Article
Biology
Melina Hussmann, Dorte Schulte, Sarah Weischer, Claudia Carlantoni, Hiroyuki Nakajima, Naoki Mochizuki, Didier Y. R. Stainier, Thomas Zobel, Manuel Koch, Stefan Schulte-Merker, Victoria L. Bautch
Summary: This study reveals the critical roles of Svep1 and Tie1 in the development of specific subpopulations of the zebrafish facial lymphatic network. It also shows that this aspect of the network is formed independently of Vegfc signaling. The findings demonstrate the importance of Tie1 signaling in lymphangiogenesis and blood vessel development in zebrafish.
Article
Biotechnology & Applied Microbiology
Hongwei Fan, Rong Ai, Suen Mu, Xuemin Niu, Zhengrong Guo, Lin Liu
Summary: Research has found that miR-19a promotes the proliferation, migration, and invasion of colorectal cancer cells. It has been discovered that miR-19a suppresses ferroptosis by negatively regulating IREB2. This finding reveals a novel mechanism of miR-19a-mediated ferroptosis in CRC.
Article
Biotechnology & Applied Microbiology
Wenxin Dai, Wangyuan Zeng, Dongwon Lee
Summary: MCM3AP-AS1 is down-regulated in colorectal cancer and its dysregulation is associated with unfavorable pathological characteristics. It significantly inhibits the proliferation and migration of CRC cells by acting as a molecular sponge to suppress miR-19a-3p expression and modulating FOXF2 expression.
JOURNAL OF GENE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Laura Dupont, Loic Joannes, Florent Morfoisse, Silvia Blacher, Christine Monseur, Christophe F. Deroanne, Agnes Noel, Alain C. M. A. Colige
Summary: The study demonstrates that ADAMTS2 and ADAMTS14 are as efficient as ADAMTS3 in activating pro-VEGFC and play a crucial role in maintaining the homeostasis of the lymphatic vasculature in adulthood.
Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Article
Oncology
Peng Shen, Lili Qu, Jingjing Wang, Quchen Ding, Chuanwen Zhou, Rui Xie, Honggang Wang, Guozhong Ji
Summary: LINC00342, identified as a novel oncogene, promotes CRC progression by competitively binding miR-19a-3p with NPEPL1. Its down-regulation inhibits cell proliferation and metastasis, and further investigation suggests that LINC00342 acts as a sponge for miR-19a-3p to regulate NPEPL1 expression.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Jingtong Li, Zhifeng Yan, Jianli Ma, Zhong Chu, Huizi Li, Jingjing Guo, Qingyuan Zhang, Hui Zhao, Ying Li, Tao Wang
Summary: Lymphangiogenesis, the growth of lymphatic vessels, is crucial for the progression and metastasis of breast cancer as well as immune response. This study reveals the role of transcription factor ZKSCAN5 in interacting with histone methyltransferase SETD7 to regulate VEGFC transcription and tumor lymphangiogenesis. High expression of ZKSCAN5 is associated with poor prognosis in breast cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yali Wang, Weimin Zhang, Wenzhong Liu, Lijie Huang, Yan Wang, Dan Li, Guangchao Wang, Zitong Zhao, Xinming Chi, Yu Xue, Yongmei Song, Xuefeng Liu, Qimin Zhan
Summary: This study revealed a novel lncRNA-guided mechanism of lymph node metastasis in ESCC, in which VESTAR played a key role in lymphatic metastasis. This may provide a potential target for the treatment of ESCC lymphatic metastasis.
Article
Mathematical & Computational Biology
Gang Xu, Junlong Li, Lihang Yu
Summary: The study found that miR-19a-3p is increased in BLCA cells, while THBS1 is less expressed in BLCA cells. miR-19a-3p acts as an oncogene in BLCA, with THBS1 being a target of miR-19a-3p and able to reverse the promoting effect of miR-19a-3p on malignant behaviors in BLCA cells. This suggests that miR-19a-3p facilitates cell progression in BLCA by binding THBS1, indicating a potential therapeutic target for BLCA treatment.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2021)
Article
Cell Biology
Huiwen Li, Bo Huang
Summary: The overexpression of miR-19a decreases CLCA4 levels to promote the oncogenesis of colorectal cancer (CRC). miR-19a inhibitors may have potential applications for future therapeutic of CRC.
EUROPEAN JOURNAL OF HISTOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Mayuki Omatsu, Yuki Nakanishi, Kosuke Iwane, Naoki Aoyama, Angeles Duran, Yu Muta, Anxo Martinez-Ordonez, Qixiu Han, Nobukazu Agatsuma, Kenta Mizukoshi, Munenori Kawai, Go Yamakawa, Mio Namikawa, Kensuke Hamada, Yuichi Fukunaga, Takahiro Utsumi, Makoto Sono, Tomonori Masuda, Akitaka Hata, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Satoshi Ogawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Toshiaki Kogame, Hiroaki Kasashima, Nobuyuki Kakiuchi, Masahiro M. Nakagawa, Kenji Kawada, Masakazu Yashiro, Kiyoshi Maeda, Yasuyuki Saito, Takashi Matozaki, Akihisa Fukuda, Kenji Kabashima, Kazutaka Obama, Seishi Ogawa, Nader Sheibani, Maria T. Diaz-Meco, Jorge Moscat, Hiroshi Seno
Summary: This study establishes a positive link between high thrombospondin-1 (THBS1) expression and mesenchymal characteristics, immunosuppression, and poor prognosis in colorectal cancer (CRC). Bone marrow-derived monocyte-like cells are identified as the primary source of THBS1, contributing to metastasis development by inducing cytotoxic T-cell exhaustion and impairing vascularization. Furthermore, THBS1 loss in the tumor microenvironment renders CRC partially sensitive to immune checkpoint inhibitors and anti-cancer drugs.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ran-Ran Ma, Hui Zhang, Hong-Fang Chen, Guo-Hao Zhang, Ya-Ru Tian, Peng Gao
Summary: This study revealed that the decreased expression of KIF26A in gastric cancer patients is associated with disease progression, metastasis, and poor survival. By regulating the focal-adhesion pathway and suppressing the occurrence of epithelial-to-mesenchymal transition, KIF26A can inhibit tumor cell migration and invasion.
Article
Oncology
Xiaohui Zhang, Tingyu Li, Ya-Nan Han, Minghui Ge, Pei Wang, Lina Sun, Hao Liu, Tianyu Cao, Yongzhan Nie, Daiming Fan, Hao Guo, Kaichun Wu, Xiaodi Zhao, Yuanyuan Lu
Summary: In this study, we identified a novel mechanism by which miR-125b enhances metastasis in CRC by targeting CFTR and CGN, promoting EMT and uPA expression and secretion, and enhancing RhoA/ROCK signaling pathway. These findings suggest miR-125b as a key functional molecule in CRC and a promising biomarker for the diagnosis and treatment of CRC.
Article
Cell Biology
Aurore Dumond, Christopher Montemagno, Valerie Vial, Renaud Grepin, Gilles Pages
Summary: The study developed specific mouse monoclonal antibodies targeting VEGFC for the treatment of mccRCC, showing potential in inhibiting the growth of metastatic clear cell renal cell carcinoma.
Article
Biochemistry & Molecular Biology
Qi Zhang, Changli Wang, Yufei Wu, Jingjing Liu, Tianyi Wang, Bing Wang
Summary: This study investigated the functions and molecular mechanism of BAP31 on the miR-206/133b cluster in colorectal cancer (CRC). The results showed that BAP31 overexpression led to a reduction in the expression of the miR-206/133b cluster, which was correlated with the transendothelial migration capability of CRC cells. The miR-206/133b cluster was found to directly regulate cell division cycle 42 (CDC42) and actin-related protein 2/3 complex subunit 5 (ARPC5) in the tight junction pathway (hsa04530), and the potential transcription regulator of the miR-206/133b cluster was identified as Homeobox D10 (HOXD10). The study further elucidated the molecular mechanisms and functional mechanisms of BAP31's regulatory role in the expression levels of the miR-206/133b cluster by inhibiting HOXD10 translocation from the cytoplasm to the nucleus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)