Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 58, Issue -, Pages 34-41Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2018.12.007
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Funding
- National Institutes of Health [R01GM075249]
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For equal chromosome segregation, a pair of kinetochores on each duplicated chromosome must attach to microtubules connecting to opposite poles. The protein kinase Aurora B plays a critical role in destabilizing microtubules attached in a wrong orientation through phosphorylating kinetochore proteins. The mechanism behind this selective destabilization of aberrant attachments remains elusive. While Aurora B is most enriched on the centromere from prophase to metaphase, emerging evidence suggests the importance of Aurora B on microtubules in this process. Here I discuss two hypothetical models that could explain the requirement of Aurora B on microtubules for selective destabilization of aberrant attachments; microtubule-induced substrate masking and treadmill-removal of Aurora B on microtubules proximal to polymerizing ends.
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