TET enzymes, DNA demethylation and pluripotency

Pluripotency Deconstructed

(2018) Masaki Kinoshita et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells

(2018) Diana Guallar et al.   NATURE GENETICS

Sin3a–Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency

(2018) Fugui Zhu et al.   NUCLEIC ACIDS RESEARCH

Single-Cell DNA Methylation Profiling: Technologies and Biological Applications

(2018) Ino D. Karemaker et al.   TRENDS IN BIOTECHNOLOGY

Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate

(2018) Jose Luis Sardina et al.   Cell Stem Cell

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

(2018) Peter W. S. Hill et al.   NATURE

Amphioxus functional genomics and the origins of vertebrate gene regulation

(2018) Ferdinand Marlétaz et al.   NATURE

Functions and mechanisms of epigenetic inheritance in animals

(2018) Ksenia Skvortsova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

(2018) Joel Hrit et al.   eLife

Lineage-specific functions of TET1 in the postimplantation mouse embryo

(2017) Rita Khoueiry et al.   NATURE GENETICS

TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells

(2017) Nipun Verma et al.   NATURE GENETICS

TET-mediated active DNA demethylation: mechanism, function and beyond

(2017) Xiaoji Wu et al.   NATURE REVIEWS GENETICS

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development

(2016) Wenhao Zhang et al.   MOLECULAR CELL

TET-mediated DNA demethylation controls gastrulation by regulating Lefty–Nodal signalling

(2016) Hai-Qiang Dai et al.   NATURE

Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction

(2016) Dylan Mooijman et al.   NATURE BIOTECHNOLOGY

De novo DNA methylation drives 5hmC accumulation in mouse zygotes

(2016) Rachel Amouroux et al.   NATURE CELL BIOLOGY

Active DNA demethylation at enhancers during the vertebrate phylotypic period

(2016) Ozren Bogdanović et al.   NATURE GENETICS

Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling

(2016) Xiang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms

(2016) Timothy Alexander Hore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming

(2015) Junjun Ding et al.   Cell Stem Cell

The pluripotent state in mouse and human

(2015) K. C. Davidson et al.   DEVELOPMENT

Molecular Evolution of the TET Gene Family in Mammals

(2015) Hiromichi Akahori et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis

(2015) Jinsuk Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence

(2015) Cheng Li et al.   Cell Reports

Unusual Characteristics of the DNA Binding Domain of Epigenetic Regulatory Protein MeCP2 Determine Its Binding Specificity

(2014) Sergei Khrapunov et al.   BIOCHEMISTRY

Hydroxymethylation of DNA influences nucleosomal conformation and stability in vitro

(2014) Agnes Mendonca et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Reprogramming the Methylome: Erasing Memory and Creating Diversity

(2014) Heather J. Lee et al.   Cell Stem Cell

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

(2014) Meelad M. Dawlaty et al.   DEVELOPMENTAL CELL

Role of Tet proteins in enhancer activity and telomere elongation

(2014) Falong Lu et al.   GENES & DEVELOPMENT

5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation

(2014) Gary C. Hon et al.   MOLECULAR CELL

Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells

(2014) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

(2013) Cornelia G. Spruijt et al.   CELL

Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming

(2013) Yawei Gao et al.   Cell Stem Cell

Stage-Specific Roles for Tet1 and Tet2 in DNA Demethylation in Primordial Germ Cells

(2013) John J. Vincent et al.   Cell Stem Cell

FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

(2013) Gabriella Ficz et al.   Cell Stem Cell

Whole-Genome Bisulfite Sequencing of Two Distinct Interconvertible DNA Methylomes of Mouse Embryonic Stem Cells

(2013) Ehsan Habibi et al.   Cell Stem Cell

Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition

(2013) Run-Rui Zhang et al.   Cell Stem Cell

PRDM14 promotes active DNA demethylation through the Ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells

(2013) N. Okashita et al.   DEVELOPMENT

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

(2013) Meelad M. Dawlaty et al.   DEVELOPMENTAL CELL

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

(2013) Rachel Deplus et al.   EMBO JOURNAL

A double take on bivalent promoters

(2013) P. Voigt et al.   GENES & DEVELOPMENT

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells

(2013) Bruno Di Stefano et al.   NATURE

Role of Tet1 in erasure of genomic imprinting

(2013) Shinpei Yamaguchi et al.   NATURE

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

(2013) Yael Costa et al.   NATURE

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

(2013) Myunggon Ko et al.   NATURE

Vitamin C modulates TET1 function during somatic cell reprogramming

(2013) Jiekai Chen et al.   NATURE GENETICS

Naive pluripotency is associated with global DNA hypomethylation

(2013) Harry G Leitch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction

(2013) Andrii Rudenko et al.   NEURON

Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells

(2013) Francesco Neri et al.   GENOME BIOLOGY

Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development

(2012) Yufei Xu et al.   CELL

5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development

(2012) Rimple D. Almeida et al.   Epigenetics

Global profiling of DNA methylation erasure in mouse primordial germ cells

(2012) S. Guibert et al.   GENOME RESEARCH

TET2 promotes histone O-GlcNAcylation during gene transcription

(2012) Qiang Chen et al.   NATURE

Tet1 controls meiosis by regulating meiotic gene expression

(2012) Shinpei Yamaguchi et al.   NATURE

Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine

(2012) J. A. Hackett et al.   SCIENCE

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

(2011) Z. Li et al.   BLOOD

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation

(2011) Luisa Cimmino et al.   Cell Stem Cell

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

(2011) Meelad M. Dawlaty et al.   Cell Stem Cell

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

(2011) Kian Peng Koh et al.   Cell Stem Cell

Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine

(2011) Atanu Maiti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

(2011) Tian-Peng Gu et al.   NATURE

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

(2011) Kristine Williams et al.   NATURE

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

(2011) Gabriella Ficz et al.   NATURE

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells

(2011) Hao Wu et al.   NATURE

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

(2011) Johannes M. Freudenberg et al.   NUCLEIC ACIDS RESEARCH

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA

(2010) Aleksandra Szwagierczak et al.   NUCLEIC ACIDS RESEARCH

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE