Article
Biochemistry & Molecular Biology
Ilenia Martinelli, Mathieu Cinato, Sokhna Keita, Dimitri Marsal, Valentin Antoszewski, Junwu Tao, Oksana Kunduzova
Summary: The study found that short-term exposure to EMF did not have a significant effect on the myocardial antioxidant defense system and apoptotic cell death in cardiac cells and tissues.
Article
Food Science & Technology
Jiahui Han, Chengni Jin, Yujie Zhong, Jiachang Zhu, Qi Liu, Dianjun Sun, Jiayu Feng, Xiaodong Xia, Xiaoli Peng
Summary: NADPH oxidase plays a critical role in PAT-induced nephrotoxicity, and inhibiting NADPH oxidase with DPI can attenuate cell injury and apoptosis by regulating oxidative damage.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ochuko L. Erukainure, Nicholisha Narainpersad, Veronica F. Salau, Moganavelli Singh, Neil A. Koorbanally, Md. Shahidul Islam
Summary: The study explores the cytotoxic effect of the chemical fractions of Allium cepa on Human Embryonic Kidney cells. The ethyl acetate fraction showed cytotoxic effects, altering oxidative, inflammatory, and apoptotic activities in the cells. Further research is needed to assess the safety and potential risks associated with the use of Allium cepa.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Marine & Freshwater Biology
Ye Zhao, Huiling Wang, Priscilla Agyemang Duah, Vladimir Retyunskiy, Yizheng Liu, Guoguang Chen
Summary: This study investigates the embryonic toxicogenomic responses induced by Zinc pyrithione (ZPT) in zebrafish. The results show that ZPT treatment causes embryogenesis toxicity, including irregular cell division and rearrangement, delayed differentiations of eyes and notochords, and defects in epiboly and germ ring formation and somite segmentation. ZPT exposure also alters gene expression during early embryonic development, leading to morphological abnormalities and metabolic dysfunctions. Additionally, ZPT induces oxidative stress, apoptosis, endoplasmic reticulum (ER) stress, and autophagy.
AQUATIC TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Hossein Amiri, Fatemeh Shabkhiz, Parisa Pournemati, Amir Hossein Saffar Kohneh Quchan, Reza Zeighami Fard
Summary: This study investigated the effects of swimming exercise on oxidative stress and liver cell damage caused by electromagnetic radiation in rats. The results showed that swimming exercise attenuated the liver damage caused by electromagnetic radiation. In the electromagnetic radiation group, the activity of superoxide dismutase and catalase decreased significantly, and the concentration of malondialdehyde and liver enzymes increased significantly; while in the swimming exercise and electromagnetic radiation + swimming exercise groups, the activity of superoxide dismutase and catalase increased significantly, and the concentration of malondialdehyde and liver enzymes decreased significantly.
Article
Nanoscience & Nanotechnology
Yuanyuan Xu, Yu Zhao, Shanji Liu, Sidi Lv, Ling Chen, Wanzhen Wang, Yueying Feng, Fen Fu, Hengyi Xu
Summary: This study found that zinc oxide nanoparticles have toxic effects on the ovaries of female mice, which are attributed to oxidative stress, endoplasmic reticulum stress, and activation of apoptosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tianhui Niu, Yan Zhi, Lizhao Wei, Wenjun Liu, Xiaoxiao Ju, Weiping Pi, Zhaojun Fu, Hao Tong, Haixiang Hu, Jing Dong
Summary: Electromagnetic radiation can cause injuries to the heart, and there is currently no therapy available to prevent these effects. This study investigated the role of Sirtuin 3 (SIRT3) in electromagnetic radiation-induced cardiomyopathy (eRIC). The study found that Sirt3 expression was down-regulated in eRIC mice, and its overexpression protected the heart from the detrimental effects of radiation. It was also found that Sirt3 maintained the AMP-activated protein kinase (AMPK) signaling pathway in stressed hearts. These findings suggest that SIRT3 could be a potential therapeutic target for treating eRIC.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Garima Singh, Namrata Mittra, Chetna Singh
Summary: Oxidative stress and inflammation play important roles in the toxic effects of sporadic Parkinson's disease and zinc-induced dopaminergic neurodegeneration. Synthetic superoxide dismutase (SOD) mimetic tempol and natural antioxidant silymarin have protective effects against oxidative stress-induced damage. This study aimed to investigate the effects of tempol and silymarin on zinc-induced dopaminergic neurodegeneration.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Suzan Attia Mawed, Carlotta Marini, Mahmoud Alagawany, Mayada R. Farag, Rasha M. Reda, Mohamed T. El-Saadony, Walaa M. Elhady, Gian E. Magi, Alessandro Di Cerbo, Wafaa G. El-Nagar
Summary: This study elucidated the ultrastructure changes in the ovary in response to exposure to zinc oxide nanoparticles (ZnO-NPs) and explored the role of autophagy and apoptosis in the fertility of female zebrafish. The results showed that ZnO-NPs induced cytotoxicity, oxidative stress, and necroptosis, leading to a reduction in the fecundity of female zebrafish.
Article
Biochemistry & Molecular Biology
Jitendra Kumar Suthar, Anuradha Vaidya, Selvan Ravindran
Summary: The cellular toxicity of zinc oxide nanoparticles depends on their size, surface coating, and cellular interactions. The release of zinc ions does not significantly contribute to the observed cytotoxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiao Cui, Yongshi Ma, Hong Wang, Jianfang Huang, Linlin Li, Jianbing Tang, Biao Cheng
Summary: The study demonstrated that pre- and post-treatment of PRP could reduce MDA content and increase antioxidant enzyme activities in UVB-damaged HaCaT cells. Additionally, PRP intervention promoted cell proliferation via PI3K/AKT pathway, suppressed the expression of gamma-H2AX, upregulated TIMP-1 expression while downregulating MMP expression levels in photoaged HaCaT cells, ultimately playing an anti-photoaging role.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Marine & Freshwater Biology
Yu Wang, Hongjing Zhao, Yachen Liu, Menghao Guo, Ye Tian, Puyi Huang, Mingwei Xing
Summary: This study investigated the brain damage caused by arsenite exposure in common carp and the protective effects of zinc ion supplementation. Results showed that zinc ion coadministration effectively alleviated oxidative damage, tight junction injuries, nerve conduction depletion, and apoptotic and autophagic cell death induced by arsenite in the brain.
AQUATIC TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiangchao Zeng, Ziqiong Wang, Lu Yu, Lei Wang, Yueling Liu, Yuxin Chen, Chunhong Wang
Summary: Zinc is an important trace element that plays a crucial role in growth, development, and male reproductive functions. Marginal zinc deficiency can lead to spermatogenic dysfunction in males. This study aimed to investigate methods to improve spermatogenic dysfunction caused by marginal zinc deficiency and explore the underlying mechanism. The results showed that zinc supplementation reduced oxidative stress levels and enhanced testicular cells' ability to resist apoptosis, thereby improving spermatogenic dysfunction caused by marginal zinc deficiency.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Food Science & Technology
Mingyue Qu, Qican He, Baoshi Guo
Summary: Lycopene has a protective effect against testicular damage induced by ionizing radiation, and the mechanism may involve inhibition of the mitochondrial apoptotic pathway and maintenance of mitochondrial respiration and biogenesis.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Junqi Men, Li Zhang, Ruiyun Peng, Yanyang Li, Meng Li, Hui Wang, Li Zhao, Jing Zhang, Haoyu Wang, Xinping Xu, Ji Dong, Juan Wang, Binwei Yao, Jiabin Guo
Summary: The present study demonstrated that exposure to 2.856 GHz microwave radiation caused significant structural and functional impairments of the male reproductive system, including hormone disorder, decreased sperm motility, depleted sperm energy, and abnormalities of testicular structure as well as mitochondrial impairment. However, metformin was found to effectively protect the reproductive system against these damages by inhibiting oxidative stress and apoptosis, indicating its potential as a promising antioxidant to mitigate the harmful effects of microwave radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nail Besli, Guven Yenmis, Matem Tuncdemir, Elif Yaprak Sarac, Sibel Dogan, Seyhun Solakoglu, Gonul Kanigur Sultuybek
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2020)
Article
Biochemistry & Molecular Biology
Dilek Duzgun Ergun, Sefa Ergun, Nural Pastaci Ozsobaci, Hafize Uzun, Dervis Ozcelik, Mustafa Taskin
TRACE ELEMENTS AND ELECTROLYTES
(2020)
Article
Biochemistry & Molecular Biology
Dilek Duzgun Ergun, Sefik Dursun, Nural Pastaci Ozsobaci, Ozden Hatirnaz Ng, Mustafa Naziroglu, Dervis Ozcelik
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
(2020)
Article
Biochemistry & Molecular Biology
D. Duzgun Ergun, S. Dursun, N. Pastaci Ozsobaci, M. Naziroglu, D. Ozcelik
Summary: This study elucidated the relationship between hypercapnia and the TRPM2 channel, as well as the effects of zinc, selenium, and glutathione. Experimental results showed that hypercapnia increased oxidative stress, but zinc, selenium, and glutathione were found to protect cells from damage caused by oxidative stress.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Cell Biology
Guven Yenmis, Elif Yaprak Sarac, Nail Besli, Tugba Soydas, Cihan Tastan, Derya Dilek Kancagi, Muhammet Yilanci, Kazim Senol, Onur Olgac Karagulle, Cumhur Gokhan Ekmekci, Ercument Ovali, Matem Tuncdemir, Turgut Ulutin, Gonul Kanigur Sultuybek
Summary: This in vitro study demonstrated that metformin can inhibit the proliferation and metastasis of primary breast cancer cells by modulating MMP-2 and MMP-9 expressions and interfering with the NF-kB signaling pathway. The highest inhibition was observed at a dose of 25 mM Metformin, which downregulated MMP-9 expression and blocked NF-kB activity and nuclear translocation. Metformin may play an essential antitumor role in the invasion and metastasis pathways of PBCCs.
Article
Biochemistry & Molecular Biology
Ahu Soyocak, Dilek Duzgun Ergun, Gulsah Koc, Sefa Ergun, Nural Pastaci Ozsobaci
Summary: Helicobacter pylori infection is the most common cause of chronic gastritis worldwide. This study investigated the relationship between serum levels of AhR, Zn, and vitamin B12 in H. pylori gastritis, finding that AhR serum levels increased in H. pylori positive chronic gastritis patients, while Zn and B12 levels were significantly decreased.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
G. Koc, A. Soyocak, D. Duzgun Ergun, N. Pastaci Ozsobaci, S. Andac-Ozturk, S. Ergun
Summary: This study found that H. pylori(+) patients have high serum Se and Cu/Zn ratios, with Cu/Zn ratio serving as a marker of bacterial inflammation. Furthermore, selenium was found to be statistically significant in the serums of H. pylori(+) patients carrying different genotypes, while levels of zinc, copper, and magnesium were significant in H. pylori(-) patients' serums as well.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biology
D. Duzgun Ergun, N. Pastaci Ozsobaci, T. Yilmaz, D. Ozcelik, M. T. Kalkan
Summary: As the use of mobile phones becomes more widespread, concerns about their impact on human health are growing. A study has found that the electromagnetic field (EMF) emitted by mobile phones may have negative effects on biological systems. This study investigates the effect of 2100 MHz EMF exposure on cancer fibroblast cells and explores the potential of zinc supplementation to mitigate these effects, finding that EMF exposure increases NF-kappa B and DNMT activities, while zinc supplementation reduces them.
ELECTROMAGNETIC BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Emre Onemli, Sulayman Joof, Cemanur Aydinalp, Nural Pastaci Ozsobaci, Fatma Ates Alkan, Nuray Kepil, Islem Rekik, Ibrahim Akduman, Tuba Yilmaz
Summary: Mammary carcinoma, or breast cancer, is the most common cancer type among women. Researchers are investigating potential new technologies for its diagnosis and treatment. One promising technique is using microwave applications to differentiate between malignant and normal tissues based on their dielectric properties. However, the current measurement technique is not accurate enough, so a new method is needed for confident detection of anomalies. This study proposes a classification method for rat mammary carcinoma based on large-scale in vivo S-11 measurements and corresponding tissue dielectric properties. Using a learning-based linear classifier, the tissues were classified with high accuracy, achieving an 86.92% accuracy when using the most discriminative S-11 measurement. These findings suggest that a narrow band microwave circuitry can support a low-cost automated microwave diagnostic system.
SCIENTIFIC REPORTS
(2022)
Article
Biophysics
Duygu Tarhan, Nural Pastaci Ozsobaci, Dilek Duzgun Ergun, Alev Meltem Ercan
Summary: Changes in extracellular medium osmolality can affect cell volume and cellular processes. This study examined the effects of zinc and regulation of extracellular osmolality on lung cancer cells, and found that zinc application and incubation time led to changes in element levels in the extracellular medium.
JOURNAL OF BIOLOGICAL PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
D. Duzgun Ergun, F. Doganer, G. Koc, A. Soyocak, N. Pastaci Ozsobaci, S. Ergun
Summary: This study aimed to investigate the association between superoxide dismutase-1 (SOD1) promoter region Ins/Del gene variations and chronic gastritis patients infected with H. pylori, as well as the effects of trace elements and viscosity. The results showed that zinc (Zn), copper (Cu), iron (Fe), and magnesium (Mg) levels decreased, while whole blood viscosity (WBV), selenium (Se), and Cu/Zn ratio increased in H. pylori (+) chronic gastritis patients. The Ins/Del gene polymorphism in the SOD1 promoter region was not associated with chronic gastritis.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Chemistry, Analytical
Bukem Tanoren, Ugur Parlatan, Melita Parlak, Berzem Selcuk, Fatma Ates Alkan, Nural Pastaci Ozsobaci, Gurcan Albeniz, Leyla Turker Sener, Isil Albeniz, Mehmet Burcin Unlu
Summary: This study investigates the effects of phthalates on rat livers using SAM, RS, and ICP-OES for the first time in the literature. The results show modifications in tissue components due to exposure to DEHP and DBP, with increased element levels within the tissues of rats exposed to these phthalates. Additionally, the presence of DEHP alters the configuration and conformation of lipids and fatty acids in liver tissues.
ANALYTICAL METHODS
(2021)
Article
Environmental Sciences
Filiz Aksu, Duygu Tarhan, Sema Sandikci Altunatmaz, Nural Pastaci Ozsobaci, Alev Meltem Ercan, Seydi Yikmis, Mehmet Erman Or, Harun Aksu
FRESENIUS ENVIRONMENTAL BULLETIN
(2020)
Article
Medicine, General & Internal
Oyku Kilinc, Hulya Arkan, Fahri Akbas, Erdal Polat, Matem Tuncdemir, Ilhan Onaran, Ahmet Ozaydin
