Article
Biology
Melissa J. Polonenko, Ross K. Maddox
Summary: The study introduced a new method that pairs re-synthesized 'peaky' speech with deconvolution analysis of electroencephalography recordings, quickly yielding robust responses involving distinct subcortical structures from the auditory nerve to rostral brainstem in adults with normal hearing. This peaky speech method shows promise as a tool for investigating speech encoding and processing, as well as for clinical applications.
Article
Acoustics
Hsuan Huang, Yu-Fu Chen, Chien-Yeh Hsu, Yen-Fu Cheng, Tzong-Hann Yang
Summary: The study aimed to establish the best cochlear-neural delay model for chirp design to maximize auditory brainstem response (ABR) and compared ABRs produced by different stimuli. The results showed that the DB-Chirp generated larger wave V than the LS-Chirp at 45 dB normal hearing level (nHL), with potential clinical applications in cochlear synaptopathy assessment and hearing sensitivity estimation.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Engineering, Biomedical
Haoshi Zhang, Mingxing Zhu, Yanbing Jiang, Dan Wang, Xin Wang, Zijian Yang, Weimin Huang, Shixiong Chen, Guanglin Li
Summary: In this study, an adaptive Kalman filtering (AKF) based ABR signal extraction method was proposed, which can constantly update parameters according to the real-time noise properties and extract reliable ABR signals in the presence of large background noises. The method showed good performance in various noise conditions and can adapt to different types and levels of noises.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Sriram Boothalingam, Abigayle Peterson, Lindsey Powell, Vijayalakshmi Easwar
Summary: Feedback networks in the brain play a role in regulating auditory function from the cochlea to the cortex. The medial olivocochlear reflex (MOCR) in the brainstem attenuates responses generated in the cochlea and cortex, but not in the brainstem itself. Our study suggests that this inhibition in the periphery is compensated for by positive feedback in the brainstem over time. Short-duration stimuli activate the MOCR and result in a reduction of responses at the periphery, brainstem, and cortex, while this inhibition diminishes for long-duration stimuli. These findings provide insights into potential compensatory mechanisms in the brainstem and their implications for auditory disorders such as tinnitus.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Xiangyu Zhu, Xinhai Zhang, Mingru Chen, Xiaomei Xu
Summary: Auditory brainstem response (ABR) technology was used to establish a fish auditory threshold detection system and study the auditory threshold of wild yellow grouper Epinephelus awoara in the Taiwan Strait. ABRs of 10 wild yellow groupers (TL150-200 mm) were recorded and analyzed in response to 12 different frequencies of sound stimulation ranging from 100 to 2000 Hz. The results showed that the auditory threshold of the fish increased with frequency. The fish was most sensitive to low frequency sound signals of 100-300Hz, with a threshold of 90 dB re 1 mu Pa.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Pediatrics
Haibin Sheng, Qian Zhou, Qixuan Wang, Yun Yu, Lihua Liu, Meie Liang, Xueyan Zhou, Hao Wu, Xiangrong Tang, Zhiwu Huang
Summary: The study found that AABR screening within 48 hours after birth can reduce the failure rate and false positive rate of the first screening compared to TEOAE. However, compared to TEOAE two-step screening, one-step AABR screening has a higher referral rate for audiological diagnosis.
FRONTIERS IN PEDIATRICS
(2021)
Article
Neurosciences
Jianxin Bao, Segun Light Jegede, John W. Hawks, Bethany Dade, Qiang Guan, Samantha Middaugh, Ziyu Qiu, Anna Levina, Tsung-Heng Tsai
Summary: This study investigates the feasibility of using curvature quantification to detect cochlear synaptic loss. The results demonstrate that curvature measurement is more sensitive and consistent in identifying cochlear synaptic loss in mice compared to amplitude and latency measurements. Furthermore, different types of ear disorders show distinct changes in curvature profiles.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Richard M. McKearney, Steven L. Bell, Michael A. Chesnaye, David M. Simpson
Summary: The aim of this study was to optimize weighted averaging for objective ABR detection using the Fmp statistical test. The VAR Whole Block method was found to be more effective in estimating noise level, especially for smaller block sizes. Caution should be exercised when selecting recording parameters for use with weighted averaging as an inflation in the response absent Fmp statistic was observed using small block sizes.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Multidisciplinary Sciences
George Ordiway, Miranda McDonnell, Sandesh Mohan, Jason Tait Sanchez
Summary: The study outlines a method for accurately and reproducibly recording auditory function in chicken hatchlings using auditory brainstem response (ABR). The results show that ABR recordings in chickens include 3-4 positive-going peak waveforms within the first 6 ms of a suprathreshold click stimulus. The research also highlights the importance of maintaining physiological body temperature for optimal recordings and identifies potential conductive-related issues in young hatchlings.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Clinical Neurology
Laura Froehlich, Alexander Mueller, Miriam H. Kropp, Parwis Mir-Salim, Oliver Dziemba, Tobias Oberhoffner, Stefan K. Plontke, Torsten Rahne
Summary: This study analyzed the intensity-latency functions of intraoperative auditory evoked brainstem responses (ABRs) to stimulation by the Vibrant Soundbridge (VSB) active middle ear implant. The results showed that the intensity-latency function slopes of VSB evoked ABRs were similar to acoustic stimulation at high stimulation levels, but with longer latencies. Saturation of latencies occurred for higher stimulation levels due to saturation of audio processor gain. The findings suggest that the analysis of VSB evoked intensity-latency functions allows for the objective assessment of a patient's individual dynamic range.
FRONTIERS IN NEUROLOGY
(2022)
Review
Otorhinolaryngology
Meliha Basoz Behmen, Nilsu Guler, Elif Kuru, Nilufer Bal, Ozge Gedik Toker
Summary: Speech-ABR is an auditory brainstem response that evaluates the temporal and spectral coding of speech. It can objectively measure the auditory cues important for speech recognition and has many clinical applications.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Computer Science, Hardware & Architecture
Hunar Abubakir Ahmed, Jafar Majidpour, Mohammed Hussein Ahmed, Samer Kais Jameel, Amir Majidpour
Summary: This study presents an automated ABR recognition model that achieved an impressive accuracy rate by collecting and expanding the dataset, and training with the Vision Transformer method.
Article
Neurosciences
Kirupa Suthakar, M. Charles Liberman
Summary: This article investigates the effects of synaptopathy, a condition caused by acoustic overexposure, on auditory processing. Through experimental studies using masking noise and analyzing ANF responses at the single-fiber level, the researchers discovered that synaptopathy leads to permanent synaptic loss and affects the discrimination of complex auditory stimuli. They also found that changes in cochlear region response contribute to altered ABR response latency. These findings offer a diagnostic method for identifying synaptic damage in human populations.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Obstetrics & Gynecology
Akihisa Okumura, Yukihiro Kitai, Hiroshi Arai, Masahiro Hayakawa, Yoshihiro Maruo, Takashi Kusaka, Tetsuya Kunikata, Satoko Kumada, Ichiro Morioka
Summary: ABR abnormalities in preterm infants with bilirubin encephalopathy may improve over time, especially in those with a lower gestational age and peak total bilirubin level. Newborn hearing screening using automated ABR may fail to detect abnormalities in some infants.
EARLY HUMAN DEVELOPMENT
(2021)
Article
Biology
Elizabeth A. McCullagh, John Peacock, Alexandra Lucas, Shani Poleg, Nathaniel T. Greene, Addison Gaut, Samantha Lagestee, Yalan Zhang, Leonard K. Kaczmarek, Thomas J. Park, Daniel J. Tollin, Achim Klug
Summary: Naked mole-rats living underground have a specialized auditory system and show similar hearing onset to other rodents, but they have developmental differences in brain structure and morphology.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Otorhinolaryngology
Makoto Hosoya, Masato Fujioka, Kaoru Ogawa
Summary: This study reports a case series of endoscopic ear surgery using a basket-type hydroxyapatite prosthesis. The postoperative results were satisfactory with no sensorineural hearing loss observed. Transient dizziness and taste disorder were observed in some cases. The hydroxyapatite prosthesis could be a possible alternative for other prostheses.
ENT-EAR NOSE & THROAT JOURNAL
(2023)
Article
Otorhinolaryngology
Yui Ishikawa, Makoto Hosoya, Sho Kanzaki, Kaoru Ogawa
Summary: Delayed facial palsy after cochlear implantation is a rare but serious complication that can occur several days to months after the surgery. Reactivation of the herpes virus and local bacterial infection may be possible causes of the facial palsy. Prompt diagnosis and treatment are necessary, and patients should be informed about the risk of facial paralysis before the surgery.
AURIS NASUS LARYNX
(2022)
Article
Medicine, General & Internal
Atsuho Morita, Ho Namkoong, Makoto Hosoya, Naoki Hasegawa
Summary: A 56-year-old woman with pulmonary Mycobacterium avium complex disease developed laryngitis one month after starting inhalation liposomal amikacin. The laryngitis healed immediately after treatment discontinuation and no recurrence occurred even after resuming intermittent inhalation.
CLINICAL CASE REPORTS
(2022)
Article
Otorhinolaryngology
Alyssa Yoshida, Makoto Hosoya, Sho Kanzaki, Masato Fujioka, Hiroyuki Ozawa
Summary: Transcanal endoscopic ear surgery (TEES) is an innovative and minimally invasive surgery for ossicular malformation. The study showed that TEES significantly improved the hearing levels of patients, with only transient discomfort observed.
ACTA OTO-LARYNGOLOGICA
(2022)
Article
Otorhinolaryngology
Makoto Hosoya, Ayumi Minami, Takanori Nishiyama, Nobuyoshi Tsuzuki, Takeshi Wakabayashi, Naoki Oishi
Summary: This article reports a case of external ear canal stenosis caused by arterial thrombosis after COVID-19 infection. Clinical and pathological findings suggest that COVID-19 can affect the external ear canal and lead to the formation of arterial thrombosis. This observation would be helpful in investigating or explaining the otological symptoms of COVID-19.
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Article
Developmental Biology
Makoto Hosoya, Masato Fujioka, Junko Okahara, Sho Yoshimatsu, Hideyuki Okano, Hiroyuki Ozawa
Summary: This study investigates early cochlear development in a non-human primate model animal, the common marmoset, and reveals significant inter-species differences between primates and rodents. The findings provide new insights into cochlear development in primates and humans.
NEURAL DEVELOPMENT
(2022)
Article
Cell & Tissue Engineering
Sho Kurihara, Masato Fujioka, Motoki Hirabayashi, Tomohiko Yoshida, Makoto Hosoya, Masashi Nagase, Fusao Kato, Kaoru Ogawa, Hideyuki Okano, Hiromi Kojima, Hirotaka James Okano
Summary: In this study, the researchers developed a stepwise protocol to differentiate human-induced pluripotent stem cells into otic organoids that contain spiral ganglion-like cells. These otic organoids serve as an experimental model for drug-induced neuropathy and can be used to evaluate the toxic effects of drugs on hearing-related cells.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Tsubasa Saeki, Sho Yoshimatsu, Mitsuru Ishikawa, Chung-Chau Hon, Ikuko Koya, Shinsuke Shibata, Makoto Hosoya, Chika Saegusa, Kaoru Ogawa, Jay W. Shin, Masato Fujioka, Hideyuki Okano
Summary: This study developed a novel differentiation system using a three-dimensional floating culture and signaling factors to efficiently differentiate otic lineage cells from human pluripotent stem cells (hPSCs). Through single-cell RNA sequencing analysis, the different clusters of otic cells in the induced spheres were identified. This protocol is important for in vitro disease modeling of sensorineural hearing loss and human inner ear development.
REGENERATIVE THERAPY
(2022)
Article
Otorhinolaryngology
Mitsuru Kitamura, Naoki Oishi, Takanori Nishiyama, Makoto Hosoya, Natsuki Hasebe, Nobuyoshi Tsuzuki, Kaoru Ogawa
Summary: This study examined the relationship between intracochlear signal in MRI and hearing in patients with CPA schwannoma. The results showed that the changes in MRI cochlear signal were related to prolonged I-wave latency in auditory brainstem response, indicating cochlear function.
ACTA OTO-LARYNGOLOGICA
(2023)
Article
Medicine, General & Internal
Makoto Hosoya, Takanori Nishiyama, Takeshi Wakabayashi, Marie N. Shimanuki, Hidemi Miyazaki, Hiroyuki Ozawa, Naoki Oishi
Summary: Surgery for vestibular schwannoma can be performed using different techniques, including the middle cranial fossa, suboccipital, translabyrinthine, and retrolabyrinthine approaches. The retrolabyrinthine approach, which preserves the labyrinth, has been modified to achieve a higher hearing preservation rate of 79% in our department. This improvement is considered helpful for hearing preservation.
Article
Otorhinolaryngology
Makoto Hosoya, Yuriko Nagaoka, Takeshi Wakabayashi, Marie N. Shimanuki, Takanori Nishiyama, Masafumi Ueno, Hiroyuki Ozawa, Naoki Oishi
Summary: In this study, a novel real-time monitoring system for the cochlear nerve was developed and successfully applied in a case of vestibular schwannoma resection. The system continuously monitored the cochlear nerve every two seconds and allowed for tumor resection and cochlear implantation after confirming nerve function preservation.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Review
Medicine, General & Internal
Marie N. Shimanuki, Takanori Nishiyama, Makoto Hosoya, Takeshi Wakabayashi, Hiroyuki Ozawa, Naoki Oishi
Summary: Tumoral lesions of the temporal bone are challenging to approach and diagnose due to their rarity and variety. In this pictorial review, the authors focused on the imaging findings of temporal bone lesions categorized by location and created a diagnostic flowchart to aid in differentiation. Capturing imaging features can be a useful method in the diagnosis of temporal bone mass lesions.
Article
Otorhinolaryngology
Kenichiro Arashi, Takanori Nishiyama, Makoto Hosoya, Nobuyoshi Tsuzuki, Takeshi Wakabayashi, Hiroyuki Ozawa, Naoki Oishi
Summary: Relapsing polychondritis (RP) is a rare chronic inflammatory disease characterized by recurrent inflammation of cartilages throughout the body, with treatment-resistant dizziness and hearing loss in 40%-50% of patients with RP. This case report describes a patient with RP who underwent cochlear implantation (CI) in the right ear and showed improvement in hearing and speech perception. Long-term follow-up is necessary due to potential decline in speech recognition.
ENT-EAR NOSE & THROAT JOURNAL
(2023)
