Article
Biotechnology & Applied Microbiology
Piaoye Ming, Pengcheng Rao, Tianli Wu, Jianghua Yang, Shi Lu, Binbin Yang, Jingang Xiao, Gang Tao
Summary: Guided tissue regeneration (GTR) technique is a promising treatment for periodontal tissue defects. A unique GTR membrane based on sericin-hydroxyapatite (Ser-HAP) can induce the differentiation of human periodontal membrane stem cells (hPDLSCs) into osteoblasts, promoting periodontal tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Sivaraj Mehnath, Velluchamy Muthuraj, Murugaraj Jeyaraj
Summary: The synthesis of a snail shell-derived bioceramic/polymeric 3D scaffold was investigated in this study. The scaffold showed improved mechanical strength, compressive strength, and porosity due to the incorporation of hydroxyapatite (HAP). The HAP grafting on the surface of the scaffold promoted mineralization and facilitated the attachment and proliferation of cells. Additionally, the scaffold exhibited biocompatible properties and demonstrated antibacterial activity against gram-positive/gram-negative bacteria, making it suitable for bone tissue engineering applications.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Bangbang Liang, Tianyi Feng, Xiaoting Yuan, Kang Zhao, Chengyu Li, Yingchao Han
Summary: The study investigated the effect of proportion on the physicochemical and osteogenic properties of electrospun nano-hydroxyapatite/polylactic acid (nHAP/PLA) fiber membrane. The addition of an appropriate amount of nHAP increased the hydrophilicity of the fiber surface and enhanced the modulus in the perpendicular direction to the membrane plane. In biological experiments, 6-10 wt% nHAP/PLA membrane significantly promoted cell proliferation and differentiation. In vivo experiments showed that the addition of 6-10 wt% nHAP/PLA promoted cell recruitment and infiltration, and increased bone tissue volume/total tissue volume and bone mineral density.
MATERIALS & DESIGN
(2022)
Article
Materials Science, Ceramics
Ammar Z. Alshemary, Rafaqat Hussain, Ali Deniz Dalgic, Zafer Evis
Summary: Hydroxyapatite (HA) particles with enhanced antibacterial properties can be prepared by integrating metal ions into the crystal structure of the nanoparticles. The HA particles containing cobalt and silicate ions exhibited reduced crystallite size, inhibited bacterial growth, and showed cytocompatibility, suggesting their potential applications in biomaterial-tissue engineering.
CERAMICS INTERNATIONAL
(2022)
Review
Engineering, Biomedical
Jue Wang, Zhihui Liu, Bingyu Ren, Qian Wang, Jia Wu, Nan Yang, Xin Sui, Lingfeng Li, Meihui Li, Xiao Zhang, Xinyue Li, Bowei Wang
Summary: Caries and dental erosion are common oral diseases. Biomimetic mineralisation is an ideal approach for restoring enamel, forming a new mineral layer that is tightly attached to the surface. This review highlights the application of various techniques in biomimetic mineralisation for enamel restoration.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Mashrafi Bin Mobarak, M. Nahidul Islam, Fariha Chowdhury, Md. Najem Uddin, Md. Sahadat Hossain, Monika Mahmud, Umme Sarmeen Akhtar, Nazmul Islam Tanvir, A. F. M. Mustafizur Rahman, Samina Ahmed
Summary: This study successfully synthesized biomimetic nano-hydroxyapatite and characterized it using various analysis methods. The material showed excellent potential for biomedical applications and can be used as a drug delivery agent for antibiotics.
Article
Engineering, Biomedical
Venkata Avadhanam, Ganesh Ingavle, Yishan Zheng, Sandeep Kumar, Christopher Liu, Susan Sandeman
Summary: A hydrogel polymer composite was developed as a synthetic substitute for the OOKP skirt, mimicking the alveo-dental lamina by incorporating nano-crystalline hydroxyapatite (nHAp) coated PLGA microspheres. The IPN hydrogel combinations supported cell adhesion and proliferation, while also showing non-inflammatory potential, making them promising materials for OOKP skirt substitutes.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Chemistry, Physical
Chingis Daulbayev, Fail Sultanov, Alina Korobeinyk, Mukhtar Yeleuov, Azamat Taurbekov, Baglan Bakbolat, Arman Umirzakov, Alzhan Baimenov, Olzhas Daulbayev
Summary: This paper presents the fabrication and characterization of electrospun graphene oxide/calcium hydroxyapatite/polycaprolactone composite, which shows excellent biocompatibility, mechanical properties, electrical and thermal conductivity. It can enhance osteogenic differentiation of osteoblasts and exhibits antimicrobial effect, making it a promising candidate for bone tissue regeneration in medical and dental applications.
SURFACES AND INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yunpeng Zhang, Xiaorong Chen, Yuan Li, Tian Bai, Chen Li, Lingyan Jiang, Yu Liu, Changying Sun, Wenhao Zhou
Summary: Developing a silk fibroin-based coating embedded with nanohydroxyapatite and silver nanoparticles is an effective approach to enhance bone healing and inhibit bacterial infection. The coating showed good antibacterial ability by inhibiting bacterial adhesion and killing planktonic bacteria efficiently. Additionally, it was beneficial for osteoblast adhesion, spreading, and proliferation, while reducing the cytotoxicity of silver nanoparticles.
Article
Chemistry, Physical
Marta Kalbarczyk, Aleksandra Szczes, Izolda Kantor, Zoltan May, Dariusz Sternik
Summary: Calcium phosphate materials can be obtained from eggshells of different animals as a calcium source via environmentally friendly wet synthesis, and these materials have potential biomedical applications.
Article
Chemistry, Multidisciplinary
Piaoye Ming, Yunfei Liu, Peiyang Yu, Xueyu Jiang, Linlin Yuan, Shuyu Cai, Pengcheng Rao, Rui Cai, Xiaorong Lan, Gang Tao, Jingang Xiao
Summary: In this study, sericin-hydroxyapatite nanoparticles and proanthocyanidins are encapsulated in sericin/sodium alginate to prepare microspheres. These microspheres have efficient ROS-scavenging, anti-inflammatory, and osteogenic abilities, promoting the osteogenic differentiation of hPDLSCs and demonstrating anti-inflammatory effects in a periodontitis rat model. They also reduce alveolar bone loss, osteoclast activity, and boost osteogenic factor expression.
Article
Chemistry, Multidisciplinary
Fatemeh Paziresh, Amin Salem, Shiva Salem
Summary: The study successfully produced hydroxyapatite from eggshell through self-combustion route, demonstrating good adsorption capacity for various disperse dyes in industrial systems. The fabricated adsorbent showed excellent thermal stability and regenerability, providing a promising strategy for reuse in the recovery process.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Kiseok Han, Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, So-young Park, Sukjin Shin, Han Bin Choi, Kumar Vishven Naveen, Myeong-Hyeon Wang
Summary: A composite composed of chitosan and natural hydroxyapatite was developed to deliver erythromycin for enhanced treatment of bacterial infections. The composite effectively inhibited the growth and biofilm formation of B. cereus and S. entrica without showing any toxicity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Juan Wu, Ya-qi Chi, Yu-jia Yan, Meng-zhen Ji, Xuan Chen, Xue-qin Yang, Yuan Gao, Qin Zou, Ling Zou, Xi-yu Li
Summary: In this study, a novel HA:Tb/Zn biomaterial was developed to simultaneously achieve antibacterial effect, osteogenic activity, and long-time tracing property. The results showed that HA:Tb/Zn exhibited strong antibacterial effects on both Gram-positive and Gram-negative clinical infectious bacteria, as well as improved osteogenic activity. Additionally, HA:Tb/Zn demonstrated stable green fluorescence in vitro and in vivo, indicating its great potential for recognizing material changes during bone reconstruction. The combination of these ternary functions is of great significance in controlling the overuse of antibiotics, achieving long-time tracing, and providing a versatile design for biomaterials in bone repair.
Article
Biochemistry & Molecular Biology
Milos Lazarevic, Sanja Petrovic, Tania Vanessa Pierfelice, Nenad Ignjatovic, Adriano Piattelli, Tamara Vlajic Tovilovic, Milena Radunovic
Summary: This study assessed the biocompatibility, osteogenic effect, and antibacterial properties of a modified collagen membrane. The results showed that the modified membrane exhibited good biocompatibility, osteogenic potential, and antimicrobial effects. Therefore, the incorporation of chitosan and hydroxyapatite nanoparticles in collagen membranes may be advantageous for promoting bone regeneration and reducing bacterial adhesion.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)