Storing memories: the distinct phases of Polycomb-mediated silencing of Arabidopsis FLC

RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

(2019) Qi Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits

(2018) Daniel T. Youmans et al.   GENES & DEVELOPMENT

Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2

(2018) Chul-Hwan Lee et al.   MOLECULAR CELL

Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding

(2018) Siming Chen et al.   MOLECULAR CELL

Capturing the Onset of PRC2-Mediated Repressive Domain Formation

(2018) Ozgur Oksuz et al.   MOLECULAR CELL

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

(2018) Jonas W. Højfeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?

(2018) David J. Hanly et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Structures of human PRC2 with its cofactors AEBP2 and JARID2

(2018) Vignesh Kasinath et al.   SCIENCE

Architecture of PRC2 Holo Complexes

(2018) Kendra R. Vann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

(2018) Jonas W. Højfeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exon Junction Complexes can have distinct functional flavours to regulate specific splicing events

(2018) Zhen Wang et al.   Scientific Reports

Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding

(2018) Vignesh Kasinath et al.   BIOCHEMISTRY

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

(2018) Kenneth KH Ng et al.   eLife

Disruption of an RNA-binding hinge region abolishes LHP1-mediated epigenetic repression

(2017) Scott Berry et al.   GENES & DEVELOPMENT

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

(2017) Jeongyoon Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells inArabidopsis thaliana

(2017) Yue Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Propagation of Polycomb-repressed chromatin requires sequence-specific recruitment to DNA

(2017) Friederike Laprell et al.   SCIENCE

Distinct phases of Polycomb silencing to hold epigenetic memory of cold inArabidopsis

(2017) Hongchun Yang et al.   SCIENCE

Transgenerational transmission of environmental information in C. elegans

(2017) Adam Klosin et al.   SCIENCE

DNA replication–coupled histone modification maintains Polycomb gene silencing in plants

(2017) Danhua Jiang et al.   SCIENCE

Causal role for inheritance of H3K27me3 in maintaining the OFF state of a Drosophila HOX gene

(2017) Rory T. Coleman et al.   SCIENCE

Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity

(2017) Daniel Holoch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

(2017) Jeongyoon Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity

(2017) Scott Berry et al.   Cell Systems

The interaction of PRC2 with RNA or chromatin is mutually antagonistic

(2016) Manuel Beltran et al.   GENOME RESEARCH

A cis cold memory element and a trans epigenome reader mediate Polycomb silencing of FLC by vernalization in Arabidopsis

(2016) Wenya Yuan et al.   NATURE GENETICS

Arabidopsis DNA polymerase ϵ recruits components of Polycomb repressor complex to mediate epigenetic gene silencing

(2016) Iván del Olmo et al.   NUCLEIC ACIDS RESEARCH

Arabidopsis transcriptional repressor VAL1 triggers Polycomb silencing at FLC during vernalization

(2016) Julia I. Qüesta et al.   SCIENCE

Nucleation and spreading of a heterochromatic domain in fission yeast

(2016) Michaela J. Obersriebnig et al.   Nature Communications

Mutually exclusive sense–antisense transcription at FLC facilitates environmentally induced gene repression

(2016) Stefanie Rosa et al.   Nature Communications

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

(2016) Neil Justin et al.   Nature Communications

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

(2016) Alexei Brooun et al.   Nature Communications

Arabidopsis Flower and Embryo Developmental Genes are Repressed in Seedlings by Different Combinations of Polycomb Group Proteins in Association with Distinct Sets of Cis-regulatory Elements

(2016) Hua Wang et al.   PLoS Genetics

The quest for mammalian Polycomb response elements: are we there yet?

(2015) Moritz Bauer et al.   CHROMOSOMA

Two distinct modes for propagation of histone PTMs across the cell cycle

(2015) Constance Alabert et al.   GENES & DEVELOPMENT

Toward a Consensus on the Binding Specificity and Promiscuity of PRC2 for RNA

(2015) Chen Davidovich et al.   MOLECULAR CELL

Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions

(2015) Jian Xu et al.   MOLECULAR CELL

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation

(2015) Serena Sanulli et al.   MOLECULAR CELL

Vernalizing cold is registered digitally atFLC

(2015) Andrew Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

(2015) L. Jiao et al.   SCIENCE

Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance

(2015) Scott Berry et al.   eLife

The Fork in the Road: Histone Partitioning During DNA Replication

(2015) Anthony Annunziato   Genes

Antagonistic Roles for H3K36me3 and H3K27me3 in the Cold-Induced Epigenetic Switch at Arabidopsis FLC

(2014) Hongchun Yang et al.   CURRENT BIOLOGY

Nascent RNA interaction keeps PRC2 activity poised and in check

(2014) Syuzo Kaneko et al.   GENES & DEVELOPMENT

Regulatory Interactions between RNA and Polycomb Repressive Complex 2

(2014) Catherine Cifuentes-Rojas et al.   MOLECULAR CELL

Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide

(2014) Eva Madi Riising et al.   MOLECULAR CELL

Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state

(2014) Pedro Crevillén et al.   NATURE

AntisenseCOOLAIRmediates the coordinated switching of chromatin states atFLCduring vernalization

(2014) Tibor Csorba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arabidopsis MSI1 connects LHP1 to PRC2 complexes

(2013) Maria Derkacheva et al.   EMBO JOURNAL

Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization

(2013) S. Rosa et al.   GENES & DEVELOPMENT

Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin

(2013) J. Son et al.   GENES & DEVELOPMENT

A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb

(2013) A. R. Pengelly et al.   SCIENCE

Regulation of the seed to seedling developmental phase transition by the LAFL and VAL transcription factor networks

(2013) Haiyan Jia et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The catalytic subunit of Arabidopsis DNA polymerase   ensures stable maintenance of histone modification

(2012) Y. Hyun et al.   DEVELOPMENT

Molecular architecture of human polycomb repressive complex 2

(2012) Claudio Ciferri et al.   eLife

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

A Polycomb-based switch underlying quantitative epigenetic memory

(2011) Andrew Angel et al.   NATURE

FLC: A Hidden Polycomb Response Element Shows Up in Silence

(2011) D. M. Buzas et al.   PLANT AND CELL PHYSIOLOGY

Transcription-dependence of histone H3 lysine 27 trimethylation at the Arabidopsis polycomb target gene FLC

(2010) Diana Mihaela Buzas et al.   PLANT JOURNAL

Vernalization-Mediated Epigenetic Silencing by a Long Intronic Noncoding RNA

(2010) J. B. Heo et al.   SCIENCE

Cold-induced silencing by long antisense transcripts of an Arabidopsis Polycomb target

(2009) Szymon Swiezewski et al.   NATURE

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL

A model for transmission of the H3K27me3 epigenetic mark

(2008) Klaus H. Hansen et al.   NATURE CELL BIOLOGY

Resetting and regulation ofFLOWERING LOCUS Cexpression during Arabidopsis reproductive development

(2008) Jean Choi et al.   PLANT JOURNAL

Resetting of FLOWERING LOCUS C expression after epigenetic repression by vernalization

(2008) C. C. Sheldon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A PHD-Polycomb Repressive Complex 2 triggers the epigenetic silencing of FLC during vernalization

(2008) F. De Lucia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA