Article
Chemistry, Analytical
Nikhil Bhalla, Amir Farokh Payam, Alessio Morelli, Preetam Kumar Sharma, Rhiannon Johnson, Alan Thomson, Pawan Jolly, Francesco Canfarotta
Summary: In this study, a single sensor platform capable of detecting multiple variants of SARS-CoV-2 was developed using synthetic binders and nanoplasmonic-based sensing technology. The sensor can detect Alpha, Beta, and Gamma spike protein variants within 30 minutes, making it a rapid and efficient tool for COVID-19 detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Aurelian John-Herpin, Deepthy Kavungal, Lea von Mucke, Hatice Altug
Summary: This study introduces a deep learning-augmented nanoplasmonic technique that can accurately discriminate between major classes of biomolecules without disrupting native processes.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Analytical
Adriano Colombelli, Elisabetta Primiceri, Silvia Rizzato, Anna Grazia Monteduro, Giuseppe Maruccio, Roberto Rella, Maria Grazia Manera
Summary: This study successfully realized the sensitive detection of LPS using nanoplasmonic transducers and specific antibodies, offering a solution to endotoxin contamination issues. By demonstrating a linear relationship and achieving a detection limit down to 5 ng/mL, this technology has the potential for application in quality determination of pharmaceutical products.
Article
Chemistry, Multidisciplinary
Jeanne Elisabeth van Dongen, Laurens Rudi Spoelstra, Johanna Theodora Wilhelmina Berendsen, Joshua Taylor Loessberg-Zahl, Jan Cornelis Titus Eijkel, Loes Irene Segerink
Summary: Multiplexed sensing in single molecule sensors increases system complexity; our novel approach using hairpin-based single-DNA molecule sensors overcomes this complexity and allows for multiplexing; through numerical modeling and distance-dependent coupling of AuNPs to gold films, we can accurately probe dynamic behavior of DNA tethers.
Article
Chemistry, Analytical
Valentina Di Meo, Massimo Moccia, Gennaro Sanita, Alessio Crescitelli, Annalisa Lamberti, Vincenzo Galdi, Ivo Rendina, Emanuela Esposito
Summary: In this study, surface-enhanced infrared absorption spectroscopy was used to monitor the denaturation process of a surface-bound protein A monolayer. By comparing the reflectance spectra of different states, changes in the protein's vibration modes can be determined. It was found that hydrogen bond breaking during denaturation caused red-shifts in the principal vibration modes, creating barriers for refolding.
Article
Chemistry, Multidisciplinary
Pengju Li, Saehyun Kim, Bozhi Tian
Summary: Cells and tissues adapt to the environment and form memories, which is crucial for survival and evolution. Understanding biological training principles can guide the design of biomimetic materials and various applications. Artificial platforms enable biological training and have a relationship with biomimetic materials design. Nanoscale material platforms are critical for bridging natural and synthetic systems.
Article
Chemistry, Multidisciplinary
Yuliana Perdomo, Joseph M. Slocik, David M. Phillips, Marc R. Knecht
Summary: The realization of multifunctional nanoparticle systems is crucial for highly efficient catalytic materials in specific applications, but their production remains challenging. While typically achieved through incorporating multiple inorganic components, functionality can also be achieved at the organic ligand layer. In this work, peptide-based ligands were used to generate multifunctional nanoparticle catalysts for tandem catalytic functionality. This study provides a unique pathway to achieve multifunctionality in nanoparticle systems through the incorporation of inorganic and bio/organic components, with potential implications for applications beyond catalysis in areas such as theranostics, sensing, and energy technologies.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Nan Li, Yang Li, Zhe Cheng, Youdi Liu, Yahao Dai, Seounghun Kang, Songsong Li, Naisong Shan, Shinya Wai, Aidan Ziaja, Yunfei Wang, Joseph Strzalka, Wei Liu, Cheng Zhang, Xiaodan Gu, Jeffrey A. Hubbell, Bozhi Tian, Sihong Wang
Summary: Researchers have developed a bioadhesive polymer semiconductor that can form strong and rapid adhesion with wet tissue surfaces. The semiconductor film exhibits high charge-carrier mobility, stretchability, and biocompatibility. By fabricating a fully bioadhesive transistor sensor, high-quality and stable electrophysiological recordings were achieved on isolated rat heart and in vivo rat muscles.
Article
Biophysics
Juxiang Liu, Xulong Hu, Yinxia Hu, Ping Chen, Hao Xu, Wenjun Hu, Yanteng Zhao, Ping Wu, Gang L. Liu
Summary: We present a low-cost, rapid, ultrasensitive, and convenient biosensing strategy for the detection of miR-21 using a nanoplasmonic array chip coupled with gold nanoparticles (AuNPs). This platform combines NanoSPR and LSPR effects, allowing real-time monitoring of subtle OD changes caused by variations in the dielectric constant during miRNA hybridization. The method has a broad detection range (100 aM to 1 mu M), a limit of detection of 1.85 aM, and single-base resolution for discriminating highly homologous miRNAs. It also exhibits high throughput characteristics, enabling simultaneous detection of 96 samples and offering more than 86.5 times enhancement in sensitivity compared to traditional biosensors.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Nanoscience & Nanotechnology
Shanshan Wang, Qilong Zhao, Jinhong Li, Xuemin Du
Summary: A bilayer hydrogel-based adaptive biointerface (HAB) was developed using two polysaccharide derivates, N-hydroxysuccinimide (NHS) ester-activated alginate and chitosan, to overcome the limitations of existing biointerfaces by leveraging differential swelling and covalent linkages between hydrogel layers. HAB demonstrated outstanding bioactivity, adaptability to various surface curvatures, and mechanical stability in physiological environments, offering new possibilities for adaptive biointerfaces and reliable medical implants.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Engineering, Biomedical
Xingzhen Zhang, Sabine van Rijt
Summary: Stem cells have great potential in tissue engineering and regenerative medicine, but the challenge lies in predicting their behavior after transplantation; understanding the interplay between stem cells and their microenvironments through biointerfaces can help control stem cell behavior.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Multidisciplinary
Binyu Wu, Zifeng Mai, Zichong Ji, Boyan Du, Si Ya Huang
Summary: This study reports the development of highly stable and robust pure biohydrogels with tissue-like mechanical and electrical properties. By controlling the gelation process of starch, tough pure starch hydrogels with a unique self-compounded heterostructure were constructed, exhibiting multifunctionality and anti-fatigue and self-adhesive properties. These hydrogels have great potential for applications in bioelectronics and biomedical fields.
MATERIALS TODAY PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Lokman Kaya, Onuralp Karatum, Ridvan Balamur, Humeyra Nur Kaleli, Asim Onal, Sharadrao Anandrao Vanalakar, Murat Hasanreisoglu, Sedat Nizamoglu
Summary: In this study, the integration of 3D MnO2 nanoflowers into flexible optoelectronic biointerfaces for safe and efficient photostimulation of neurons is demonstrated. The MnO2 nanoflowers facilitate a high interfacial capacitance and photogenerated charge density under low light intensity. They induce safe capacitive currents and do not cause any toxicity on hippocampal neurons in vitro, making them a promising material for biointerfacing with electrogenic cells.
Article
Materials Science, Multidisciplinary
Youngkyu Hwang, Abdul Rahim Ferhan, Bo Kyeong Yoon, Tun Naw Sut, Won-Yong Jeon, Dong Jun Koo, Joshua A. Jackman, Nam-Joon Cho
Summary: Plasmonic chips consisting of gold nanoisland structures fabricated by thiol-based surface functionalization exhibit broad application potential in biosensing, and the optimization of nanostructure dimensions can enhance sensing performance.
APPLIED MATERIALS TODAY
(2022)
Article
Multidisciplinary Sciences
Le Cai, Alex Burton, David A. Gonzales, Kevin Albert Kasper, Amirhossein Azami, Roberto Peralta, Megan Johnson, Jakob A. Bakall, Efren Barron Villalobos, Ethan C. Ross, John A. Szivek, David S. Margolis, Philipp Gutruf
Summary: This study introduces a new type of implantable bioelectronics that interface with the osseosurface for advanced monitoring of chronic musculoskeletal system.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tun Naw Sut, Sue Woon Tan, Won-Yong Jeon, Bo Kyeong Yoon, Nam-Joon Cho, Joshua A. Jackman
Summary: There is a strong interest in developing a simplified method for fabricating hybrid lipid bilayer coatings on titanium oxide surfaces for medical applications. This study characterized the deposition kinetics and adlayer properties of phosphonic acid-functionalized molecules on titanium oxide surfaces and identified optimal conditions for preparing self-assembled monolayers (SAMs). The results showed that a two-tail molecule could form a rigidly attached SAM, enabling the fabrication of hybrid lipid bilayers through vesicle fusion for biosensing applications.
Article
Materials Science, Multidisciplinary
Youngkyu Hwang, Abdul Rahim Ferhan, Bo Kyeong Yoon, Tun Naw Sut, Won-Yong Jeon, Dong Jun Koo, Joshua A. Jackman, Nam-Joon Cho
Summary: Plasmonic chips consisting of gold nanoisland structures fabricated by thiol-based surface functionalization exhibit broad application potential in biosensing, and the optimization of nanostructure dimensions can enhance sensing performance.
APPLIED MATERIALS TODAY
(2022)
Article
Materials Science, Multidisciplinary
Qian Shi, Mohammed Shahrudin Bin Ibrahim, Xingyu Zhang, Youngkyu Hwang, Hokyun Chin, Shengyang Chen, Wen See Tan, Hua Li, Juha Song, Nam-Joon Cho
Summary: This study unraveled the mechanical and morphological variations in the exine capsules of pollen and spore grains, revealing their impact on germination origin. It also provided insights for selecting pollen and spore species for potential biomaterial applications.
APPLIED MATERIALS TODAY
(2022)
Article
Biochemistry & Molecular Biology
Sigalit Meker, Oded Halevi, Hokyun Chin, Tun Naw Sut, Joshua A. Jackman, Ee-Lin Tan, Michael G. Potroz, Nam-Joon Cho
Summary: Functional biointerfaces are important for designing cell-responsive medical implants and sensor devices. This study demonstrates a new method for patterning covalently tethered lipid bilayer membranes on titanium oxide surfaces, providing new capabilities for creating stable lipid bilayer patterns.
Review
Chemistry, Multidisciplinary
Abdul Rahim Ferhan, Soohyun Park, Hyeonjin Park, Hyunhyuk Tae, Joshua A. Jackman, Nam-Joon Cho
Summary: This article focuses on the development of next-generation lipid-based nanoparticles from a nanoarchitectonics perspective, analyzing the design, nucleic acid encapsulation methods, scalable production, and application prospects. It also compares and contrasts different nanoarchitectures, such as traditional lipid nanoparticles, lipoplexes, and bicelles, and evaluates the current development status and possible future directions in overcoming clinical translation challenges and exploring new application opportunities.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Environmental
Jingyu Deng, Mohammed Shahrudin Ibrahim, Li Yang Tan, Xin Yi Yeo, Yong An Lee, Sung Jin Park, Torsten Wuestefeld, Park June-Woo, Sangyong Jung, Nam-Joon Cho
Summary: The ingestion and accumulation of microplastics, released from plastic food containers, pose a serious threat to human health and ecosystem. In vitro experiments demonstrated that both micro- and nanoplastics are readily taken up by cells, leading to inflammation and suppression of lysosomal activities. The widespread use of plastic packaging presents significant health risks to consumers.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Youngkyu Hwang, Min Ku Kim, Ze Zhao, Bongjoong Kim, Taehoo Chang, Teng Fei Fan, Mohammed Shahrudin Ibrahim, Subra Suresh, Chi Hwan Lee, Nam-Joon Cho
Summary: This study developed a novel 2D plant-based substrate for flexible electronics, which can be prepared from eco-friendly and biodegradable microgel. The results suggest that flexible green electronics based on plant-based materials have promising applications.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Multidisciplinary
Tae-Sik Jang, Seong Je Park, Ji Eun Lee, Jeongho Yang, Suk-Hee Park, Martin Byung-Guk Jun, Young Won Kim, Clodualdo Aranas, Joon Phil Choi, Yu Zou, Rigoberto C. Advincula, Yufeng Zheng, Hae Lin Jang, Nam-Joon Cho, Hyun-Do Jung, Sang Hoon Kim
Summary: Orthopedic implants reinforced with titanium dioxide nanoparticles via dopamine-induced polymerization and coated with hydroxyapatite show enhanced mechanical strength and biocompatibility. PEEK with internal TiO2 reinforcement improves bone cell proliferation and differentiation, while the HA coating leads to increased osteoblast absorption. Micro-CT and histological analyses confirm new bone formation and high bone-to-implant contact ratio on the HA-coated PEEK structure reinforced with TiO2 nanoparticles.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Carmen C. Mayorga-Martinez, Michaela Fojtu, Jan Vyskocil, Nam-Joon Cho, Martin Pumera
Summary: This article describes the preparation of magnetic biological robots (BioBots) using defatted sunflower pollen microparticles by depositing a ferromagnetic metal layer on one side of the particles. The magnetic properties introduced to the pollen microparticles enable their magnetic actuation, allowing them to attract and transport cancer cells. Additionally, these magnetic BioBots can be used for drug delivery to kill cancer cells. With the ability for mass production and natural programmability, sunflower-based BioBots show promise for cancer cell therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Soohyun Park, Nam-Joon Cho
Summary: Membrane-enveloped viruses are responsible for most viral pandemics in history, and more effort is needed to advance broadly applicable countermeasures to mitigate the impact of future outbreaks. Biosensing techniques associated with lipid model membrane platforms are contributing to improving our mechanistic knowledge of membrane fusion and destabilization, vaccine development, and antiviral drug development. By abrogating the function of viral membranes, these techniques can provide valuable information that could be translated into biomedicines and improve their selectivity and performance.
Article
Biochemistry & Molecular Biology
Sungmin Shin, Hyunhyuk Tae, Soohyun Park, Nam-Joon Cho
Summary: Antimicrobial fatty acids derived from natural sources and renewable feedstocks are a promising surface-active substance with a wide range of applications. Their ability to target bacterial membrane in multiple mechanisms offers a promising antimicrobial approach. However, the interaction and destabilization of bacterial cell membranes by these compounds are not yet fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Hyeonjin Park, Tun Naw Sut, Abdul Rahim Ferhan, Bo Kyeong Yoon, Vladimir P. Zhdanov, Nam-Joon Cho, Joshua A. Jackman
Summary: The multivalent ligand-receptor interactions between receptor-presenting lipid membranes and ligand-modified nanoparticles play a crucial role in cellular entry and fusion processes. This study investigates the effects of environmental pH changes on these interactions and the deformation of lipid vesicles. The results demonstrate that the extent of the multivalent interactions and vesicle shape deformation are influenced by the pH conditions, with a higher degree of deformation observed under acidic conditions. These findings highlight the sensitivity of high-curvature lipid membranes to solution pH and the significance of multivalency-induced shape deformation in biological environments.
Article
Chemistry, Multidisciplinary
Tun Naw Sut, Sigalit Meker, Dong Jun Koo, Joshua A. Jackman, Nam-Joon Cho
Summary: In this study, the effect of solution pH and ionic strength on the adsorption behavior of DOCP lipid vesicles on titania and silica surfaces was systematically investigated. The results showed that the adsorption behavior of DOCP lipid vesicles on these surfaces was opposite to that of conventional phosphocholine lipids. The interplay of solution pH and ionic strength was found to modulate the adsorption behavior of DOCP lipid vesicles, providing insights for the fabrication of stabilized inverse-phosphocholine lipid bilayers on oxide surfaces.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Meeting Abstract
Cell & Tissue Engineering
Nam Joon Cho
TISSUE ENGINEERING PART A
(2022)
Article
Chemistry, Multidisciplinary
Hyunhyuk Tae, Chungmo Yang, Nam-Joon Cho
Summary: This article discusses the importance and applications of supported lipid bilayers (SLBs), as well as a new SLB fabrication method called the solvent-assisted lipid bilayer (SALB) method. By comparing the SALB method with the traditional vesicle fusion method, the authors explain the advantages and applicability of SALB method. The article provides a detailed introduction to the development and experimental analysis techniques of SALB method, as well as its applications in biocompatible coatings, biomolecular interaction monitoring, and extracellular matrix remodeling.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
