wide activity changes upon metabolic challenges through phasic volume transmission primed by neuron-ependyma coupling. Here, we discuss emerging data for an ependymal interface and its breaches in neuropsychiatric disease.
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