Article
Obstetrics & Gynecology
C. Tomassetti, C. Bafort, A. Vanhie, C. Meuleman, S. Fieuws, M. Welkenhuysen, D. Timmerman, D. Van Schoubroeck, T. D'Hooghe
Summary: The study demonstrates that the Endometriosis Fertility Index (EFI) can be accurately estimated before surgery, providing valuable guidance for individualized treatment decisions for women with endometriosis-related infertility.
HUMAN REPRODUCTION
(2021)
Editorial Material
Obstetrics & Gynecology
Carlo Alboni, Ludovica Camacho Mattos, Laura Botticelli, Stefania Malmusi, Fabio Facchinetti, Annarita Pecchi
Summary: The management of deep endometriosis requires careful preoperative assessment to provide accurate information about the extent of the disease and patient's objectives. Imaging techniques such as ultrasound and MRI, along with clinical evaluation, play a crucial role in detecting lesions not visible during initial laparoscopy. In this case study, a young woman underwent laparoscopic excision of endometriosis which was found to be safe and effective in improving fertility and alleviating pain symptoms.
FERTILITY AND STERILITY
(2021)
Article
Pathology
Elma Pasalic, Murtaza M. Tambuwala, Altijana Hromic-Jahjefendic
Summary: The human endometrium is a complex tissue that undergoes a monthly cycle of thickening and shedding without scarring or loss of function. Endometriosis is a reproductive disease where endometrium is found outside the uterus, affecting 6-10% of reproductive-age women worldwide. It causes pain, heavy bleeding, and infertility. The disease is believed to originate from viable endometrial cells that flow back into the peritoneum during retrograde menstruation. Treatment options include surgery, hormonal therapy, medication, diet and exercise, and in severe cases, hysterectomy.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Obstetrics & Gynecology
Mauricio S. Abrao, Marina Paula Andres, Julian A. Gingold, Mariona Rius, Joao Siufi Neto, Manoel Orlando Goncalves, Alessandra Di Giovanni, Mario Malzoni, Francisco Carmona
Summary: This study aimed to compare the accuracy of preoperative ultrasound in predicting the 2021 AAGL Endometriosis Staging. The study included 878 patients from three specialized endometriosis centers in Brazil, Spain, and Italy. The results showed a substantial agreement between ultrasound and laparoscopic staging, especially in patients without endometriosis and those with stage 1 and 4 disease.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Daisy Martins Rodrigues, Ivete de Avila, Leci Veiga Caetano Amorim, Marcia Mendonca Carneiro, Marcia Cristina Franca Ferreira
Summary: The study evaluated the Endometriosis Fertility Index (EFI) in predicting pregnancy outcomes in Brazilian patients with moderate to severe endometriosis. The results showed that EFI scores were correlated with natural pregnancy and live birth rates after surgery, as well as with pregnancy rates after IVF in these patients.
Article
Oncology
Namita Sindan, Adheesh Bhandari, Namrata Sindan, Rajan Kc, Erjie Xia, Yue Lin
Summary: The study found that age, infertility type, surgical treatment, GnRH-a treatment, disease grading, and operative method are significant factors influencing pregnancy outcome.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Sawsan As-Sanie, Marc R. Laufer, Stacey A. Missmer, Ally Murji, Katy Vincent, Samantha Eichner, Sarah Cross, Ahmed M. Soliman, Frank Tu
Summary: This study developed a patient-reported assessment tool called EndoWheel to visualize the multi-dimensional burden of endometriosis, facilitating improved communication between patients and healthcare providers. Through interviews and discussions, it was found that the tool can enable more comprehensive discussions about symptoms and impact areas, ultimately enhancing patient-provider communication.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)
Review
Obstetrics & Gynecology
Nathalie Vermeulen, Mauricio S. Abrao, Jon Einarsson, Andrew W. Horne, Neil P. Johnson, Ted T. M. Lee, Stacey Missmer, John Petrozza, Carla Tomassetti, Krina T. Zondervan, Grigoris Grimbizis, Rudy Leon De Wilde
Summary: In the field of endometriosis, multiple classification, staging and reporting systems have been developed, but there is currently no international consensus on how to describe the condition. Studies evaluating these systems show that most of them have little to no correlation with patient outcomes. The ENZIAN system has been confirmed valuable for surgical description of deep endometriosis, while the endometriosis fertility index has been validated for its intended purpose related to infertility.
HUMAN REPRODUCTION OPEN
(2021)
Review
Endocrinology & Metabolism
Brunella Zizolfi, Virginia Foreste, Alessandra Gallo, Simona Martone, Peirluigi Giampaolino, Attilio Di Spiezio Sardo
Summary: Endometriosis is a complex disease that affects around 10% of reproductive age women. Alterations in the microbiota have been suggested as a possible factor in the pathogenesis of endometriosis, including bacterial contamination, immune activation, impaired gut function, and altered estrogen metabolism. Dysbiosis disrupts normal immune function, leading to increased proinflammatory cytokines, compromised immunity, and changed immune cell profiles, all of which contribute to the development of endometriosis. This review aims to summarize the available literature on the relationship between microbiota and endometriosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Hai-Ning Jiao, Wei Song, Wei-Wei Feng, Hua Liu
Summary: Tubal endometriosis (TEM) is a category of pelvic endometriosis characterized by ectopic endometrial glands and/or stroma within the fallopian tube. Diagnosis relies on pathological examination, with a high rate of TEM combined with endometriosis at other pelvic sites, suggesting a connection to ovarian endometriosis.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Obstetrics & Gynecology
Elvin Piriyev, Mona Mariella Gertz, Sven Schiermeier, Thomas Roemer
Summary: This study demonstrates the significance of Ki67 expression in endometriosis patients for postoperative pregnancy onset. High Ki67 expression is associated with a higher pregnancy rate, while low expression is associated with a lower pregnancy rate. These results highlight the importance of endometrial resection in infertility treatment.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Paul Pirtea, Nicolas Vulliemoz, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Endometriosis was traditionally diagnosed through laparoscopic surgery, but modern imaging techniques have provided a reliable alternative. In cases of infertility, endometriosis can be diagnosed or excluded based on past medical history and physical examination.
FERTILITY AND STERILITY
(2022)
Editorial Material
Obstetrics & Gynecology
Dong Bach Nguyen, Sebastien Gilbert, Kristina Arendas, Caitlin A. Jago, Sukhbir S. Singh
Summary: The article presents a five-step approach to laparoscopic excision of pericardial and diaphragmatic endometriosis for the treatment of chronic pelvic pain and infertility. The successful completion of the surgical procedure demonstrates that pericardial and diaphragmatic endometriosis can be managed effectively through multidisciplinary and stepwise surgical intervention.
FERTILITY AND STERILITY
(2021)
Review
Medicine, General & Internal
Sabrina Rangi, Christine Hur, Elliott Richards, Tommaso Falcone
Summary: Several mechanisms are involved in the infertility caused by endometriosis. For patients considering surgery, the risk of iatrogenic injury is a crucial factor in preserving fertility. Excision of endometriomas significantly reduces ovarian reserve, with a decrease of up to 30% for unilateral and up to 44% for bilateral cases. Surgical interventions should use fertility-conserving methods to minimize postoperative iatrogenic diminished ovarian reserve.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Mara Simopoulou, Anna Rapani, Sokratis Grigoriadis, Agni Pantou, Petroula Tsioulou, Evangelos Maziotis, Despina Tzanakaki, Olga Triantafyllidou, Theodoros Kalampokas, Charalampos Siristatidis, Panagiotis Bakas, Nikolaos Vlahos
Summary: The article discusses the infertility associated with endometriosis, highlighting the various pathological mechanisms that contribute to impaired reproductive dynamics. Reactive oxygen species, immune system dysregulation, and cellular architectural disruption are key mechanisms affecting oocyte and embryo development potential in endometriosis patients.
Review
Surgery
Evelyne Verhulst, Celine Bafort, Carla Tomassetti, Albert Wolthuis, Didier Bielen, Johan Coolen, Birgit Weynand, Lieven Platteeuw, Christel Meuleman, Dirk Van Raemdonck
Summary: A rare case of endometriotic lung cyst was reported in a 47-year-old woman with recurrent catamenial hemoptysis. After hormonal treatment and surgical resection, the diagnosis was confirmed and the symptoms were relieved.
ACTA CHIRURGICA BELGICA
(2022)
Editorial Material
Obstetrics & Gynecology
C. Tomassetti, T. Beukeleirs, A. Conforti, S. Debrock, K. Peeraer, C. Meuleman, T. D'Hooghe
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2022)
Review
Obstetrics & Gynecology
Krina T. Zondervan, Stacey Missmer, Mauricio S. Abrao, Jon Einarsson, Andrew W. Horne, Neil P. Johnson, Ted T. M. Lee, John Petrozza, Carla Tomassetti, Nathalie Vermeulen, Grigoris Grimbizis, Rudy Leon De Wilde
Summary: In the field of endometriosis, most clinicians would like a new simple surgical descriptive system for endometriosis, despite the existing classification systems.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Celine Bafort, Nada Mourad Tawfic, Christel Meuleman, Annouschka Laenen, Dirk Timmerman, Dominique Van Schoubroeck, Carla Tomassetti
Summary: This study compared the recurrence rate of endometrioma(s) after cystectomy versus CO2 laser vaporization of the cyst wall. The results showed similar recurrence rates between the two surgical techniques. For women wishing to preserve their reproductive potential, CO2 laser vaporization can be considered as a safe alternative to cystectomy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Acoustics
E. Pascoal, J. M. Wessels, M. K. Aas-Eng, M. S. Abrao, G. Condous, D. Jurkovic, M. Espada, C. Exacoustos, S. Ferrero, S. Guerriero, G. Hudelist, M. Malzoni, S. Reid, S. Tang, C. Tomassetti, S. S. Singh, T. van den Bosch, M. Leonardi
Summary: Endometriosis is a chronic systemic disease that can greatly impact patients' quality of life. Diagnosing endometriosis is challenging, and various methods have their strengths and limitations. Currently, there is no single gold-standard diagnostic method, and different circumstances may require different diagnostic approaches.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Krina T. Zondervan, Stacey Missmer, Mauricio S. Abrao, Jon Einarsson, Andrew W. Horne, Neil P. Johnson, Ted T. M. Lee, John Petrozza, Carla Tomassetti, Nathalie Vermeulen, Grigoris Grimbizis, Rudy L. de Wilde
Summary: This study examined the current use of endometriosis classification systems in clinical practice and the motivations of clinicians. The findings showed that while existing systems are widely used, most clinicians expressed the need for a new simple surgical descriptive system.
FACTS VIEWS AND VISION IN OBGYN
(2022)
Meeting Abstract
Obstetrics & Gynecology
C. Tomassetti
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Brecht Geysenbergh, Anne-Sophie Boes, Celine Bafort, Anne-Sophie van Rompuy, Sara Neyens, Sharon Lie Fong, Sophie Debrock, Joris Vriens, Peter De Loecker, Eline Dancet, Thomas D'Hooghe, Karen Peeraer
Summary: This study aimed to investigate the prevalence of chronic endometritis (CE) in infertile women, its impact on reproductive outcomes, and the accuracy of hysteroscopy as a screening tool for CE. The study included 514 asymptomatic patients with infertility who underwent hysteroscopy and endometrial biopsy (EMB). CE was identified in 2.8% of patients starting assisted reproductive technologies (ART). The clinical pregnancy rate (CPR) did not differ significantly between patients with CE and the entire cohort of patients without CE, but was significantly lower in the 2 years after EMB in patients with CE compared to matched controls. Hysteroscopy had low sensitivity and high specificity in diagnosing CE.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2023)
Article
Genetics & Heredity
Nilufer Rahmioglu, Sally Mortlock, Marzieh Ghiasi, Peter L. Moller, Lilja Stefansdottir, Genevieve Galarneau, Constance Turman, Rebecca Danning, Matthew H. Law, Yadav Sapkota, Paraskevi Christofidou, Sini Skarp, Ayush Giri, Karina Banasik, Michal Krassowski, Maarja Lepamets, Blazej Marciniak, Margit Noukas, Danielle Perro, Eeva Sliz, Marta Sobalska-Kwapis, Gudmar Thorleifsson, Nura F. Topbas-Selcuki, Allison Vitonis, David Westergaard, Ragnheidur Arnadottir, Kristoffer S. Burgdorf, Archie Campbell, Cecilia S. K. Cheuk, Caterina Clementi, James Cook, Immaculata De Vivo, Amy DiVasta, O. Dorien, Jacqueline F. Donoghue, Todd Edwards, Pierre Fontanillas, Jenny N. Fung, Reynir T. Geirsson, Jane E. Girling, Paivi Harkki, Holly R. Harris, Martin Healey, Oskari Heikinheimo, Sarah Holdsworth-Carson, Isabel C. Hostettler, Henry Houlden, Sahar Houshdaran, Juan C. Irwin, Marjo-Riitta Jarvelin, Yoichiro Kamatani, Stephen H. Kennedy, Ewa Kepka, Johannes Kettunen, Michiaki Kubo, Bartosz Kulig, Venla Kurra, Hannele Laivuori, Marc R. Laufer, Cecilia M. Lindgren, Stuart MacGregor, Massimo Mangino, Nicholas G. Martin, Charoula Matalliotaki, Michail Matalliotakis, Alison D. Murray, Anne Ndungu, Camran Nezhat, Catherine M. Olsen, Jessica Opoku-Anane, Sandosh Padmanabhan, Manish Paranjpe, Maire Peters, Grzegorz Polak, David J. Porteous, Joseph Rabban, Kathyrn M. Rexrode, Hanna Romanowicz, Merli Saare, Liisu Saavalainen, Andrew J. Schork, Sushmita Sen, Amy L. Shafrir, Anna Siewierska-Gorska, Marcin Slomka, Blair H. Smith, Beata Smolarz, Tomasz Szaflik, Krzysztof Szyllo, Atsushi Takahashi, Kathryn L. Terry, Carla Tomassetti, Susan A. Treloar, Arne Vanhie, Katy Vincent, Kim C. Vo, David J. Werring, Eleftheria Zeggini, Maria Zervou, Kari Stefansson, Mette Nyegaard, Outi Uimari, Piraye Yurttas-Beim, Joyce Y. Tung, Sosuke Adachi, Julie E. Buring, Paul M. Ridker, Thomas D'Hooghe, George N. Goulielmos, Dharani K. Hapangama, Caroline Hayward, Andrew W. Horne, Siew-Kee Low, Hannu Martikainen, Daniel Chasman, Peter A. W. Rogers, Philippa T. Saunders, Marina Sirota, Tim Spector, Dominik Strapagiel, David C. Whiteman, Linda C. Giudice, Digna R. Velez-Edwards, Peter Kraft, Andres Salumets, Dale R. Nyholt, Reedik Magi, Christian M. Becker, Valgerdur Steinthorsdottir, Stacey A. Missmer, Grant W. Montgomery, Andrew P. Morris, Krina T. Zondervan
Summary: Endometriosis is a common condition associated with pelvic pain and infertility. A genome-wide association study identified 42 significant loci and found genetic correlations between endometriosis and other pain conditions. Targeted investigations are needed to understand the shared genetic mechanisms and develop new treatments.
Meeting Abstract
Obstetrics & Gynecology
Eleonora Persoons, Marie Mulier, Catherine Luyten, Carla Tomassetti, Thomas Voets, Joris Vriens
REPRODUCTIVE SCIENCES
(2023)
Meeting Abstract
Obstetrics & Gynecology
C. Becker, A. Bokor, O. Heikinheimo, A. Horne, F. Jansen, L. Kiesel, K. King, M. Kvaskoff, A. Nap, K. Petersen, E. Saridogan, C. Tomassetti, N. Van Hanegem, N. Vulliemoz, N. Vermeulen
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Christian M. Becker, Attila Bokor, Oskari Heikinheimo, Andrew Horne, Femke Jansen, Ludwig Kiesel, Kathleen King, Marina Kvaskoff, Annemiek Nap, Katrine Petersen, Ertan Saridogan, Carla Tomassetti, Nehalennia van Hanegem, Nicolas Vulliemoz, Nathalie Vermeulen
Summary: This guideline provides clinicians with evidence-based recommendations for the diagnosis and management of endometriosis. It covers various aspects including diagnosis, treatment of pain symptoms, management of infertility, and discusses different treatment options. Despite some limitations, this guideline is important for improving the care of patients with endometriosis.
HUMAN REPRODUCTION OPEN
(2022)
Article
Obstetrics & Gynecology
Krina T. Zondervan, Stacey Missmer, Mauricio S. Abrao, Jon Einarsson, Andrew W. Horne, Neil P. Johnson, Ted T. M. Lee, John Petrozza, Carla Tomassetti, Nathalie Vermeulen, Grigoris Grimbizis, Rudy Leon De Wilde
Summary: The majority of clinicians managing endometriosis express a desire for a new simple surgical descriptive system, despite high uptake of existing classification systems.
HUMAN REPRODUCTION OPEN
(2022)