Article
Clinical Neurology
Carmen Barba, Sylvain Rheims, Lorella Minotti, Laura Grisotto, Stephan Chabardes, Marc Guenot, Jean Isnard, Simona Pellacani, Marc Hermier, Philippe Ryvlin, Philippe Kahane
Summary: This study suggests that tailored, multilobar resection can improve surgical outcome in patients with TPE and confirms that SEEG is mandatory when a TPE is suspected.
Article
Clinical Neurology
Jason K. Hsieh, Francesco G. Pucci, Swetha J. Sundar, Efstathios Kondylis, Akshay Sharma, Shehryar R. Sheikh, Deborah Vegh, Ahsan N. Moosa, Ajay Gupta, Imad Najm, Richard Rammo, William Bingaman, Lara Jehi
Summary: The study aims to understand the long-term palliative and disease-modifying effects of surgical resection on patients with drug-resistant epilepsy. Results show that patients who continue to have seizures after resection often experience considerable reductions in seizure frequency and many are able to achieve seizure freedom after a delayed period.
Article
Psychology, Multidisciplinary
Lilia Maria Morales Chacon, Judith Gonzalez Gonzalez, Martha Rios Castillo, Sheila Berrillo Batista, Karla Batista Garcia-Ramo, Aisel Santos Santos, Nelson Quintanal Cordero, Marilyn Zaldivar Bermudez, Randis Garbey Fernandez, Barbara Estupinan Diaz, Zenaida Hernandez Diaz, Juan E. Bender del Busto, Abel Sanchez Coroneux, Margarita M. Baez Martin, Lourdes Lorigados Pedre
Summary: This study presented the postsurgical outcome of ExTLE patients undergoing preoperative multimodal evaluation and intraoperative sequential ECoG. Results indicated that using SISCOM and ESI data alongside intraoperative ECoG allowed for seizure control in pharmacoresistant ExTLE epilepsy patients.
BEHAVIORAL SCIENCES
(2021)
Review
Oncology
Kalman A. Katlowitz, Prazwal Athukuri, Himanshu Sharma, Huy Dang, Astitva Soni, A. Basit Khan, Fatema Malbari, Nisha Gadgil, Howard L. Weiner
Summary: Primary brain neoplasms in pediatric patients are often associated with seizures. Surgical intervention can reduce seizure burden and achieve high rates of seizure freedom. Complete tumor resection significantly improves seizure outcomes compared to subtotal resection.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Scellig S. D. Stone, Eun-Hyoung Park, Jeffrey Bolton, Chellamani Harini, Mark H. Libenson, Alexander Rotenberg, Masanori Takeoka, Melissa Tsuboyama, Phillip L. Pearl, Joseph R. Madsen
Summary: Statistical analysis of interictal sEEG can help identify surgical target sites and predict surgical outcomes. Granger causality can identify seizure foci and correlate with favorable treatment outcomes.
Article
Clinical Neurology
Baibing Chen, Sanjeet S. Grewal, Erik H. Middlebrooks, William O. Tatum, Anthony L. Ritaccio, Joseph I. Sirven, Brin E. Freund, Anteneh M. Feyissa
Summary: Magnetic resonance-guided laser interstitial thermal therapy (MRLiTT) has gained popularity for treating temporal lobe epilepsy. This pilot study investigated the predictive value of pre- and post-MRLiTT epileptiform discharges (EDs) on intraoperative electrocorticography (iECoG) for seizure outcomes in patients with mesial temporal lobe epilepsy (mTLE). The study found that a reduction in ED frequency during MRLiTT may potentially predict seizure outcomes. Larger prospective studies are needed to confirm these findings and evaluate the utility of iECoG during MRLiTT.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Bertrand Mathon, Stephane Clemenceau, Alexandre Carpentier
Summary: This study evaluated the efficacy of ultrasound SWE techniques for intraoperative detection of FCDs, showing that SWE was more sensitive in detecting FCDs compared to conventional B-mode imaging. Stiffness ratios were significantly different between MRI-positive and -negative cases. Interoperative SWE more frequently detected FCDs in women and in patients with FCD visible on MRI, with good seizure outcomes at 1 year post-surgery and last follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Valeri Borger, Motaz Hamed, Julia Taube, Gulsah Aydin, Inja Ilic, Matthias Schneider, Patrick Schuss, Erdem Guresir, Albert Becker, Christoph Helmstaedter, Christian E. Elger, Hartmut Vatter
Summary: Temporal lobe epilepsy (TLE) is a common form of epilepsy, and about 30% of patients have drug-resistant seizures. This study evaluated the seizure outcomes of patients with drug-refractory TLE who underwent resective temporal lobe surgery (rTLS), finding that the lack of MRI lesions and placement of depth electrodes before surgery were associated with unfavorable postsurgical seizure outcomes.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Georgia Ramantani, Dorottya Cserpan, Martin Tisdall, Willem M. Otte, Georg Dorfmuller, J. Helen Cross, Monique van Schooneveld, Pieter van Eijsden, Frauke Nees, Gitta Reuner, Niklaus Krayenbuhl, Josef Zentner, Christine Bulteau, Kees P. J. Braun
Summary: This study retrospectively investigated the functional outcomes after hemispherotomy in a cohort of 455 children, and identified the determinants of these outcomes. The results showed that the use of antiseizure medication and independent walking ability were good, but language ability and voluntary grasping with the hemiplegic hand were affected by certain factors.
ANNALS OF NEUROLOGY
(2023)
Review
Clinical Neurology
Carmen Barba, Sabrina Giometto, Ersilia Lucenteforte, Simona Pellacani, Giulia Matta, Alessandra Bettiol, Sara Minghetti, Lavinia Falorni, Federico Melani, Gianpiero Di Giacomo, Flavio Giordano, Salvatore De Masi, Renzo Guerrini
Summary: The efficacy of temporal lobe epilepsy (TLE) surgery varies between children and adults, with higher seizure freedom rates observed in children. Histopathology and surgical approach have an impact on seizure outcome, with age being an important variable.
Article
Clinical Neurology
Lara Jehi, Kees Braun
Summary: Various factors, including etiology and histopathology, play crucial roles in determining the outcomes of epilepsy surgery. This review aims to investigate the relationship between etiology and surgical outcomes, while exploring possible explanatory mechanisms.
Article
Clinical Neurology
Valeri Borger, Motaz Hamed, Majd Bahna, Attila Racz, Inja Ilic, Anna-Laura Potthoff, Tobias Baumgartner, Theodor Rueber, Albert Becker, Alexander Radbruch, Florian Mormann, Rainer Surges, Hartmut Vatter, Matthias Schneider
Summary: This study aimed to evaluate the impact of piriform cortex (PiC) resection on long-term seizure outcome in patients with mesial temporal lobe epilepsy (mTLE) treated with selective amygdalo-hippocampectomy (tsSAHE). The results showed that the extent of PiC resection strongly correlated with long-term seizure outcome, suggesting PiC to be a key target volume in tsSAHE for achieving long-term seizure freedom.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Georgia Ramantani, Christine Bulteau, Dorottya Cserpan, Willem M. Otte, Georg Dorfmueller, J. Helen Cross, Josef Zentner, Martin Tisdall, Kees P. J. Braun
Summary: This study aimed to evaluate the determinants of seizure outcome following pediatric hemispherotomy. Through a retrospective analysis of 457 children who underwent hemispheric surgery, variables such as acquired etiology, hemimegalencephaly, contralateral MRI findings, prior resective surgery, and left hemispherotomy were identified as significant determinants of seizure recurrence. The study found no significant difference in seizure-freedom rates between vertical and horizontal hemispherotomy techniques.
Article
Clinical Neurology
David Satzer, Yasar T. Esengul, Peter C. Warnke, Naoum P. Issa, Douglas R. Nordli
Summary: This study aimed to assess the validity of ictal SEEG source localization, and the results showed that SEEG source localization accurately mapped the onset of seizures compared to conventional interpretation. Additionally, the proximity of dipoles to the surgical treatment volume predicted the outcome of seizures when near-field recordings were analyzed.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Emanuele Cerulli Irelli, Enrico Cocchi, Georgia Ramantani, Antonella Riva, Roberto Horacio Caraballo, Alessandra Morano, Loretta Giuliano, Tulay Yilmaz, Eleni Panagiotakaki, Francesca F. Operto, Beatriz Gonzalez Giraldez, Simona Balestrini, Katri Silvennoinen, Sara Casciato, Marion Comajuan, Francesco Fortunato, Anna Teresa Giallonardo, Rimma Gamirova, Antonietta Coppola, Giancarlo Di Gennaro, Angelo Labate, Vito Sofia, Gerhard Josef Kluger, Antonio Gambardella, Dorothee G. A. Kasteleijn-NolstTrenite, Betul Baykan, Sanjay M. Sisodiya, Alexis Arzimanoglou, Pasquale Striano, Carlo Di Bonaventura
Summary: Based on age at epilepsy onset (AEO), this study identified three subtypes of objective epilepsy with eyelid myoclonia (EEM) and analyzed their distinct clinical features. Early onset EEM was associated with higher rates of intellectual disability, antiseizure medication refractoriness, and psychiatric comorbidities, while late onset EEM had the highest proportion of myoclonia involving body regions other than eyelids and generalized tonic-clonic seizures. Intermediate onset EEM had the lowest observed rate of additional findings. Family history of EEM was more frequent in the subtypes with intermediate and late onset. Patients with body-MYO showed higher rates of migraine and generalized tonic-clonic seizures.
Article
Clinical Neurology
Linda Baettig, Corinne Duenner, Dorottya Cserpan, Andrea Rueegger, Cornelia Hagmann, Bernhard Schmitt, Francesco Pisani, Georgia Ramantani
Summary: This study compared the safety and efficacy of levetiracetam (LEV) and phenobarbital (PB) as first-line antiseizure medications for neonatal seizures. The results suggest that LEV may be as effective and potentially safer than PB as a first-line treatment option.
PEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Vasileios Dimakopoulos, Giorgio Selmin, Luca Regli, Johannes Sarnthein
Summary: This study systematically optimized the repetition rate of stimulus presentation and found that a repetition rate of 12.7 Hz achieved the highest signal-to-noise ratio for medianus nerve SEP recordings in a short duration.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Georgia Ramantani, M. Brandon Westover, Stephen Gliske, Johannes Sarnthein, Sridevi Sarma, Yujiang Wang, Maxime O. Baud, William C. Stacey, Erin C. Conrad
Summary: Electroencephalography (EEG) has been the primary diagnostic tool in clinical epilepsy for almost a century. With the development of higher resolution digital EEG and analytical tools, there is a need to re-explore relevant methodology. This review provides an overview of the passive and active markers of cortical excitability in epilepsy based on EEG and discusses the techniques developed to identify these markers.
Article
Multidisciplinary Sciences
Jin Li, Dan Cao, Shan Yu, Xinyu Xiao, Lukas Imbach, Lennart Stieglitz, Johannes Sarnthein, Tianzi Jiang
Summary: Both the hippocampus and amygdala play important roles in working memory processing, but their specific functions in working memory are still unclear. In this study, intracranial EEG was recorded from epilepsy patients' amygdala and hippocampus during a working memory task, and their representations during the encoding and maintenance periods were compared. The results showed functional specialization and interaction within the amygdala-hippocampus circuit, with distinct mnemonic representations in the amygdala decreasing from encoding to maintenance, and more similar but stable representations in the hippocampus. The encoding and maintenance of working memory were associated with bidirectional information flow between the amygdala and hippocampus in low-frequency bands (1-40 Hz). Decoding accuracy on working memory load was higher when using representational features from the amygdala during encoding and from the hippocampus during maintenance, as well as information flow from the amygdala during encoding and from the hippocampus during maintenance.
NATURE COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Giulio Gennari, Dorottya Cserpan, Ilona Stefanos-Yakoub, Raimund Kottke, Ruth O'Gorman Tuura, Georgia Ramantani
Summary: This study investigated the potential of diffusion tensor imaging (DTI) in paediatric structural epilepsy associated with focal cortical dysplasia (FCD). The results showed that DTI indices can differentiate between FCD and contralateral brain parenchyma (CBP), and that clinical features have an impact on these indices.
INSIGHTS INTO IMAGING
(2023)
Review
Pediatrics
Mario Mastrangelo, Valentina Gasparri, Katerina Bernardi, Silvia Foglietta, Georgia Ramantani, Francesco Pisani
Summary: A systematic review of published pediatric cases with vitamin B6-dependent epilepsy showed that this condition is characterized by early onset, diverse seizure types, and responsiveness to vitamin B6 supplementation.
Article
Health Care Sciences & Services
Leopold Simma, Fabrizio Romano, Steffen Schmidt, Georgia Ramantani, Bigna K. Bolsterli
Summary: Central nervous system (CNS) disorders are common in critically ill children, with non-convulsive status epilepticus (NCSE) often being unrecognized but significantly impacting neurological outcomes and hospitalization. We developed a simplified point-of-care EEG recording method (pocEEG) for pediatric emergency departments to enable timely diagnosis and treatment initiation when standard EEG is not readily available.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Dorottya Cserpan, Greta Guidi, Beatrice Alessandri, Tommaso Fedele, Andrea Ruegger, Francesco Pisani, Johannes Sarnthein, Georgia Ramantani
Summary: This study aimed to investigate the detection of scalp high-frequency oscillations (HFO) in neonates using an automated detector and whether HFO rates can differentiate neonates with seizures from healthy neonates. The study found that HFO rates were significantly higher in neonates with seizures and can be detected automatically. These findings are significant for neuromonitoring in neonates.
Article
Clinical Neurology
Konstantin L. Makridis, Kerstin Alexandra Klotz, Georgia Ramantani, Lena-Luise Becker, Victoria San Antonio-Arce, Steffen Syrbe, Kathrin Wagner, Mukesch Johannes Shah, Ulrich-Wilhelm Thomale, Anna Tietze, Christian E. Elger, Ingo Borggraefe, Angela M. Kaindl
Summary: Epilepsy surgery in the first 6 months of life can achieve seizure control in about two thirds of children, but data on surgical complications and postoperative cognitive development are lacking.
Article
Clinical Neurology
Vasileios Dimakopoulos, Marian C. Neidert, Johannes Sarnthein
Summary: This study found that low impedance electrodes can reduce thermal noise and improve the detection rate of epileptic fast ripple oscillations in the high frequency range. This is of great significance for accurate diagnosis of epileptogenic tissue.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Georgia Ramantani, Dorottya Cserpan, Martin Tisdall, Willem M. Otte, Georg Dorfmuller, J. Helen Cross, Monique van Schooneveld, Pieter van Eijsden, Frauke Nees, Gitta Reuner, Niklaus Krayenbuhl, Josef Zentner, Christine Bulteau, Kees P. J. Braun
Summary: This study retrospectively investigated the functional outcomes after hemispherotomy in a cohort of 455 children, and identified the determinants of these outcomes. The results showed that the use of antiseizure medication and independent walking ability were good, but language ability and voluntary grasping with the hemiplegic hand were affected by certain factors.
ANNALS OF NEUROLOGY
(2023)
Review
Clinical Neurology
Ilona Stefanos-Yakoub, Kevin Wingeier, Ulrike Held, Beatrice Latal, Elaine Wirrell, Mary Lou Smith, Georgia Ramantani
Summary: In addition to seizure freedom, pediatric epilepsy surgery aims to stabilize and potentially optimize cognitive development. The study conducted a systematic review and meta-analysis to evaluate the changes in intelligence or developmental quotients (IQ/DQ) before and after surgery in children with focal lesional epilepsy. The findings suggest stabilization of intellectual and developmental functioning at long-term follow-up. Cessation of antiseizure medication after achieving seizure freedom may further optimize intellectual and developmental trajectories in affected children.
Article
Oncology
Stefanos Voglis, Luis Padevit, Christiaan Hendrik Bas van Niftrik, Vincens Kalin, Benjamin Beyersdorf, Raffaele Da Mutten, Vittorio Stumpo, Jacopo Bellomo, Johannes Sarnthein, Victor Egon Staartjes, Alessandro Carretta, Niklaus Krayenbuehl, Luca Regli, Carlo Serra
Summary: Micro-neurosurgery is a safe and effective option for resecting brain metastases, with a low rate of major adverse events even in challenging anatomical locations or deep-seated lesions.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
