Article
Computer Science, Interdisciplinary Applications
Jun Zhan, Ziyan Zhang, Shun Zhang, Jiabao Zhao, Fuhong Wang
Summary: This research examines the impact of dynamic capabilities on servitization in the digital economy, and explores the role of factors such as firm ownership, firm lifecycle stage, digital economy level, and environmental uncertainty. The findings suggest that the success of manufacturing servitization depends on the interaction between dynamic capabilities and these contingency factors.
INDUSTRIAL MANAGEMENT & DATA SYSTEMS
(2023)
Article
Endocrinology & Metabolism
Angela Cristina Nicola, Larissa Brazoloto Ferreira, Milene Mantovani Mata, Tatiane Vilhena-Franco, Cristiane Mota Leite, Andressa Busetti Martins, Jose Antunes-Rodrigues, Maristela Oliveira Poletini, Rita Cassia Menegati Dornelles
Summary: During early embryonic development, there are complex interactions and changes in gene expression to adapt to the needs of different stages of embryonic development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Gabrielle Zuniga, Simon Levy, Paulino Ramirez, Jasmine De Mange, Elias Gonzalez, Maria Gamez, Bess Frost
Summary: This study investigates the mechanisms behind altered RNA processing in tauopathies, specifically focusing on the reduction of nonsense-mediated mRNA decay (NMD) activity. The researchers find that deficits in NMD contribute to neurodegeneration in tauopathy through aberrant RNA export and accumulation. They identify a pharmacological activator of NMD that suppresses neurodegeneration in a tau transgenic Drosophila model, suggesting potential therapeutic value for tauopathy patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Hana Mikova, Viktor Kuchtiak, Irena Svobodova, Veronika Spisska, Dominika Pacesova, Ales Balik, Zdenka Bendova
Summary: The study evaluated the circadian rhythmicity of AMPA receptor GluA2 subunit in the SCN and other brain structures in Wistar rats, revealing differences in expression patterns and correlations in different brain regions.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biology
Jonas Engert, Julia Doll, Barbara Vona, Totta Ehret Kasemo, Bjoern Spahn, Rudolf Hagen, Kristen Rak, Johannes Voelker
Summary: This study investigated the changes in mRNA abundance of genes influencing neural stem cell development and neurogenesis in the rat cochlear nucleus over time. Age- and hearing-specific patterns of changes in mRNA abundance of neurogenically relevant genes were detected. Crucial neurogenic factors with significant and relevant influence on neurogenesis were identified. These findings contribute to a better understanding of the molecular mechanisms underlying the neurogenesis of the auditory pathway.
Article
Psychiatry
Xiaojie Li, Bing Xie, Yun Lu, Hongyu Yang, Jian Wang, Feng Yu, Ludi Zhang, Bin Cong, Di Wen, Chunling Ma
Summary: Recent research suggests that non-coding RNAs (ncRNAs) play an important role in regulating chromatin dynamics and gene expression in the nervous system. This study used RNA sequencing to examine the expression profiles of ncRNAs, miRNAs, and mRNAs in mice trained with morphine or saline, and identified differentially expressed genes. A ceRNA network was established to explore the interactions between these genes, and functional pathways related to synaptic plasticity were identified. The results provide new insights into the ceRNA regulatory mechanisms underlying morphine addiction and may serve as potential biomarkers for diagnosis and prognosis.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Estanislao Navarro, Adrian Mallen, Miguel Hueso
Summary: This paper discusses the polymorphic nature of 3'UTR regions in mRNAs and the mechanisms that control their length and sequence, impacting the accessibility of functional effectors and ultimately gene expression regulation.
Review
Oncology
Shanshan Wang, Wei Lv, Tao Li, Shubing Zhang, Huihui Wang, Xuemei Li, Lianzi Wang, Dongyue Ma, Yan Zang, Jilong Shen, Yuanhong Xu, Wei Wei
Summary: N-6-Methyladenosine (m6A) is the most abundant internal modification associated with eukaryotic mRNAs, and it plays a dynamic regulatory role in gene expression by affecting various steps of mRNA metabolism. This review discusses the general role of m6A, focusing on the three major types of enzymes that determine the level of m6A modification and the regulatory mechanism by which m6A influences RNA metabolism. Understanding the role of m6A in physiological and pathophysiological processes, especially in tumorigenesis, is of great importance.
CANCER CELL INTERNATIONAL
(2022)
Article
Green & Sustainable Science & Technology
Keyur K. Moradiya, Kumudinee V. Marathe
Summary: The environmental impacts of marine microalgae cultivation and harvesting from an Indian context were evaluated in this study. It was found that the algal-based technology could reduce emissions by 1.28 kg CO2 eq./kg algae produced. The source of electricity was identified as the main contributor to the marine aquatic ecotoxicity potential (MAETP). Replacing a higher percentage of Indian mixed grid electricity with solar-based electricity resulted in greater CO2 mitigation.
SUSTAINABLE ENERGY TECHNOLOGIES AND ASSESSMENTS
(2023)
Article
Management
Jie Hou, Baizhou Li, Shi Yin
Summary: External resources play a crucial role in the development of corporate dynamic core capabilities. This study examines the impact of external technical coordination on the development of dynamic core capabilities for product innovation in IoT firms. The findings reveal that the influence of external technical coordination on dynamic core capabilities and innovation performance varies throughout the product lifecycle, with a weakening trend overall. The study also highlights the heterogeneous impact of external technical coordination at different stages of the product lifecycle.
TECHNOLOGY ANALYSIS & STRATEGIC MANAGEMENT
(2022)
Article
Multidisciplinary Sciences
Yun-Wen Wu, Sen Li, Wei Zheng, Yan-Chu Li, Lu Chen, Yong Zhou, Zuo-Qi Deng, Ge Lin, Heng-Yu Fan, Qian-Qian Sha
Summary: The decrease in oocyte developmental potential in women of advanced age is influenced by age-related epigenetic modifications and dynamic transcriptome changes. This study investigates the decreased storage of key factor-encoding transcripts and impaired mRNA clearance in aged oocytes, along with a decrease in histone H3K4 trimethylation. Furthermore, the knockout of the CXXC1 gene results in accelerated aging and impaired oocyte development.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yi-Lan Chen, Jin-Der Wen
Summary: Initiation of protein synthesis in bacteria requires the correct recognition of the start codon on mRNA. This study investigates how the ribosome accommodates the short and degenerate information in the ribosome-binding site (RBS) to initiate translation. The researchers found that the initiation factors and the initiator tRNA play a crucial role in stabilizing the mRNA structure and promoting its unwinding by the 30S subunit. This dynamic assembly-disassembly process ensures the selection of the correct RBS. The findings provide insights into the mechanism of translation initiation in bacteria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Krishna C. Suddala, Janghyun Yoo, Lixin Fan, Xiaobing Zuo, Yun-Xing Wang, Hoi Sung Chung, Jinwei Zhang
Summary: T-box riboswitch RNAs directly bind to specific tRNA and regulate the transcription or translation of downstream genes in bacteria. Using single-molecule FRET and ensemble biophysical analyses, here the authors uncover a Venus flytrap-like mechanism where tRNA binding to a T-box riboswitch mRNA triggers its rapid domain closure.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Ming-Chao Yang, Zi-Chen Wu, Ri-Yao Chen, Farhat Abbas, Gui-Bing Hu, Xu-Ming Huang, Wei-Song Guan, Yi-Song Xu, Hui-Cong Wang
Summary: Single-nucleus RNA sequencing combined with mRNA hybridization identified key genes involved in floral initiation in litchi apical buds. The analysis of 41,641 nuclei revealed 35 cell clusters and proposed a model profiling the key events associated with litchi floral meristem identity. Interestingly, the transportability of FT and TFL1 mRNA from leaf to shoot apical meristem was proposed based on hybridization results. These findings provide insights into the molecular events during litchi floral transition and the identification of new regulators.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Information Science & Library Science
Ferran Vendrell-Herrero, Emanuel Gomes, Marco Opazo-Basaez, Oscar F. Bustinza
Summary: This paper distinguishes between industry lifecycle (ILC) and product lifecycle (PLC) models, highlighting implications for learning and innovation in digital manufacturing. The study identifies different types of learning associated with each phase of the ILC and explores how they influence PLC in digital innovation. Learning-by-feedback is crucial for co-creation, co-production, and open innovation, while learning-by-doing and learning-by-memory are essential for production and usage stages.
JOURNAL OF KNOWLEDGE MANAGEMENT
(2022)
Editorial Material
Biochemistry & Molecular Biology
Timir Tripathi, Jay Prakash, Yaron Shav-Tal
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Hodaya Hochberg-Laufer, Avital Schwed-Gross, Karla M. Neugebauer, Yaron Shav-Tal
NUCLEIC ACIDS RESEARCH
(2019)
Article
Cell Biology
Rakefet Ben-Yishay, Amir Mor, Amit Shraga, Asaf Ashkenazy-Titelman, Noa Kinor, Avital Schwed-Gross, Avi Jacob, Noga Kozer, Pramod Kumar, Yuval Garini, Yaron Shav-Tal
JOURNAL OF CELL BIOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Asaf Ashkenazy-Titelman, Yaron Shav-Tal, Ralph H. Kehlenbach
BIOCHEMICAL JOURNAL
(2020)
Article
Biochemical Research Methods
Abed Saady, Melissa Wojtyniak, Eli Varon, Verena Boettner, Noa Kinor, Yaron Shav-Tal, Christian Ducho, Bilha Fischer
BIOCONJUGATE CHEMISTRY
(2020)
Article
Genetics & Heredity
Naama Sebbag-Sznajder, Yehuda Brody, Hodaya Hochberg-Laufer, Yaron Shav-Tal, Joseph Sperling, Ruth Sperling
FRONTIERS IN GENETICS
(2020)
Article
Biochemistry & Molecular Biology
Sarah E. Hasenson, Yaron Shav-Tal
Article
Cell Biology
Ella Alkalay, Chen Gam Ze Letova Refael, Irit Shoval, Noa Kinor, Ronit Sarid, Yaron Shav-Tal
Article
Virology
Daniela Dunn-Kittenplon, Asaf Ashkenazy-Titelman, Inna Kalt, Jean-Paul Lellouche, Yaron Shav-Tal, Ronit Sarid
Summary: This study investigates the docking of KSHV capsids at NPCs, finding a significantly lower attachment rate of ORF43-null capsids to the nuclear envelope compared to wild-type capsids. The study concludes that although not essential, the portal plays a role in mediating the interaction of CVSC proteins with Nups, suggesting a model where WT capsids can dock at the nuclear envelope through a non-portal penton vertex, leading to a potential infection 'dead end'.
Article
Multidisciplinary Sciences
Noa Dahan, Yury S. Bykov, Elizabeth A. Boydston, Amir Fadel, Zohar Gazi, Hodaya Hochberg-Laufer, James Martenson, Vlad Denic, Yaron Shav-Tal, Jonathan S. Weissman, Naama Aviram, Einat Zalckvar, Maya Schuldiner
Summary: This study discovered that translation of specific peroxisomal membrane proteins (PMPs) occurs on the surface of peroxisomes in yeast, similar to chloroplasts, mitochondria, and the endoplasmic reticulum. This localized translation process ensures the correct insertion of hydrophobic proteins into the peroxisomal membrane. Proper targeting of PMP transcripts to peroxisomes is crucial for cellular and peroxisomal function, highlighting the importance of localized translation in cellular physiology.
Article
Cell Biology
Avital Schwed-Gross, Hila Hamiel, Gabriel P. Faber, Mor Angel, Rakefet Ben-Yishay, Jennifer I. C. Benichou, Dana Ishay-Ronen, Yaron Shav-Tal
Summary: Glucocorticoids, when combined with chemotherapies, can induce the formation of stress granules, enhance cell death, and affect cell sensitivity to chemotherapy.
JOURNAL OF CELL SCIENCE
(2022)
Review
Cell Biology
Gabriel P. Faber, Shani Nadav-Eliyahu, Yaron Shav-Tal
Summary: Nuclear speckles are membraneless structures in the cell nucleus that harbor RNAs and proteins, including splicing factors, with complex biophysical properties. Recent genomic analysis combined with microscopy approaches has shed light on their essential functions in gene activity modulation. Nuclear speckles play a role in enhancing gene expression, gene positioning, and RNA processing, and have been implicated in certain diseases, particularly viral infections. They represent an intriguing target for further study and potential therapeutic interventions.
JOURNAL OF CELL SCIENCE
(2022)
Article
Cell Biology
Sarah E. Hasenson, Ella Alkalay, Mohammad K. Atrash, Alon Boocholez, Julianna Gershbaum, Hodaya Hochberg-Laufer, Yaron Shav-Tal
Summary: Using live-cell imaging, we found that MEG3 lncRNA is a transient resident of nuclear speckles and its association with this nuclear body is modulated by the levels of transcription and splicing activities in the cell.
Article
Multidisciplinary Sciences
Asaf Ashkenazy-Titelman, Mohammad Khaled Atrash, Alon Boocholez, Noa Kinor, Yaron Shav-Tal
Summary: The organization and directionality of mRNA during nucleo-cytoplasmic transport and export have been investigated in this study. The authors found that mRNP is compact during nucleoplasmic travels and exhibits 5'-first directionality during export.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Gabriel P. Faber, Hagit Hauschner, Mohammad K. Atrash, Liat Bilinsky, Yaron Shav-Tal
Summary: Endogenous gene knock-in using CRISPR is the standard method for fluorescent tagging of endogenous proteins. However, current protocols may result in off-target insertions that lead to false positives. This study demonstrates a new gating strategy during flow cytometry to highly enrich for positively integrated cells, improving the generation of cell lines with correctly integrated gene knock-ins.
