Review
Chemistry, Inorganic & Nuclear
Christopher C. Rennie, Robert M. Edkins
Summary: Phototherapy, using light to selectively ablate cancerous tissue, shows promising prospects. The use of Pc-drug conjugates as targeted anticancer phototherapeutic systems has shown potential in improving treatment specificity and achieving precise, synergistic phototherapy.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Chang-Hee Whang, Jungwoo Hong, Dohyeon Kim, Hong Ryu, Wonsik Jung, Youngju Son, Hyeongseop Keum, Jinjoo Kim, Hocheol Shin, Eugene Moon, Ilkoo Noh, Hee-Seung Lee, Sangyong Jon
Summary: This study reports a library of glycocalyx-mimicking nanoparticles for screening and identification of cancer-targeting nanomedicines. The researchers found that certain nanoparticles selectively targeted different tumors and exhibited potent therapeutic effects. The results suggest that this nanoparticle library has a versatile application potential beyond cancer treatment.
ADVANCED MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Seong-Bin Yang, Nipa Banik, Bomin Han, Dong-Nyeong Lee, Jooho Park
Summary: With advancements in bioinformatics, amino acid-based drug-design strategies have become increasingly important in pharmaceutics. Despite previous limitations of low selectivity and rapid degradation, peptide-based therapeutics combined with drug-delivery systems have emerged, particularly in anticancer therapy.
Article
Chemistry, Multidisciplinary
Xue-Liang Liu, Xiao Dong, Si-Cong Yang, Xing Lai, Hai-Jun Liu, Yuhao Gao, Hai-Yi Feng, Mao-Hua Zhu, Yihang Yuan, Qin Lu, Jonathan F. Lovell, Hong-Zhuan Chen, Chao Fang
Summary: Nano-Pt loaded liposomal system enhances photodynamic therapy and chemotherapy in cancer treatment by increasing oxygen supply and releasing nanoparticles for better penetration, leading to inhibited tumor growth and extended survival without toxicity in animal models.
Article
Engineering, Biomedical
Sudipta Mallick, Ramadan Abouomar, David Rivas, Max Sokolich, Fatma Ceren Kirmizitas, Aditya Dutta, Sambeeta Das
Summary: Micro-sized magnetic particles, known as microrobots, have shown potential for biomedical applications such as drug delivery and cell manipulation. This study used microrobots to deliver anticancer drugs to cancer cells, resulting in cell death. The findings confirm the promise of microrobots as precise couriers for targeted delivery of therapeutic biomolecules for cancer therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Lu Tang, Jing Li, Qingqing Zhao, Ting Pan, Hui Zhong, Wei Wang
Summary: Nanotechnology plays a crucial role in cancer treatment, improving drug delivery efficiency and pharmacokinetics. Small molecule drugs and biological macromolecule drugs are the main types of anticancer agents, with nano-encapsulation technology playing a key role in their delivery.
Review
Polymer Science
Magdalena J. Bigaj-Jozefowska, Bartosz F. Grzeskowiak
Summary: Nanotechnology is a widely researched approach to improve cancer therapies, with polymeric nanocarriers playing a crucial role in delivering drugs and enhancing treatment outcomes. Biological membranes, such as those derived from red blood cells or cancer cells, have been extensively studied for their potential in improving biosafety and targeting properties. This review summarizes the development of biomimetic polymeric nanocarriers for efficient cancer treatment.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yu Geng, Jiajia Xiang, Shiqun Shao, Jianbin Tang, Youqing Shen
Summary: This study presents a drug delivery system using a block copolymer as a carrier for celastrol, a natural anticancer compound. The system can self-assemble into nanoparticles and has improved pharmacokinetics and efficient mitochondria targeting capacity, enhancing the therapeutic effects of celastrol in cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Yukiya Takayama, Kosuke Kusamori, Chihiro Tsukimori, Yosuke Shimizu, Mika Hayashi, Ikumi Kiyama, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto, Makiya Nishikawa
Summary: In this study, MSCs were modified with DOX-Lips to efficiently deliver doxorubicin to tumor cells, demonstrating significant tumor growth inhibition in murine models. The results suggest that DOX-Lip-modified MSCs could serve as an effective carrier system for targeted tumor therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Bing-Bing Liang, Qian Liu, Bin Liu, Hua-Gang Yao, Juan He, Cheng-Fei Tang, Kun Peng, Xu-Xian Su, Yue Zheng, Jia-Yi Ding, Jianliang Shen, Qian Cao, Zong-Wan Mao
Summary: Regulating autophagy through targeting Golgi apparatus shows promise as an anticancer strategy. Researchers have developed a novel Golgi-targeted platinum (II) complex, Pt3, which exhibits high cytotoxicity against lung carcinoma. Pt3 induces Golgi stress, triggering Golgiphagy and blocking fusion between autophagosomes and lysosomes, ultimately leading to apoptotic cell death. Pt3 represents a significant advancement in cancer therapy by regulating autophagic flux and the interplay between autophagy and apoptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Oncology
Rajeswari Raguraman, Dhaval Bhavsar, Dongin Kim, Xiaoyu Ren, Vassilios Sikavitsas, Anupama Munshi, Rajagopal Ramesh
Summary: Exosomes are small vesicles that can be used as drug delivery vehicles for cancer treatment due to their unique characteristics. Preclinical studies have shown that exosomes can effectively deliver chemotherapeutics, biologicals, and natural products with potent anticancer activity. However, challenges in large-scale production, storage, and stability have limited the number of exosome-based clinical trials.
Article
Materials Science, Multidisciplinary
Lingli Jin, Yanwen Xu, Fengjiao Chen, Dingle Yu, Hongze Liang, Zhenjiang Liang, Ziyu Liu, Haiyan Li, Junying Liu, Hui Tan, Lingling Zhao
Summary: A mitochondria-targeted and pH-triggered charge-convertible polymeric micellar system was developed for doxorubicin delivery and targeted anticancer therapy. It showed sustained drug release and enhanced cellular uptake, accumulation in mitochondria, and efficient release of doxorubicin in tumor cells.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Physical
Ke Yan, Yecheng Feng, Ke Gao, Xiaojing Shi, Xubo Zhao
Summary: A novel drug delivery system based on hyaluronic acid-tetraphenyl ethylene conjugate (HA-SS-TPE) with glutathione (GSH) responsiveness is designed for targeted drug delivery, showing potential therapeutic effects on CD44-overexpressing cancer cells in in vivo studies.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Hanhee Cho, Seong Ik Jeon, Cheol-Hee Ahn, Man Kyu Shim, Kwangmeyung Kim
Summary: Albumin has the potential to improve the delivery of anticancer drugs by acting as a natural carrier. It can enhance the circulation time of the drugs and passively target tumors through enhanced permeability and retention. However, the delivery efficiency of exogenous albumin formulations is low, which increases the risk of systemic toxicity. Prodrugs that bind endogenous albumin have been investigated as a safer and more effective drug delivery option.
Article
Chemistry, Multidisciplinary
Zongqi Feng, Tingyu Yang, Shichao Dong, Ting Wu, Wen Jin, Zhouying Wu, Bingping Wang, Tiantian Liang, Lei Cao, Lan Yu
Summary: This study successfully developed an industrialized method for synthesizing high drug-loaded vaterite hollow calcium carbonate, showing promising applications in tumor therapy.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Aydan Dag, Eda Cakilkaya, Pinar Sinem Omurtag Ozgen, Sezen Atasoy, Gulsah Yigit Erdem, Busra Cetin, Aytac Cavus Kokuroglu, Ayse Gul Gurek
Summary: This study focused on the preparation of glycopolymeric nanoparticles containing a photosensitizer and an anticancer drug for combined cancer therapy. The nanoparticles demonstrated remarkable photophysical and photochemical properties, as well as targetability towards breast cancer cells. In vitro experiments showed superior chemo-photodynamic combination therapeutic efficacy compared to traditional treatments.
Article
Plant Sciences
Ece Sevgi, Aydan Dag, Cagla Kizilarslan-Hancer, Sezen Atasoy, Belma Zengin Kurt, Oznur Aksakal
Summary: This study aimed to evaluate the phytochemical composition and biological activities of extracts from Dittrichia viscosa collected in Turkey, showing high antioxidant and anticancer activities against breast and prostate cancer cells. The results suggest the potential medicinal use of this plant as an anticancer agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Bengisu Gokkaya, Sezen Atasoy, Ayse Cirakoglu, Yelda Tarkan Arguden, R. Dilhan Kuru, Sukriye Yilmaz, Seniz Ongoren, Ayhan Deviren
Summary: This study investigated the recurrent aberrations in acute lymphoblastic leukemia (ALL) patients with normal karyotype or unsuccessful karyotyping using the fluorescence in situ hybridization (FISH) method. The results showed that FISH probes had higher diagnostic sensitivity in detecting multiple chromosomal rearrangements with prognostic significance compared to conventional cytogenetic analysis (CCA). Combining FISH panels with CCA can improve cytogenetic examination and achieve better treatment outcomes for ALL patients.
Article
Chemistry, Organic
Feyzi Sinan Tokali, Halil Senol, Tugba Gencoglu Katmerlikaya, Aydan Dag, Kivilcim Sendil
Summary: In this study, 24 new compounds were synthesized and characterized, and compounds 6k and 7f were found to have high anticancer activity, being more selective and potent than the standard drug Doxorubicin.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Tugba Gencoglu Katmerlikaya, Aydan Dag, Pinar Sinem Omurtag Ozgen, Busra Cetin Ersen
Summary: Drug-conjugated nanoassemblies enhance the efficiency of anticancer drugs through high drug-loading capacity and targeting ability. This study successfully synthesized dual-drug-functionalized glyco-nanoassemblies that can effectively release drugs in the tumor environment and exhibit high selectivity and preferential cellular internalization in cancer cells.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Busra Cetin Ersen, Beyza Goncu, Aydan Dag, Gokcen Birlik Demirel
Summary: In this study, targeted and multimodal therapeutic hybrid nanocarriers were fabricated for breast cancer treatments. The carrier consists of synthesized gold nanorods coated with doxorubicin conjugated glycopeptide polymer. A photosensitizer molecule was loaded into the particles for photodynamic therapy, and antisense oligonucleotides were integrated to prevent apoptotic resistance. The biocompatibility and therapeutic efficacy of these nanoparticles were evaluated on human normal skin fibroblast and breast cancer cell lines.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Medicinal
Kaluvu Balaraman, Emre Deniz, Eryn Nelson, Samantha L. Pilicer, Sezen Atasoy, Anna Molotkova, Handan Sevim, Purushottam B. Tiwari, Aykut Uren, Christian Wolf
Summary: Ewing Sarcoma (ES) is a cancer that affects the bones and soft tissues, mainly in children and young adults. CD99, a trans-membrane protein abundantly expressed on ES cells, is a diagnostic marker and a potential therapeutic target. Researchers have developed new derivatives of clofarabine and cladribine that specifically target CD99 and inhibit ES cell growth. These findings provide a roadmap for the future development of selective CD99 inhibitors for targeted treatment of ES.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Halil Senol, Ahmet Gokhan Aggul, Sezen Atasoy
Summary: In this study, 16 new compounds were synthesized and tested for their anti-cancer activity against MCF-7 breast cancer cells and MCF10A breast healthy tissue. Molecular docking studies were conducted to understand the inhibition mechanism. Compounds 5a and 5e showed the highest selectivity and activity against breast cancer cells.
Article
Chemistry, Physical
Halil Senol, Ahmet Gokhan Aggul, Sezen Atasoy, Nuray Ulusoy Guzeldemirci
Summary: This study synthesized 16 new hybrid compounds consisting of eight 1,2,3-triazole-arylidenehydrazide derivatives and eight 1,2,3-triazole-thiazolidin-4-one derivatives, starting from methyl-paraben. These compounds were tested for their anti-cancer activity against MCF-7 breast cancer cells and MCF10A breast healthy tissue. The results showed that compound 7g is a promising anti-cancer drug candidate for the treatment of breast cancer.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Pharmacology & Pharmacy
Pinar Sinem Omurtag Ozgen, Sevde Nur Biltekin, Tugba Idug, Caglar Macit, Irem Ayran, Sadiye Ayse Celik, Sukran Kultur, Yuksel Kan, Gulden Zehra Omurtag
Summary: The essential oil obtained from Lavandula angustifolia Mill. has pharmacological effects such as antioxidant, antifungal, antibacterial, and carminative effects. The main components of the essential oil are monoterpene compounds and phenolic acids. LEO shows low cytotoxicity and potential for future studies.
JOURNAL OF RESEARCH IN PHARMACY
(2022)
Article
Medicine, Research & Experimental
Guzin Gokay, Beyza Goncu, Sezen Atasoy, Nur Ozten Kandas, Aydan Dag
Summary: This study aimed to evaluate the toxicological effects of sulforaphane (SFN) on renal cells. The results showed that SFN could alter apoptotic/necrotic behavior in renal carcinoma cells and had an impact on cell cycle and proliferation status. The use of SFN as an alternative treatment for renal cell carcinoma should be cautious.
INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Aydan Dag, Pinar Sinem Omurtag Ozgen, Belma Zengin Kurt, Zehra Durmus
Summary: This study demonstrates the successful preparation of graphene nanomaterials decorated with glycopolymers for biomedical applications using RAFT polymerization and non-covalent interactions. The results show that the modified nanographene has a homogeneous glycoblock copolymer coating and excellent binding properties. Promising results were achieved in interactions with ConA lectin, suggesting the potential for designing new multifunctional glyconanomaterials with favorable binding properties with lectins.
TURKISH JOURNAL OF CHEMISTRY
(2022)
