Journal
CLINICS IN CHEST MEDICINE
Volume 40, Issue 2, Pages 385-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2019.02.004
Keywords
Oxygen supplementation; Exercise-induced hypoxemia; COPD
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Supplemental long-term oxygen therapy (LTOT) is a well-established therapy that improves mortality in patients with chronic obstructive pulmonary disease (COPD) with resting hypoxemia. In the large number of patients with COPD who do not have severe resting hypoxemia but who desaturate with exercise, the clinical benefits that can be obtained by supplemental O-2 therapy during exercise is an area of interest and active research. A summary of current evidence for benefits of supplemental O-2 therapy and a review of physiologic mechanisms underlying published observations are reviewed in this article.
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