Journal
CELL STEM CELL
Volume 24, Issue 6, Pages 877-894Publisher
CELL PRESS
DOI: 10.1016/j.stem.2019.05.016
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Funding
- Nanyang Assistant Professorship Grant from Lee Kong Chian School of Medicine
- Nanyang Technological University
- Singapore National Medical Research Council [NMRC/OFIRG/0076/2018, NMRC/OFLCG/001/2017]
- G. Harold and Leila Y. Mathers Charitable Foundation
- Universidad Catolica San Antonio de Murcia
- Leona M. and Harry B. Helmsley Charitable Trust [2012-PG-MED002]
- Moxie Foundation
- NIH [R21 AG055938]
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Organ constructs are organ-like structures grown in vitro or in vivo that harbor the components, architecture and function of in vivo organs, in part or in toto. The convergence of stem cell biology, bioengineering, and gene editing tools have substantially broadened our ability to generate various types of organ constructs for regenerative medicine as well as to address pressing biomedical questions. In this Review, we highlight prevailing approaches for generating organ constructs, from organoids to chimeric organ engineering We also discuss design principles of different approaches, their utility and limitations and propose strategies to resolve existing hurdles.
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