Article
Clinical Neurology
Madison K. Titone, Namni Goel, Tommy H. Ng, Laura E. MacMullen, Lauren B. Alloy
Summary: This study examined the relationships between impulsivity, sleep and circadian rhythm disturbance, and symptoms in individuals at high-risk for or with recent-onset bipolar spectrum disorders. The findings revealed that less total sleep time predicted increased next-day mood symptoms, and the relationship between impulsivity and mood symptoms was moderated by sleep time and circadian rhythm alterations.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Madison K. Titone, Namni Goel, Tommy H. Ng, Laura E. MacMullen, Lauren B. Alloy
Summary: Impulsivity, sleep disturbance, and circadian rhythm alterations are closely associated with bipolar spectrum disorders. Less total sleep time predicts increased mood symptoms, and individuals with less sleep and later circadian rhythms are more likely to exhibit a positive relationship between impulsivity and mood symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Hongliang Feng, Amy Wing -Yin Ho, Binbin Lei, Joey Wing Yan Chan, Jing Wang, Yaping Liu, Jessie Chi Ching Tsang, Ngan Yin Chan, Siu Ping Lam, Kathleen Ries Merikangas, Chung Shun Ho, Jihui Zhang, Yun Kwok Wing
Summary: This study found that unaffected offspring of parents with bipolar disorder already exhibited circadian rhythm dysregulation, with lower nocturnal melatonin levels, smaller melatonin AUC within two hours after DLMO, and larger phase angle between DLMO and sleep onset compared to offspring of control parents.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Francy Cruz-Sanabria, Ugo Faraguna, Miriam Violi, Simone Bruno, Davide Gravina, Chiara Bonelli, Andrea Bazzani, Leonardo Massoni, Laura Musetti, Marly Simoncini, Paolo Frumento, Liliana Dell 'Osso, Claudia Carmassi
Summary: The present study evaluates the effect of exogenous melatonin on sleep and circadian parameters in patients with bipolar disorder and delayed sleep-wake phase disorder. Results indicate that personalized treatment with exogenous melatonin can modify self-reported chronotype, sleep onset time, and sleep efficiency and duration in patients with comorbid bipolar disorder and delayed sleep-wake phase disorder, suggesting potential efficacy in improving sleep patterns in this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Clinical
Jennifer L. Burgess, Andrew J. Bradley, Kirstie N. Anderson, P. Gallagher, R. Hamish McAllister-Williams
Summary: This study suggests an association between sleep abnormalities and cognition in patients with bipolar disorder, with little or no relationship with physical activity, BMI, and circadian rhythm.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Psychiatry
John F. Gottlieb, Namni Goel, Shenghao Chen, Michael A. Young
Summary: Sleep deprivation may be effective in treating bipolar depression, especially when used in conjunction with medication.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Balthazar Bazin, Pierre A. A. Geoffroy, Helene Benzaquen, Julia Maruani, Alix Romier, Michel Lejoyeux, Marie-Pia D'ortho, Justine Frija-Masson
Summary: This case report describes a 46-year-old man with autism spectrum disorder (ASD) and agoraphobia who was referred for suspected obstructive sleep apnea syndrome (OSAS). Polysomnography confirmed moderate OSAS associated with hypoventilation, and treatment with continuous positive airway pressure (CPAP) showed excellent results. However, follow-up revealed an irregular sleep-wake rhythm, which was effectively treated with melatonin and light therapy. This case highlights the importance of addressing sleep and circadian rhythm sleep-wake disorders (CRSWD) in individuals with psychiatric disorders, and suggests that CPAP data could be an objective alternative to sleep diary.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Medicine, Research & Experimental
Zhen Xuen Brandon Low, Xin Ru Lee, Tomoko Soga, Bey Hing Goh, Deepa Alex, Yatinesh Kumari
Summary: Sleep is a crucial biological process for maintaining homeostasis and key functions in animals. Dysfunctional sleep can lead to negative effects on health and cognition. Cannabinoids have been found to play a role in sleep modulation, with cannabinoid receptors being involved in sleep promotion. The alteration of cannabinoid receptors could potentially be used in treating sleep disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Psychiatry
Zhi Xu, Lei Chen, Yunyun Hu, Tian Shen, Zimu Chen, Tingting Tan, Chenjie Gao, Suzhen Chen, Wenji Chen, Bingwei Chen, Yonggui Yuan, Zhijun Zhang
Summary: The study found that factors such as age of onset, suicide attempts, and hospitalizations are associated with MDD-to-BD conversion, and established a predictive model with specific guiding significance for clinical diagnosis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Himanshu K. Mishra, Heather Wei, Kayla E. Rohr, Insu Ko, Caroline M. Nievergelt, Adam X. Maihofer, Paul D. Shilling, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark Frye, Fred Gage, Elliot Gershon, Melvin G. McInnis, John Nurnberger, Ketil J. Oedegaard, Peter P. Zandi, John R. Kelsoe, Michael J. McCarthy
Summary: Bipolar disorder (BD) is characterized by mood episodes, disrupted circadian rhythms, and gray matter reduction in the brain. Lithium, an effective pharmacotherapy for BD, has neuroprotective properties and beneficial effects on circadian rhythms that may distinguish lithium responders (Li-R) from non-responders (Li-NR). Patterns of co-expression among circadian clock and cell survival genes were found in BD patients and controls, as well as in Li-R vs. Li-NR cells. The coordination between circadian clock and cell survival genes in BD may help predict lithium response.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Clinical Neurology
Ni Xu, Kiyomi Shinohara, Kate E. A. Saunders, John R. Geddes, Andrea Cipriani
Summary: This study found a potential association between lithium and shifts towards morningness, suggesting insufficient evidence for the effect of lithium on circadian rhythm. Chronotype may be a potential target for further exploration of biomarkers in lithium treatment for patients with bipolar disorder. Further prospective and longitudinal studies using actigraphy to monitor daily circadian rest-activity changes are needed.
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Yuichi Esaki, Kenji Obayashi, Keigo Saeki, Kiyoshi Fujita, Nakao Iwata, Tsuyoshi Kitajima
Summary: This study investigated the association between light exposure in daily life and circadian activity rhythms in patients with bipolar disorder. The results showed that daytime light exposure was positively associated with circadian activity rhythms, while nighttime light exposure was negatively associated.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Wan-Ju Cheng, Liang-Wen Hang, Tomohide Kubo, Paivi Vanttola, Sheng-Che Huang
Summary: The study aimed to examine the effect of sleep timing intervention on sleep quality, attention, and sleepiness at work among night shift workers with shift work disorder. The results showed that participants had longer sleep duration, higher sleep quality, shorter reaction times, and fewer lapses during evening sleep schedules compared to morning sleep schedules. The differences between sleep schedules were most prominent among those with late chronotypes.
Article
Biology
Katarina Evansova, Katerina Cervena, Ondrej Novak, Daniela Dudysova, Tereza Nekovarova, Eva Farkova, Iveta Fajnerova
Summary: This study aimed to determine if the time of assessment has an important impact on individuals with extreme chronotypes. The results showed that the time of assessment influenced declarative memory measures, while chronotype-specific differences were only observed in the processing speed test. These findings have important implications for clinical practice.
BIOLOGICAL RHYTHM RESEARCH
(2022)
Article
Clinical Neurology
Janos L. Kalman, Tomoya Yoshida, Till F. M. Andlauer, Eva C. Schulte, Kristina Adorjan, Martin Alda, Raffaela Ardau, Jean-Michel Aubry, Katharina Brosch, Monika Budde, Caterina Chillotti, Piotr M. Czerski, Raymond J. DePaulo, Andreas Forstner, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Dominik Grotegerd, Tim Hahn, Maria Heilbronner, Roland Hasler, Urs Heilbronner, Stefanie Heilmann-Heimbach, Pawel Kapelski, Tadafumi Kato, Mojtaba Oraki Kohshour, Susanne Meinert, Tina Meller, Igor Nenadic, Markus M. Nothen, Tomas Novak, Nils Opel, Joanna Pawlak, Julia-Katharina Pfarr, James B. Potash, Daniela Reich-Erkelenz, Jonathan Repple, Helene Richard-Lepouriel, Marcella Rietschel, Kai G. Ringwald, Guy Rouleau, Sabrina Schaupp, Fanny Senner, Giovanni Severino, Alessio Squassina, Frederike Stein, Pavla Stopkova, Fabian Streit, Katharina Thiel, Florian Thomas-Odenthal, Gustavo Turecki, Joanna Twarowska-Hauser, Alexandra Winter, Peter P. Zandi, John R. Kelsoe, Peter Falkai, Udo Dannlowski, Tilo Kircher, Thomas G. Schulze, Sergi Papiol
Summary: Personality traits have an influence on the risk of suicidal behavior. This study examined the associations between the Big Five personality traits and suicidal ideation and attempts in patients with major depressive disorder, bipolar disorder, schizoaffective disorder, and schizophrenia. The findings suggest that higher neuroticism and lower extraversion scores are associated with a higher likelihood of reporting suicidal ideation, but there is no significant genetic association with polygenic load for these personality traits. This study provides new insights into the link between personality and suicidal behavior across different mental illnesses.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jitka Buskova, Tomas Novak, Eva Miletinova, Radana Kralova, Jana Kost Alova, Monika Klikova, Karolina Veldova
Summary: This study aimed to differentiate idiopathic hypersomnia (IH) from hypersomnia associated with psychiatric disorder (PSY) by comparing self-reported symptoms, depressive symptoms, personality traits, and objective sleep measures. The results showed significant differences between the IH and PSY groups, with IH patients experiencing more difficulties waking up in the morning, memory problems, and attention deficits, while having better sleep quality. However, there were no differences in depressive symptoms or personality characteristics between the two groups. Therefore, a multidisciplinary approach involving sleep specialists and psychotherapists/psychiatrists may be beneficial for IH patients.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Psychiatry
Micah Cearns, Azmeraw T. Amare, Klaus Oliver Schubert, Anbupalam Thalamuthu, Joseph Frank, Fabian Streit, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J. Raymond De Paulo, Bruno Etain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Yi Hsiang Hsu, Stephane Jamain, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara Konig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nothen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Vincent Millischer, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil Tekola-Ayele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H. Witt, Gloria Roberts, Peter P. Zandi, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Thomas G. Schulze, Marcella Rietschel, Scott R. Clark, Bernhard T. Baune
Summary: This study utilized a combination of genetic and clinical factors to predict lithium response in patients with bipolar disorder. By stratifying patients genetically and training machine-learning models with clinical predictors, significant improvements in lithium response prediction were achieved.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Correction
Psychiatry
Micah Cearns, Azmeraw T. Amare, Klaus Oliver Schubert, Anbupalam Thalamuthu, Joseph Frank, Fabian Streit, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, JeanMichel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, HsiChung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Bruno etain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara Konig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nothen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Vincent Millischer, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil TekolaAyele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H. Witt, Gloria Roberts, Peter P. Zandi, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Thomas G. Schulze, Marcella Rietschel, Scott R. Clark, Bernhard T. Baune
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Obstetrics & Gynecology
A. Horakova, E. Noskova, R. Svancer, V Marcianova, R. Koliba, A. Sebela
Summary: This study assessed the accuracy of the Edinburgh Postnatal Depression Scale (EPDS) in screening for severe depression and other mental disorders at the end of puerperium. The results showed that an EPDS score of >=11 achieved good sensitivity and specificity for detecting major depressive disorder.
CESKA GYNEKOLOGIE-CZECH GYNAECOLOGY
(2022)
Letter
Clinical Neurology
Monika Klirova, Olga Laskov, Jiri Renka, Martin Brunovsky, Tomas Novak
Review
Behavioral Sciences
Michaela Langmajerova, Radka Roubalova, Antonin Sebela, Jan Vevera
Summary: The impact of the microbiome on brain function and behavior has become an important research topic. This study aimed to explore the link between the gut microbiome and impulsive and violent behavior. The results showed associations between specific bacterial taxa and symptoms of ADHD and violent behavior in patients with schizophrenia. However, there was no association found between delivery mode or infant feeding mode and impulsive or violent behavior. The limited number of studies and heterogeneity of data highlight the need for further research in this area.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Nursing
Renata Banasova, Eliska Noskova, Renata Vodickova, Jozef Hasto, Antonin Sebela
Summary: This study uses qualitative research methods to analyze women's perception of emotional difficulties and their coping strategies during the perinatal period, as well as their help-seeking patterns. The findings provide important information for women-centered innovations in perinatal mental health care in Czechia and the region of Central and Eastern Europe.
Article
Neurosciences
Natalie Gornerova, Martin Brunovsky, Monika Klirova, Tomas Novak, Yuliya Zaytseva, Jana Koprivova, Anna Bravermanova, Jiri Horacek
Summary: This study aimed to assess the efficacy of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) in reducing auditory hallucinations (AHs), and to investigate its effects on brain electrophysiology and functional connectivity (FC). The results showed that patients receiving active rTMS had significantly improved AHRS scores, with a decrease in alpha-2 and beta-1, -2 bands in the left hemisphere and a decrease in lagged phase connectivity in beta bands near the stimulation site, as well as an increase in alpha-2 FC. These findings suggest that LF-rTMS can attenuate AHs and modulate cortico-cortical coupling. Overall, this study is of great importance for understanding and treating schizophrenia and auditory hallucinations.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Veronika Langova, Petra Horka, Jan Hubeny, Tomas Novak, Karel Vales, Petr Adamek, Katerina Holubova, Jiri Horacek
Summary: The present study investigates the potential of Gnathonemus petersii (G. petersii), a weakly electric fish, as a model organism for studying the glutamatergic theory of schizophrenia. By examining the effects of the NMDA antagonist ketamine on the fish's electric signaling and behavior, the study found disruption in fish navigation, increased locomotion and erratic movement at lower doses of ketamine, and reduced electric organ discharges at higher doses, indicating successful induction of positive schizophrenia-like symptoms and impairment of fish navigation. Additionally, the study tested the normalization of positive symptoms using a low dose of haloperidol, but further testing with different doses of typical and atypical antipsychotic drugs is needed for confirming the predictive validity of the model.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Correction
Biochemistry & Molecular Biology
Sean R. McWhinney, Katharina Brosch, Vince D. Calhoun, Benedicto Crespo-Facorro, Nicolas A. Crossley, Udo Dannlowski, Erin Dickie, Lorielle M. F. Dietze, Gary Donohoe, Stefan Du Plessis, Stefan Ehrlich, Robin Emsley, Petra Furstova, David C. Glahn, Alfonso Gonzalez-Valderrama, Dominik Grotegerd, Laurena Holleran, Tilo T. J. Kircher, Pavel Knytl, Marian Kolenic, Rebekka Lencer, Igor Nenadic, Nils Opel, Julia-Katharina Pfarr, Amanda L. Rodrigue, Kelly Rootes-Murdy, Alex J. Ross, Kang Sim, Antonin Skoch, Filip Spaniel, Frederike Stein, Patrik Svancer, Diana Tordesillas-Gutierrez, Juan Undurraga, Javier Vaquez-Bourgon, Aristotle Voineskos, Esther Walton, Thomas W. Weickert, Cynthia Shannon Weickert, Paul M. Thompson, Theo G. M. van Erp, Jessica A. Turner, Tomas Hajek
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Filip Tyls, Cestmir Vejmola, Vlastimil Koudelka, Vaclava Piorecka, Lukas Kaderabek, Marcel Bochin, Tomas Novak, Martin Kuchar, Zdenka Bendova, Martin Brunovsky, Jiri Horacek, Tomas Palenicek
Summary: This study aims to elucidate the pharmacological mechanisms underlying psilocin-induced broadband desynchronization and disconnection in an animal model. The results showed that the use of 5-HT2A antagonist could reverse the psilocin-induced decrease in global functional connectivity and fronto-temporal disconnection, while other drugs had no effect.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Jitka Buskova, Eva Miletinova, Radana Kralova, Tereza Dvorakova, Adela Tefr Faridova, Hynek Herman, Kristyna Hrdlickova, Antonin Sebela
Summary: Pregnancy is associated with increased prevalence of parasomnias, including sleepwalking, night terrors, vivid dreams, and nightmares. There is also a significant impact of psychiatric and neurological comorbidities, anxiety and depression symptoms, and pregnancy complications on the occurrence of parasomnia episodes during pregnancy.
Article
Biochemistry & Molecular Biology
Azmeraw T. Amare, Anbupalam Thalamuthu, Klaus Oliver Schubert, Janice M. Fullerton, Muktar Ahmed, Simon Hartmann, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Liping Hou, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Roland Hasler, Helene Richard-Lepouriel, Nader Perroud, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Maria Del Zompo, J. Raymond DePaulo, Bruno etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Andreas J. Fallgatter, Sophia Stegmaier, Thomas Ethofer, Silvia Biere, Kristiyana Petrova, Ceylan Schuster, Kristina Adorjan, Monika Budde, Maria Heilbronner, Janos L. Kalman, Mojtaba Oraki Kohshour, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Thomas Vogl, Ion-George Anghelescu, Volker Arolt, Udo Dannlowski, Detlef Dietrich, Christian Figge, Markus Jaeger, Fabian U. Lang, Georg Juckel, Carsten Konrad, Jens Reimer, Max Schmauss, Andrea Schmitt, Carsten Spitzer, Martin von Hagen, Jens Wiltfang, Joerg Zimmermann, Till F. M. Andlauer, Andre Fischer, Felix Bermpohl, Philipp Ritter, Silke Matura, Anna Gryaznova, Irina Falkenberg, Cueneyt Yildiz, Tilo Kircher, Julia Schmidt, Marius Koch, Kathrin Gade, Sarah Trost, Ida S. Haussleiter, Martin Lambert, Anja C. Rohenkohl, Vivien Kraft, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Scott R. Clark, Bernhard T. Baune
Summary: A polygenic score (Li-PGS(+)) for lithium treatment response in bipolar disorder patients was developed in this study. Li-PGS(+) was found to be positively associated with lithium treatment response. Gene-based analysis also identified 36 candidate genes related to lithium's molecular mechanism.
MOLECULAR PSYCHIATRY
(2023)