Article
Chemistry, Multidisciplinary
Xiudi Zhou, Qiang Chen, Chunjing Guo, Yanguo Su, Huimin Guo, Min Cao, Zhongxin Liu, Dandan Zhang, Ningning Diao, Huaying Fan, Daquan Chen
Summary: A novel drug delivery system has been developed to precisely deliver drugs to pathological renal tissue for attenuating renal ischemia-reperfusion injury. The system exhibits responsive properties to reactive oxygen species, biocompatibility, and cell penetration. The intracellular concentration of hydrogen sulfide released by the system is threefold higher than that in the control group, and it demonstrates anti-inflammatory effects by blocking the NF-KB signaling pathway. This research provides a promising strategy for pharmaceutical treatment of renal ischemia-reperfusion injury.
Review
Immunology
Parth M. Patel, Margaret R. Connolly, Taylor M. Coe, Anthony Calhoun, Franziska Pollok, James F. Markmann, Lars Burdorf, Agnes Azimzadeh, Joren C. Madsen, Richard N. Pierson
Summary: Recent advances in minimizing ischemia have shown promising results in reducing initial xenograft dysfunction in pig-to-non-human primate heart transplantation, indicating the significant role of ischemia reperfusion injury (IRI) in cardiac xenotransplantation. Understanding the molecular, cellular, and immune mechanisms of IRI and primary graft dysfunction in allotransplantation can help develop genetic modifications and technical strategies to minimize IRI and improve clinical xenotransplantation outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Fei Yang, Cuizhen Shen
Summary: Based on a mice pressure ulcers (PU) model, this study investigated the protective effect and potential mechanism of sodium Danshensu (SDSS) cream against PU. The results showed that SDSS cream promoted wound healing and regulated inflammatory factors and oxidative stress markers in the serum. Additionally, SDSS cream exerted its protective effect by modulating the Nrf2/HO-1 and NF-kappa B pathways.
Editorial Material
Gastroenterology & Hepatology
Ugo Boggi, Mark Truty, Nicholas J. Zyromski
Summary: This manuscript summarizes a debate on arterial resection in pancreatic cancer from a recent symposium. Two world-renowned experts shared their views on the role of arterial resection in advanced pancreatic ductal adenocarcinoma, emphasizing factors beyond technique. The subsequent review provides an excellent overview of the current status quo in this field.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Nutrition & Dietetics
Fayez T. Hammad, Suhail Al-Salam, Rahaf Ahmad, Javed Yasin, Awwab F. Hammad, Jasmine Abdul Rasheed, Loay Lubbad
Summary: It has been found that nerolidol has a protective effect on renal ischemia-reperfusion injury, improving renal function and reducing tissue damage.
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zhihong Peng, Trung T. Nguyen, Man Wang, Bowen Anderson, Mohini Mohan Konai, Valerie A. Schroeder, William R. Wolter, Toni Page-Mayberry, Charles E. Peterson, Shahriar Mobashery, Mayland Chang
Summary: Pressure ulcers (PUs) are chronic wounds that are difficult to heal. The role of matrix metalloproteinases (MMPs) in wound healing and the presence of specific MMPs in PUs were investigated. Higher concentrations of MMP-8, MMP-9, and MMP-14 were found in human PUs compared to healthy tissue. In a mouse model, a selective inhibitor for MMP-9 and MMP-14 accelerated wound closure and improved ulcer stage, suggesting its potential as a treatment for PUs.
ACS CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kun-Ling Tsai, Pei-Ling Hsieh, Wan-Ching Chou, Hui-Ching Cheng, Yu-Ting Huang, Shih-Hung Chan
Summary: The study suggests that DAPA may alleviate oxidative stress and cardiac apoptosis induced by ischemia/reperfusion injury through modulation of AMPK, improving cardiac function. Additionally, DAPA may protect cardiac cells by influencing mitochondrial function.
CELL AND BIOSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Wenjun Li, Yuriko Terada, Yulia Y. Tyurina, Vladimir A. Tyurin, Amit Bery, Jason M. Gauthier, Ryuji Higashikubo, Alice Y. Tong, Dequan Zhou, Felix Nunez-Santana, Emilia Lecuona, Adil Hassan, Kohei Hashimoto, Davide Scozzi, Varun Puri, Ruben G. Nava, Alexander S. Krupnick, Kory J. Lavine, Andrew E. Gelman, Mark J. Miller, Valerian E. Kagan, Ankit Bharat, Daniel Kreisel
Summary: Ischemia reperfusion injury is a common pathological condition triggered by the release of endogenous ligands. In this study, the researchers discovered that necroptosis, a nonapoptotic form of cell death, triggers the recruitment of neutrophils in injured lungs. Initially, neutrophils traffic predominantly to subpleural vessels, guided by chemoattractants produced by nonclassical monocytes. The disruption of pulmonary capillaries by neutrophils leads to vascular leakage and impaired graft function. The study also found that TLR4 signaling and NADPH oxidase 4 expression mediate the arrest of neutrophils, preventing their extravasation. The formation of neutrophil extracellular traps in injured lungs can be disrupted with DNase to prevent vascular leakage and improve graft dysfunction. These findings could have important implications for the development of therapeutics to protect lungs from ischemia reperfusion injury.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Zexin Li, Ying Wang, Yu Zhang, Xiao Wang, Baoqin Gao, Yan Li, Rong Li, Jianguo Wang
Summary: Fisetin was found to alleviate liver damage, cell apoptosis, and oxidative stress induced by liver IRI, at least through the Nrf2/HO-1 signaling pathway, suggesting its potential as a targeted drug for liver IRI treatment.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Khaled Dastagir, Jaba Gamrekelashvili, Nadjib Dastagir, Anne Limbourg, Dustin Kijas, Tamar Kapanadze, Peter M. Vogt, Florian P. Limbourg
Summary: In this study, the researchers found that the Notch ligand Delta-like 1 (Dll1), expressed in vascular endothelial cells, regulates flap arteriogenesis, inflammation, and survival. The loss of Dll1 impaired collateral vessel formation and led to aberrant vascularization and necrosis of the tissue. Furthermore, Dll1 deficiency also resulted in severe inflammation in the flap dominated by monocytes and macrophages. These findings demonstrate the importance of Dll1 in vascular adaptation to flap surgery and provide insights into the molecular and cellular regulators of flap healing and survival.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Hongji Zhang, Tianmeng Chen, Jinghua Ren, Yujia Xia, Amblessed Onuma, Yu Wang, Jiayi He, Junru Wu, Han Wang, Ahmad Hamad, Chengli Shen, Jinxiang Zhang, John M. Asara, Gregory K. Behbehani, Haitao Wen, Meihong Deng, Allan Tsung, Hai Huang
Summary: The research demonstrates that pre-operative exercise protects against liver injury by driving Kupffer cells towards an anti-inflammatory phenotype through itaconate metabolism.
Article
Multidisciplinary Sciences
Jong Woo Kang, Jong Woong Park, Tae Hyun Lim, Keun Tae Kim, Song Joo Lee
Summary: This study investigated the physiological changes in a newly developed in vivo porcine acute atraumatic CS model. The results showed that shear wave elastography may serve as a non-invasive diagnostic tool for atraumatic CS, with potential value in diagnosing the condition.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Jinwei Gao, Zheng Wang, Zhangzhang Ye
Summary: This study examined the effectiveness of madder as a medicine to treat ischemia-reperfusion injury. The results showed that madder treatment can effectively reduce the area of myocardial infarction, restore arterial blood flow velocity and myocardial contractility, and inhibit the expression of inflammatory factors, autophagy factors, and apoptosis factors in mice. Madder treatment can also alleviate myocardial ischemia-reperfusion injury in mice and inhibit the occurrence of inflammatory response by inhibiting the activity of the NF-kappa B pathway.
MEDIATORS OF INFLAMMATION
(2023)