Article
Biochemical Research Methods
Sebastian Shaner, Anna Savelyeva, Anja Kvartuh, Nicole Jedrusik, Lukas Matter, Jose Leal, Maria Asplund
Summary: This study investigates the impact of direct current (DC) stimulation on the in vitro wound healing models of human keratinocytes. The results show that uni-directional electric stimulation significantly enhances the wound closure rate for both healthy and diabetic-like keratinocytes. This research provides hope for using controlled electrical stimulation to accelerate wound repair and serves as a baseline for optimizing electrode design for in vivo DC stimulation.
Article
Neurosciences
Yuxiao Ma, Chun Yang, Qian Liang, Zhenghui He, Weiji Weng, Jin Lei, Loren Skudder-Hill, Jiyao Jiang, Junfeng Feng
Summary: This study reveals the electrotaxis of BV2 microglia and highlights the essential role of the ERK/GSK3 beta/cofilin axis in regulating cell migration.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Thayaalini Subramaniam, Mh Busra Fauzi, Yogeswaran Lokanathan, Jia Xian Law
Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Ibrahim Tabakan, Ahmet Umut Yuvaci, Bora Tastekin, Isil Ocal, Aykut Pelit
Summary: This study evaluated the effect of pulsed electromagnetic field (PEMF) on cutaneous wound healing in an animal burn model. The results showed that two weeks of PEMF treatment significantly improved the stasis zone of burn wounds.
Article
Biochemistry & Molecular Biology
Junwei Xu, Yunxue Jia, Weizhen Huang, Qiusheng Shi, Xuemei Sun, Lisha Zheng, Ming Wang, Ping Li, Yubo Fan
Summary: Electrical stimulation has beneficial effects in skin tissue repair. Using non-contact electrical stimulation (NCES) reduces potential risks, and the study shows that NCES promotes cell and mice migration, proliferation, wound healing, and has potential for clinical treatment.
BIOELECTROCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jinrui Yang, Xiaoqiang Liu, Wenping Wang, Ying Chen, Jie Liu, Ze Zhang, Chao Wu, Xupin Jiang, Yi Liang, JiaPing Zhang
Summary: This study investigated the coordination function of electric fields (EFs) on wound healing and found that EF promotes wound contraction and re-epithelialization, accelerating the healing process. In vitro experiments demonstrated that EFs promote cell migration and collagen secretion. These findings support the continued development of EF for wound treatment applications.
BIOELECTROCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhang Feng, Chengyu Zang, Linfeng Zhang, Siyuan Yin, Qianqian Zhuang, Xiaojie Wang
Summary: The activation of STING is associated with delayed wound repair in diabetic skin, and enhanced STING expression may contribute to sustained inflammatory responses. In addition, the dysfunction of autophagy is correlated with STING expression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Engineering, Biomedical
Shuduan Mao, Junjie Man, Jialei Wang, Li Fu, Chengliang Yin, Hassan Karimi-Maleh
Summary: As the largest organ in the body, the skin plays vital roles in barrier function, immune response, water loss prevention, and waste excretion. Traditional treatment methods for skin lesions are still inadequate in terms of repair time, costs, and results. The rapid development of bioprinting technology has provided new ideas to overcome these challenges.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Medicine, Research & Experimental
T. B-D Mcewan, R. A. Sophocleous, P. Cuthbertson, K. J. Mansfield, M. L. Sanderson-Smith, R. Sluyter
Summary: The study revealed that scratched cells release adenosine 5'-triphosphate (ATP) which activates P2Y(2) receptors to facilitate wound closure in HaCaT keratinocytes. Inhibition of ATP release and P2Y(2) receptor activation impaired wound healing, highlighting the importance of autocrine purinergic signaling in this process.
Article
Biochemistry & Molecular Biology
Sun-Hye Choi, Kyung-Jong Won, Rami Lee, Han-Sung Cho, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study demonstrates that gintonin promotes wound healing by enhancing migration and proliferation of skin cells, as well as increasing vascular endothelial growth factor release, possibly through activation of LPA receptors and downstream signaling pathways involving VEGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
George Bibby, Blerta Krasniqi, Izaak Reddy, Durairaj Sekar, Kehinde Ross
Summary: Inhibition strategies targeting miRNAs can promote wound healing, and comparing chemical modifications of different miRNAs is essential to determine the most translationally viable options.
Review
Chemistry, Medicinal
Shasha Jia, Xueya Wang, Guowei Wang, Xiaojing Wang
Summary: Soft tissue damage stimulates the release of catecholamine hormones which bind to beta-adrenergic receptors on the cell membrane surface, impairing soft tissue wound healing. Beta-blockers inhibit this activation and accelerate wound healing by reducing inflammation, promoting cell migration, and inhibiting bacterial effects. They are being studied for their efficacy in various soft tissue wound repair applications, but further investigation into their mechanisms of action is necessary.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Engineering, Environmental
Xiao-Wei Xiang, Hao-Tian Liu, Wei Liu, Ze-Yao Yan, Yu-Lian Zeng, Ya-Jun Wang, Jing Liu, Yu-Chen Chen, Sai-Xi Yu, Cai-Hui Zhu, Xiao-Nan Tao, Chen Wang, Jin-Tao Wu, Yang Du, Xin-Xin Xu, Hai Gao, Yaming Jiu, Jiong Ma, Jian Qiu, Lingqian Chang, Guangyin Jing, Ke-Fu Liu, Yan-Jun Liu
Summary: Electrical stimulations, specifically ultrashort pulse electric field (PEF), can promote wound healing by regulating fibroblast migration and extracellular matrix alignment. In a mouse model, microsecond PEF treatment demonstrated a significant enhancement in wound healing. This technology has potential applications in regenerative medicine and tissue engineering.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Xixi Chen, Gaozan Tong, Junfu Fan, Yingjie Shen, Nan Wang, Wenjie Gong, Zijing Hu, Kunxuan Zhu, Xiaokun Li, Litai Jin, Weitao Cong, Jian Xiao, Zhongxin Zhu
Summary: FGF21 plays a crucial role in promoting migration and differentiation of epidermal cells during wound healing, potentially through activation of fibroblasts and regulation of autophagy-related pathways. It may serve as a novel therapeutic target for accelerating wound healing processes.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Keyan Hu, Xueying Liu, Hongfeng Chang, Yi Zhang, Hui Zhou, Lei Liu, Xin Zhang, Ziying Jiao, Bing Shen, Qiu Zhang
Summary: The study found that miR-221-3p can promote wound healing in diabetes by targeting THBS1. Lack of miR-221-3p may result in impaired healing in chronic wounds of type 2 diabetes.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Dermatology
Yi-ming Zhang, Zhi-qing Zhang, Yuan-yuan Lu, Xin Zhou, Xiao-hua Shi, Qin Jiang, Dong-li Fan, Cong Cao
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2015)
Article
Nanoscience & Nanotechnology
Ze-yuan Lei, Ting Liu, Wei-juan Li, Xiao-hua Shi, Dong-li Fan
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2016)
Article
Surgery
Xin Zhou, Xing Chen, Tong-cun Mao, Xiang Li, Xiao-hua Shi, Dong-li Fan, Yi-ming Zhang
PLASTIC AND RECONSTRUCTIVE SURGERY
(2016)
Review
Surgery
Xiao-hua Shi, Xin Zhou, Yi-ming Zhang, Ze-yuan Lei, Ting Liu, Dong-li Fan
AESTHETIC SURGERY JOURNAL
(2016)
Article
Dermatology
Xin Chen, Xin Zhou, Xiaohua Shi, Xin Xia, Yiming Zhang, Dongli Fan
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Surgery
Shu-qing Huang, Yao Chen, Qiong Zhu, Yi-ming Zhang, Ze-yuan Lei, Xin Zhou, Dong-li Fan
Summary: This study investigated the effects of different surface textures of silicone breast implants on the behaviors of fibroblasts and capsular formation. The results showed that as surface roughness increased, the adhesion and cell spreading of fibroblasts decreased, while the proliferation of fibroblasts and capsule thickness increased. The number of myofibroblasts may have a more significant influence on the process of contracture than capsule thickness in the early stage of capsular formation.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Cell & Tissue Engineering
Chengcheng Shen, Yuangang Lu, Jianghe Zhang, Yujie Li, Yiming Zhang, Dongli Fan
Summary: The study demonstrated that downregulation of c-Cbl could attenuate the impairment of proangiogenic functions in MSCs induced by long-term culture in vitro, thereby improving the effect of long-term cultured MSCs in promoting diabetic wound healing.
CELL TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Priyanga Kumar, Noel Nesakumar, Jayashree Gopal, Sakthivel Sivasubramanian, Srinivasan Vedantham, John Bosco Balaguru Rayappan
Summary: This study developed an electrochemical biosensor for measuring MG levels in the plasma of type-2 diabetes mellitus patients. The biosensor showed a wide linear concentration range, high sensitivity, and a 90% correlation with ELISA data. It also exhibited a significant correlation with HbA1c and fasting plasma glucose levels.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Cristina Tortolini, Valeria Gigli, Antonio Angeloni, Federico Tasca, Nguyen T. K. Thanh, Riccarda Antiochia
Summary: The development of a novel voltammetric immunosensor for the detection of salivary MMP-8 at the point-of-care is described. The sensor showed good performance and comparable results to the conventional ELISA method when tested in real saliva samples. This biosensor is single-use, cost-effective, and requires a small quantity of test medium and a short preparation time.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Rimsha B. Jamal, Ulrich Bay Gosewinkel, Elena E. Ferapontova
Summary: Pathogen-triggered infections are a severe global threat to human health. Researchers have developed a fast and inexpensive electrocatalytic aptamer assay for the specific and ultrasensitive detection of E. coli, allowing for timely treatment and prevention. The method is fast, sensitive, and can be used in field and point-of-care applications for analysis of bacteria in the human environment.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Miao Liu, Yuwei Wang, Shanshan Tang, Wei Wang, Axin Liang, Aiqin Luo
Summary: An unlabeled ratiometric molecular imprinted electrochemiluminescence sensor was developed for the determination of trace uric acid using MXene@NaAsc, CdSe@ZnS quantum dots, and molecularly imprinted polymer composites modified glass carbon electrode. This sensor, with easy preparation, great selectivity, and excellent sensitivity, successfully detected uric acid in human serum.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Charlotte Da Silva, Camille Lamarche, Carole Pichereaux, Emmanuelle Mouton-Barbosa, Gauthier Demol, Sebastien Boisne, Etienne Dague, Odile Burlet-Schiltz, Flavien Pillet, Marie-Pierre Rols
Summary: Low-energy electron beams (LEEB) are a safe and practical sterilization solution for industrial applications. To address the limitations of LEEB, we developed a low-energy pulsed electron beam generator (LEPEB) that can effectively and efficiently eradicate bacteria in a wide range of industrial applications.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Daniel Dobrovodsky, Ales Danhel, Daniel Renciuk, Jean-Louis Mergny, Miroslav Fojta
Summary: In this study, N-methyl mesoporphyrin IX (NMM) was utilized as a voltammetric probe for the electrochemical detection of G4s. The detection of NMM was achieved by cyclic voltammetry on a hanging mercury drop electrode (HMDE) with a limit of detection (LOD) of 40 nM. The reduction signal of NMM was found to be significantly higher when G4 oligodeoxynucleotides (G4 ODNs) were present compared to single- or double-stranded ODNs or unfolded ODNs capable of forming G4s. Gradual transition from unstructured single strand to G4, induced by increasing concentrations of the G4 stabilizing K+ ions, was detected for the first time using electrochemical methods. Circular dichroism spectroscopy provided support for the obtained results. This work expands on the utilization of electrochemical probes for DNA secondary structure recognition and offers a proof of principle for the development of novel electroanalytical methods for nucleic acid structure studies.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Mengjiao Zhu, Yu Liu, Meiyue Wang, Tao Liu, Zhenyu Chu, Wanqin Jin
Summary: Early rapid diagnosis of COVID-19 is crucial for reducing the risk of severe symptoms and loss of lung function. Researchers have proposed an ultrafast and ultrasensitive DNA sensor that can accurately detect the virus in a short period of time, with outstanding selectivity.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fatima-Zahra Ait-Itto, James A. Behan, Mathieu Martinez, Frederic Barriere
Summary: This study investigated the feasibility of using ancient marine sediments as inoculum for bioanode development in microbial fuel cells (MFC). The results showed the presence of two exoelectrogenic bacterial genera in these iron-rich sediments and confirmed that the development of the bioanode derived from the native microbiota. This study has important implications for understanding the role of these bacteria in broader paleoenvironmental phenomena.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Issa Fall, Bastien Doumeche, Sofiene Abdellaoui, Caroline Remond, Harivony Rakotoarivonina, Marjorie Ochs
Summary: This article presents a novel electrochemical tool based on lignin-coated paper electrodes for the detection and characterization of ligninolytic activity. The suitability of this method has been demonstrated using a catalaseperoxidase isolated from Thermobacillus xylanilyticus.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Chenyi Zhuo, Dehong Yu, Jiuying Cui, Zichun Song, Qianli Tang, Xianjiu Liao, Zhao Liu, Ning Xin, Lu Lou, Fenglei Gao
Summary: A label-free detection strategy for quantification of Apolipoprotein A4 (Apo-A4) has been developed based on rolling circle amplification (RCA) and proximity hybridization-induced DNAzyme-driven bipedal DNA walker. This method shows high sensitivity and selectivity for a wide range of protein targets.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Niloufar Fattahi, Jeffrey Reed, Evan Heronemus, Priyasha Fernando, Ryan Hansen, Prathap Parameswaran
Summary: In this study, polyethylene glycol hydrogels were developed as protective coatings for electroactive biofilms, improving their viability under low resource conditions and ammonia-N shocks.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiaopeng Hou, Qiongyi Cheng, Hui Wang
Summary: A self-cleaning paper-based microfluidic biosensor was developed using hydrophobic paper decorated with polymeric octadecyl trichlorosilane. The biosensor showed improved performance and could effectively measure the concentration of copper ions in livestock feed and manure.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yanling Zhang, Jie Wang, Min Liu, Yun Ni, Yao Yue, Dawei He, Ruijiang Liu
Summary: An innovative electrochemical biosensor has been developed for sensitive detection of HER2 protein, an important tumor marker for breast cancer diagnosis and treatment evaluation. The biosensor utilizes specific recognition probes and nanomaterials, along with a unique sensing strategy, to achieve ultra-low detection limit and demonstrate excellent selectivity, reproducibility, and stability.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Humayun Amir, Vasanth Subramanian, Sundaram Sornambikai, Nagamony Ponpandian, Chinnusamy Viswanathan
Summary: In this study, the electrochemical detection of breast cancer biomarker HER2 was successfully achieved using the N-CQDs/GS as the detector. The BSA-modified HER2 Antibody/N-CQDs/GS immunoelectrode preserved excellent activity for the biosensor, while the GS electrode provided high stability and conductivity. The method exhibited a low detection limit and optimal specificity, stability, and reproducibility for detecting HER-2 protein in untreated blood samples from breast cancer patients.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ilona Uzieliene, Anton Popov, Raminta Vaiciuleviciute, Gailute Kirdaite, Eiva Bernotiene, Almira Ramanaviciene
Summary: This review discusses the application of polypyrrole (Ppy), an electroconductive polymer, in cell culture experiments with electrical stimulation (ES) and its potential for tissue regeneration. Ppy can direct ES to cells and stimulate differentiation towards different cell lineages. Different types of Ppy materials and their combination with active molecules are explored.
BIOELECTROCHEMISTRY
(2024)