Journal
CURRENT MOLECULAR MEDICINE
Volume 19, Issue 3, Pages 157-163Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1566524019666190226104909
Keywords
Small cell lung cancer; chemotherapy resistance; multidrug resistance; intracellular enzyme system; apoptosis escape; cell repair system; cancer stem cells
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Funding
- Natural Science Foundation of Shandong Province [Z2007C18]
- Science and Technology Program of Shandong Province [2007GG30002024, 2013GGB14099]
- Medical Health Technology Development Program of Shandong Province [2016WS0430]
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The malignancy of small cell lung cancer (SCLC) is the highest amongst all lung cancer types. It is characterized by rapid growth, early occurrence of distant sites metastasis, poor survival rates and is initially sensitive to chemotherapy and radiotherapy. However, most patients eventually relapse or disease progresses because of chemotherapy resistance. Because of lack of effective second-line therapies, the prognosis of SCLC patients is usually poor. For the development of novel therapies, it is necessary to understand the mechanisms of chemotherapy resistance in SCLC. The mechanism is complex, because multiple factors could lead to chemotherapy resistance. An overview of multiple events triggering the formation of chemotherapy resistance phenotypes of SCLC cells is discussed.
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