Article
Biochemistry & Molecular Biology
Leo Bogdanov, Daria Shishkova, Rinat Mukhamadiyarov, Elena Velikanova, Anna Tsepokina, Alexander Terekhov, Vladislav Koshelev, Anastasia Kanonykina, Amin Shabaev, Alexey Frolov, Nikita Zagorodnikov, Anton Kutikhin
Summary: This study investigated the relationship between vasa vasorum (VV), myeloperoxidase-positive (MPO+) clusters, and intimal hyperplasia (IH) in vascular pathology. Using rat models and a clinical scenario, the study found a strong correlation between the quantities of VV and MPO+ clusters, and demonstrated that MPO+ cluster density was significantly associated with IH. Additionally, the study showed that the quantity and density of VV correlated with IH in bypass grafts for coronary artery bypass graft surgery. These findings highlight the pathophysiological importance of excessive VV in vascular injury and exposure to cardiovascular risk factors, and propose an explanatory mechanism for the higher long-term patency of arterial grafts in coronary artery bypass graft surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Nana Burns, Hala Nijmeh, Martin Lapel, Suzette Riddle, Gennady G. Yegutkin, Kurt R. Stenmark, Evgenia Gerasimovskaya
Summary: Isolated endothelial cells are valuable in vitro models for studying vascular research. However, methods for isolating and culturing vasa vasorum endothelial cells (VVEC) have not been reported. This study presents a detailed protocol for reproducible isolation, purification, and culture of VVEC from the pulmonary artery (PA) and demonstrates their characteristics and growth potential. This protocol provides opportunities for further research on VVEC and advances in vascular research.
MICROVASCULAR RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Xinlong Xie, Qiying Wu, Yuhong Liu, Chunyang Chen, Zeguo Chen, Chao Xie, Mingzhe Song, Zhenlin Jiang, Xiaoke Qi, Sixi Liu, Zhenjie Tang, Zhongshi Wu
Summary: This study evaluated the effect of VEGF on neointimal hyperplasia and local inflammatory responses in decellularized small-diameter vascular grafts. The results showed that local administration of VEGF attenuated neointimal hyperplasia by inducing macrophage M2 polarization and modulating the inflammatory response.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaoyan Yang, Lei Wang, Zihao Zhang, Jiayi Hu, Xiaoling Liu, Hao Wen, Minghao Liu, Xue Zhang, Hongyan Dai, Mei Ni, Rui Li, Rong Guo, Lei Zhang, Xiaorong Luan, Huili Lin, Mei Dong, Huixia Lu
Summary: The study demonstrated that Ginsenoside Rb-1 can stabilize atherosclerotic plaques by inhibiting adventitial vasa vasorum proliferation and inflammation, reducing plaque burden. These anti-angiogenic and anti-inflammatory effects are exerted through the modulation of miR-33 and its target gene PEDF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Hematology
Dong Chen, Zixi Zhao, Peng Liu, Xinbang Liu, Xin Wang, Qiuyue Ren, Bai Chang
Summary: This study aimed to assess the relationship between adventitial vasa vasorum neovascularization (VVn) and macroangiopathy in type 2 diabetic patients, and its association with the recruitment of macrophages and lymphocytes as well as the occurrence of cardiovascular events. The results indicate that high VVn density is positively correlated with the risk of cardiovascular disease in type 2 diabetic patients, and increased VVn density is associated with adverse cardiovascular events.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Javier Rodriguez-Carrio, Natalia Carrillo-Lopez, Catalina Ulloa, Beatriz Martin-Carro, Carmen Rodriguez-Suarez, Manuel Naves-Diaz, Emilio Sanchez-Alvarez, Minerva Rodriguez-Garcia, Maria Vittoria Arcidiacono, Belinda Fernandez-Marino, Jorge B. Cannata-Andia, Ana Suarez, Adriana S. Dusso
Summary: Novel T cell and monocyte subsets are altered in CKD. Altered T-cell subpopulations, but not monocytes, exhibited distinct associations with different vascular outcomes in CKD. Tang are emerging biomarkers of subclinical vascular deterioration in CKD.
FRONTIERS IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinlan Chen, Liming Liang, Ziheng Zhang, Jing Du, Lijun Tang, Wei Cao, Xianglei Kong, Dongmei Xu
Summary: This study assessed venous wall vascularization and its correlation with neointimal hyperplasia in failed arteriovenous fistulae. The results showed that vascularization was more developed in the arterialized veins, especially at regions of neointimal hyperplasia in failed AVFs.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tasuku Watanabe, Yasuharu Matsumoto, Kensuke Nishimiya, Tomohiko Shindo, Hirokazu Amamizu, Jun Sugisawa, Satoshi Tsuchiya, Koichi Sato, Susumu Morosawa, Kazuma Ohyama, Tomomi Watanabe-Asaka, Moyuru Hayashi, Yoshiko Kawai, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa
Summary: This study aimed to investigate whether low-intensity pulsed ultrasound therapy could suppress drug-eluting stent-induced coronary hyperconstricting responses in pigs in vivo, and identified the mechanisms involved. The results demonstrated that the LIPUS therapy effectively suppressed coronary vasoconstricting responses to serotonin, increased lymph transport speed, and reduced inflammatory changes and Rho-kinase activity at DES edges.
Article
Biochemistry & Molecular Biology
Victoria Markova, Leo Bogdanov, Elena Velikanova, Anastasia Kanonykina, Alexey Frolov, Daria Shishkova, Anastasia Lazebnaya, Anton Kutikhin
Summary: Current techniques for detecting vasa vasorum (VV) in vascular pathology have limitations in evaluating vascular geometry and clinical relevance. This study found that markers for smooth muscle cells, such as alpha-SMA and SM-MHC, provide better results irrespective of the primary antibody origin, fluorophore, or VV type. Furthermore, these markers allow unbiased evaluation of VV area under vasospasm. Identification of specific markers for arterial, venous, lymphatic, or capillary differentiation requires high-throughput searches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Boao Xie, Liwei Zhang, Chunyang Lou, Shunbo Wei, Jing'an Li, Hualong Bai, Alan Dardik
Summary: The study found that wood can be used as a vascular patch material and can improve drug delivery. These plant-derived materials may serve as alternatives to prosthetic or animal-based materials in vascular applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xu Zhou, Ruth A. Franklin, Miri Adler, Trevor S. Carter, Emily Condiff, Taylor S. Adams, Scott D. Pope, Naomi H. Philip, Matthew L. Meizlish, Naftali Kaminski, Ruslan Medzhitov
Summary: This article reports on the mechanisms controlling the population numbers of different cell types in animal tissues. The study shows that fibroblasts are limited in proliferation due to space availability, while macrophages are constrained by growth factor availability. The transcriptional coactivator YAP1 in fibroblasts directly regulates the expression of the macrophage-specific growth factor Csf1. The findings suggest that tissue environment sensing is a general strategy for controlling tissue composition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nutrition & Dietetics
Enric Sanchez, Maria-Dolores Santos, Maitane Nunez-Garcia, Marta Bueno, Ignacio Sajoux, Andree Yeramian, Albert Lecube
Summary: Weight loss after bariatric surgery can reduce the expansion of the adventitial vasa vasorum (VV), but the effect of very low calorie ketogenic diets (VLCKD) on VV and lipid-based atherogenic indices is unclear. A 6-month VLCKD intervention in moderately obese individuals led to significant improvements in BMI, total body fat, and quality of life, as well as decreases in atherogenic plasma index and sICAM-1 serum concentration. While VV density did not change significantly, VLCKD induced changes in markers of endothelial dysfunction and cardiovascular risk.
Review
Medicine, General & Internal
Cameron D. A. Mackay, Anshul S. Jadli, Paul W. M. Fedak, Vaibhav B. Patel
Summary: Aortic aneurysm is a degenerative vascular disease, and understanding the mechanisms involved in fibroblast activation and regulation may provide potential therapeutic targets for preventing or delaying the progression of this disease.
Article
Biochemistry & Molecular Biology
A. Ra Kho, Dae Ki Hong, Beom Seok Kang, Woo-Jung Park, Kyung Chan Choi, Kyoung-Ha Park, Sang Won Suh
Summary: The study shows that atorvastatin can reduce neuronal death, oxidative stress, inflammation, and blood-brain barrier disruption in global cerebral ischemia, improving cognitive function. Additionally, atorvastatin can also reduce endothelial cell damage and VV proliferation. These results suggest that atorvastatin may be an effective option in managing global cerebral ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Zhaojun Li, Quan Wang, Hongshu Jing, Xianghong Luo, Lianfang Du, Yourong Duan
Summary: This study developed a targeting nanodelivery system, cRGD peptide-modified RNPs, for delivering the antiangiogenesis drug PEDF to inhibit neovascularization in plaque. In vitro and in vivo experiments demonstrated the effectiveness of PEDF RNPs in reducing plaque area and thickness, suggesting their potential for future clinical applications in atherosclerosis treatment.
ACS APPLIED NANO MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Guannan Zhang, Xiaodong Li, Chengyu Sheng, Xiaohui Chen, Yu Chen, Dingliang Zhu, Pingjin Gao
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2016)
Article
Oncology
Mo-Na Hong, Xiao-Dong Li, Dong-Rui Chen, Cheng-Chao Ruan, Jian-Zhong Xu, Jing Chen, Yong-Jie Wu, Yu Ma, Ding-Hang Zhu, Ping-Jin Gao
Article
Cardiac & Cardiovascular Systems
Caojian Zuo, Xiaodong Li, Jun Huang, Dongrui Chen, Kaida Ji, Yan Yang, Tingyan Xu, Dingliang Zhu, Chen Yan, Pingjin Gao
CARDIOVASCULAR RESEARCH
(2018)
Article
Hematology
Xiao-Dong Li, Jing Chen, Cheng-Chao Ruan, Ding-Liang Zhu, Ping-Jin Gao
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Yuan-Yuan Lu, Xiao-Dong Li, Han-Dan Zhou, Shuai Shao, Shun He, Mo-Na Hong, Jia-Chen Liu, Ying-Le Xu, Yong-Jie Wu, Ding-Liang Zhu, Ji-Guang Wang, Ping-Jin Gao
Article
Peripheral Vascular Disease
Shuai Shao, Xiao-Dong Li, Yuan-Yuan Lu, Shi-Jin Li, Xiao-Hui Chen, Han-Dan Zhou, Shun He, Yue-Tong Guo, Xiao Lu, Ping-Jin Gao, Ji-Guang Wang
Summary: The study found that NPR-C protein regulates NCC function, contributing to sodium retention-mediated hypertension. Therefore, NPR-C may be a promising candidate for the treatment of sodium retention-related hypertension.
Article
Cell Biology
Shun He, Yuanyuan Lu, Yuetong Guo, Shijin Li, Xiao Lu, Shuai Shao, Handan Zhou, Ruiqi Wang, Jiguang Wang, Pingjin Gao, Xiaodong Li
Summary: The study revealed that KLF15 in cardiac fibroblasts negatively regulates the CXCL1/CXCR2 axis-mediated inflammatory response and subsequent cardiac remodeling in hypertension.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yue-Tong Guo, Yuan-Yuan Lu, Xiao Lu, Shun He, Shi-Jin Li, Shuai Shao, Han-Dan Zhou, Rui-Qi Wang, Xiao-Dong Li, Ping-Jin Gao
Summary: IL-11 plays a crucial role in hypertension-associated vascular remodeling, IL-11 neutralizing antibody can alleviate adventitial fibrosis and inflammatory response, Krüppel-like factor 15 negatively regulates Ang II-induced IL-11 expression in adventitial fibroblasts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)