Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma

Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance

(2018) Qi-Nian Wu et al.   CANCER LETTERS

Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases

(2018) Ari Elson   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

(2018) Dietrich A. Ruess et al.   NATURE MEDICINE

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

(2018) Yu-Ru Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BCI induces apoptosis via generation of reactive oxygen species and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells

(2018) Jong-Woon Shin et al.   Science China-Life Sciences

Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment

(2018) Etienne D. Foucher et al.   Frontiers in Immunology

PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma

(2018) Ann E. Zeleniak et al.   NEOPLASIA

The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma

(2018) Yide Huang et al.   Cancers

SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models

(2018) Carmine Fedele et al.   Cancer Discovery

PTPRT and PTPRD Deleterious Mutations and Deletion Predict Bevacizumab Resistance in Metastatic Colorectal Cancer Patients

(2018) Hung-Chih Hsu et al.   Cancers

Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3

(2017) Chen Qi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity

(2017) Christof T. Kaltenmeier et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia

(2017) J Wakim et al.   ONCOGENE

Targeting Tyrosine Phosphatases: Time to End the Stigma

(2017) Stephanie M. Stanford et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3)

(2017) Sumit Bhattacharyya et al.   Oncotarget

Autocrine DUSP28 signaling mediates pancreatic cancer malignancy via regulation of PDGF-A

(2017) Jungwhoi Lee et al.   Scientific Reports

Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases

(2016) Zhong-Yin Zhang   ACCOUNTS OF CHEMICAL RESEARCH

Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma

(2016) N. Hijiya et al.   CANCER RESEARCH

Tyrosine Phosphatase PTPRJ/DEP-1 Is an Essential Promoter of Vascular Permeability, Angiogenesis, and Tumor Progression

(2016) P. Fournier et al.   CANCER RESEARCH

Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL Phosphatase

(2016) Y. Bai et al.   CANCER RESEARCH

Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival

(2016) Petra den Hollander et al.   CANCER RESEARCH

PTEN alterations of the stromal cells characterise an aggressive subpopulation of pancreatic cancer with enhanced metastatic potential

(2016) Martin Wartenberg et al.   EUROPEAN JOURNAL OF CANCER

Protein tyrosine phosphatase 1B dephosphorylates PITX1 and regulates p120RasGAP in hepatocellular carcinoma

(2016) Wei-Tien Tai et al.   HEPATOLOGY

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

(2016) Vinit Kumar et al.   IMMUNITY

Small cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2

(2016) Huanyu Xu et al.   Journal of Translational Medicine

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells

(2016) Jungwhoi Lee et al.   TUMOR BIOLOGY

Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome

(2016) Elmer Hoekstra et al.   Oncotarget

Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells

(2016) Xiaolin Luo et al.   Cell Reports

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors

(2016) Wenhan Mei et al.   PLoS One

Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma

(2016) Hao-Wei Teng et al.   Scientific Reports

Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

(2015) Seyedmehdi Shojaee et al.   CANCER CELL

PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer

(2015) Hongbing Liu et al.   CANCER LETTERS

Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis

(2015) A. V. Sorokin et al.   CANCER RESEARCH

Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients

(2015) Na Wang et al.   CELL CYCLE

Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo

(2015) Stefanie Grosskopf et al.   ChemMedChem

PTPRN2 and PLC 1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling

(2015) C. A. Sengelaub et al.   EMBO JOURNAL

The extended human PTPome: a growing tyrosine phosphatase family

(2015) Andrés Alonso et al.   FEBS Journal

Stromal biology and therapy in pancreatic cancer: a changing paradigm

(2015) Albrecht Neesse et al.   GUT

PI3King the Lock

(2015) David King et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis

(2015) K Spring et al.   ONCOGENE

Epigenetic silencing of DUSP9 induces the proliferation of human gastric cancer by activating JNK signaling

(2015) FANG WU et al.   ONCOLOGY REPORTS

Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer

(2015) TAKASHI SATO et al.   ONCOLOGY REPORTS

Expression and prognosis value of SHP2 in patients with pancreatic ductal adenocarcinoma

(2015) Jiawei Zheng et al.   TUMOR BIOLOGY

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

(2015) Severa Bunda et al.   Nature Communications

Dual-specificity phosphatases: critical regulators with diverse cellular targets

(2015) Kate I. Patterson et al.   BIOCHEMICAL JOURNAL

Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility

(2015) Annika M. Bourgonje et al.   Oncotarget

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility

(2014) Zhichuan Zhu et al.   CARCINOGENESIS

In Vivo Structure-Activity Relationship Studies Support Allosteric Targeting of a Dual Specificity Phosphatase

(2014) Vasiliy N. Korotchenko et al.   CHEMBIOCHEM

Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver

(2014) Birgit Hoeger et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activating Mutations in PTPN3 Promote Cholangiocarcinoma Cell Proliferation and Migration and Are Associated With Tumor Recurrence in Patients

(2014) Qiang Gao et al.   GASTROENTEROLOGY

DUSP28 contributes to human hepatocellular carcinoma via regulation of the p38 MAPK signaling

(2014) DONG WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Protease Storm Cleaves a Cell-Cell Adhesion Molecule in Cancer: Multiple Proteases Converge to Regulate PTPmu in Glioma Cells

(2014) Polly J. Phillips-Mason et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

(2014) Li-Fan Zeng et al.   JOURNAL OF MEDICINAL CHEMISTRY

PTN signaling: Components and mechanistic insights in human ovarian cancer

(2014) Geetika Sethi et al.   MOLECULAR CARCINOGENESIS

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

(2014) Navasona Krishnan et al.   Nature Chemical Biology

Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation

(2014) O Shimozato et al.   ONCOGENE

Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice

(2014) Julie M. Cramer et al.   Stem Cell Research

The Genesis of Tyrosine Phosphorylation

(2014) T. Hunter   Cold Spring Harbor Perspectives in Biology

When Overgrowth Bumps Into Cancer: The PTEN-Opathies

(2013) JESSICA MESTER et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Receptor-like protein tyrosine phosphatase κ negatively regulates the apoptosis of prostate cancer cells via the JNK pathway

(2013) PING-HUI SUN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

DNA methylation of membrane-bound tyrosine phosphatase genes in acute lymphoblastic leukaemia

(2013) W S Stevenson et al.   LEUKEMIA

Deregulation of protein phosphatase expression in acute myeloid leukemia

(2013) Nuzhat N. Kabir et al.   MEDICAL ONCOLOGY

Phosphatase of Regenerating Liver 3 (PRL3) Provokes a Tyrosine Phosphoproteome to Drive Prometastatic Signal Transduction

(2013) Chad D. Walls et al.   MOLECULAR & CELLULAR PROTEOMICS

Tyrosine phosphatase PTPα contributes to HER2-evoked breast tumor initiation and maintenance

(2013) D S Meyer et al.   ONCOGENE

Src-Mediated Phosphorylation of the Tyrosine Phosphatase PRL-3 Is Required for PRL-3 Promotion of Rho Activation, Motility and Invasion

(2013) James J. Fiordalisi et al.   PLoS One

The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis

(2013) Irina Alho et al.   TUMOR BIOLOGY

Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma

(2013) Marius Distler et al.   BMC Surgery

New insights into pancreatic cancer biology

(2012) M. Hidalgo   ANNALS OF ONCOLOGY

Dual-Specificity MAP Kinase Phosphatases as Targets of Cancer Treatment

(2012) Caroline Nunes-Xavier et al.   Anti-Cancer Agents in Medicinal Chemistry

Impact of Oncogenic Protein Tyrosine Phosphatases in Cancer

(2012) Serge Hardy et al.   Anti-Cancer Agents in Medicinal Chemistry

Pathology and Molecular Genetics of Pancreatic Neoplasms

(2012) Laura D. Wood et al.   CANCER JOURNAL

PTP1B Is an Androgen Receptor-Regulated Phosphatase That Promotes the Progression of Prostate Cancer

(2012) L. Lessard et al.   CANCER RESEARCH

Dual-specificity MAP kinase phosphatases (MKPs)

(2012) Christopher J. Caunt et al.   FEBS Journal

An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72

(2012) K. Xiang et al.   GENES & DEVELOPMENT

Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma

(2012) Wai Chin Foo et al.   HUMAN PATHOLOGY

The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma

(2012) Chengying Jiang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

(2012) Kathryn M. Kinross et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular pathways in pancreatic carcinogenesis

(2012) Anne M. Macgregor-Das et al.   JOURNAL OF SURGICAL ONCOLOGY

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein tyrosine phosphatase mu regulates glioblastoma cell growth and survival in vivo

(2012) H. Kaur et al.   NEURO-ONCOLOGY

Targeting the Yin and the Yang

(2012) Evan G. Gomes et al.   PANCREAS

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

(2011) Aftabul Haque et al.   CELL

Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome”

(2011) Robert Karisch et al.   CELL

Activation of Src and transformation by an RPTPα splice mutant found in human tumours

(2011) Jian Huang et al.   EMBO JOURNAL

Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype

(2011) Victor Chun Lam Wong et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Protein-tyrosine Phosphatase 1B (PTP1B) Mediates Ubiquitination and Degradation of Bcr-Abl Protein

(2011) Daniel Alvira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling

(2011) Deepika Arora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of dual-specificity phosphatase–2 by hypoxia increases chemoresistance and malignancy in human cancer cells

(2011) Shih-Chieh Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

PTP1B expression contributes to gastric cancer progression

(2011) Jinguo Wang et al.   MEDICAL ONCOLOGY

Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas

(2011) S Messina et al.   ONCOGENE

Increased levels of DUSP6 phosphatase stimulate tumourigenesis in a molecularly distinct melanoma subtype

(2011) Weiling Li et al.   Pigment Cell & Melanoma Research

The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

(2010) O. Bermudez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Identification and functional analysis of genes which confer resistance to cisplatin in tumor cells

(2010) Zchong-Zcho Wu et al.   BIOCHEMICAL PHARMACOLOGY

PTPH1 Dephosphorylates and Cooperates with p38γ MAPK to Increase Ras Oncogenesis through PDZ-Mediated Interaction

(2010) Song-Wang Hou et al.   CANCER RESEARCH

PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development

(2010) R. Hill et al.   CANCER RESEARCH

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells

(2010) Zhenfeng Zhang et al.   CARCINOGENESIS

Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development

(2010) Wade A. Znosko et al.   DEVELOPMENTAL BIOLOGY

Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function

(2010) Andrew Manford et al.   EMBO JOURNAL

PTPD1 Supports Receptor Stability and Mitogenic Signaling in Bladder Cancer Cells

(2010) Annalisa Carlucci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

(2010) Maria Kleppe et al.   NATURE GENETICS

Inhibition of PTP1B by Trodusquemine (MSI-1436) Causes Fat-specific Weight Loss in Diet-induced Obese Mice

(2010) Kristen A. Lantz et al.   Obesity

PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization

(2010) H-Y Zhi et al.   ONCOGENE

The two faces of PTP1B in cancer

(2009) Laurent Lessard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

TC-PTP is required for the maintenance of MYC-driven B-cell lymphomas

(2009) R. M. Young et al.   BLOOD

Proteolytic Cleavage of Protein Tyrosine Phosphatase   Regulates Glioblastoma Cell Migration

(2009) A. M. Burgoyne et al.   CANCER RESEARCH

Protein tyrosine phosphatase SHP-2: A proto-oncogene product that promotes Ras activation

(2009) Takashi Matozaki et al.   CANCER SCIENCE

Mitogen-Activated Protein Kinase Phosphatase-1 in Human Breast Cancer Independently Predicts Prognosis and Is Repressed by Doxorubicin

(2009) F. Rojo et al.   CLINICAL CANCER RESEARCH

Use of Protein Tyrosine Phosphatase Inhibitors as Promising Targeted Therapeutic Drugs

(2009) P. Heneberg   CURRENT MEDICINAL CHEMISTRY

Drug Discovery and Protein Tyrosine Phosphatases

(2009) Mark Blaskovich   CURRENT MEDICINAL CHEMISTRY

Tyrosine phosphorylation: thirty years and counting

(2009) Tony Hunter   CURRENT OPINION IN CELL BIOLOGY

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

(2009) Gabriela Molina et al.   Nature Chemical Biology

Negative Regulators of Insulin Signaling Revealed in a Genome-Wide Functional Screen

(2009) Shih-Min A. Huang et al.   PLoS One

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian phosphoinositide kinases and phosphatases

(2009) Takehiko Sasaki et al.   PROGRESS IN LIPID RESEARCH

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within theDUSP6/MKP-3gene promoter

(2008) Maria Ekerot et al.   BIOCHEMICAL JOURNAL

Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability

(2008) Sebastian Korff et al.   BMC CANCER

Targeting PTPs with small molecule inhibitors in cancer treatment

(2008) Zhong-Xing Jiang et al.   CANCER AND METASTASIS REVIEWS

The tyrosine phosphatase Shp2 (PTPN11) in cancer

(2008) Gordon Chan et al.   CANCER AND METASTASIS REVIEWS

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

(2008) Stephen M. Keyse   CANCER AND METASTASIS REVIEWS

Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

(2008) D. A. Solomon et al.   CANCER RESEARCH

A Selective Phosphatase of Regenerating Liver Phosphatase Inhibitor Suppresses Tumor Cell Anchorage-Independent Growth by a Novel Mechanism Involving p130Cas Cleavage

(2008) S. Daouti et al.   CANCER RESEARCH

Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells

(2008) David W. Chan et al.   CARCINOGENESIS

Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells

(2008) X-D Zhou et al.   CELL DEATH AND DIFFERENTIATION

From immune response to cancer: a spot on the low molecular weight protein tyrosine phosphatase

(2008) A. C. S. Souza et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The complexity of mitogen-activated protein kinases (MAPKs) made simple

(2008) M. Krishna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis

(2008) X Zhou et al.   HISTOPATHOLOGY

Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTPα and src RNAi

(2008) Xinmin Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

The Catalytic Acid in the Dephosphorylation of the Cdk2-pTpY/CycA Protein Complex by Cdc25B Phosphatase

(2008) Guilherme Menegon Arantes   JOURNAL OF PHYSICAL CHEMISTRY B

Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells

(2008) B. Stephens et al.   MOLECULAR CANCER THERAPEUTICS

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

Adjuvant therapy for pancreatic cancer

(2007) Dan S. Zuckerman et al.   CANCER

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

(2007) Marie Dance et al.   CELLULAR SIGNALLING