Article
Biochemical Research Methods
Weiyang Yang, Yan Gong, Cheng-You Yao, Maheshwar Shrestha, Yaoyao Jia, Zhen Qiu, Qi Hua Fan, Arthur Weber, Wen Li
Summary: Integrative neural interfaces combining neurophysiology, optogenetics, and neural imaging offer opportunities for studying neural circuits in the brain. The development of ultra-flexible, highly conductive and fully transparent microscale electrocorticogram (mu ECoG) electrode arrays with PEDOT:PSS-ITO-Ag-ITO assembly shows enhanced mechanical flexibility, robustness, and resilience to photon-induced artifacts. In vivo experiments demonstrate successful recording of light-evoked ECoG oscillations from the primary visual cortex (V1) of an anesthetized rat.
Article
Materials Science, Multidisciplinary
Md Eshrat E. Alahi, Yonghong Liu, Zhen Xu, Hao Wang, Tianzhun Wu, Subhas Chandra Mukhopadhyay
Summary: Implantable electrodes have great potential for neural signal recording in various fields, with advancements in micro/nanotechnologies and material science helping to overcome challenges. Electrodes like ECoG allow large-scale signal recording and bi-directional communication between the brain and external electronics, with promising applications in the future.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Engineering, Electrical & Electronic
Yaoyao Li, Wei Zhou, Chengzhong Liu, Da Geng, Jishen Dai, Yu Xie, Songyue Chen, Tao Luo, Zheng Shen
Summary: This study proposed a flexible dry bioelectrode inspired by plant leaves, featuring microneedle structures that improve mechanical and electrical properties. The curved-hook type microneedle structures significantly enhance anti-destructive and bonding performance, leading to better performance in EMG detection compared with traditional electrodes.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Engineering, Electrical & Electronic
Kyeong Jae Lee, Daun Hong, Jae-Won Jang, Kyeong Yeon Lee, Byungwook Park, Joong-Hyun Kim, June Sic Kim, Sohee Kim
Summary: A high-throughput wireless recording system was developed using off-the-shelf components, enabling high-resolution recording of neural signals without restricting subject movement.
IEEE SENSORS JOURNAL
(2023)
Article
Biochemical Research Methods
Ui-Jin Jeong, Jungpyo Lee, Namsun Chou, Kanghwan Kim, Hyogeun Shin, Uikyu Chae, Hyun-Yong Yu, Il-Joo Cho
Summary: The device proposed in the study utilizes magnetic force-assisted positioning of a flexible electrode array to record ECoG signals from multiple brain regions with minimal exposure of the brain surface, causing minimal damage to the animal.
Article
Chemistry, Multidisciplinary
Jingxian Yu, Wei Ling, Ya Li, Ning Ma, Ziyue Wu, Rong Liang, Huizhuo Pan, Wentao Liu, Bo Fu, Kun Wang, Chenxi Li, Hanjie Wang, Hui Peng, Baoan Ning, Jiajia Yang, Xian Huang
Summary: The integration of optical fibers and flexible electronics allows for more sophisticated applications in biomedicine and biology. A multi-channel flexible device has been demonstrated in vivo with rats for optical stimulation and simultaneous monitoring of spontaneous/evoked signals using microelectrode arrays. The device's biocompatibility has been characterized, showing potential for long-term animal studies.
Article
Materials Science, Multidisciplinary
Ayano Imai, Shunta Takahashi, Sho Furubayashi, Yosuke Mizuno, Masaki Sonoda, Tomoyuki Miyazaki, Eizo Miyashita, Toshinori Fujie
Summary: A flexible thin-film electrode, fabricated using printed electronics, is capable of long-term monitoring and electrical stimulation of the cerebral cortex without causing severe inflammatory reactions. This electrode, with 35 channels, successfully visualized epileptiform activity in a drug-induced epilepsy rat model, showing potential for the management of intractable epilepsy.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Biophysics
Max Eickenscheidt, Thoralf Herrmann, Marius Weisshap, Annette Mittnacht, Linda Rudmann, Gunther Zeck, Thomas Stieglitz
Summary: Optogenetics provides a new method for cell-specific activation, which is more precise compared to electrical stimulation. This study presents the design of a miniaturized optoelectronic device that allows simultaneous optical and electrical stimulation at the same spot.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Longchun Wang, Chaofan Ge, Fang Wang, Zhejun Guo, Wen Hong, Chunpeng Jiang, Bowen Ji, Minghao Wang, Chengyu Li, Bomin Sun, Jingquan Liu
Summary: The research introduces a new three-dimensional high-density drivable optrode array for multiple-brain recording and precise optical stimulation. With optimized recording performance of microelectrodes and precise implantation depth control, long-term tracking of neural activities has been achieved through this innovative technology.
Article
Biochemistry & Molecular Biology
Bangbang Guo, Ye Fan, Minghao Wang, Yuhua Cheng, Bowen Ji, Ying Chen, Gaofeng Wang
Summary: The article introduces a new flexible polyimide-based neural probe with modified microelectrodes and optical fibers to reduce stimulation artifacts induced by light. The probe allows for quick and accurate implantation and high-resolution recording capabilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Inorganic & Nuclear
Haihan Zhou, Yuqin Liu, Mengyao Ren, Hua-Jin Zhai
Summary: A low-cost and scalable method for the fabrication of mechanically exfoliated graphite paper (MEGP) as a current collector in electrochemical capacitors (ECs) is proposed. The MEGP is used to load multi-walled carbon nanotube@polypyrrole (MWCNT@PPy) core-shell hybrids as active materials. The resulting MEGP/MWCNT@PPy electrodes exhibit superior electrochemical properties and high flexibility, with good cycling stability and mechanical deformation resistance.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Physics, Applied
Hiroto Sekiguchi, Hayate Matsuhira, Ryota Kanda, Shuto Tada, Taiki Kitade, Masataka Tsutsumi, Atsushi Nishikawa, Alexander Loesing, Izumi Fukunaga, Susumu Setogawa, Noriaki Ohkawa
Summary: In this study, a biocompatible optical stimulation device was developed that can adhere to the brain surface and activate spatially separated brain regions. By using a hollow structure and a thermal release sheet, microLEDs were successfully transferred onto a biocompatible parylene film without any rotation or misalignment while retaining their characteristics.
APPLIED PHYSICS EXPRESS
(2022)
Article
Biochemical Research Methods
Annie Vahedipour, Matthew R. Short, Azadeh Timnak, Omid Haji Maghsoudi, Thomas Hallowell, Jonathan Gerstenhaber, Ornella Cappellari, Michel Lemay, Andrew J. Spence
Summary: Neural stimulation and recording in rodents play a crucial role in understanding the nervous system and improving the quality of life for individuals with neurological disorders. A lightweight 'snap-in' electromagnetic headmount is introduced to minimize the impact on animal movement and reduce tissue damage during implantation, allowing for reliable connection and successful electrical stimulation and recording.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Chemistry, Analytical
Samuel Ong, Aura Kullmann, Steve Mertens, Dave Rosa, Camilo A. Diaz-Botia
Summary: This study characterizes a new thin-film polyimide-based electrode array through electrochemical characterization. The results show that the array has good electrical performance and stable electrode material. This provides a new option for monitoring brain activity and mapping brain function clinically.
Article
Engineering, Electrical & Electronic
Binru Zhou, Teng Zhan, Jinpeng Huang, Xiaoyan Yi, Junxi Wang, Jinmin Li
Summary: In this study, a wireless-operated miniaturized implantable system with superior biocompatibility was introduced. The system allows remote operation of LEDs and recording of animal movement traces, providing an effective route for evaluating the functions and analyzing the structures of complicated animals.
IEEE PHOTONICS TECHNOLOGY LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Liyun Zhen, Zengda Liu, Zhitian Liu, Qi Wang, Jingquan Liu, Zhengrong Yao, Bin Yang
Summary: This article reports a simple and low-cost strategy to realize a high-performance flexible piezoelectric sensor array with high sensitivity and density. The sensor array is analyzed and characterized through sound pressure measurement and motion monitoring. It exhibits high sensitivity and an ultralow detection limit, making it suitable for smart wearable electronics and human-machine interaction.
IEEE SENSORS JOURNAL
(2023)
Article
Engineering, Multidisciplinary
XiuFeng Wang, JieLong Huang, YangChengYi Liu, JinYuan Tan, ShangDa Chen, Raudel Avila, ZhaoQian Xie
Summary: Elastomeric encapsulation layers are commonly used to protect the electronic components in wearable devices. However, these layers may affect the measurement accuracy of physiological signals. An analytic model is developed to analyze and understand the strain- and stress-isolation effects in wearable devices with elastomeric encapsulation layers.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Hyeonseok Han, Yong Suk Oh, Seokjoo Cho, Hyunwoo Park, Sung-Uk Lee, Kabseok Ko, Jae-Man Park, Jungrak Choi, Ji-Hwan Ha, Chankyu Han, Zichen Zhao, Zhuangjian Liu, Zhaoqian Xie, Je-Sang Lee, Weon Gi Min, Byeong-Ju Lee, Jahyun Koo, Dong Yun Choi, Minkyu Je, Jeong-Yun Sun, Inkyu Park
Summary: This paper presents a method for continuous multi-site monitoring of pressure and temperature distribution using wireless ionic liquid pressure sensors on bedridden or wheelchair-bound patients. The wirelessly delivered power enables stable operation of the sensors, which exhibit enhanced sensitivity, negligible hysteresis, high linearity, and cyclic stability. Experimental investigations and numerical simulations support the real-time, continuous, long-term monitoring capabilities of the sensor arrays. Clinical trials on two hemiplegic patients demonstrate the feasibility of reducing pressure and temperature distribution with minimal repositioning using the sensor arrays.
Article
Chemistry, Multidisciplinary
Lanxin Yang, Chengyu Li, Wenhao Lu, Jie An, Di Liu, Jianzhe Luo, Yusheng Li, Zhong Lin Wang, Wei Tang, Bo Meng
Summary: Presented a wearable displacement sensing system for diagnosing ACL injuries. The system measures the displacement difference between the affected leg and the healthy leg during the Lachman test to determine the risk of ACL injury. Compared with arthroscopy, the wearable system has a higher consistency rate and shows the feasibility of becoming a convenient method for diagnosing ACL injuries.
Article
Engineering, Electrical & Electronic
Minghao Wang, Minyi Jin, Longchun Wang, Ye Fan, Jiahui Xu, Siyan Shang, Chuner Ni, Yili Hu, Yuhua Cheng, Linxi Dong, Bowen Ji, Jingquan Liu, Gaofeng Wang
Summary: A silicon optrode with heavy-doped probes, LD-coupled optical fiber, and electrochemical modified microelectrodes has been developed for low-noise and high-fidelity optical modulation. The developed noise mitigation strategies show promising potential for optogenetics-based neural circuit research.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Physical
Chengyu Li, Zijie Xu, Shuxing Xu, Tingyu Wang, Siyu Zhou, Zhuoran Sun, Zhong Lin Wang, Wei Tang
Summary: Respiratory signals are important physiological indicators that can reflect or predict the severity of diseases. Designing a wearable respiratory monitoring system with convenience, durability, and high precision is a challenge. In this study, a retractable self-powered sensor (RSPS) was developed, which has high precision, sensitivity, and durability for continuous detection of respiratory indicators. A wearable respiratory monitoring system (MWRMS) was designed to demonstrate its wearability and real-time monitoring capabilities, providing a new strategy for respiratory monitoring.
Article
Multidisciplinary Sciences
Zijie Xu, Leo N. Y. Cao, Chengyu Li, Yingjin Luo, Erming Su, Weizhe Wang, Wei Tang, Zhaohui Yao, Zhong Lin Wang
Summary: Real-time monitoring of flow turbulence is challenging but crucial in fluid dynamics for flight safety and control. A lightweight and conformable system on the wing surface of aircraft has been developed to sense stall. By utilizing conjunct signals provided by triboelectric and piezoelectric effects, the system provides quantitative data on airflow turbulence and boundary layer separation in situ. This enables visualization and direct measurement of airflow detachment and sensing of airflow separation during and after a stall for large aircraft and unmanned aerial vehicles.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Yueqi Zhai, Jiaqi Niu, Yusheng Liu, Xiang Chen, Jingquan Liu, Bin Yang
Summary: This work reports on a bionic imaging device, inspired by the compound eyes of insects, that utilizes an optical waveguide integrated with an isolation-layer microlens array (WIMLA) to achieve high-contrast, high-resolution imaging. The WIMLA is fabricated through self-written optical waveguide formation and the introduction of a black photoresist for double isolation. Experimental results show significant improvements in image contrast and resolution compared to microlens arrays without isolation layers. The prepared WIMLA, combined with commercial cameras, has potential applications in mobile navigation, face recognition, and medical monitoring.
ADVANCED OPTICAL MATERIALS
(2023)
Review
Materials Science, Ceramics
Liyun Zhen, Lijun Lu, Yongtao Yao, Jingquan Liu, Bin Yang
Summary: Piezoelectric materials are playing an increasingly important role in various applications such as energy harvesters, sensors, and actuators. This article summarizes recent advances in flexible inorganic piezoelectric thin films, covering their structural designs, fabrication techniques, and applications in practical scenarios. Different fabrication techniques suitable for various inorganic piezoelectric nanostructures are reviewed, as well as the integration process with flexible substrates. The article also highlights the biomedical and industrial applications of flexible piezoelectric thin films, and discusses existing challenges and future perspectives.
JOURNAL OF ADVANCED CERAMICS
(2023)
Article
Engineering, Biomedical
Wei Ouyang, Wei Lu, Yamin Zhang, Yiming Liu, Jong Uk Kim, Haixu Shen, Yunyun Wu, Haiwen Luan, Keith Kilner, Stephen P. Lee, Yinsheng Lu, Yiyuan Yang, Jin Wang, Yongjoon Yu, Amy J. Wegener, Justin A. Moreno, Zhaoqian Xie, Yixin Wu, Sang Min Won, Kyeongha Kwon, Changsheng Wu, Wubin Bai, Hexia Guo, Tzu-li Liu, Hedan Bai, Giuditta Monti, Jason Zhu, Surabhi R. Madhvapathy, Jacob Trueb, Maria Stanslaski, Elizabeth M. Higbee-Dempsey, Iwona Stepien, Nayereh Ghoreishi-Haack, Chad R. Haney, Tae-il Kim, Yonggang Huang, Roozbeh Ghaffari, Anthony R. Banks, Thomas C. Jhou, Cameron H. Good, John A. Rogers
Summary: This article describes a tether-less and battery-less implant that can record electroencephalograms, electromyograms and body temperature in freely moving small animals, as well as perform closed-loop neuromodulation via optogenetics and pharmacology. The wireless and battery-less technology allows for studies that require the use of unconstrained animals and eliminates the limitations of physical tethers and batteries. The implant has a system-on-a-chip with Bluetooth Low Energy for data transmission and a compressed deep-learning module for autonomous operation.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Seokjoo Cho, Hyeonseok Han, Hyunwoo Park, Sung-Uk Lee, Jae-Hwan Kim, Sung Woo Jeon, Mengqiu Wang, Raudel Avila, Zhaoqian Xi, Kabseok Ko, Minsu Park, Jungyup Lee, Myungwoo Choi, Je-Sang Lee, Weon Gi Min, Byeong-Ju Lee, Soyeong Lee, Jungrak Choi, Jimin Gu, Jaeho Park, Min Seong Kim, Junseong Ahn, Osman Gul, Chankyu Han, Gihun Lee, Seunghwan Kim, Kyuyoung Kim, Jeonghyun Kim, Chang-Mo Kang, Jahyun Koo, Sung Soo Kwak, Sungbong Kim, Dong Yun Choi, Seokwoo Jeon, Hyung Jin Sung, Yong Bae Park, Minkyu Je, Young Tae Cho, Yong Suk Oh, Inkyu Park
Summary: Individuals who are unable to walk independently are at high risk for pressure injuries caused by sitting. To address this challenge, a battery-free, wireless, multimodal sensor system is introduced for continuous measurement of pressure, temperature, and hydration at skin interfaces. The system includes a crack-activated pressure sensor, a temperature sensor, and a galvanic skin response sensor, and enables power harvesting and data communication to multiple wireless devices mounted at skin-cushion interfaces. Experimental evaluations and clinical trials demonstrate the feasibility and stability of the sensor system for preventing pressure injuries caused by sitting.
NPJ FLEXIBLE ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Jiahui Xu, Ye Fan, Minghao Wang, Bowen Ji, Le Li, Minyi Jin, Siyan Shang, Chuner Ni, Yuhua Cheng, Linxi Dong, Gaofeng Wang
Summary: High-quality recording of human bio-signals is crucial for biomedical engineering research and clinical medical diagnosis. This study introduces a highly reliable and reusable microneedle array electrode (MAE) technology, which overcomes the issues associated with traditional wet electrodes. The MAE, modified with silver nanoparticles and poly(3,4-ethylenedioxythiophene):poly(sodiumstyrenesulfonate), exhibits significantly improved impedance and signal-to-noise ratio, providing a promising alternative for stable bio-signal recording on the skin.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Physical
Yurui Shang, Chengyu Li, Gao Yu, Yuhan Yang, Wenting Zhao, Wei Tang
Summary: This study proposes a multilayer spring TENG with a cushion layer structure, which improves the output performance of the basic TENG structure. The energy harvesting circuit is optimized based on the electrical performance parameters of the generator, and suitable electronic components are selected for the actual circuit. The small-size TENG (2 cm(3)) achieved a high storable power density (5.45 mW m(-2)). The fabrication method of the small-size TENG and the selection of electronic components based on the intrinsic electrical parameters of the TENG are summarized. This work provides valuable guidance for designing and fabricating self-powered IoT node devices.
Article
Computer Science, Information Systems
Jiabin Zhang, Erming Su, Chengyu Li, Shuxing Xu, Wei Tang, Leo N. Y. Cao, Ding Li, Zhong Lin Wang
Summary: This study introduces an intelligent artifact-monitoring system (SAMS) based on a porous carbon black (CB)/Ecoflex triboelectric nanogenerator (PCE-TENG) that can monitor collisions in real-time and absorb vibrations during artifact transportation. The system consists of six PCE-TENGs attached to the inner wall of the artifact transport package, allowing collision monitoring and protection in different directions. This research presents a practical strategy for artifact transportation monitoring and package engineering, which could have significant implications for the field.
Article
Chemistry, Physical
Xue Shi, Pengfei Chen, Kai Han, Chengyu Li, Renyun Zhang, Jianjun Luo, Zhong Lin Wang
Summary: The demand for fast, reliable, and accessible information in the connected world has made disposable sensors increasingly important. A low-cost, biodegradable, and recyclable all-lignocellulosic triboelectric nanogenerator (AL-TENG) has been developed for self-powered disposable medical monitoring. This work expands the application of self-powered systems to disposable medical sensing and promotes the development of intelligent wards and disposable electronics.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
