Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A1 and A2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells

Published 2019 View Full Article

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Title
Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A1 and A2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells
Authors
Keywords
G protein-coupled receptors, Adenosine receptors, Adenosine receptor antagonists, 1,2,4-triazolo[4,3-a]pyrazin-3-ones, Alzheimer disease, Ligand-adenosine receptor modeling studies
Journal
BIOORGANIC CHEMISTRY
Volume 87, Issue -, Pages 380-394
Publisher
Elsevier BV
Online
2019-03-17
DOI
10.1016/j.bioorg.2019.03.046

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