Article
Nanoscience & Nanotechnology
Jia Dong, Bin Wu, Weidong Tian
Summary: Studies have shown that fat transplantation can be used for skin wound repair and scar management with beneficial effects. Recently, it has been found that transplanted cells undergo apoptosis and apoptotic extracellular vesicles (ApoEVs) may play a therapeutic role. This study successfully isolated ApoEVs from adipose tissue and found that they can promote high-quality skin wound healing by modulating fibroblasts and endothelial cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Cell Biology
Adrian Sowka, Pawel Dobrzyn
Summary: Adipose tissue serves as both an energy-storing tissue and an endocrine organ due to its secretion of adipose-specific factors called adipokines. Among these, adiponectin is a well-known adipokine with metabolic, anti-inflammatory, and antidiabetic properties. Perivascular adipose tissue (PVAT) acts on the vascular wall through adipokine secretion and adiponectin can affect the vascular wall through endothelial cells and vascular smooth muscle cells. Studies have suggested that adiponectin and its receptors may be potential therapeutic targets.
Article
Medicine, Research & Experimental
Shijie Liu, Jinzi Wu, Amanda Stolarz, Huiliang Zhang, Marjan Boerma, Stephanie D. Byrum, Nancy J. Rusch, Zufeng Ding
Summary: This study demonstrates the significant impact of PCSK9 on efferocytosis in ECs and its implications in vascular aging. The findings suggest that PCSK9 deficiency can restore efferocytosis and inhibit the expression of aging markers. Treatment with a PCSK9 inhibitor shows potential in improving vascular aging and reducing inflammation.
Article
Biochemistry & Molecular Biology
Yuping Quan, Yuteng Zhang, Jian Li, Feng Lu, Junrong Cai
Summary: In this study, researchers fabricated syngeneic adipose organoids using microvascular fragments and transplanted them beneath fibrotic skin to restore subcutaneous fat and reverse the pathological manifestation of localized scleroderma. The findings showed that the prefabricated ad-organoids improved skin sclerosis by restoring cutaneous fat, attenuating skin fibrosis, and promoting dermal adipocyte regeneration.
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuping Quan, Yuteng Zhang, Jian Li, Feng Lu, Junrong Cai
Summary: This study aimed to prefabricate syngeneic adipose organoids (ad-organoids) using microvascular fragments (MVFs) and evaluate their therapeutic effect on localized scleroderma. The results showed that ad-organoids contained mature adipocytes and a well-established vessel network, and their transplantation improved skin sclerosis by restoring cutaneous fat and attenuating skin fibrosis.
Article
Multidisciplinary Sciences
Anna Axelsson Raja, Hiroko Wakimoto, Daniel M. DeLaughter, Daniel Reichart, Joshua Gorham, David A. Conner, Mingyue Lun, Clemens K. Probst, Norihiko Sakai, Rachel S. Knipe, Sydney B. Montesi, Barry Shea, Leonard P. Adam, Leslie A. Leinwand, William Wan, Esther Sue Choi, Eric L. Lindberg, Giannino Patone, Michela Noseda, Norbert Huebner, Christine E. Seidman, Andrew M. Tager, J. G. Seidman, Carolyn Y. Ho
Summary: This study found that lysophosphatidic acid receptor 1 (LPAR1) plays a crucial role in the development of hypertrophy and fibrosis in a mouse model of hypertrophic cardiomyopathy (HCM). LPAR1 is primarily expressed by lymphatic endothelial cells (LECs) and cardiac fibroblasts in the heart. In addition, LPAR1 ablation affects the population and distribution of LECs and fibroblasts.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Maria Buron, Teodoro Palomares, Patricia Garrido-Pascual, Borja Herrero de la Parte, Ignacio Garcia-Alonso, Ana Alonso-Varona
Summary: Preconditioned stem cells have shown a photoprotective effect against UVB-induced damage through enhanced antioxidant activity and cell migration, as well as modulating the functions of fibroblasts to promote cell viability and collagen synthesis.
Review
Cardiac & Cardiovascular Systems
John P. P. Cooke, Li Lai
Summary: Tissue repair involves multiple cellular effectors and pathways, including angiogenesis, vasculogenesis, and arteriogenesis. Fibroblasts, traditionally believed to not be involved in vascular regeneration, may undergo angiogenic transdifferentiation and directly contribute to microvasculature expansion. Inflammatory signaling initiates the transdifferentiation of fibroblasts to endothelial cells, which can be harnessed for therapeutic approaches to diseases like peripheral artery disease (PAD).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Sheng Hong, Zhangwen Peng, Meiying Wu, Yichu Nie, Yunfei Yi, Hui Cai, Xian-Zheng Zhang
Summary: Extraction of multifunctional particles from human hair provides an ingenious tactic for the design and development of sunscreens, which can effectively protect skin from UV radiation and prevent potential toxicity.
Article
Cell & Tissue Engineering
Junling Gao, Juntao Yuan, Qun Liu, Yuanli Wang, Huiwen Wang, Yingjie Chen, Wenjun Ding, Guangju Ji, Zhongbing Lu
Summary: The research found that ADSCs can protect against the adverse health effects of PM2.5 exposure by attenuating pulmonary inflammation and cell death. This suggests that ADSC transplantation may be a potential therapeutic approach for severe air pollution-associated diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Jordan Whisler, Somayeh Shahreza, Karin Schlegelmilch, Nil Ege, Yousef Javanmardi, Andrea Malandrino, Ayushi Agrawal, Alessandro Fantin, Bianca Serwinski, Hesham Azizgolshani, Clara Park, Victoria Shone, Olukunle O. Demuren, Amanda Del Rosario, Vincent L. Butty, Natalie Holroyd, Marie-Charlotte Domart, Steven Hooper, Nicolas Szita, Laurie A. Boyer, Simon Walker-Samuel, Boris Djordjevic, Graham K. Sheridan, Lucy Collinson, Fernando Calvo, Christiana Ruhrberg, Erik Sahai, Roger Kamm, Emad Moeendarbary
Summary: Vascularization is driven by morphogen signals and mechanical cues that regulate cellular force generation, migration, and shape change. The developing vasculature actively regulates its own mechanical properties to achieve effective vascularization. Tissue stiffness increases during vascular morphogenesis resulting from interactions between endothelial cells, fibroblasts, and ECM, and correlates with enhanced vascular function. Contractile cellular forces, synergizing with ECM mechanical properties and mediated by YAP1, play a key role in emergent tissue stiffening and vascular function. Mouse embryos lacking YAP1 in fibroblasts exhibit reduced tissue stiffness and lethal vascular defects. Translating these findings through biology-inspired vascular tissue engineering approaches will have substantial implications in regenerative medicine.
Article
Cell & Tissue Engineering
Abid Hussain, Virginie Deleuze, Leila El Kebriti, Hulya Turali, Nelly Pirot, Yael Glasson, Daniele Mathieu, Valerie Pinet
Summary: Lyl1 deficiency in mice leads to mild hematopoietic and vascular defects. Interestingly, Lyl1(-/-) mice exhibit transient overweight due to early differentiation of adipose stem cells into adipocytes, driven by an immature vascular niche in the adipose tissue. The impaired vascular compartment in Lyl1(-/-) mice promotes ASC differentiation, leading to premature adipocyte expansion and ASC depletion.
Review
Nutrition & Dietetics
Agata Stanek, Klaudia Brozyna-Tkaczyk, Wojciech Myslinski
Summary: PVAT plays a significant role in regulating vascular tone, thermoregulation, and VSMC proliferation. Obesity-induced dysfunction can be improved by physical activity and diet interventions.
Article
Pharmacology & Pharmacy
Ji Hu, Ru Chen, Jie An, Yilong Wang, Minglu Liang, Kai Huang
Summary: The study demonstrates that dauricine can alleviate endothelial inflammation by suppressing the NF-κB pathway, leading to a decrease in adhesion of THP-1 cells to HUVECs and protection against acute lung injury in mice.
FRONTIERS IN PHARMACOLOGY
(2021)
