Journal
BIOORGANIC CHEMISTRY
Volume 87, Issue -, Pages 516-522Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2019.03.062
Keywords
Carbonic Anhydrases (CAs); Carbonic Anhydrase Activators (CAM); Selenium; Metalloenzymes; Tellurium
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A new series of beta-aminochalcogenides were designed and synthesized to identify new carbonic anhydrase activator (CAA) agents as novel tools for the management of several neurodegenerative and metabolic disorders which represent a clinical challenge without effective therapies available. Some beta-aminoselenides and beta-aminotellurides showed effective CA activating effects and a potent antioxidant activity. CAAs may have applications for memory therapy and CA deficiency syndromes.
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