Review
Oncology
Lin Su, Lei She, Liangfang Shen
Summary: Nasopharyngeal carcinoma is a common malignant tumor of the head and neck, originating from the mucous epithelium of the nasopharynx. Symptoms are often missed, with majority of patients presenting with locally advanced disease. Concurrent radiation therapy with chemotherapy can improve regional control, but distant metastasis remains a challenge. Adjuvant chemotherapy's role in treating locally advanced NPC is still unclear and associated with increased toxicity.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Trang Thanh Pham, Brendan Whelan, Bradley M. Oborn, Geoff P. Delaney, Shalini Vinod, Caterina Brighi, Michael Barton, Paul Keall
Summary: MRI-guided proton therapy combines the excellent soft tissue imaging of MRI with the superior dose conformity of proton therapy, holding great promise in radiation oncology. It has the potential to benefit patients with substantial tumor motion or anatomical variation, as well as those who cannot safely receive dose escalation due to nearby critical structures.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Oncology
Kenneth C. W. Wong, Edwin P. Hui, Kwok-Wai Lo, Wai Kei Jacky Lam, David Johnson, Lili Li, Qian Tao, Kwan Chee Allen Chan, Ka-Fai To, Ann D. King, Brigette B. Y. Ma, Anthony T. C. Chan
Summary: Over the past three decades, significant progress has been made in understanding the molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-associated cancer. Technological advances have led to the introduction of proton therapy and other contemporary radiotherapy approaches, with continued efforts to determine the optimal sequencing of chemotherapy with radiotherapy through decades of clinical trials.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Oncology
Jing Feng Zong, Po-Ju Lin, Hsiao-Hui Tsou, Qiaojuan Guo, Yi-Chun Liu, Hanchuan Xu, Chih-Wen Twu, Wei Zheng, Rong-San Jiang, Kai -Li Liang, Tian-Yun Lin, Jian Ji Pan, Shao Jun Lin, Jin-Ching Lin
Summary: The purpose of this study was to compare the acute toxicity of two different induction chemotherapy regimens in patients with advanced nasopharyngeal carcinoma. The results showed that the weekly chemotherapy regimen significantly reduced acute toxicities and had higher complete response rates and lower relapse rates, without compromising tumor response and survivals.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Wenhui Wang, Tiejun Wang, Zi Liu, Jianli He, Xiaoge Sun, Wei Zhong, Fengjv Zhao, Xiaomei Li, Sha Li, Hong Zhu, Zhanshu Ma, Ke Hu, Fuquan Zhang, Xiaorong Hou, Lichun Wei, Lijuan Zou
Summary: This study analyzed the impact of different radiation modalities on survival and toxicity in Chinese stage I to II endometrial cancer patients. The results showed that external beam pelvic radiotherapy (EBRT) significantly increased survival in the high-risk group, but had higher rates of toxicity as well.
Article
Oncology
Wen-Shan Liu, Kuo-Wang Tsai, Bor-Hwang Kang, Ching-Chieh Yang, Wei-Lun Huang, Ching-Chih Lee, Yu-Chang Hu, Kuo-Ping Chang, Hsiu-Min Chen, Yaoh-Shiang Lin
Summary: The study compared the treatment outcomes and adverse effects in patients with nasopharyngeal carcinoma using different treatment methods. The group with simultaneously reduced volume and dose showed better overall survival and salvage survival, along with a lower ratio of severe lung infection.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Yoon Young Jo, Ji Woon Yea, Jaehyeon Park, Se An Oh, Jae Won Park
Summary: Bladder filling variation presents a challenge for radiotherapy delivery. Adaptive radiotherapy using individualized plan libraries has shown good survival outcomes and high local control rates.
Article
Oncology
Jingbo Wang, Xiaodong Huang, Shiran Sun, Kai Wang, Yuan Qu, Xuesong Chen, Runye Wu, Ye Zhang, Qingfeng Liu, Jianghu Zhang, Jingwei Luo, Jianping Xiao, Li Gao, Guozhen Xu, Chen Hu, Ye-Xiong Li, Junlin Yi
Summary: The study investigated conditional survival and dynamic failure hazard in non-metastatic nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy. Results showed that survival prospects improve over years with distinct patterns across stages, highlighting the importance of personalized decision-making in clinical management and surveillance counseling.
Article
Oncology
Hans H. B. Wenzel, Ruud L. M. Bekkers, Valery E. P. P. Lemmens, Maaike A. Van der Aa, Hans W. Nijman
Summary: Surgery remains the preferred treatment for early-stage cervical cancer patients aged 15-74, with higher application rates seen in younger patients. The use of chemoradiation has increased over time in locally advanced cervical cancer patients, while radiotherapy remains common in older patients aged 75 and above.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Gowoon Yang, Chang Young Lee, Eun Young Kim, Chang Geol Lee, Min Hee Hong, Byung Jo Park, Hong In Yoon, Kyung Hwan Kim, Sang Hoon Lee, Hwa Kyung Byun, Jaeho Cho
Summary: This study aimed to determine the role of radiotherapy (RT) and the optimal RT target volume in the treatment of thymic carcinoma. A total of 116 patients who received multimodal treatment were included. The target volume was defined as the tumor bed or gross tumor with margin, and selective irradiation of the regional nodal area was performed when involved. The results showed a high local control rate with RT, and a target volume confined to the tumor bed or gross tumor plus margin with the involved lymph node stations seems reasonable.
Article
Oncology
Pui Lam Yip, Wai Him Brian Fung, Francis Ann Shing Lee, Chak Fei Lee, Natalie Sean Man Wong, Shing Fung Lee
Summary: This retrospective study reports the real-world effectiveness and safety of modified CAPIRI-P (mCAPIRI-P) regimen in patients with metastatic colorectal cancer. The results show that mCAPIRI-P is a safe and effective first-line treatment for RAS wild-type advanced colorectal cancer, and further research is warranted.
FRONTIERS IN ONCOLOGY
(2023)
Article
Otorhinolaryngology
Ariel E. Pollock, Danielle Arons, Gregory S. Alexander, David Alicia, Kayla M. Birkman, Jason K. Molitoris, Ranee Mehra, Kevin J. Cullen, Kyle M. Hatten, Rodney J. Taylor, Jeffrey S. Wolf, William F. Regine, Matthew E. Witek
Summary: A retrospective analysis showed that the extent of high-dose gross tumor volume (GTV) to clinical target volume (CTV) expansion is associated with local control in patients with p16-positive oropharynx cancer (p16+ OPC) treated with intensity modulated proton therapy (IMPT). Excellent local control was achieved using IMPT for p16+ OPC independent of GTV expansion.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Han Gyul Yoon, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, Seyjoon Park
Summary: In treating oropharynx cancer patients, the combination of IMRT and IMPT achieved more favorable acute toxicity profiles compared to IMRT alone, while maintaining comparable oncologic outcomes.
Article
Biochemistry & Molecular Biology
Yang Wang, Fan Xiao, Yi Zhao, Chen-Xue Mao, Lu-Lu Yu, Lei-Yun Wang, Qi Xiao, Rong Liu, Xi Li, Howard L. McLeod, Bi-Wen Hu, Yu-Ling Huang, Qiao-Li Lv, Xiao-Xue Xie, Wei-Hua Huang, Wei Zhang, Cheng-Xian Guo, Jin-Gao Li, Ji-Ye Yin
Summary: This study identified novel risk loci for skin toxicity and dysphagia in nasopharyngeal carcinoma patients receiving radiotherapy, including rs6711678, rs4848597, rs4848598, rs2091255, and rs584547. Prediction models integrating genetic and clinical factors were also established.
Review
Biochemistry & Molecular Biology
Nhan Hau Tran, Tatiana Shtam, Yaroslav Yu Marchenko, Andrey L. Konevega, Dmitry Lebedev
Summary: The development of new methods to increase the effectiveness of proton therapy has garnered interest in radiation oncology. The use of binary technologies, combining proton radiation with radiosensitizers, has shown potential to significantly enhance the efficacy of radiation therapy. Proton boron capture therapy (PBCT), which utilizes the capture of protons on the B-11 isotope to generate alpha particles, has been proposed to increase the absorbed dose in tumor targets. This review summarizes theoretical and experimental studies on the effectiveness and prospects of PBCT.
Article
Physics, Multidisciplinary
Kwangzoo Chung, Jihyun Park, Sung Hwan Ahn, Youngyih Han, Do Hoon Lim
JOURNAL OF THE KOREAN PHYSICAL SOCIETY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seonghoon Jeong, Kwangzoo Chung, Sung Hwan Ahn, Boram Lee, Jaehyeon Seo, Myonggeun Yoon
Article
Physics, Multidisciplinary
Seonghoon Jeong, Myonggeun Yoon, Kwangzoo Chung
JOURNAL OF THE KOREAN PHYSICAL SOCIETY
(2020)
Article
Physics, Multidisciplinary
Jaehyeon Seo, Yunhui Jo, Sunyoung Moon, Myonggeun Yoon, Sung Hwan Ahn, Boram Lee, Kwangzoo Chung, Seonghoon Jeong
JOURNAL OF THE KOREAN PHYSICAL SOCIETY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seonghoon Jeong, Myonggeun Yoon, Kwangzoo Chung, Sung Hwan Ahn, Boram Lee, Jaehyeon Seo
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2020)
Article
Oncology
Jiyun Park, Jun Park, Jung Hee Shin, Young-Lyun Oh, Hyun-Ae Jung, Man-Ki Chung, Jun-Ho Choe, Yong-Chan Ahn, Sun-Wook Kim, Jae-Hoon Chung, Tae-Hyuk Kim, Jae-Myoung Noh
Summary: The study found that high NLR before and after radiotherapy was associated with poor survival in patients with anaplastic thyroid cancer (ATC), indicating the importance of host immunity in ATC patients. This suggests that this finding may provide important information for designing future investigations on the impact of immune system modulating therapy in ATC.
Article
Oncology
Han Gyul Yoon, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, Seyjoon Park
Summary: In treating oropharynx cancer patients, the combination of IMRT and IMPT achieved more favorable acute toxicity profiles compared to IMRT alone, while maintaining comparable oncologic outcomes.
Article
Oncology
Chae Hong Lim, Soo Bin Park, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Yong Chan Ahn, Myung-ju Ahn, Joon Young Choi
Summary: This study evaluated the diagnostic value of FDG PET/CT surveillance for detecting clinically unsuspected recurrence or SPC in NSCLC patients after curative therapy. It found that surveillance PET/CT showed good diagnostic efficacy, especially in certain subgroups of patients.
Article
Biology
Kyungmi Yang, Yang-Gun Suh, Hyunju Shin, Hongryull Pyo, Sung Ho Moon, Yong Chan Ahn, Dongryul Oh, Eunah Chung, Kwanghyun Jo, Jae Myoung Noh
Summary: This study evaluated the toxicity of radiation techniques in patients with recurrent non-small cell lung cancer (NSCLC) in the thoracic region who underwent curative re-irradiation (re-RT). The study found that salvage re-RT was feasible, even in patients with local recurrence within the previous radiation therapy (RT) field. Proton beam therapy (PBT) showed similar survival outcomes and toxicity to other techniques. Careful consideration of tumor location and RT regimens is necessary for thoracic re-RT.
Article
Oncology
Bong Kyung Bae, Kyungmi Yang, Jae Myung Noh, Hongryull Pyo, Yong Chan Ahn
Summary: This study reports the clinical outcomes of proton and photon stereotactic body radiation therapy (SBRT) for early-stage lung cancer. The findings suggest that proton SBRT may be considered for patients at high risk of developing radiation pneumonitis, as it showed comparable oncologic outcomes and toxicity profiles to photon SBRT.
Article
Oncology
Kangpyo Kim, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Han -Sin Jeong, Man Ki Chung, Sang Duk Hong, Chung-Hwan Baek
Summary: This study compared the oncologic outcomes of sinonasal squamous cell carcinoma patients treated with radiation therapy or surgical resection. The results showed no significant differences in overall survival, local progression-free survival, and overall progression-free survival between the two treatment modalities. Radiation therapy may be considered for locally advanced sinonasal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Yong-Pyo Lee, Sang Eun Yoon, Junhun Cho, Young Hyeh Ko, Dongryul Oh, Yong Chan Ahn, Won Seog Kim, Seok Jin Kim
Summary: In this study, we analyzed the clinical characteristics and survival outcomes of 65 testicular DLBCL patients. Treatment with orchiectomy, six cycles of chemotherapy, and contralateral RT showed survival benefits, but CNS prophylaxis therapy did not reduce CNS recurrence. MYD88, CD79B, and PIM1 mutations were frequent.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Oncology
Tae Hoon Lee, Sang Hee Ahn, Kwangzoo Chung, Won Park, Won Kyung Cho, Nalee Kim, Tae Gyu Kim, Haeyoung Kim
Summary: This study aimed to quantify the changes in breast volume associated with radiotherapy in patients undergoing breast-conserving surgery and whole-breast irradiation (WBI). The study found that breast volume decreases following WBI, and this decrease is correlated with an increased duration after WBI. These findings highlight the long-term consequences of WBI on breast asymmetry.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Yoon Kyoung So, Zero Kim, Taek Yoon Cheong, Myung Jin Chung, Chung-Hwan Baek, Young-Ik Son, Jungirl Seok, Yuh-Seog Jung, Myung-Ju Ahn, Yong Chan Ahn, Dongryul Oh, Baek Hwan Cho, Man Ki Chung
Summary: This study aimed to investigate the clinical significance of temporal changes in NLR and PLR values after treatment in head and neck cancer patients. A DNN model was developed to predict recurrence after CCRT, and its performance was compared with traditional ML models. The results showed that the DNN model outperformed other models, and feature selection using the RFE algorithm further improved the performance. These findings could improve prognostication and risk assessment in head and neck cancers, and inspire further research in utilizing advanced ML techniques for cancer management.