Article
Cardiac & Cardiovascular Systems
Lisa O. F. Bearpark, Ulrik Sartipy, Anders Franco-Cereceda, Natalie Glaser
Summary: This study investigated clinical outcomes in patients with bicuspid aortic valves (BAV) after surgical treatment for endocarditis. The results showed that BAV patients had improved survival after surgical treatment, especially in those with native valve endocarditis. However, the original valve morphology did not affect survival in patients with prosthetic valve endocarditis.
ANNALS OF CARDIOTHORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Albert Roque, Maria N. Pizzi, Nuria Fernandez-Hidalgo, Guillermo Romero-Farina, Gemma Burcet, Jose Luis Reyes-Juarez, Carina Espinet, Joan Castell-Conesa, Manuel Escobar, Ignacio Ferreira-Gonzalez, Santiago Aguade-Bruix, Hug Cuellar-Calabria
Summary: This study validated a new parameter, the valve uptake index (VUI), for the diagnosis of prosthetic valve endocarditis (PVE). VUI showed good diagnostic accuracy for PVE and increased the diagnostic ability of traditional morphometabolic parameters. Further research is needed to assess the potential value of integrating VUI into the PVE diagnostic algorithm.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Review
Immunology
Morgan Ashley Hill, Jennie H. Kwon, Brielle Gerry, William A. Hardy, Olivia Agata Walkowiak, Minoo N. Kavarana, Satish N. Nadig, T. Konrad Rajab
Summary: Immune privilege is an evolutionary adaptation that provides protection to tissues with important functions and limited regenerative capacity from immune response damage. Tissues such as the anterior chamber of the eye, brain, placenta, testes, and articular cartilage are examples of immune privilege, sharing vital functions for evolutionary fitness and limited regenerative capabilities. This concept has clinical relevance, particularly seen in corneal transplantation and meniscal transplantation where immunosuppression is not required, and in the heart valves where alloimmune injury is sparingly observed, suggesting a potential immune privileged status for these sites.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Syed Ihtesham Hussain Shah, Muddasar Naeem, Giovanni Paragliola, Antonio Coronato, Mykola Pechenizkiy
Summary: Medical examinations at the Nuclear Medicine Department involve multiple stages, with nurses accompanying and guiding patients to avoid potential hazardous situations. However, even nurses face risks of exposure to harmful radiation. Artificial Intelligence (AI) technologies can mitigate these risks by supporting patient movement and injury prevention.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Review
Engineering, Biomedical
Hieu T. Bui, Nipa Khair, Breandan Yeats, Shelley Gooden, Susan P. James, Lakshmi Prasad Dasi
Summary: This review provides a comprehensive overview of the materials development for transcatheter heart valve replacements (THVR), including fabrication, preparation, and assembly processes, as well as current and future biomaterial trends in THVR.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Medicinal
Nidaa Mikail, Fabien Hyafil
Summary: Infective endocarditis (IE) is a life-threatening disease that remains prevalent despite advancements in prophylaxis, diagnosis, and treatment. With the increasing number of patients with cardiac devices, the occurrence of IE on prosthetic valves and cardiac implanted electronic devices (CIED) is rising rapidly. The diagnosis of IE is challenging, but nuclear imaging techniques such as F-18-fluorodeoxyglucose positron emission tomography with computed tomography (F-18-FDG-PET/CT) and white blood cells single photon emission tomography with computed tomography (WBC-SPECT) have emerged as valuable tools in managing prosthetic valve and CIED IE.
Article
Infectious Diseases
Sebastien Lalanne, Francois Guerin, Erwan Flecher, Vincent Cattoir, Nicolas Nesseler, Matthieu Revest, Marie-Clemence Verdier
Summary: This study assessed the distribution of amoxicillin in infected heart valves and the achievement of related pharmacokinetic/pharmacodynamic (PK/PD) targets in IE patients undergoing heart valve surgery. The results showed significant penetration of amoxicillin into the infectious site and supported the need for combination antibiotic therapy for enterococcal IE.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Oncology
Jordan Eber, Cyrille Blondet, Clara Le Fevre, Isabelle Chambrelant, Fabrice Hubele, Olivier Morel, Delphine Antoni, Georges Noel
Summary: Radiotherapy can unintentionally expose the heart to radiation, leading to cardiac damage. Early detection and monitoring of radiation-induced heart disease are crucial, and nuclear medicine imaging techniques show promise in detecting subclinical effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Daniel Kwon, Zhengxing Zhang, Jutta Zeisler, Hsiou-Ting Kuo, Kuo-Shyan Lin, Francois Benard
Summary: The study developed a radiotracer [Ga-68]Ga-BL31 targeting CXCR4, which showed lower kidney retention and excellent imaging contrast, making it suitable for PET imaging and radioligand therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Domenico Albano, Francesco Dondi, Matteo Bauckneht, Manuela Albertelli, Rexhep Durmo, Angelina Filice, Annibale Versari, Silvia Morbelli, Alfredo Berruti, Francesco Bertagna
Summary: This study combined [Ga-68]-DOTA-peptides and [F-18]FDG-PET/CT findings to differentiate typical and atypical pulmonary carcinoids and investigate their prognostic role. The dual-tracer analysis effectively distinguished tumor types and had prognostic implications for patient outcomes.
EUROPEAN RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria A. Rezvova, Kirill Y. Klyshnikov, Aleksander A. Gritskevich, Evgeny A. Ovcharenko
Summary: The development of a novel artificial heart valve with outstanding durability and safety has been a challenge. Recent progress in high-molecular compounds has opened new horizons in overcoming major drawbacks of mechanical and tissue heart valves. This review summarizes the evolution and state-of-the-art approaches to the development of polymeric heart valves, discussing biocompatibility, durability testing, and new developments in functional polymers and valve designs. Several concepts are proposed to address the challenges, and additive manufacturing, nanotechnology, anisotropy control, and advanced modeling tools are highlighted as new directions for polymeric heart valves.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Daniel Kwon, Jerome Lozada, Zhengxing Zhang, Jutta Zeisler, Richel Poon, Chengcheng Zhang, Aron Roxin, Kuo-Shyan Lin, David Perrin, Francois Benard
Summary: C-X-C chemokine receptor 4 (CXCR4) is highly expressed in cancer and plays a role in metastasis and poor prognosis. Two new radiotracers, BL08 and BL09, demonstrate high tumor uptake and visualization, showing potential for CXCR4-targeted PET imaging with improved contrast ratios compared to existing radioligands.
MOLECULAR PHARMACEUTICS
(2021)
Article
Surgery
Rizwan Q. Attia, Shahzad G. Raja
Summary: Valve disease is a significant global burden, with the number of heart valve procedures expected to greatly increase. Advances in the design and manufacturing of pericardial heart valves have been achieved through collaboration across various scientific disciplines.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Review
Biology
Aro Daniela Arockiam, Ankit Agrawal, Joseph El Dahdah, Bianca Honnekeri, Tahir S. Kafil, Saleem Halablab, Brian P. Griffin, Tom Kai Ming Wang
Summary: Infective endocarditis (IE) is a diverse disease with high morbidity and mortality rates. It can affect native valves, prosthetic valves, and intra-cardiac devices, causing systemic complications. Early diagnosis and risk stratification of IE rely on a combination of clinical, laboratory, and cardiac imaging evaluation. Various imaging modalities, including transthoracic echocardiography and advanced techniques such as cardiac computed tomography and F-18-fluorodeoxyglucose positron emission tomography, play important roles in providing essential diagnostic and prognostic information for IE.
Article
Cardiac & Cardiovascular Systems
Weimin Zhang, Abdunabi Maimaitiaili, Yan Xing, Fei Yan, Qiang Huo
Summary: This case report presents a 32-year-old woman with a giant left main coronary artery to right atrium fistula accompanied by endocarditis. The diagnosis of coronary artery fistula was made using transthoracic echocardiography and subsequently confirmed by cardiac computerized tomographic and coronary angiography. The patient received 6 weeks of antibiotic treatment for infective endocarditis before undergoing successful surgical repair. The patient remains well after 18 months of follow-up.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Mary E. Roth, Benyam Muluneh, Brian C. Jensen, Chaitanya Madamanchi, Carrie B. Lee
AMERICAN JOURNAL OF THERAPEUTICS
(2016)
Article
Cardiac & Cardiovascular Systems
Paul M. Johnson, Chaitanya Madamanchi, Zarina M. Sharalaya, Zahra Iqbal, Anil K. Gehi, Prashant Kaul, George A. Stouffer
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2017)
Meeting Abstract
Cardiac & Cardiovascular Systems
Chaitanya Madamanchi, Thomas Brickner, Eugene Chung
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2017)
Review
Cardiac & Cardiovascular Systems
Chaitanya Madamanchi, Hassan Alhosaini, Arihiro Sumida, Marschall S. Runge
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2014)
Article
Cardiac & Cardiovascular Systems
Megan Sattler, John Moscona, Paul M. Johnson, Chaitanya Madamanchi, Joseph S. Rossi, George A. Stouffer
Summary: In heavily calcified coronary artery lesions, there is no correlation between angiographic stenosis and either resting Pd/Pa or FFR. However, the diagnostic accuracy of QCA for predicting hemodynamic significance varies in arteries with different calcium scores.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Ron Blankstein, Chaitanya Madamanchi
JACC-CARDIOVASCULAR IMAGING
(2020)
Review
Cardiac & Cardiovascular Systems
Chaitanya Madamanchi, Matthew C. Konerman, Venkatesh L. Murthy
Summary: This review highlights the importance of cardiac PET and CMR in the diagnosis and prognosis of CAV. Relative myocardial perfusion imaging and quantitative myocardial blood flow using PET, as well as late gadolinium enhancement and quantitative measures including myocardial perfusion reserve and mean diastolic rate using CMR, are useful in the diagnosis and prognosis of CAV. Further research with larger, multicenter studies is needed to fully understand the clinical implications of using these imaging modalities to detect early CAV and improve patient outcomes.
CURRENT CARDIOLOGY REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Chaitanya Madamanchi, Richard L. L. Weinberg, Venkatesh L. L. Murthy
Summary: This study aimed to determine the optimal timing and diagnostic thresholds of serum beta-hydroxybutyrate (BHB) levels in identifying incomplete suppression of myocardial glucose utilization (MGU). The results showed that BHB levels had a high sensitivity and specificity in suppressing MGU, which could simplify the interpretation of F-18-FDG PET/CT inflammation studies.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chaitanya Madamanchi, Marcelo F. Di Carli, Ron Blankstein
Meeting Abstract
Oncology
Aasakiran Madamanchi, David Cappel, Chaitanya Madamanchi, Roman Covarrubias, John Micheal Thomson
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2014)
Article
Hematology
Aleksandr E. Vendrov, Zeenat S. Hakim, Nageswara R. Madamanchi, Mauricio Rojas, Chaitanya Madamanchi, Marschall S. Runge
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2007)
