Article
Hematology
Qingya Wang, Zeyin Liang, Hanyun Ren, Yujun Dong, Yue Yin, Qingyun Wang, Wei Liu, Bingjie Wang, Na Han, Yangliu Li, Yuan Li
Summary: This retrospective study analyzed data from 323 AML patients who underwent allo-HSCT at Peking University First Hospital. The study found that the annual number of transplantations increased steadily and there was a rise in high-risk cytogenetic and MRD-positive patients since 2013. The engraftment time has decreased over the past 20 years and both overall survival and disease-free survival have significantly improved, while non-relapse mortality has decreased since 2013. Risk factors for NRM were identified as transplantation before 2013, patients in CR2 or non-CR, and recipients older than 50 years, while non-CR and positive MRD were risk factors for recurrence.
ANNALS OF HEMATOLOGY
(2023)
Review
Immunology
Asim Saha, Bruce R. Blazar
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment option for hematological malignancies. However, conventional allo-HSCT methods have adverse effects and can lead to graft-versus-host-disease. Recent developments in targeted radiotherapy and antibody-based conditioning show promise in improving the outcomes of allo-HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biophysics
Kaito Harada, Shun-ichi Kimura, Shigeo Fuji, Yuho Najima, Kimikazu Yakushijin, Naoyuki Uchida, Makoto Onizuka, Kazuhiro Ikegame, Shingo Yano, Naoki Shingai, Ken-ichi Matsuoka, Yasushi Onishi, Masashi Sawa, Satoru Takada, Toshiro Kawakita, Takahiro Fukuda, Junya Kanda, Yoshiko Atsuta, Hideaki Nakasone
Summary: A comprehensive scoring system was developed to assess mortality risk after salvage stem cell transplant for graft failure, stratifying patients into different survival rate groups to provide a useful predictive tool for clinical outcomes.
BONE MARROW TRANSPLANTATION
(2021)
Article
Immunology
Yue Lu, Jian-Ping Zhang, Yan-Li Zhao, Min Xiong, Rui-Juan Sun, Xing-Yu Cao, Zhi-Jie Wei, Jia-Rui Zhou, De-Yan Liu, Jun-Fang Yang, Xian Zhang, Dao-Pei Lu, Peihua Lu
Summary: This study retrospectively analyzed 199 hematological malignancy patients who received a second allogeneic stem cell transplantation (allo-HSCT2) after relapse following the first allo-HSCT (allo-HSCT1), aiming to evaluate prognostic factors. The results showed that disease status of MRD-negative complete remission, HCT-CI score of 0 prior to allo-HSCT2, and a new mismatched haplotype donor were predictive factors for improved overall survival and leukemia-free survival. Based on these factors, a predictive scoring system was developed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Hiroyuki Kubo, Osamu Imataki, Tetsuya Fukumoto, Yui Kawanaka, Tomoya Ishida, Yukiko Hamasaki Kubo, Jun-ichiro Kida, Makiko Uemura, Haruyuki Fujita, Norimitsu Kadowaki
Summary: Ascites is a potential complication after allo-HSCT, and this study investigated its factors and impact on patient prognosis. The study found that ascites correlated with lower overall survival and higher non-relapse mortality rates.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Hiroyuki Kubo, Osamu Imataki, Tetsuya Fukumoto, Yui Kawanaka, Tomoya Ishida, Yukiko Hamasaki Kubo, Jun-ichiro Kida, Makiko Uemura, Haruyuki Fujita, Norimitsu Kadowaki
Summary: This study found that veno-occlusive disease/sinusoidal obstruction syndrome and myeloablative conditioning were important factors for the development of small ascites, while Thrombotic microangiopathy was a significant factor for moderate-large ascites. The incidence of both small and moderate-large ascites correlated with lower overall survival and higher non-relapse mortality rates. Further research is needed to determine whether ascites can improve the diagnostic quality of Thrombotic microangiopathy.
SCIENTIFIC REPORTS
(2023)
Review
Health Care Sciences & Services
Heather R. Wolfe, Mitchell E. Horwitz, Lindsay A. M. Rein
Summary: Primary myelofibrosis is a BCR-ABL1 negative myeloproliferative neoplasm characterized by clonal proliferation of myeloid cells. Allogenic hematopoietic stem cell transplantation may provide a safe and effective curative option for a broader range of primary myelofibrosis patients in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Yuanfeng Zhang, Xin Chen, Donglin Yang, Aiming Pang, Rongli Zhang, Qiaoling Ma, Weihua Zhai, Yi He, Jialin Wei, Erlie Jiang, Mingzhe Han, Sizhou Feng
Summary: This study conducted a retrospective cohort analysis on patients with severe aplastic anemia (SAA) who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) to compare their survival between those with infection and those without infection. The study found that patients with infection before transplantation had inferior survival compared to those without infection, highlighting the importance of prophylaxis and complete control of infectious complications before transplantation among SAA patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Erika S. Varady, L. Angel Ayala, Pauline U. Nguyen, Vanessa M. Scarfone, Alborz Karimzadeh, Cuiwen Zhou, Xiyu Chen, Scott A. Greilach, Craig M. Walsh, Matthew A. Inlay
Summary: Donor cell conditioning with the glucocorticoid fluticasone propionate (FLU) prior to transplantation increases HSC engraftment and reduces the severity and incidence of graft-versus-host disease (GvHD) in allogeneic hosts.
EMBO MOLECULAR MEDICINE
(2023)
Article
Oncology
Sanghee Hong, Ruta Brazauskas, Kyle M. Hebert, Siddhartha Ganguly, Hisham Abdel-Azim, Miguel Angel Diaz, Sara Beattie, Stefan O. Ciurea, David Szwajcer, Sherif M. Badawy, Alois A. Gratwohl, Charles LeMaistre, Mahmoud D. S. M. Aljurf, Richard F. Olsson, Neel S. Bhatt, Nosha Farhadfar, Jean A. Yared, Ayami Yoshimi, Sachiko Seo, Usama Gergis, Amer M. Beitinjaneh, Akshay Sharma, Hillard Lazarus, Jason Law, Matthew Ulrickson, Hasan Hashem, Helene Schoemans, Jan Cerny, David Rizzieri, Bipin N. Savani, Rammurti T. Kamble, Bronwen E. Shaw, Nandita Khera, William A. Wood, Shahrukh Hashmi, Theresa Hahn, Stephanie J. Lee, J. Douglas Rizzo, Navneet S. Majhail, Wael Saber
Summary: This study analyzed the impact of community health status on allogeneic HCT outcomes using data from CHRR and CIBMTR, finding that patients residing in counties with a worse community health status have inferior survival due to increased risk of NRM after allogeneic HCT. There was no significant association between the community health status of the transplant center location and allogeneic HCT outcomes.
Article
Pediatrics
Irina Zaidman, Tamar Shaziri, Dina Averbuch, Ehud Even-Or, Yael Dinur-Schejter, Adeeb NaserEddin, Rebecca Brooks, Bella Shadur, Aharon Gefen, Polina Stepensky
Summary: Infectious and noninfectious neurological complications are significant factors affecting morbidity and mortality in children following allogeneic HSCT. Further research is needed to understand the risk factors and outcomes of different neurological complications regarding sequelae and survival.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Eleni Gavriilaki, Ioanna Sakellari, Thomas Chatziconstantinou, Despina Mallouri, Ioannis Batsis, Eleni Katsifa, Stergios Papadimitriou, Alkistis Panteliadou, Eirini Baldoumi, Christos Demosthenous, Zoi Bousiou, Varnavas Constantinou, Damianos Sotiropoulos, Achilles Anagnostopoulos
Summary: The study investigated the incidence, risk factors, and outcomes of Kp infections in patients undergoing alloHCT. Results showed a high rate of KPC-Kp infection and identified Kp infections and GVHD as independent predictive factors of TRM.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Suguru Uemura, Daiichiro Hasegawa, Kenji Kishimoto, Tomoko Fujikawa, Sayaka Nakamura, Aiko Kozaki, Atsuro Saito, Toshiaki Ishida, Takeshi Mori, Kayo Ozaki, Yoshiyuki Kosaka
Summary: This study examined the association between conditioning intensity and height growth in pediatric patients who underwent allo-HSCT. The results showed significant differences in height SDS between MAC and RIC groups at 2 and 3 years after allo-HSCT. Multivariate logistic regression analysis indicated that MAC regimen was associated with an increased risk of short stature at 3 years after allo-HSCT.
Article
Pediatrics
Yuhua Qu, Hao Liu, Likun Wei, Shushan Nie, Wenjiao Ding, Sha Liu, Haiyan Liu, Hua Jiang
Summary: This study examined the efficacy of hematopoietic stem cell transplantation (HSCT) for mucopolysaccharidosis (MPS) IV and VI. The results showed that HSCT can restore lysosomal enzyme levels, improve organ function, and increase overall survival rate. Umbilical cord blood (UCB) is a suitable donor source, and using a specific conditioning regimen can achieve better treatment outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biophysics
Marjan Cruijsen, Jacobien R. Hilberink, Walter J. F. M. van der Velden, Joop H. Jansen, Brigitte Bar, Nicolaas P. M. Schaap, Anton de Haan, Andre B. Mulder, Marco R. de Groot, Frederic Baron, Edo Vellenga, Nicole N. M. Blijlevens, Gerwin Huls
Summary: The combination of decitabine with a standard non-myeloablative conditioning regimen prior to allogeneic hematopoietic cell transplantation can effectively reduce relapse incidence in poor risk AML patients. The study demonstrated a one-year relapse rate of 23% and a one-year overall survival of 70% in this patient population.
BONE MARROW TRANSPLANTATION
(2021)
Article
Medicine, Research & Experimental
Jason P. Cooper, C. Patrick Reynolds, Hwangeui Cho, Min H. Kang
EXPERIMENTAL BIOLOGY AND MEDICINE
(2017)
Editorial Material
Hematology
Jason P. Cooper, Bart L. Scott
AMERICAN JOURNAL OF HEMATOLOGY
(2018)
Article
Pharmacology & Pharmacy
Jason P. Cooper, Kyunghwa Hwang, Hardeep Singh, Dong Wang, C. Patrick Reynolds, Robert W. Curley, Simon C. Williams, Barry J. Maurer, Min H. Kang
BRITISH JOURNAL OF PHARMACOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Tatiana V. Cohen, Kimberly D. Klarmann, Krisada Sakchaisri, Jason P. Cooper, Douglas Kuhns, Miriam Anver, Peter F. Johnson, Simon C. Williams, Jonathan R. Keller, Colin L. Stewart
HUMAN MOLECULAR GENETICS
(2008)
Article
Oncology
Jason P. Cooper, Sookhee Bang, Hardeep Singh, Simon C. Williams, Min H. Kang
PEDIATRIC BLOOD & CANCER
(2012)
Article
Multidisciplinary Sciences
Xiuhai Ren, Jingying Xu, Jason P. Cooper, Min H. Kang, Anat Erdreich-Epstein
Article
Critical Care Medicine
Katharine R. Clapham, Rupal D. Bhimani, Jason P. Cooper, Theodore A. Stern
JOURNAL OF INTENSIVE CARE MEDICINE
(2015)
Article
Hematology
Jason P. Cooper, Rafic J. Farah, Philip A. Stevenson, Ted A. Gooley, Rainer Storb, Bart L. Scott
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2019)
Article
Oncology
Janon P. Cooper, Sirin Khajaviyan, Stephen D. Smith, David G. Maloney, Andrei R. Shustov, Edus H. Warren, Lorinda A. Soma, Ryan C. Lynch, Chaitra Ujjani, Brian Till, Anna B. Halpern, Ajay K. Gopal, H. Joachim Deeg, Bart L. Scott, Mazyar Shadman
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2019)
Review
Anesthesiology
Melissa E. Bauer, Roulhac D. Toledano, Timothy Houle, Yaakov Beilin, Mark MacEachern, Madeline McCabe, Dana Rector, Jason P. Cooper, Terry Gernsheimer, Ruth Landau, Lisa Leffert
JOURNAL OF CLINICAL ANESTHESIA
(2020)
Article
Hematology
Jason P. Cooper, Barry E. Storer, Noa Granot, Boglarka Gyurkocza, Mohamed L. Sorror, Thomas R. Chauncey, Judith Shizuru, Georg-Nikolaus Franke, Michael B. Maris, Michael Boyer, Benedetto Bruno, Firoozeh Sahebi, Amelia A. Langston, Parameswaran Hari, Edward D. Agura, Soren Lykke Petersen, Richard T. Maziarz, Wolfgang Bethge, Julie Asch, Jonathan A. Gutman, Gitte Olesen, Andrew M. Yeager, Kai Hubel, William J. Hogan, David G. Maloney, Marco Mielcarek, Paul J. Martin, Mary E. D. Flowers, George E. Georges, Ann E. Woolfrey, H. Joachim Deeg, Bart L. Scott, George B. McDonald, Rainer Storb, Brenda M. Sandmaier
Summary: Over the past 20 years, improvements in clinical practice have led to a reduction in morbidity and mortality in allogeneic hematopoietic cell transplantation. Comparing outcomes from different years, it was found that overall survival, progression-free survival, and non-relapse mortality have significantly improved.
Article
Oncology
Linde M. Morsink, Brenda M. Sandmaier, Megan Othus, Raffaele Palmieri, Noa Granot, Evandro D. Bezerra, Brent L. Wood, Marco Mielcarek, Gary Schoch, Chris Davis, Mary E. D. Flowers, H. Joachim Deeg, Frederick R. Appelbaum, Rainer Storb, Roland B. Walter