Article
Oncology
Wentao Wang, Yilin Tong, Shulan Sun, Yuen Tan, Zexing Shan, Fan Sun, Chengyao Jiang, Yanmei Zhu, Jianjun Zhang
Summary: This study found that pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can independently predict tumor regression grade (TRG) after neoadjuvant chemotherapy in patients with locally advanced gastric cancer. Patients with high NLR and PLR values may benefit from alternative treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Agnieszka Pikula, Magdalena Skorzewska, Zuzanna Pelc, Radoslaw Mlak, Katarzyna Geca, Katarzyna Sedlak, Bogumila Cisel, Magdalena Kwietniewska, Karol Rawicz-Pruszynski, Wojciech P. Polkowski
Summary: The study confirmed the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in advanced gastric cancer patients, serving as significant prognostic factors.
Article
Oncology
Zhenhua Liu, Haijue Ge, Zhilong Miao, Shoupeng Shao, Hongtai Shi, Congsong Dong
Summary: The systemic inflammation response index (SIRI) is a reliable indicator for evaluating the prognosis of patients with operable gastric cancer. The dynamic change in SIRI before and after surgery is significantly related to the prognosis of patients with gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Nobuhiro Nakazawa, Makoto Sohda, Yasunari Ubukata, Kengo Kuriyama, Akiharu Kimura, Norimichi Kogure, Hisashi Hosaka, Atsushi Naganuma, Masanori Sekiguchi, Kana Saito, Kyoichi Ogata, Akihiko Sano, Makoto Sakai, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki
Summary: This study aimed to analyze the association between Gustave Roussy Immune Score (GRIm-s) and the therapeutic sensitivity of nivolumab in patients with advanced gastric cancer (AGC). The study found that after two courses of nivolumab, GRIm-s significantly increased and there were more PD cases in the high-risk group, with significantly worse overall survival and progression-free survival. Evaluation of GRIm-s and its changes can be beneficial in predicting nivolumab sensitivity.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Alessandra Mangone, Barbara Altieri, Mario Detomas, Alessandro Prete, Haider Abbas, Miriam Asia, Yasir S. Elhassan, Giovanna Mantovani, Cristina L. Ronchi
Summary: Inflammation-based scores calculated from routinely measured parameters may help predict response to chemotherapy in advanced adrenocortical carcinoma (ACC).
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Qifei He, Longtao Huangfu, Biao Fan, Qianzheng Zhuang, Liu He, Lin Li, Wei You, Xiaofang Xing
Summary: Neutrophil/lymphocyte ratio (NLR) is an important index for systemic inflammation and a prognostic indicator for gastric cancer (GC). This study analyzed the role of NLR in different prognostic models and subgroups, and investigated the mediating effects of immune infiltrates between NLR and survival.
Article
Biochemistry & Molecular Biology
Andrea Plaja, Iris Teruel, Maria Ochoa-de-Olza, Marc Cucurull, Alvaro Javier Arroyo, Beatriz Pardo, Irene Ortiz, Marta Gil-Martin, Josep Maria Piulats, Helena Pla, Claudia Fina, Anna Carbo, Maria-Pilar Barretina-Ginesta, Sergio Martinez-Roman, Elvira Carballas, Andrea Gonzalez, Anna Esteve, Margarita Romeo
Summary: Despite a multimodal radical treatment, mortality of advanced epithelial ovarian cancer (AEOC) remains high. This study investigates the prognostic value of neutrophil, monocyte, and platelet to lymphocyte ratios (NLR, MLR, PLR) in newly diagnosed AEOC patients undergoing primary debulking surgery (PDS) or interval debulking surgery (IDS). The results suggest that NLR and PLR may have prognostic value in PDS, but not in IDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Xianyang Hu, Tengfei Tian, Qin Sun, Wenxiu Jiang
Summary: This meta-analysis study investigated the relationship between high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and laryngeal cancer prognosis. The results showed that high NLR was associated with poor overall survival, progression-free survival, and disease-free survival, while high PLR was linked to poor overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jingliang Zhang, Li Zhang, Shusheng Duan, Zhi Li, Guodong Li, Haiyan Yu
Summary: This study investigated the diagnostic value of platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII) in gastric cancer (GC). The results showed that all three markers were significantly higher in GC patients compared to healthy individuals, with SII having the best diagnostic efficacy. The combination of PLR, NLR, and SII further improved diagnostic efficiency.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Guang-Liang Chen, Yan Huang, Wen Zhang, Xu Pan, Wan-Jing Feng, Xiao-Ying Zhao, Xiao-Dong Zhu, Wen-Hua Li, Mingzhu Huang, Zhi-Yu Chen, Wei-Jian Guo
Summary: The study identified female predominance and poorly differentiated tumors in young patients with advanced gastric cancer. Hypoproteinemia and high neutrophil-lymphocyte ratio were poor prognostic factors, while previous radical gastrectomy was associated with favorable survival outcomes. A three-tier prognostic index was constructed to stratify patients into different risk groups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mingyu Wan, Yongfeng Ding, Chenyu Mao, Xiaolu Ma, Ning Li, Cheng Xiao, Jiong Qian, Haiping Jiang, Yulong Zheng, Luntao Wu, Lisong Teng, Nong Xu
Summary: This study aimed to investigate the prognostic significance of inflammatory markers in advanced gastric cancer patients receiving immunotherapy combined with chemotherapy. It was found that neutrophil-to-lymphocyte ratio (NLR) was an independent predictor of progression-free survival and overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shu-Bei Wang, Jia-Yi Chen, Cheng Xu, Wei-Guo Cao, Rong Cai, Lu Cao, Gang Cai
Summary: The study showed that pretreatment NLR can serve as a prognostic factor for survival in LAGC patients treated with adjuvant chemoradiotherapy after D2 dissection, especially for predicting locoregional recurrence rate and paraaortic lymph node metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
M. Nakano, R. Kuromatsu, T. Niizeki, S. Okamura, H. Iwamoto, S. Shimose, T. Shirono, Y. Noda, N. Kamachi, H. Koga, T. Torimura
Summary: The neutrophil-to-lymphocyte ratio is an independent prognostic factor for patients with advanced hepatocellular carcinoma receiving molecular-targeted agents as primary treatment, affecting survival significantly. Decreases in the neutrophil-to-lymphocyte ratio after one month of treatment are associated with longer survival among these patients.
Article
Immunology
Wei Fu, Weixia Ye, Xianqiang Liu, Sirui Zhu, Hu Fu, Rui Zhu, Hongmin Li, Haoyun Zeng, Qin Wang
Summary: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are valuable biomarkers for assessing the clinical significance of Henoch-Schonlein purpura (HSP) and its complications, with NLR particularly useful in predicting gastrointestinal complications and renal involvement in HSP patients. Further well-designed and large cohort studies are needed to confirm these findings.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)