Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction

Post-transcriptional regulation of gene expression and human disease

(2018) Anita H Corbett   CURRENT OPINION IN CELL BIOLOGY

Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function

(2018) Laura Padrón-Barthe et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Overexpression of mRNA-decapping enzyme 1a predicts disease-specific survival in malignant melanoma

(2018) Yong Tang et al.   MELANOMA RESEARCH

RNA Therapeutics in Cardiovascular Precision Medicine

(2018) Ageliki Laina et al.   Frontiers in Physiology

Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus

(2018) Marco Gaviraghi et al.   EMBO JOURNAL

An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms

(2017) Javier Tapial et al.   GENOME RESEARCH

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA)

(2017) Ariamala Gopalsamy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential analysis of RNA-seq incorporating quantification uncertainty

(2017) Harold Pimentel et al.   NATURE METHODS

Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines

(2017) Yung-Lung Chang et al.   Oncotarget

Diverging mRNA and Protein Networks in Activated Microglia Reveal SRSF3 Suppresses Translation of Highly Upregulated Innate Immune Transcripts

(2017) Hejer Boutej et al.   Cell Reports

Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis

(2016) Meritxell Nus et al.   CARDIOVASCULAR RESEARCH

SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export

(2016) Michaela Müller-McNicoll et al.   GENES & DEVELOPMENT

Erratum: Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Genome-wide quantification of 5′-phosphorylated mRNA degradation intermediates for analysis of ribosome dynamics

(2016) Vicent Pelechano et al.   Nature Protocols

The transcription factor ERG recruits CCR4–NOT to control mRNA decay and mitotic progression

(2016) Xavier Rambout et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation

(2016) Bárbara González-Terán et al.   Nature Communications

The transcription factor ERG recruits CCR4–NOT to control mRNA decay and mitotic progression

(2016) Xavier Rambout et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis

(2015) Hui Wang et al.   DIABETES

RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure

(2015) Chen Gao et al.   JOURNAL OF CLINICAL INVESTIGATION

Trbp regulates heart function through microRNA-mediated Sox6 repression

(2015) Jian Ding et al.   NATURE GENETICS

Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure

(2015) Chaoliang Wei et al.   Cell Reports

A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains

(2014) Manuel Irimia et al.   CELL

Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice

(2014) Supriya Sen et al.   HEPATOLOGY

Crosstalk between Edc4 and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in mRNA Decapping

(2014) Hazir Rahman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of gene expression programmes by serine–arginine rich splicing factors

(2014) Minna-Liisa Änkö   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Splicing factor SRSF3 represses the translation of programmed cell death 4 mRNA by associating with the 5′-UTR region

(2013) J Kim et al.   CELL DEATH AND DIFFERENTIATION

Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function

(2013) Supriya Sen et al.   Nature Communications

SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance

(2012) Rong Jia et al.   International Journal of Biological Sciences

Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer’s disease

(2012) Jenny Wong et al.   JOURNAL OF NEUROCHEMISTRY

The Sam68 STAR RNA-Binding Protein Regulates mTOR Alternative Splicing during Adipogenesis

(2012) Marc-Étienne Huot et al.   MOLECULAR CELL

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

(2012) Wei Guo et al.   NATURE MEDICINE

The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes

(2012) Minna-Liisa Änkö et al.   GENOME BIOLOGY

Reciprocal Transcriptional Regulation of Metabolic and Signaling Pathways Correlates With Disease Severity in Heart Failure

(2011) Andreas S. Barth et al.   Circulation-Cardiovascular Genetics

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)

(2010) J. L. Manley et al.   GENES & DEVELOPMENT

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2010) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of mRNA decapping

(2010) You Li et al.   Wiley Interdisciplinary Reviews-RNA

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

SRp38 Regulates Alternative Splicing and Is Required for Ca2+ Handling in the Embryonic Heart

(2009) Ying Feng et al.   DEVELOPMENTAL CELL

Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways

(2009) Vânia Gonçalves et al.   HUMAN MOLECULAR GENETICS

Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals

(2008) M J Byrne et al.   GENE THERAPY

SRp20 and CUG-BP1 Modulate Insulin Receptor Exon 11 Alternative Splicing

(2008) S. Sen et al.   MOLECULAR AND CELLULAR BIOLOGY

The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases

(2008) Yoshiaki Kawase et al.   Nature clinical practice. Cardiovascular medicine