Research progress on adenosine in central nervous system diseases

Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice

(2019) Xuzhao Zhou et al.   NEUROCHEMISTRY INTERNATIONAL

Extracellular adenosine: a critical signal in liver fibrosis

(2018) Michel Fausther   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Corticostriatal Adenosine A 2A Receptor Controls Maintenance and Retrieval of Spatial Working Memory

(2018) Zhihui Li et al.   BIOLOGICAL PSYCHIATRY

Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect

(2018) Guoping Liu et al.   BRAIN RESEARCH

New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism

(2018) Elizabeth A Vecchio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endogenous Adenosine May Be Related to Left Ventricular Dysfunction, Dilation, and Wall Thinning in Patients With Heart Disease

(2018) Yujiro Kinomura et al.   CIRCULATION JOURNAL

Isoflurane anesthesia in aged mice and effects of A1 adenosine receptors on cognitive impairment

(2018) Chun-Long Zuo et al.   CNS Neuroscience & Therapeutics

Early-life hyperthermic seizures upregulate adenosine A 2A receptors in the cortex and promote depressive-like behavior in adult rats

(2018) María Crespo et al.   EPILEPSY & BEHAVIOR

Role of adenosine A2A receptors in motor control: relevance to Parkinson’s disease and dyskinesia

(2018) Annalisa Pinna et al.   JOURNAL OF NEURAL TRANSMISSION

The combination of ribose and adenine promotes adenosine release and attenuates the intensity and frequency of epileptiform activity in hippocampal slices: Evidence of the rapid depletion of cellular ATP during electrographic seizures

(2018) Jessicka Hall et al.   JOURNAL OF NEUROCHEMISTRY

Blockade of adenosine A 2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

(2018) António C. Silva et al.   NEUROBIOLOGY OF DISEASE

Inosine alleviates depression-like behavior and increases the activity of the ERK-CREB signaling in adolescent male rats

(2018) Shuai Yuan et al.   NEUROREPORT

Adenosine role in brain functions: Pathophysiological influence on Parkinson's disease and other brain disorders

(2018) Amira M. Soliman et al.   Pharmacological Reports

Early changes in transient adenosine during cerebral ischemia and reperfusion injury

(2018) Mallikarjunarao Ganesana et al.   PLoS One

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A1receptors

(2018) Eva-Maria Elmenhorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Behavioral changes induced through adenosine A2A receptor ligands in a rat depression model induced by olfactory bulbectomy

(2018) Karla Margarita Padilla et al.   Brain and Behavior

Adenosine A2A Receptors Facilitate Synaptic NMDA Currents in CA1 Pyramidal Neurons

(2018) Francisco Mouro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Caffeine Consumption Prevents Memory Impairment, Neuronal Damage, and Adenosine A2A Receptors Upregulation in the Hippocampus of a Rat Model of Sporadic Dementia

(2018) Janaína Espinosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Different Adenosine A2A Receptor Expression in Peripheral Cells from Elderly Patients with Vascular Dementia and Alzheimer's Disease

(2018) Cristina Gussago et al.   JOURNAL OF ALZHEIMERS DISEASE

Sitagliptin attenuates intestinal ischemia/reperfusion injury via cAMP/PKA, PI3K/Akt pathway in a glucagon-like peptide 1 receptor-dependent manner

(2018) Rehab M. Khedr et al.   LIFE SCIENCES

Accurate measurement of endogenous adenosine in human blood

(2018) Lars Löfgren et al.   PLoS One

Flipping ATP to AMPlify Kinase Functions

(2018) Joshua B. Sheetz et al.   CELL

The role of adenosine in up-regulation of p38 MAPK and ERK during limb ischemic preconditioning-induced brain ischemic tolerance

(2018) Qiang Yuan et al.   BRAIN RESEARCH

Cobalamin riboswitches exhibit a broad range of ability to discriminate between methylcobalamin and adenosylcobalamin

(2017) Jacob T. Polaski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase

(2017) Zhengan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of Long-Term Caffeine Consumption on the Adenosine A1 Receptor in the Rat Brain: an In Vivo PET Study with [18F]CPFPX

(2017) Danje Nabbi-Schroeter et al.   MOLECULAR IMAGING AND BIOLOGY

The Ying and Yang of Adenosine A1 and A2A Receptors on ERK1/2 Activation in a Rat Model of Global Cerebral Ischemia Reperfusion Injury

(2017) Reham M. Atef et al.   MOLECULAR NEUROBIOLOGY

Effective Attenuation of Adenosine A1R Signaling by Neurabin Requires Oligomerization of Neurabin

(2017) Yunjia Chen et al.   MOLECULAR PHARMACOLOGY

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

(2017) Emrin Horgusluoglu-Moloch et al.   NEUROBIOLOGY OF AGING

Intracellular acidification increases adenosine transport in human umbilical vein endothelial cells

(2017) Natalia Celis et al.   PLACENTA

Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

(2017) Carmen Corciulo et al.   Nature Communications

Adenosine A1-A2A Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease

(2017) Víctor Fernández-Dueñas et al.   Frontiers in Neuroscience

A Meta-Analysis of Adenosine A2A Receptor Antagonists on Levodopa-Induced Dyskinesia In Vivo

(2017) Wen-Wen Wang et al.   Frontiers in Neurology

The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain

(2017) Marina Matyash et al.   PLoS One

Synergistic Action of Presynaptic Muscarinic Acetylcholine Receptors and Adenosine Receptors in Developmental Axonal Competition at the Neuromuscular Junction

(2016) Laura Nadal et al.   DEVELOPMENTAL NEUROSCIENCE

Promising therapeutic agents for the treatment of Parkinson’s disease

(2016) Zsófia Majláth et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Adenosine Type A2A Receptor in Peripheral Cell from Patients with Alzheimer’s Disease, Vascular Dementia, and Idiopathic Normal Pressure Hydrocephalus: A New/Old Potential Target

(2016) Beatrice Arosio et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective effects of adenosine deaminase in the striatum

(2016) Risa Tamura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Evidence that adenosine contributes to Leao’s spreading depression in vivo

(2016) Britta E Lindquist et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission

(2016) Sarah Beggiato et al.   JOURNAL OF NEUROCHEMISTRY

Peripheral adenosine levels in euthymic patients with bipolar disorder

(2016) Carolina Gubert et al.   PSYCHIATRY RESEARCH

Correlating Calmodulin Landscapes with Chemical Catalysis in Neuronal Nitric Oxide Synthase using Time-Resolved FRET and a 5-Deazaflavin Thermodynamic Trap

(2016) Tobias M. Hedison et al.   ACS Catalysis

Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction

(2016) Laura Nadal et al.   Molecular Brain

A critical role of striatal A2AR-mGlu5R interactions in modulating the psychomotor and drug-seeking effects of methamphetamine

(2015) Sherie R. Wright et al.   ADDICTION BIOLOGY

Adenosine A2Areceptors are necessary and sufficient to trigger memory impairment in adult mice

(2015) N Pagnussat et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endogenous adenosine release is involved in the control of heart rate in rats

(2015) Yves Jammes et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review

(2014) Marla Rivera-Oliver et al.   LIFE SCIENCES

Epigenetic Features Induced by Ischemia-Hypoxia in Cultured Rat Astrocytes

(2014) Qinglin Yang et al.   MOLECULAR NEUROBIOLOGY

A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release

(2014) Hiroaki Tani et al.   NEURON

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

(2013) Rebecca L. Williams-Karnesky et al.   JOURNAL OF CLINICAL INVESTIGATION

Potential Therapeutic Relevance of Adenosine A2B and A2A Receptors in the Central Nervous System

(2012) Patrizia Popoli et al.   CNS & Neurological Disorders-Drug Targets

Parasynaptic NMDA Receptor Signaling Couples Neuronal Glutamate Transporter Function to AMPA Receptor Synaptic Distribution and Stability

(2012) L. A. Jarzylo et al.   JOURNAL OF NEUROSCIENCE

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

(2012) Tobias Eckle et al.   NATURE MEDICINE

Adenosine kinase as a target for therapeutic antisense strategies in epilepsy

(2011) Panos Theofilas et al.   EPILEPSIA

Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: A first step in epileptogenesis?

(2011) Tianfu Li et al.   GLIA

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

(2011) Susan A. Masino et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine A1 receptor agonist N6-cyclohexyl-adenosine induced phosphorylation of delta opioid receptor and desensitization of its signaling

(2010) Yun Cheng et al.   ACTA PHARMACOLOGICA SINICA

The K+-Cl−cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

(2010) Tero Viitanen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Direct blockade of inflammatory hypernociception by peripheral A1 adenosine receptors: Involvement of the NO/cGMP/PKG/KATP signaling pathway

(2010) Flávia Oliveira Lima et al.   PAIN

Antiepileptic effects of silk-polymer based adenosine release in kindled rats

(2009) Cory Szybala et al.   EXPERIMENTAL NEUROLOGY